{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:23:26Z","timestamp":1787289806856,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including  non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy.<\/jats:p>","DOI":"10.3390\/ijms160922137","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T03:46:33Z","timestamp":1442288793000},"page":"22137-22150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["RETRACTED: MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line"],"prefix":"10.3390","volume":"16","author":[{"given":"Debin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases, General Hospital of Shenyang Military Command,  Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, General Hospital of Shenyang Military Command,  Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University,  Beijing 100022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of  the Chinese PLA, Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erguang","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of  the Chinese PLA, Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofu","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Radiation, Medicine Military Medical Science Academy of the Chinese PLA,  Beijing 100850, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, General Hospital of Shenyang Military Command,  Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1470-2045(08)70073-1","article-title":"Activation of the PI3-K\/AKT pathway and implications for radioresistance mechanisms in head and neck cancer","volume":"9","author":"Bussink","year":"2008","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1002\/ijc.26259","article-title":"Downregulation and growth inhibitory role of FHL1 in lung cancer","volume":"130","author":"Niu","year":"2012","journal-title":"Int. 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