{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:30:55Z","timestamp":1790271055109,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders.  In this context, it has been reported that different pancreatic compartments from rats were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of coenzyme Q was administered life-long in rats in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of rats were fed normocaloric diets containing Coenzyme Q (CoQ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that CoQ supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, CoQ supplementation seems to improve endocrine pancreas structure and in particular \u03b2-cell mass resembling positive effects of virgin olive oil. Conversely, CoQ intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed rats. Therefore CoQ may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.<\/jats:p>","DOI":"10.3390\/ijms161023425","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T11:05:55Z","timestamp":1443524755000},"page":"23425-23445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after  Life-Long Coenzyme Q Addition"],"prefix":"10.3390","volume":"16","author":[{"given":"Adri\u00e1n","family":"Gonz\u00e1lez-Alonso","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \"Jose Mataix\",  University of Granada, Biomedical Research Center, lab. 250, Avda. Conocimiento s\/n, 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-707X","authenticated-orcid":false,"given":"C\u00e9sar","family":"Ram\u00edrez-Tortosa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Complejo Hospitalario de Ja\u00e9n, 23007 Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-5086","authenticated-orcid":false,"given":"Alfonso","family":"Varela-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \"Jose Mataix\",  University of Granada, Biomedical Research Center, lab. 250, Avda. Conocimiento s\/n, 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Roche","sequence":"additional","affiliation":[{"name":"Bioengineering Institute, University Miguel Hernandez and CIBEROBN  (CB 12\/03\/30038, Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III), 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Arribas","sequence":"additional","affiliation":[{"name":"Bioengineering Institute, University Miguel Hernandez and CIBEROBN  (CB 12\/03\/30038, Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III), 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-0881","authenticated-orcid":false,"given":"M.","family":"Ram\u00edrez-Tortosa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology \"Jose Mataix\", University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-9132","authenticated-orcid":false,"given":"Francesca","family":"Giampieri","sequence":"additional","affiliation":[{"name":"Dip. Scienze Cliniche Specialistiche ed Odontostomatologiche,  Universit\u00e0 Politecnica delle Marche, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-6296","authenticated-orcid":false,"given":"Julio","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \"Jose Mataix\",  University of Granada, Biomedical Research Center, lab. 250, Avda. Conocimiento s\/n, 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-9086","authenticated-orcid":false,"given":"Jos\u00e9","family":"Quiles","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \"Jose Mataix\",  University of Granada, Biomedical Research Center, lab. 250, Avda. Conocimiento s\/n, 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0959-437X(02)00338-6","article-title":"Signaling and transcriptional control of pancreatic organogenesis","volume":"12","author":"Kim","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.cellbio.19.111301.144752","article-title":"Genes, signals, and lineages in pancreas development","volume":"19","author":"Murtaugh","year":"2003","journal-title":"Ann. Rev. Cell Dev. 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