{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:30:56Z","timestamp":1791725456718,"version":"4.3.4"},"reference-count":175,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic 5-HT1A agonists could form a new class of antidepressant drugs, and mixed 5-HT1A receptor ligands\/serotonin transporter (SERT) inhibitors seem to possess an interesting pharmacological profile. It should, however, be noted that 5-HT1A receptors can activate several different biochemical pathways and signal through both G protein-dependent and G protein-independent pathways. The variables that affect the multiplicity of 5-HT1A receptor signaling pathways would thus result from the summation of effects specific to the host cell milieu. Moreover, receptor trafficking appears different at pre- and postsynaptic sites. It should also be noted that the 5-HT1A receptor cooperates with other signal transduction systems (like the 5-HT1B or 5-HT2A\/2B\/2C receptors, the GABAergic and the glutaminergic systems), which also contribute to its antidepressant and\/or anxiolytic activity. Thus identifying brain specific molecular targets for 5-HT1A receptor ligands may result in a better targeting, raising a hope for more effective medicines for various pathologies.<\/jats:p>","DOI":"10.3390\/ijms160818474","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:21Z","timestamp":1438943121000},"page":"18474-18506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands"],"prefix":"10.3390","volume":"16","author":[{"given":"Zdzis\u0142aw","family":"Chilmonczyk","sequence":"first","affiliation":[{"name":"National Medicines Institute, Che\u0142mska 30\/34, 00-725 Warszawa, Poland"},{"name":"Institute of Nursing and Health Sciences, University of Rzesz\u00f3w, W. Kopisto 2A, 35-310 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Bojarski","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Pilc","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingebrigt","family":"Sylte","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Troms\u00f8\u2014The Arctic University of Norway, No-9037 Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0163-7258(01)00169-3","article-title":"Multiplicity of mechanisms of serotonin receptor signal transduction","volume":"92","author":"Raymond","year":"2001","journal-title":"Pharmacol. 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