{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:58:53Z","timestamp":1790755133778,"version":"4.1.0"},"reference-count":167,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31472159"],"award-info":[{"award-number":["No. 31472159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.<\/jats:p>","DOI":"10.3390\/ijms17010048","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T10:25:05Z","timestamp":1451471105000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Notch Signaling in Pancreatic Development"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-8854","authenticated-orcid":false,"given":"Xu-Yan","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Science, Northeast Forestry University, Harbin 150040, China"},{"name":"College of Life Sciences, Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Zhai","sequence":"additional","affiliation":[{"name":"College of Life Science, Northeast Forestry University, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Bo","family":"Teng","sequence":"additional","affiliation":[{"name":"College of Life Science, Northeast Forestry University, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.7716513","article-title":"Notch signaling","volume":"268","author":"Matsuno","year":"1995","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1006\/scdb.1998.0262","article-title":"Notch signalling in drosophila: Three ways to use a pathway","volume":"9","author":"Bray","year":"1998","journal-title":"Semin. 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