{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:53:38Z","timestamp":1775022818806,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Owing to progress in perinatal medicine, the survival of preterm newborns has markedly increased. However, the incidence of cerebral palsy has risen in association with increased preterm birth. Cerebral palsy is largely caused by cerebral hypoxic ischemia (HI), for which there are no effective medical treatments. We evaluated the effects of stromal cell-derived factor-1\u03b1 (SDF-1\u03b1) on neonatal brain damage in rats. Left common carotid (LCC) arteries of seven-day-old Wistar rat pups were ligated, and animals were exposed to hypoxic gas to cause cerebral HI. Behavioral tests revealed that the memory and spatial perception abilities were disturbed in HI animals, and that SDF-1\u03b1 treatment improved these cognitive functions. Motor coordination was also impaired after HI but was unimproved by SDF-1\u03b1 treatment. SDF-1\u03b1 reduced intracranial inflammation and induced cerebral remyelination, as indicated by the immunohistochemistry results. These data suggest that SDF-1\u03b1 specifically influences spatial perception abilities in neonatal HI encephalopathy.<\/jats:p>","DOI":"10.3390\/ijms160818018","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T05:43:13Z","timestamp":1439876593000},"page":"18018-18032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Stromal Cell-Derived Factor-1\u03b1 Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats"],"prefix":"10.3390","volume":"16","author":[{"given":"Miki","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Uchikura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrcardio.2011.85","article-title":"The therapeutic potential of ischemic conditioning: An updated","volume":"8","author":"Hausenloy","year":"2011","journal-title":"Nat. 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