{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:14:21Z","timestamp":1777706061030,"version":"3.51.4"},"reference-count":231,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epigenetic variability (DNA methylation\/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodegenerative disorders, such as Alzheimer\u2019s disease (AD). Epigenetics affect life span and longevity. AD-related genes exhibit epigenetic changes, indicating that epigenetics might exert a pathogenic role in dementia. Epigenetic modifications are reversible and can potentially be targeted by pharmacological intervention. Epigenetic drugs may be useful for the treatment of major problems of health (e.g., cancer, cardiovascular disorders, brain disorders). The efficacy and safety of these and other medications depend upon the efficiency of the pharmacogenetic process in which different clusters of genes (pathogenic, mechanistic, metabolic, transporter, pleiotropic) are involved. Most of these genes are also under the influence of the epigenetic machinery. The information available on the pharmacoepigenomics of most drugs is very limited; however, growing evidence indicates that epigenetic changes are determinant in the pathogenesis of many medical conditions and in drug response and drug resistance. Consequently, pharmacoepigenetic studies should be incorporated in drug development and personalized treatments.<\/jats:p>","DOI":"10.3390\/ijms161226236","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T10:43:59Z","timestamp":1450694639000},"page":"30483-30543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Epigenetics of Aging and Alzheimer\u2019s Disease: Implications for Pharmacogenomics and Drug Response"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-4037","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Cacabelos","sequence":"first","affiliation":[{"name":"EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, 15165-Bergondo, Corunna, Spain"},{"name":"Chair of Genomic Medicine, Camilo Jos\u00e9 Cela University, 28692-Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Torrellas","sequence":"additional","affiliation":[{"name":"EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, 15165-Bergondo, Corunna, Spain"},{"name":"Chair of Genomic Medicine, Camilo Jos\u00e9 Cela University, 28692-Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/bies.201300090","article-title":"Integrating DNA methylation dynamics into a framework for understanding epigenetic codes","volume":"36","author":"Szulwach","year":"2014","journal-title":"Bioessays"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/evo.12320","article-title":"Epigenetic variation in asexually reproducing organisms","volume":"68","author":"Verhoeven","year":"2014","journal-title":"Evolution"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gavery, M.R., and Roberts, S.B. (2013). Predominant intragenic methylation is associated with gene expression characteristics in a bivalve mollusc. PeerJ, 1.","DOI":"10.7717\/peerj.215"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1152\/physiolgenomics.00096.2014","article-title":"The mitochondrial side of epigenetics","volume":"47","author":"Castegna","year":"2015","journal-title":"Physiol. Genom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/MCO.0000000000000194","article-title":"Genetic and metabolic determinants of human epigenetic variation","volume":"18","author":"Haggarty","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/ph5040369","article-title":"Epigenetic mechanisms and therapeutic perspectives for neurodevelopmental disorders","volume":"5","author":"Kubota","year":"2012","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.molonc.2012.09.004","article-title":"Trials with epigenetic drugs: An update","volume":"6","author":"Nebbioso","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/17460441.2014.930124","article-title":"Epigenetic drug discovery for Alzheimer\u2019s disease","volume":"9","author":"Cacabelos","year":"2014","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ddr.21219","article-title":"Epigenomic networking in drug development: From pathogenic mechanisms to pharmacogenomics","volume":"75","author":"Cacabelos","year":"2014","journal-title":"Drug Dev. Res."},{"key":"ref_10","first-page":"75","article-title":"Epigenomics of Alzheimer\u2019s disease","volume":"6","author":"Cacabelos","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11729","DOI":"10.1523\/JNEUROSCI.4339-14.2015","article-title":"Experience modulates the effects of histone deacetylase inhibitors on gene and protein expression in the hippocampus: Impaired plasticity in aging","volume":"35","author":"Sewal","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.brainres.2015.07.034","article-title":"Epigenetics and therapeutic targets mediating neuroprotection","volume":"1628","author":"Qureshi","year":"2015","journal-title":"Brain Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-1-4939-0956-8_13","article-title":"Pharmacogenomics of Alzheimer\u2019s disease: Novel therapeutic strategies for drug development","volume":"1175","author":"Cacabelos","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.arr.2013.05.003","article-title":"Epigenetic mechanisms in Alzheimer\u2019s disease: Implications for pathogenesis and therapy","volume":"12","author":"Wang","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1101\/gr.101907.109","article-title":"Dynamic changes in the human methylome during differentiation","volume":"2","author":"Laurent","year":"2010","journal-title":"Genome Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vascn.2012.08.001","article-title":"Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders","volume":"66","author":"Konsoula","year":"2012","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.pneurobio.2010.01.002","article-title":"Epigenetic regulation in the pathophysiology of Alzheimer\u2019s disease","volume":"90","author":"Chouliaras","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.biochem.77.062706.153223","article-title":"The biology of chromatin remodeling complexes","volume":"78","author":"Clapier","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1474-4422(12)70309-5","article-title":"Epigenetic mechanisms in multiple sclerosis: Implications for pathogenesis and treatment","volume":"12","author":"Huynh","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Xu, K., Dai, X.L., Huang, H.C., and Jiang, Z.F. (2011). Targeting HDACs: A promising therapy for Alzheimer\u2019s disease. Oxid. Med. Cell. Longev., 2011.","DOI":"10.1155\/2011\/143269"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-pharmtox-011112-140216","article-title":"The potential of HDAC inhibitors as cognitive enhancers","volume":"53","author":"Tsai","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ernst, C., and Morton, C.C. (2013). Identification and function of long non-coding RNA. Front. Cell. Neurosci., 7.","DOI":"10.3389\/fncel.2013.00168"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4161\/epi.26830","article-title":"Chromatin remodeling by the small RNA machinery in mammalian cells","volume":"9","author":"Li","year":"2014","journal-title":"Epigenetics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4161\/epi.26942","article-title":"RNA-mediated gene activation","volume":"9","author":"Jiao","year":"2014","journal-title":"Epigenetics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainresbull.2013.06.001","article-title":"Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases","volume":"97","author":"Wu","year":"2013","journal-title":"Brain Res. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4161\/epi.26700","article-title":"Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs","volume":"9","author":"Roberts","year":"2014","journal-title":"Epigenetics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2217\/epi.13.65","article-title":"Modulation of epigenetic regulators and cell fate decisions by miRNAs","volume":"5","author":"Gruber","year":"2013","journal-title":"Epigenomics"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, X., Chen, X., Yu, X., Tao, Y., Bode, A.M., Dong, Z., and Cao, Y. (2013). Regulation of microRNAs by epigenetics and their interplay involved in cancer. J. Exp. Clin. Cancer Res., 32.","DOI":"10.1186\/1756-9966-32-96"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1515\/bmc-2014-0038","article-title":"Longevity: Epigenetic and biomolecular aspects","volume":"6","author":"Taormina","year":"2015","journal-title":"Biomol. Concepts"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-4939-2404-2_9","article-title":"Epigenetics of aging","volume":"847","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/acel.12349","article-title":"DNA methylation and healthy human aging","volume":"14","author":"Jones","year":"2015","journal-title":"Aging Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/MCB.00637-12","article-title":"HBP1-mediated transcriptional regulation of DNMT1 and its impact on cell senescence","volume":"33","author":"Pan","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/carcin\/bgt391","article-title":"Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression, and cancer","volume":"35","author":"Xu","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Acevedo, N., Reinius, L.E., Vitezic, M., Fortino, V., S\u00f6derh\u00e4ll, C., Honkanen, H., Veijola, R., Simell, O., Toppari, J., and Ilonen, J. (2015). Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes. Clin. Epigenet., 7.","DOI":"10.1186\/s13148-015-0064-6"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4161\/epi.20117","article-title":"Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life","volume":"7","author":"Wang","year":"2012","journal-title":"Epigenetics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/hmg\/ddt511","article-title":"A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects","volume":"23","author":"McClay","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biocel.2015.05.009","article-title":"Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies","volume":"67","author":"Yang","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.2009.05374.x","article-title":"Biological significance of protein modifications in aging and calorie restriction","volume":"1197","author":"Nakamura","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10522-009-9231-5","article-title":"Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8","volume":"11","author":"Wang","year":"2010","journal-title":"Biogerontology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2005.01.029","article-title":"Calorie restriction\u2014The SIR2 connection","volume":"120","author":"Guarente","year":"2005","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: Biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Raddatz, G., Hagemann, S., Aran, D., S\u00f6hle, J., Kulkarni, P.P., Kaderali, L., Hellman, A., Winnefeld, M., and Lyko, F. (2013). Aging is associated with highly defined epigenetic changes in the human epidermis. Epigenet. Chromatin, 6.","DOI":"10.1186\/1756-8935-6-36"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Spallotta, F., Cencioni, C., Straino, S., Sbardella, G., Castellano, S., Capogrossi, M.C., Martelli, F., and Gaetano, C. (2013). Enhancement of lysine acetylation accelerates wound repair. Commun. Integr. Biol., 6.","DOI":"10.4161\/cib.25466"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1101\/gad.263707.115","article-title":"H3K36 methylation promotes longevity by enhancing transcriptional fidelity","volume":"29","author":"Sen","year":"2015","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/15592294.2015.1040619","article-title":"Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes","volume":"10","author":"Dozmorov","year":"2015","journal-title":"Epigenetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1101\/gad.254144.114","article-title":"Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span","volume":"29","author":"Pu","year":"2015","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A.B., and Evans, M.K. (2010). microRNA expression patterns reveal differential expression of target genes with age. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010724"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2010.00549.x","article-title":"miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging","volume":"9","author":"Hackl","year":"2010","journal-title":"Aging Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.neurobiolaging.2009.04.020","article-title":"Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylationtarget genes, during aging in mouse brain","volume":"32","author":"Li","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Montes, M., Nielsen, M.M., Maglieri, G., Jacobsen, A., H\u00f8jfeldt, J., Agrawal-Singh, S., Hansen, K., Helin, K., van de Werken, H.J., and Pedersen, J.S. (2015). The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence. Nat. Commun., 6.","DOI":"10.1038\/ncomms7967"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ebiom.2015.04.008","article-title":"Blood telomere length attrition and cancer development in the normative aging study cohort","volume":"2","author":"Hou","year":"2015","journal-title":"EBioMedicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1289\/ehp.9951","article-title":"Environmental exposures and gene regulation in disease etiology","volume":"115","author":"Edwards","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbagrm.2013.10.009","article-title":"Nuclear lncRNAs as epigenetic regulators-beyond skepticism","volume":"1839","author":"Nakagawa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/leu.2013.343","article-title":"Epigenetics of myelodysplastic syndromes","volume":"28","author":"Itzykson","year":"2014","journal-title":"Leukemia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/cancers5020676","article-title":"Epigenetics and colorectal cancer pathogenesis","volume":"5","author":"Bardhan","year":"2013","journal-title":"Cancers (Basel)"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3892\/ol.2013.1606","article-title":"DNA methylation as an epigenetic biomarker in colorectal cancer","volume":"6","author":"Silva","year":"2013","journal-title":"Oncol. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lee, J.J., Sholl, L.M., Lindeman, N.I., Granter, S.R., Laga, A.C., Shivdasani, P., Chin, G., Luke, J.J., Ott, P.A., and Hodi, F.S. (2015). Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-na\u00efve patient melanomas. Clin. Epigenet., 7.","DOI":"10.1186\/s13148-015-0091-3"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lee, D.W., Han, S.W., Cha, Y., Rhee, Y.Y., Bae, J.M., Cho, N.Y., Lee, K.H., Kim, T.Y., Oh, D.Y., and Im, S.A. (2015). Different prognostic effect of CpG island methylation according to sex in colorectal cancer patients treated with adjuvant FOLFOX. Clin. Epigenet., 7.","DOI":"10.1186\/s13148-015-0106-0"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Liefke, R., Windhof-Jaidhauser, I.M., Gaedcke, J., Salinas-Riester, G., Wu, F., Ghadimi, M., and Dango, S. (2015). The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells. Genome Med., 7.","DOI":"10.1186\/s13073-015-0180-0"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Schierding, W., and O\u2019Sullivan, J.M. (2015). Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci. Front. Endocrinol. (Lausanne), 6.","DOI":"10.3389\/fendo.2015.00102"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Greenhill, C. (2015). Epigenetics: Obesity-induced hypermethylation of adiponectin gene. Nat. Rev. Endocrinol., 6.","DOI":"10.1038\/nrendo.2015.116"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Agardh, E., Lundstig, A., Perfilyev, A., Volkov, P., Freiburghaus, T., Lindholm, E., R\u00f6nn, T., Agardh, C.D., and Ling, C. (2015). Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. BMC Med., 13.","DOI":"10.1186\/s12916-015-0421-5"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gu, T., Gu, H.F., Hilding, A., Sj\u00f6holm, L.K., Ostenson, C.G., Ekstr\u00f6m, T.J., and Brismar, K. (2013). Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men. Clin. Epigenet., 5.","DOI":"10.1186\/1868-7083-5-21"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00125-013-3072-0","article-title":"Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons","volume":"57","author":"Wang","year":"2013","journal-title":"Diabetologia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/em.21831","article-title":"Are we ready to consider transgenerational epigenetic effects in human health risk assessment?","volume":"55","author":"Alyea","year":"2014","journal-title":"Environ. Mol. Mutagenes."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3390\/nu5030887","article-title":"Genomic and epigenomic insights into nutrition and brain disorders","volume":"5","author":"Dauncey","year":"2013","journal-title":"Nutrients"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12031-013-0122-5","article-title":"Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: Role of folic acid","volume":"52","author":"Kalani","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Wang, X., Sundquist, K., Hedelius, A., Palm\u00e9r, K., Memon, A.A., and Sundquist, J. (2015). Circulating microRNA-144\u20135p is associated with depressive disorders. Clin. Epigenet., 7.","DOI":"10.1186\/s13148-015-0099-8"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2217\/epi.14.85","article-title":"An update on the epigenetics of psychotic diseases and autism","volume":"7","author":"Abdolmaleky","year":"2015","journal-title":"Epigenomics"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Azpurua, J., and Eaton, B.A. (2015). Neuronal epigenetics and the aging synapse. Front. Cell Neurosci., 9.","DOI":"10.3389\/fncel.2015.00208"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","article-title":"The epigenetics of aging and neurodegeneration","volume":"131","author":"Lardenoije","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1176\/appi.ajp.2014.14030382","article-title":"IMAGEN consortium. Association of protein phosphatase PPM1G with alcohol use disorder and brain activity during behavioral control in a genome-wide methylation analysis","volume":"172","author":"Ruggeri","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbiomolbio.2015.04.008","article-title":"Epigenetic mechanisms in schizophrenia","volume":"118","author":"Shorter","year":"2015","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s13311-013-0206-5","article-title":"Epigenetic mechanisms of neurodegeneration in Huntington\u2019s Disease","volume":"10","author":"Lee","year":"2013","journal-title":"Neurotherapeutics"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Moumn\u00e9, L., Betuing, S., and Caboche, J. (2013). Multiple aspects of gene dysregulation in Huntington\u2019s Disease. Front. Neurol., 4.","DOI":"10.3389\/fneur.2013.00127"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/ajmg.a.36264","article-title":"Epigenetics, fragile X syndrome and transcriptional therapy","volume":"161","author":"Tabolacci","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s13311-013-0227-0","article-title":"Epigenetics, autism spectrum, and neurodevelopmental disorders","volume":"10","author":"Rangasamy","year":"2013","journal-title":"Neurotherapeutics"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2217\/epi.13.54","article-title":"Role of epigenetics in Rett syndrome","volume":"5","author":"Kubota","year":"2013","journal-title":"Epigenomics"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Mbadiwe, T., and Millis, R.M. (2013). Epigenetics and Autism. Res. Treat., 2013.","DOI":"10.1155\/2013\/826156"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Lahiri, D.K., Sokol, D.K., Erickson, C., Ray, B., Ho, C.Y., and Maloney, B. (2013). Autism as early neurodevelopmental disorder: Evidence for an sAPP\u03b1-mediated anabolic pathway. Front. Cell Neurosci., 7.","DOI":"10.3389\/fncel.2013.00094"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1177\/1362361313503501","article-title":"The contribution of epigenetics to understanding genetic factors in autism","volume":"18","author":"Hall","year":"2014","journal-title":"Autism"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ijdevneu.2013.10.001","article-title":"Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex","volume":"31","author":"Blaze","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Philibert, R.A., Beach, S.R., Lei, M.K., and Brody, G.H. (2013). Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking. Clin. Epigenet., 5.","DOI":"10.1186\/1868-7083-5-19"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Waitkus, M.S., Diplas, B.H., and Yan, H. (2015). Isocitrate dehydrogenase mutations in gliomas. Neuro. Oncol.","DOI":"10.1093\/neuonc\/nov136"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, G., Warden, C., Zou, Z., Neman, J., Krueger, J.S., Jain, A., Jandial, R., and Chen, M. (2013). Altered expression of polycomb group genes in glioblastoma multiforme. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080970"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"37256","DOI":"10.1074\/jbc.M113.527531","article-title":"The histone deacetylase Sirtuin 1 deacetylates IRF1 and programs dendritic cells to control Th17 differentiation during autoimmune inflammation","volume":"288","author":"Yang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cyto.2013.09.019","article-title":"Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury","volume":"64","author":"Kiguchi","year":"2013","journal-title":"Cytokine"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/epi.13.66","article-title":"Epigenetic deregulation of genomic imprinting in humans: Causal mechanisms and clinical implications","volume":"5","author":"Girardot","year":"2013","journal-title":"Epigenomics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4161\/epi.27160","article-title":"Differentially methylated regions in maternal and paternal uniparental disomy for chromosome 7","volume":"9","author":"Muurinen","year":"2014","journal-title":"Epigenetics"},{"key":"ref_90","first-page":"1","article-title":"Molecular genetics of Alzheimer\u2019s disease and aging","volume":"27","author":"Cacabelos","year":"2005","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1440-1819.2010.02148.x","article-title":"Apolipoprotein E and central nervous system disorders: Reviews of clinical findings","volume":"64","author":"Takeda","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.3390\/ph3103040","article-title":"Future trends in the pharmacogenomics of brain disorders and dementia: Influence of APOE and CYP2D6 variants","volume":"3","author":"Cacabelos","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_93","first-page":"5","article-title":"Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer\u2019s disease","volume":"31","author":"Cacabelos","year":"2006","journal-title":"Drugs Future"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s13311-013-0219-0","article-title":"Epigenetics of Alzheimer\u2019s disease and frontotemporal dementia","volume":"10","author":"Veerappan","year":"2013","journal-title":"Neurotherapeutics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neurobiolaging.2010.08.017","article-title":"Epigenetic mechanisms in Alzheimer\u2019s disease","volume":"32","author":"Mastroeni","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.neurobiolaging.2010.10.021","article-title":"Toward an integrated genetic and epigenetic approach to Alzheimer\u2019s disease","volume":"32","author":"Mill","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/1533317513505132","article-title":"Global long interspersed nuclear element 1 DNA methylation in a Colombian sample of patients with late-onset Alzheimer\u2019s disease","volume":"29","author":"Mahecha","year":"2014","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbi.2011.01.017","article-title":"DNA methylation in repetitive elements and Alzheimer disease","volume":"25","author":"Bollati","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0169-328X(99)00163-1","article-title":"Reduction with age in methylcytosine in the promoter region-224 approximately-101 of the amyloid precursorprotein gene in autopsy human cortex","volume":"70","author":"Tohgi","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/jnc.12239","article-title":"From synaptic spines to nuclear signaling: Nuclear and synaptic actions of the amyloid precursor protein","volume":"126","author":"Octave","year":"2013","journal-title":"J. Neurochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10495-010-0541-5","article-title":"LXR-\u03b1 genomics programmes neuronal death observed in Alzheimer\u2019s disease","volume":"15","author":"Raina","year":"2010","journal-title":"Apoptosis"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/138920210791233090","article-title":"One-carbon metabolism and Alzheimer\u2019s disease: Focus on epigenetics","volume":"11","year":"2010","journal-title":"Curr. Genom."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Wang, S.C., Oelze, B., and Schumacher, A. (2008). Age-specific epigenetic drift in late-onset Alzheimer\u2019s disease. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002698"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Caesar, I., and Gandy, S. (2012). Evidence that an APOE 4 \u201cdouble whammy\u201d increases risk for Alzheimer\u2019s disease. BMC Med., 10.","DOI":"10.1186\/1741-7015-10-36"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/ijc.23658","article-title":"Clusterin is epigenetically regulated in prostate cancer","volume":"123","author":"Rauhala","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3940(99)00731-4","article-title":"The methylation status of cytosines in a gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex","volume":"275","author":"Tohgi","year":"1999","journal-title":"Neurosci. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1523\/JNEUROSCI.3316-06.2007","article-title":"Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation","volume":"27","author":"Sontag","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.nbd.2008.05.013","article-title":"Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A","volume":"31","author":"Zhou","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1093\/brain\/awt237","article-title":"DNA methylation map of mouse and human brain identifies target genes in Alzheimer\u2019s disease","volume":"136","author":"Aso","year":"2013","journal-title":"Brain"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3233\/JAD-130428","article-title":"Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer\u2019s Disease Patients","volume":"38","author":"Silva","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer\u2019s disease patients","volume":"34","author":"Chouliaras","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2217\/epi.15.22","article-title":"DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: Replicated evidence from two mild cognitive impairment cohorts","volume":"7","author":"Chouliaras","year":"2015","journal-title":"Epigenomics"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pharmthera.2013.03.010","article-title":"Epigenetics: A novel therapeutic approach for the treatment of Alzheimer\u2019s disease","volume":"139","author":"Adwan","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/pmic.201200010","article-title":"Targeted proteomics for quantification of histone acetylation in Alzheimer\u2019s disease","volume":"12","author":"Zhang","year":"2012","journal-title":"Proteomics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/j.1471-4159.2008.05564.x","article-title":"Histone deacetylase 6 interacts with the microtubule-associated protein tau","volume":"106","author":"Ding","year":"2008","journal-title":"Neurochemistry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/emmm.201201923","article-title":"Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer\u2019s disease","volume":"5","author":"Govindarajan","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/NEN.0b013e3181922348","article-title":"SIRT1 decrease parallels the accumulation of tau in Alzheimer disease","volume":"68","author":"Julien","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses-amyloid production by activating the \u03b1-secretase gene ADAM10","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Ryu, H., Barrup, M., Kowall, N.W., and McKee, A.C. (2008). P3\u2013260: Epigenetic modification in a monozygotic twin with Alzheimer\u2019s disease. Alzheimers Dement., 4.","DOI":"10.1016\/j.jalz.2008.05.1828"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00401-003-0684-3","article-title":"Ectopic localization of phosphorylated histone H3 in Alzheimer\u2019s disease: A mitotic catastrophe?","volume":"105","author":"Ogawa","year":"2003","journal-title":"Acta Neuropathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11357-008-9050-7","article-title":"Evidence of DNA damage in Alzheimer disease: Phosphorylation of histone H2AX in astrocytes","volume":"30","author":"Myung","year":"2008","journal-title":"Age (Dordr)"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/JAD-2009-1134","article-title":"Dysregulation of histone acetylation in the APP\/PS1 mouse model of Alzheimer\u2019s disease","volume":"18","author":"Francis","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11357-011-9375-5","article-title":"Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Walker","year":"2013","journal-title":"Age (Dordr.)"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.nbd.2011.12.007","article-title":"Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer\u2019s disease","volume":"45","author":"Liu","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1523\/JNEUROSCI.3610-09.2009","article-title":"Protein phosphatase 1 regulates the histone code for long-term memory","volume":"29","author":"Koshibu","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1186088","article-title":"Altered histone acetylation is associated with age-dependent memory impairment in mice","volume":"328","author":"Peleg","year":"2010","journal-title":"Science"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature05772","article-title":"Recovery of learning and memory is associated with chromatin remodelling","volume":"447","author":"Fischer","year":"2007","journal-title":"Nature"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Rei","year":"2012","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1523\/JNEUROSCI.2089-12.2012","article-title":"An essential role for histone deacetylase 4 in synaptic plasticity and memory formation","volume":"32","author":"Kim","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbrc.2010.02.139","article-title":"Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2\u2032-deoxycytidine in Neuro-2a cells","volume":"394","author":"Ishimaru","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1749-6632.2009.05175.x","article-title":"Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons","volume":"1199","author":"Tian","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1523\/JNEUROSCI.3732-09.2010","article-title":"Histone methylation regulates memory formation","volume":"30","author":"Gupta","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Lithner, C.U., Hernandez, C.M., Nordberg, A., and Sweatt, J.D. (2009). Epigenetic changes related to \u03b2-amyloid-implications for Alzheimer\u2019s disease. Alzheimers Dement., 5.","DOI":"10.1016\/j.jalz.2009.04.457"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neurobiolaging.2013.10.082","article-title":"Epigenetically regulated microRNAs in Alzheimer\u2019s disease","volume":"35","author":"Kompotis","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Kumar, P., Dezso, Z., MacKenzie, C., Oestreicher, J., Agoulnik, S., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., and Oda, Y. (2013). Circulating miRNA biomarkers for Alzheimer\u2019s disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069807"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Leidinger, P., Backes, C., Deutscher, S., Schmitt, K., Mueller, S.C., Frese, K., Haas, J., Ruprecht, K., Paul, F., and St\u00e4hler, C. (2013). A blood-based 12-miRNA signature of Alzheimer disease patients. Genome Biol., 14.","DOI":"10.1186\/gb-2013-14-7-r78"},{"key":"ref_138","first-page":"365","article-title":"microRNA (miRNA) speciation in Alzheimer\u2019s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)","volume":"3","author":"Alexandrov","year":"2012","journal-title":"Int. J. Biochem. Mol. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11910-011-0210-2","article-title":"Advances in epigenetics and epigenomics for neurodegenerative diseases","volume":"11","author":"Qureshi","year":"2011","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s11033-011-0973-1","article-title":"MicroRNAs in brain development and degeneration","volume":"39","author":"Enciu","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4161\/rna.8.4.15584","article-title":"A complex crosstalk between polymorphic microRNA target sites and AD prognosis","volume":"8","author":"Mallick","year":"2011","journal-title":"RNA Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbrc.2010.12.053","article-title":"MicroRNA-101 downregulates Alzheimer\u2019s amyloid-\u03b2 precursor protein levels in human cell cultures and is differentially expressed","volume":"404","author":"Long","year":"2011","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neurobiolaging.2010.04.034","article-title":"MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer\u2019s-associated pathogenesis in SAMP8 mice","volume":"33","author":"Liu","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1471-4159.2010.07097.x","article-title":"In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs","volume":"116","author":"Smith","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.toxlet.2011.11.032","article-title":"The miR-124 regulates the expression of BACE1\/-secretase correlated with cell death in Alzheimer\u2019s disease","volume":"209","author":"Fang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/-secretase expression","volume":"105","author":"Papadopoulou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2011.04.035","article-title":"miR-29c regulates BACE1 protein expression","volume":"1395","author":"Zong","year":"2011","journal-title":"Brain Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1523\/JNEUROSCI.5065-07.2008","article-title":"The expression of microRNA miR-107 decreases early in Alzheimer\u2019s disease and may accelerate disease progression through regulation of \u03b2-site amyloid precursor protein-cleaving enzyme 1","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1074\/jbc.M807530200","article-title":"MicroRNA-298 and microRNA-328 regulate expression of mouse \u03b2-amyloid precursor protein-converting enzyme 1","volume":"284","author":"Boissonneault","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.brainresbull.2012.05.018","article-title":"MicroRNA-195 downregulates Alzheimer\u2019s disease amyloid-\u03b2 production by targeting BACE1","volume":"88","author":"Zhu","year":"2012","journal-title":"Brain Res. Bull."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","article-title":"Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of \u03b2-secretase","volume":"14","author":"Faghihi","year":"2008","journal-title":"Nat. Med."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Faghihi, M.A., Zhang, M., Huang, J., Modarresi, F., Van der Brug, M.P., Nalls, M.A., Cookson, M.R., St-Laurent, G., and Wahlestedt, C. (2010). Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol., 11.","DOI":"10.1186\/gb-2010-11-5-r56"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bbamcr.2012.05.001","article-title":"NDM29, A RNA polymerase III-dependent non-coding RNA, promotes amyloidogenic processing of amyloid precursor protein (APP) and amyloid secretion","volume":"1823","author":"Massone","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-010-0756-0","article-title":"Patterns of microRNA expression in normal and early Alzheimer\u2019s disease human temporal cortex: White matter versus gray matter","volume":"121","author":"Wang","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2353\/ajpath.2010.091202","article-title":"miR-107 regulates granulin\/progranulin with implications for traumatic brain injury and neurodegenerative disease","volume":"177","author":"Wang","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"14820","DOI":"10.1523\/JNEUROSCI.3883-11.2011","article-title":"MicroRNA-137\/181c regulates serine palmitoyltransferase and in turn amyloid \u03b2, novel targets in sporadic Alzheimer\u2019s Disease","volume":"31","author":"Geekiyanage","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2010.01.006","article-title":"Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus","volume":"1318","author":"Akram","year":"2010","journal-title":"Brain Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.nbd.2010.09.019","article-title":"17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease","volume":"41","author":"Massone","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1093\/hmg\/ddr330","article-title":"MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy","volume":"20","author":"Smith","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1093\/hmg\/ddq311","article-title":"Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration","volume":"19","author":"Papadopoulou","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Caputo, V., Sinibaldi, L., Fiorentino, A., Parisi, C., Catalanotto, C., Pasini, A., Cogoni, C., and Pizzuti, A. (2011). Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028656"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"29336","DOI":"10.1074\/jbc.M110.101147","article-title":"Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase 3","volume":"285","author":"Mohamed","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.molcel.2006.07.030","article-title":"MicroRNA pathways modulate polyglutamine-induced neurodegeneration","volume":"24","author":"Bilen","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","article-title":"Acetylation of tau inhibits its degradation and contributes to tauopathy","volume":"67","author":"Min","year":"2010","journal-title":"Neuron"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12031-011-9587-2","article-title":"Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-\u03b2","volume":"46","author":"Schonrock","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/emboj.2011.327","article-title":"microRNA-34c is a novel target to treat dementias","volume":"30","author":"Zovoilis","year":"2011","journal-title":"EMBO J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1523\/JNEUROSCI.4660-08.2009","article-title":"The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule","volume":"29","author":"Carrettiero","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-(B in stressed human astroglial cells and in Alzheimer disease","volume":"285","author":"Cui","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-(B-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2011.05.044","article-title":"Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells","volume":"499","author":"Li","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer\u2019s disease temporal lobe neocortex","volume":"459","author":"Sethi","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4161\/epi.5.8.12996","article-title":"Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health","volume":"5","author":"Popov","year":"2010","journal-title":"Epigenetics"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/phar.1362","article-title":"Epigenetic changes in gene expression for drug-metabolizing enzymes and transporters","volume":"34","author":"Kim","year":"2014","journal-title":"Pharmacotherapy"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1124\/dmd.113.053942","article-title":"Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport","volume":"41","author":"Zhong","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"ref_177","first-page":"54","article-title":"Alzheimer\u2019s disease 2011: Where are we heading?","volume":"8","author":"Cacabelos","year":"2011","journal-title":"Gen-T"},{"key":"ref_178","first-page":"3","article-title":"The path to personalized medicine in mental disorders","volume":"Volume 4","author":"Ritsner","year":"2011","journal-title":"The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ddr.21039","article-title":"Pharmacogenomics of central nervous system (CNS) drugs","volume":"73","author":"Cacabelos","year":"2012","journal-title":"Drug Dev. Res."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Cacabelos, R. (2012). The metabolomics paradigm of pharmacogenomics in complex disorders. Metabolomics, 2.","DOI":"10.4172\/2153-0769.1000e119"},{"key":"ref_181","unstructured":"Cacabelos, R. (2015). Pharmacoepigenomics and the metabolomics of drug efficacy and safety. Metabolomics, 5."},{"key":"ref_182","unstructured":"Cacabelos, R. (2012). World Guide for Drug Use and Pharmacogenomics, Corunna EuroEspes Publishing."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/138920021602150713114159","article-title":"Epigenetic Regulation of Cytochrome P450 Enzymes and Clinical Implication","volume":"16","author":"Tang","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1742-4658.2011.08317.x","article-title":"Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland\u2014Involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1","volume":"279","author":"Zmrzljak","year":"2012","journal-title":"FEBS J."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mrd.20756","article-title":"DNA methylation and chromatin accessibility of the proximal Cyp 19 promoter region 1.5\/2 correlate with expression levels in sheep placentomes","volume":"75","author":"Selimyan","year":"2008","journal-title":"Mol. Reprod. Dev."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Park, H.J., Choi, Y.J., Kim, J.W., Chun, H.S., Im, I., Yoon, S., Han, Y.M., Song, C.W., and Kim, H. (2015). Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132992"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/acer.12772","article-title":"Identification of ethanol and 4-nitroquinoline-1-oxide induced epigenetic and oxidative stress markers during oral cavity carcinogenesis","volume":"39","author":"Urvalek","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcb.25108","article-title":"In utero exposure to phthalate downregulates critical genes in leydig cells of F1 male progeny","volume":"116","author":"Sekaran","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-12-800095-3.00008-0","article-title":"Epigenetic effects of methoxychlor and vinclozolin on male gametes","volume":"94","year":"2014","journal-title":"Vitam. Horm."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Casati, L., Sendra, R., Sibilia, V., and Celotti, F. (2015). Endocrine disrupters: The new players able to affect the epigenome. Front. Cell Dev. Biol., 3.","DOI":"10.3389\/fcell.2015.00037"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.3390\/ijms150813916","article-title":"Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB 126)","volume":"15","author":"Vorrink","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.gene.2013.11.097","article-title":"Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme","volume":"536","author":"Naselli","year":"2014","journal-title":"Gene"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.taap.2015.04.016","article-title":"CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit","volume":"286","author":"Baccarelli","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/15592294.2015.1026031","article-title":"Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates","volume":"10","author":"Gurnot","year":"2015","journal-title":"Epigenetics"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3892\/ijo_00000235","article-title":"CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers","volume":"34","author":"Habano","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Habano, W., Gamo, T., Terashima, J., Sugai, T., Otsuka, K., Wakabayashi, G., and Ozawa, S. (2011). Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-81"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.metabol.2010.01.013","article-title":"In utero tobacco exposure epigenetically modifies placental CYP1A1 expression","volume":"59","author":"Suter","year":"2010","journal-title":"Metabolism"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1096\/fj.13-233320","article-title":"Sex-dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA","volume":"28","author":"Penaloza","year":"2014","journal-title":"FASEB J."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/me.2006-0007","article-title":"Growth hormone regulation of sex-dependent liver gene expression","volume":"20","author":"Waxman","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mce.2015.07.002","article-title":"HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17\u03b2-estradiol production in granulosa cells","volume":"414","author":"Mehta","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bcp.2013.11.001","article-title":"Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10","volume":"87","author":"Oda","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"17204","DOI":"10.3390\/ijms140817204","article-title":"Post-transcriptional controls by ribonucleoprotein complexes in the acquisition of drug resistance","volume":"14","author":"Kang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Dillenburg, C.S., Martins, M.A., Almeida, L.O., Meurer, L., Squarize, C.H., Martins, M.D., and Castilho, R.M. (2015). Epigenetic modifications and accumulation of DNA double-strand breaks in oral lichen planus lesions presenting poor response to therapy. Medicine (Baltimore), 94.","DOI":"10.1097\/MD.0000000000000997"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Wu, J., Li, S., Jia, W., Deng, H., Chen, K., Zhu, L., Yu, F., and Su, F. (2015). Reduced let-7a is associated with chemoresistance in primary breast cancer. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133643"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4161\/epi.27111","article-title":"High-density array analysis of DNA methylation in tamoxifen-resistant breast cancer cell lines","volume":"9","author":"Williams","year":"2014","journal-title":"Epigenetics"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"231","DOI":"10.18632\/genesandcancer.67","article-title":"RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker","volume":"6","author":"Jin","year":"2015","journal-title":"Genes Cancer"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yexcr.2015.05.017","article-title":"Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells","volume":"336","author":"Kim","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"671","DOI":"10.7150\/jca.11616","article-title":"A MicroRNA expression signature in taxane-anthracycline-based neoadjuvant chemotherapy response","volume":"6","author":"Zheng","year":"2015","journal-title":"J. Cancer"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"8326","DOI":"10.1073\/pnas.1424220112","article-title":"The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation","volume":"112","author":"Pastori","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2015.06.112","article-title":"Development and characterization of a hydrogen peroxide-resistant cholangiocyte cell line: A novel model of oxidative stress-related cholangiocarcinoma genesis","volume":"464","author":"Thanan","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1212\/WNL.0b013e3181fc29dd","article-title":"Antiepileptic drug response in temporal lobe epilepsy: A clinical and MRI morphometry study","volume":"75","author":"Bilevicius","year":"2010","journal-title":"Neurology"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.nbd.2013.08.015","article-title":"Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi","volume":"60","author":"Grimminger","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31887\/DCNS.2015.17.2\/rpost","article-title":"Heading off depressive illness evolution and progression to treatment resistance","volume":"17","author":"Post","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbr.2013.08.041","article-title":"Ketamine and imipramine in the nucleus accumbens regulate histone deacetylation induced by maternal deprivation and are critical for associated behaviors","volume":"256","author":"Abelaira","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Powell, T.R., Smith, R.G., Hackinger, S., Schalkwyk, L.C., Uher, R., McGuffin, P., Mill, J., and Tansey, K.E. (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl. Psychiatry, 3.","DOI":"10.1038\/tp.2013.73"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Schroeder, F.A., Lewis, M.C., Fass, D.M., Wagner, F.F., Zhang, Y.L., Hennig, K.M., Gale, J., Zhao, W.N., Reis, S., and Barker, D.D. (2013). A selective HDAC 1\/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071323"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"22287","DOI":"10.1074\/jbc.M115.671222","article-title":"Non-antibiotic effects of fluoroquinolones in mammalian cells","volume":"290","author":"Badal","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Pappas, J.J., Petropoulos, S., Suderman, M., Iqbal, M., Moisiadis, V., Turecki, G., Matthews, S.G., and Szyf, M. (2014). The multidrug resistance 1 gene ABCB1 in brain and placenta: Comparative analysis in human and guinea pig. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111135"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.4161\/epi.29675","article-title":"ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC-100 box in its promoter","volume":"9","author":"Binato","year":"2014","journal-title":"Epigenetics"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1096\/fj.14-254045","article-title":"PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis","volume":"28","author":"Yang","year":"2014","journal-title":"FASEB J."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-60761-416-6_9","article-title":"Epigenetic regulation of multidrug resistance 1 gene expression: Profiling CpG methylation status using bisulphite sequencing","volume":"596","author":"Baker","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/tpj.2010.1","article-title":"The temporal relationship between ABCB1 promoter hypomethylation, ABCB1 expression and acquisition of drug resistance","volume":"10","author":"Reed","year":"2010","journal-title":"Pharmacogenom. J."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Henrique, R., Oliveira, A.I., Costa, V.L., Baptista, T., Martins, A.T., Morais, A., Oliveira, J., and Jer\u00f3nimo, C. (2013). Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-898"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/bcp.12251","article-title":"MicroRNAs and their relevance to ABC transporters","volume":"77","author":"Haenisch","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Stewart, D.J., Nunez, M.I., Jelinek, J., Hong, D., Gupta, S., Issa, J.P., Wistuba, I.I., and Kurzrock, R. (2014). Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. Clin. Epigenet., 6.","DOI":"10.1186\/1868-7083-6-2"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s11064-015-1605-2","article-title":"GLAST but not least-distribution, function, genetics and epigenetics of l-glutamate transport in brain-focus on GLAST\/EAAT1","volume":"40","author":"Sultana","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/tpj.2011.60","article-title":"Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3","volume":"13","author":"Chen","year":"2013","journal-title":"Pharmacogenom. J."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2217\/epi.12.39","article-title":"miRNAs as mediators of drug resistance","volume":"4","author":"Haenisch","year":"2012","journal-title":"Epigenomics"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"10195","DOI":"10.18632\/oncotarget.3555","article-title":"The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/15384047.2015.1046023","article-title":"Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy","volume":"16","author":"Hersi","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.canlet.2015.03.045","article-title":"miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1","volume":"362","author":"Fan","year":"2015","journal-title":"Cancer Lett."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/16\/12\/26236\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:54:29Z","timestamp":1760216069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/16\/12\/26236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":231,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["ijms161226236"],"URL":"https:\/\/doi.org\/10.3390\/ijms161226236","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]}}}