{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:30:58Z","timestamp":1791307858490,"version":"4.3.1"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maurocalcine (MCa) is the first natural cell penetrating peptide to be discovered in animal venom. In addition to the fact that it represents a potent vector for the cell penetration of structurally diverse therapeutic compounds, MCa also displays several distinguishing features that make it a potential peptide of choice for clinical and biotechnological applications. The aim of the present study was to gain new information about the properties of MCa in vivo in order to delineate the future potential applications of this vector. For this purpose, two analogues of this peptide with (Tyr-MCa) and without (Lin-Tyr-MCa) disulfide bridges were synthesized, radiolabeled with 125I, and their in vitro stabilities were first evaluated in mouse blood. The results indicated that 125I-Tyr-MCa was stable in vitro and that the disulfide bridges conferred a competitive advantage for the stability of peptide. Following in vivo injection in mice, 125I-Tyr-MCa targeted peripheral organs with interesting quantitative differences and the main route of peptide elimination was renal.<\/jats:p>","DOI":"10.3390\/ijms161126054","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T01:57:02Z","timestamp":1448330222000},"page":"27730-27740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice"],"prefix":"10.3390","volume":"16","author":[{"given":"Pascale","family":"Perret","sequence":"first","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Riou","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bacot","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Pecher","sequence":"additional","affiliation":[{"name":"Smartox Biotechnologies, B\u00e2timent Nanobio, 570 rue de la Chimie, 38400 Saint Martin d\u2019H\u00e8res, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Poillot","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Science and Therapeutics, LabEx Ion Channels, Grenoble Institute of Neuroscience, INSERM, U836, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Broisat","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Waard","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, 38041 Saint-Martin-d'H\u00e8res, France"},{"name":"Smartox Biotechnologies, B\u00e2timent Nanobio, 570 rue de la Chimie, 38400 Saint Martin d\u2019H\u00e8res, France"},{"name":"Science and Therapeutics, LabEx Ion Channels, Grenoble Institute of Neuroscience, INSERM, U836, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/1097-0134(20000815)40:3<436::AID-PROT90>3.0.CO;2-9","article-title":"A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel","volume":"40","author":"Mosbah","year":"2000","journal-title":"Proteins"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12833","DOI":"10.1074\/jbc.M412521200","article-title":"Transduction of the scorpion toxin maurocalcine into cells. 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