{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:48Z","timestamp":1791310668407,"version":"4.3.1"},"reference-count":28,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bronchopulmonary dysplasia (BPD) is one of the most common complications  of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids \u03c9-3 (PUFA \u03c9-3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA \u03c9-3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia. Pregnant female Wistar rats (n = 14) were fed a control diet (n = 2), a PUFA \u03c9-6 diet (n = 6), or a PUFA \u03c9-3 diet (n = 6), starting with the 14th gestation day. At Day 1, female and newborn rats (10 per female) were exposed to hyperoxia (O2, n = 70) or to the ambient air (Air, n = 70). Six groups of newborns rats were obtained: PUFA \u03c9-6\/O2 (n = 30), PUFA \u03c9-6\/air (n = 30), PUFA \u03c9-3\/O2 (n = 30), PUFA \u03c9-3\/air (n = 30), control\/O2 (n = 10), and control\/air (n = 10). After 10 days, lungs were removed for analysis of alveolarization and pulmonary vascular development. Survival rate was 100%. Hyperoxia reduced alveolarization and increased pulmonary vascular wall thickness in both control (n = 20) and PUFA \u03c9-6 groups (n = 60). Maternal PUFA \u03c9-3 supplementation prevented the decrease in alveolarization caused by hyperoxia (n = 30) compared to PUFA \u03c9-6\/O2 (n = 30) or to the control\/O2 (n = 10), but did not significantly increase the thickness of the lung vascular wall. Therefore, maternal PUFA \u03c9-3 supplementation may protect newborn rats from lung injuries induced by hyperoxia. In clinical settings, maternal PUFA \u03c9-3 supplementation during pregnancy and during lactation may prevent BPD development after premature birth.<\/jats:p>","DOI":"10.3390\/ijms160922081","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T03:46:33Z","timestamp":1442288793000},"page":"22081-22093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Maternal PUFA \u03c9-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats"],"prefix":"10.3390","volume":"16","author":[{"given":"Dyuti","family":"Sharma","sequence":"first","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de Chirurgie et Orthop\u00e9die de l'Enfant, P\u00f4le Enfant, H\u00f4pital Jeanne de Flandre,  CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armande","family":"Nkembi","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Aubry","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de Chirurgie et Orthop\u00e9die de l'Enfant, P\u00f4le Enfant, H\u00f4pital Jeanne de Flandre,  CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Houeijeh","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de N\u00e9onatologie, P\u00f4le Femme, M\u00e8re et Nouveau-N\u00e9, H\u00f4pital Jeanne de Flandre,  CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Butruille","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Houfflin-Debarge","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de Gyn\u00e9cologie-Obst\u00e9trique, P\u00f4le Femme, M\u00e8re et Nouveau-N\u00e9,  H\u00f4pital Jeanne de Flandre, CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Besson","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de Chirurgie et Orthop\u00e9die de l'Enfant, P\u00f4le Enfant, H\u00f4pital Jeanne de Flandre,  CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Deruelle","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de Gyn\u00e9cologie-Obst\u00e9trique, P\u00f4le Femme, M\u00e8re et Nouveau-N\u00e9,  H\u00f4pital Jeanne de Flandre, CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[{"name":"EA 4489 Environnement P\u00e9rinatal et Sant\u00e9, P\u00f4le Recherche Facult\u00e9 de M\u00e9decine,  Universit\u00e9 Lille Nord de France, Lille 59045, France"},{"name":"Clinique de N\u00e9onatologie, P\u00f4le Femme, M\u00e8re et Nouveau-N\u00e9, H\u00f4pital Jeanne de Flandre,  CHRU Lille, Lille 59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1165\/rcmb.2013-0014TR","article-title":"Chronic lung disease in the preterm infant","volume":"50","author":"Hilgendorff","year":"2014","journal-title":"Am. 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