{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:59:10Z","timestamp":1791644350276,"version":"4.3.4"},"reference-count":65,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1\/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1\/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of  sFlt-1\/PlGF and propose a new protocol for its clinical integration.<\/jats:p>","DOI":"10.3390\/ijms160819009","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T11:13:57Z","timestamp":1439464437000},"page":"19009-19026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Angiogenesis-Related Biomarkers (sFlt-1\/PLGF) in the Prediction and Diagnosis of Placental Dysfunction:  An Approach for Clinical Integration"],"prefix":"10.3390","volume":"16","author":[{"given":"Ignacio","family":"Herraiz","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"G\u00f3mez-Arriaga","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mart\u00ednez-Moratalla","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Garc\u00eda-Burguillo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Hospital Universitario \"12 de Octubre\", Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Galindo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario \"12 de Octubre\",  Universidad Complutense de Madrid, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semperi.2014.03.002","article-title":"Prediction and prevention of ischemic placental disease","volume":"38","author":"Friedman","year":"2014","journal-title":"Semin. 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