{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:42:25Z","timestamp":1790347345950,"version":"4.1.0"},"reference-count":195,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cadmium (Cd) is a non-essential transition metal which is introduced into the biosphere by various anthropogenic activities. Environmental pollution with Cd poses a major health risk and Cd toxicity has been extensively researched over the past decades. This review aims at changing the perspective by discussing protection mechanisms available to counteract a Cd insult. Antioxidants, induction of antioxidant enzymes, and complexation of Cd to glutathione (GSH) and metallothionein (MT) are the most potent protective measures to cope with Cd-induced oxidative stress. Furthermore, protection mechanisms include prevention of endoplasmic reticulum (ER) stress, mitophagy and metabolic stress, as well as expression of chaperones. Pre-exposure to Cd itself, or co-exposure to other metals or trace elements can improve viability under Cd exposure and cells have means to reduce Cd uptake and improve Cd removal. Finally, environmental factors have negative or positive effects on Cd toxicity. Most protection mechanisms aim at preventing cellular damage. However, this might not be possible without trade-offs like an increased risk of carcinogenesis.<\/jats:p>","DOI":"10.3390\/ijms17010139","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T11:36:13Z","timestamp":1453462573000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Cadmium Protection Strategies\u2014A Hidden Trade-Off?"],"prefix":"10.3390","volume":"17","author":[{"given":"Adolf","family":"Sandbichler","sequence":"first","affiliation":[{"name":"University of Innsbruck, Institute of Zoology, Technikerstra\u00dfe 25, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"H\u00f6ckner","sequence":"additional","affiliation":[{"name":"University of Innsbruck, Institute of Zoology, Technikerstra\u00dfe 25, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of Cd as an environmental health problem","volume":"238","author":"Akesson","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2014.01.007","article-title":"Interplay of Calcium and cadmium in mediating cadmium toxicity","volume":"211","author":"Choong","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1365-2958.2010.07166.x","article-title":"Endoplasmic reticulum is a major target of cadmium toxicity in yeast","volume":"76","author":"Gardarin","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0891-5849(94)00159-H","article-title":"Oxidative mechanisms in the toxicity of metal ions","volume":"18","author":"Stohs","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_6","first-page":"201","article-title":"Oxidative mechanisms in the toxicity of chromium and cadmium ions","volume":"19","author":"Stohs","year":"2000","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1096\/fasebj.1.3.2887478","article-title":"Glutathione, a first line of defense against cadmium toxicity","volume":"1","author":"Singhal","year":"1987","journal-title":"FASEB J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1385\/BTER:88:1:71","article-title":"Influence of antioxidants on metallothionein-mediated protection in cadmium-fed rats","volume":"88","author":"Rana","year":"2002","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0009-2797(92)90017-F","article-title":"Glutathione is the antioxidant responsible for resistance to oxidative stress in V79 Chinese hamster fibroblasts rendered resistant to cadmium","volume":"82","author":"Chubatsu","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s00204-014-1401-9","article-title":"Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney","volume":"89","author":"Nair","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jcp.20246","article-title":"Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2","volume":"203","author":"Sakurai","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.taap.2009.07.038","article-title":"Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells","volume":"241","author":"Chen","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chemosphere.2015.01.022","article-title":"Metal detoxification and gene expression regulation after a Cd and Zn contamination: An experimental study on Danio rerio","volume":"128","author":"Arini","year":"2015","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","article-title":"The complexity of the Nrf2 pathway: Beyond the antioxidant response","volume":"26","author":"Huang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.01.029","article-title":"Role of oxidative stress in cadmium toxicity and carcinogenesis","volume":"238","author":"Liu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","article-title":"Cadmium stress: An oxidative challenge","volume":"23","author":"Cuypers","year":"2010","journal-title":"BioMetals"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.biochi.2006.10.001","article-title":"Cadmium: Cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)","volume":"88","author":"Bertin","year":"2006","journal-title":"Biochimie"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mrfmmm.2009.09.013","article-title":"Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium","volume":"685","author":"Bravard","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.toxlet.2004.02.019","article-title":"The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice","volume":"151","author":"Eybl","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tox.2006.05.011","article-title":"Comparative study of natural antioxidants\u2014Curcumin, resveratrol and melatonin\u2014In cadmium-induced oxidative damage in mice","volume":"225","author":"Eybl","year":"2006","journal-title":"Toxicology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jinorgbio.2003.10.014","article-title":"Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain","volume":"98","author":"Daniel","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbrc.2011.11.096","article-title":"Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium","volume":"417","author":"Rennolds","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Baiomy, A.A., and Mansour, A.A. (2015). Genetic and histopathological responses to cadmium toxicity in rabbit\u2019s kidney and liver: Protection by Ginger (Zingiber officinale). Biol. Trace Elem. Res., in press.","DOI":"10.1007\/s12011-015-0491-4"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12011-014-0066-9","article-title":"The protective effect of Physalis peruviana L. against cadmium-induced neurotoxicity in rats","volume":"160","author":"Bauomy","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1089\/jmf.2012.0023","article-title":"Protective effect of grapefruit juice on the teratogenic and genotoxic damage induced by cadmium in mice","volume":"15","author":"Chamorro","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1016\/j.scitotenv.2009.05.030","article-title":"Ascorbic acid, garlic extract and taurine alleviate cadmium-induced oxidative stress in freshwater catfish (Clarias batrachus)","volume":"407","author":"Kumar","year":"2009","journal-title":"Sci. Total Environ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1089\/jmf.2008.0203","article-title":"Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice","volume":"12","author":"Yapar","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_29","first-page":"1","article-title":"Amelioration of cadmium-produced teratogenicity and genotoxicity in mice given Arthrospira maxima (Spirulina) Treatment","volume":"2013","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/jmf.2010.0070","article-title":"Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice","volume":"14","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1179\/135100005X83671","article-title":"Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice","volume":"10","author":"Jahangir","year":"2005","journal-title":"Redox Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.fct.2012.06.031","article-title":"Protective effect of theaflavins on cadmium-induced testicular toxicity in male rats","volume":"50","author":"Wang","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.etap.2015.04.021","article-title":"Taxifolin mitigates oxidative DNA damage in vitro and protects zebrafish (Danio rerio) embryos against cadmium toxicity","volume":"39","author":"Krishnan","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.reprotox.2010.12.057","article-title":"Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles","volume":"31","author":"Jia","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.fct.2008.03.009","article-title":"Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity","volume":"46","author":"Egido","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ar.21317","article-title":"Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice","volume":"294","author":"Bu","year":"2011","journal-title":"Anat. Rec."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","article-title":"Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jobaz.2015.01.002","article-title":"Rosemary extract ameliorates cadmium-induced histological changes and oxidative damage in the liver of albino rat","volume":"71","author":"Sakr","year":"2015","journal-title":"J. Basic Appl. Zool."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0024-3205(03)00433-8","article-title":"Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats","volume":"73","author":"Choi","year":"2003","journal-title":"Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/19396368.2013.843039","article-title":"Comparative analysis of antioxidants against cadmium induced reproductive toxicity in adult male rats","volume":"60","author":"Jahan","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, W., He, Y., Yu, G., Li, B., Sexton, D.W., Wileman, T., Roberts, A.A., Hamilton, C.J., Liu, R., and Chao, Y. (2015). Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138771"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/128_2012_340","article-title":"A perspective on dietary phytochemicals and cancer chemoprevention: Oxidative stress, Nrf2, and epigenomics","volume":"329","author":"Su","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ecoenv.2009.09.014","article-title":"Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat","volume":"73","author":"Nafady","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1620\/tjem.186.205","article-title":"Effect of melatonin on cadmium-induced hepatotoxicity in male Sprague\u2013Dawley rats","volume":"186","author":"Kim","year":"1998","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/15548627.2015.1052208","article-title":"SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin","volume":"11","author":"Pi","year":"2015","journal-title":"Autophagy"},{"key":"ref_46","first-page":"T18","article-title":"Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats\u2019 pups","volume":"75","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_47","first-page":"563","article-title":"Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium","volume":"52","author":"Stajn","year":"2003","journal-title":"Physiol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09603120050021128","article-title":"Effect of \u03b1-tocopherol on superoxide radical and toxicity of cadmium exposure","volume":"10","author":"Novelli","year":"2000","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1876528901104010001","article-title":"The protective role of Vitamin C against cerebral and pulmonary damage induced by cadmium chloride in male adult albino rat","volume":"4","author":"Awadalla","year":"2011","journal-title":"Open Neuroendocrinol. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0748233710386408","article-title":"Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells","volume":"27","author":"Liu","year":"2011","journal-title":"Toxicol. Ind. Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0304-4165(97)00144-X","article-title":"Concentration-dependent differential effects of N-acetyl-l-cysteine on the expression of HSP70 and metallothionein genes induced by cadmium in human amniotic cells","volume":"1380","author":"Abe","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","first-page":"1193","article-title":"Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells","volume":"27","author":"Odewumi","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4142\/jvs.2014.15.4.485","article-title":"N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes","volume":"15","author":"Wang","year":"2014","journal-title":"J. Vet. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0022-3565(24)37796-1","article-title":"Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK1 cells","volume":"287","author":"Wispriyono","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.bbamcr.2013.01.025","article-title":"Nutrient deprivation induces the Warburg effect through ROS\/AMPK-dependent activation of pyruvate dehydrogenase kinase","volume":"1833","author":"Wu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tox.2007.10.005","article-title":"Oxidative stress and DNA damage induced by cadmium in the human keratinocyte HaCaT cell line: Role of glutathione in the resistance to cadmium","volume":"243","author":"Nzengue","year":"2008","journal-title":"Toxicology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/01480545.2015.1028068","article-title":"N-acetylcysteine effectively mitigates cadmium-induced oxidative damage and cell death in Leydig cells in vitro","volume":"39","author":"Khanna","year":"2015","journal-title":"Drug Chem. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.taap.2005.07.018","article-title":"A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation","volume":"212","author":"Oh","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Odewumi, C.O., Latinwo, L.M., Ruden, M.L., Badisa, V.L.D., Fils-Aime, S., and Badisa, R.B. (2015). Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells. Environ. Toxicol.","DOI":"10.1002\/tox.22165"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1159\/000430127","article-title":"Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1\/2 Pathways","volume":"36","author":"Hu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aquatox.2012.09.020","article-title":"Cadmium (Cd)-induced oxidative stress down-regulates the gene expression of DNA mismatch recognition proteins MutS homolog 2 (MSH2) and MSH6 in zebrafish (Danio rerio) embryos","volume":"126","author":"Hsu","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cbi.2006.11.007","article-title":"Cadmium inhibits \u03b4-aminolevulinate dehydratase from rat lung in vitro: Interaction with chelating and antioxidant agents","volume":"165","author":"Luchese","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.reprotox.2012.04.011","article-title":"Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes","volume":"34","author":"Ji","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00726-008-0094-x","article-title":"Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction","volume":"36","author":"Manna","year":"2009","journal-title":"Amino Acids"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0160-4120(01)00127-1","article-title":"The use of the oxidative stress responses as biomarkers in Nile tilapia (Oreochromis niloticus) exposed to in vivo cadmium contamination","volume":"27","author":"Almeida","year":"2002","journal-title":"Environ. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1023\/A:1026108306755","article-title":"Antioxidant enzyme activities, metallothioneins and lipid peroxidation as biomarkers in Ruditapes decussatus?","volume":"12","author":"Geret","year":"2003","journal-title":"Ecotoxicology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/eesa.1997.1582","article-title":"Glutathione reductase, selenium-dependent glutathione peroxidase, glutathione levels, and lipid peroxidation in freshwater bivalves, Unio tumidus, as biomarkers of aquatic contamination in field studies","volume":"38","author":"Cossu","year":"1997","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0166-445X(97)00024-6","article-title":"Antioxidant enzymes, glutathione and lipid peroxidation as relevant biomarkers of experimental or field exposure in the gills and the digestive gland of the freshwater bivalve Unio tumidus","volume":"39","author":"Doyotte","year":"1997","journal-title":"Aquat. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00204-013-1110-9","article-title":"Cadmium and cellular signaling cascades: Interactions between cell death and survival pathways","volume":"87","author":"Lee","year":"2013","journal-title":"Arch. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.toxlet.2010.04.013","article-title":"Mitochondria, reactive oxygen species and cadmium toxicity in the kidney","volume":"198","author":"Gobe","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.mito.2009.08.009","article-title":"Cadmium and mitochondria","volume":"9","author":"Cannino","year":"2009","journal-title":"Mitochondrion"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/jat.2913","article-title":"In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells","volume":"34","author":"Poteet","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3109\/15376516.2014.943444","article-title":"Cadmium induces mitophagy through ROS-mediated PINK1\/Parkin pathway","volume":"24","author":"Wei","year":"2014","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4161\/auto.25665","article-title":"Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium","volume":"9","author":"Pi","year":"2013","journal-title":"Autophagy"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/2012\/136063","article-title":"Mitochondrial electron transport chain in heavy metal-induced neurotoxicity: Effects of cadmium, mercury, and copper","volume":"2012","author":"Belyaeva","year":"2012","journal-title":"Sci. World J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0162-0134(03)00314-3","article-title":"A proposed sequence of events for cadmium-induced mitochondrial impairment","volume":"97","author":"Dorta","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0300-483X(03)00327-5","article-title":"Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis","volume":"194","author":"Li","year":"2003","journal-title":"Toxicology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"F27","DOI":"10.1152\/ajprenal.00224.2004","article-title":"Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: Role of mitochondrial permeability transition pore and Ca2+ uniporter","volume":"288","author":"Lee","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1038\/cddis.2013.7","article-title":"Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing Calcium homeostasis in its hepatotoxicity","volume":"4","author":"Xu","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/toxsci\/kfu164","article-title":"Melatonin Improves mitochondrial function by promoting MT1\/SIRT1\/PGC-1 \u03b1-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro","volume":"142","author":"Guo","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/mol.106.023515","article-title":"Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis","volume":"70","author":"Kil","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1017\/S0025315400002472","article-title":"Temperature-dependent physiological responses of the dogwhelk Nucella lapillus to cadmium exposure","volume":"80","author":"Leung","year":"2000","journal-title":"J. Mar. Biol. Assoc. UK"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1039\/C4EM00453A","article-title":"Mitochondrial energy metabolism in the hepatopancreas of freshwater crabs (Sinopotamon henanense) after cadmium exposure","volume":"17","author":"Yang","year":"2015","journal-title":"Environ. Sci. Process. Impacts"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e00214","DOI":"10.1042\/BSR20140170","article-title":"Cadmium toxicity induces ER stress and apoptosis via impairing energy homeostasis in cardiomyocytes","volume":"35","author":"Chen","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1289\/ehp.8454249","article-title":"Chelation of cadmium","volume":"54","author":"Andersen","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"ref_86","first-page":"407","article-title":"Antioxidant role of metallothioneins: A comparative overview","volume":"46","author":"Viarengo","year":"2000","journal-title":"Cell. Mol. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1620\/tjem.196.9","article-title":"Recent studies on metallothionein: Protection against toxicity of heavy metals and oxygen free radicals","volume":"196","author":"Sato","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/protein\/12.3.265","article-title":"In vivo copper- and cadmium-binding ability of mammalian metallothionein beta domain","volume":"12","author":"Cols","year":"1999","journal-title":"Protein Eng."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Palacios, O., Pagani, A., P\u00e9rez-Rafael, S., Egg, M., H\u00f6ckner, M., Brandst\u00e4tter, A., Capdevila, M., Atrian, S., and Dallinger, R. (2011). Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: Evolutionary differentiation of mollusc metallothioneins. BMC Biol., 9.","DOI":"10.1186\/1741-7007-9-4"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1021\/acs.biochem.5b00452","article-title":"Domain Selection in Metallothionein 1A: Affinity-controlled mechanisms of zinc binding and cadmium exchange","volume":"54","author":"Pinter","year":"2015","journal-title":"Biochemistry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10534-013-9636-0","article-title":"Evolution of metallotionein isoforms complexes in hepatic cells of Mus musculus along cadmium exposure","volume":"26","author":"Pueyo","year":"2013","journal-title":"Biometals"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00775-014-1127-4","article-title":"Cognate and noncognate metal ion coordination in metal-specific metallothioneins: The Helix pomatia system as a model","volume":"19","author":"Palacios","year":"2014","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10534-011-9466-x","article-title":"Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus","volume":"24","author":"Stefanon","year":"2011","journal-title":"Biometals"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.fob.2013.01.005","article-title":"The sea urchin metallothionein system: Comparative evaluation of the SpMTA and SpMTB metal-binding preferences","volume":"3","author":"Tomas","year":"2013","journal-title":"FEBS Open Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2443.2006.00971.x","article-title":"The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification","volume":"11","author":"Egli","year":"2006","journal-title":"Genes Cells"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00775-011-0826-3","article-title":"Nematode and snail metallothioneins","volume":"16","author":"Dallinger","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbapap.2008.01.008","article-title":"Comparative insight into the Zn(II)-, Cd(II)- and Cu(I)-binding features of the protozoan Tetrahymena pyriformis MT1 metallothionein","volume":"1784","author":"Bofill","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.abb.2011.02.015","article-title":"Functional comparison of metallothioneins MTT1 and MTT2 from Tetrahymena thermophila","volume":"509","author":"Wang","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/138920309788922243","article-title":"Metallothioneins and cancer","volume":"10","author":"Eckschlager","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.proghi.2008.10.001","article-title":"The role of metallothionein in oncogenesis and cancer prognosis","volume":"44","author":"Pedersen","year":"2009","journal-title":"Prog. Histochem. Cytochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.bbamcr.2012.01.005","article-title":"The taste of heavy metals: Gene regulation by MTF-1","volume":"1823","author":"Lindert","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_102","first-page":"776","article-title":"Coping with cadmium exposure in various ways: The two helicid snails Helix pomatia and Cantareus aspersus share the metal transcription factor-2, but differ in promoter organization and transcription of their Cd-metallothionein genes","volume":"311","author":"Stefanon","year":"2009","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bbrc.2015.03.065","article-title":"Metallothionein gene activation in the earthworm (Lumbricus rubellus)","volume":"460","author":"Dallinger","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_104","first-page":"339","article-title":"Cadmium in metallothioneins","volume":"11","author":"Freisinger","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.toxlet.2014.01.049","article-title":"Differential transcytosis and toxicity of the hNGAL receptor ligands cadmium-metallothionein and cadmium-phytochelatin in colon-like Caco-2 cells: Implications for in vivo cadmium toxicity","volume":"226","author":"Langelueddecke","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.toxlet.2011.03.014","article-title":"Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells","volume":"203","author":"Wolff","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Li, L., Dong, F., Xu, D., Du, L., Yan, S., Hu, H., Lobe, C.G., Yi, F., Kapron, C.M., and Liu, J. (2015). Short-term, low-dose cadmium exposure induces hyperpermeability in human renal glomerular endothelial cells. J. Appl. Toxicol.","DOI":"10.1002\/jat.3168"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2012.05.012","article-title":"Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo","volume":"212","author":"Onodera","year":"2012","journal-title":"Toxicol. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1111\/j.1742-4658.2010.07913.x","article-title":"Cadmium-glutathione solution structures provide new insights into heavy metal detoxification","volume":"277","author":"Delalande","year":"2010","journal-title":"FEBS J."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Liebeke, M., Garcia-Perez, I., Anderson, C.J., Lawlor, A.J., Bennett, M.H., Morris, C.A., Kille, P., Svendsen, C., Spurgeon, D.J., and Bundy, J.G. (2013). Earthworms produce phytochelatins in response to arsenic. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081271"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/toxsci\/kfs166","article-title":"Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans","volume":"128","author":"Hall","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_112","first-page":"127","article-title":"Cadmium toxicity on cultured neonatal rat hepatocytes: Biochemical and ultrastructural analyses","volume":"6","author":"Hirano","year":"1991","journal-title":"Histol. Histopathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ceca.2007.05.003","article-title":"Endoplasmic reticulum stress and alteration in Calcium homeostasis are involved in cadmium-induced apoptosis","volume":"43","author":"Biagioli","year":"2008","journal-title":"Cell Calcium"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pharmthera.2012.02.003","article-title":"Stress management at the ER: Regulators of ER stress-induced apoptosis","volume":"134","author":"Gorman","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/onc.2012.130","article-title":"The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anti-cancer therapies","volume":"32","author":"Luo","year":"2013","journal-title":"Oncogene"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1289\/ehp.8920","article-title":"Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells","volume":"114","author":"Liu","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Liu, J., Wu, K.C., Lu, Y.-F., Ekuase, E., and Klaassen, C.D. (2013). Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid. Med. Cell. Longev., 2013.","DOI":"10.1155\/2013\/305861"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2131\/jts.39.861","article-title":"FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation","volume":"39","author":"Du","year":"2014","journal-title":"J. Toxicol. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2010.06.010","article-title":"Autophagy involvement in cadmium resistance through induction of multidrug resistance-associated protein and counterbalance of endoplasmic reticulum stress WI38 lung epithelial fibroblast cells","volume":"276","author":"Lim","year":"2010","journal-title":"Toxicology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0167-4889(99)00149-4","article-title":"Implication of free radicals and glutathione in the mechanism of cadmium-induced expression of stress proteins in the A549 human lung cell-line","volume":"1495","author":"Gaubin","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2014.04.008","article-title":"Differential HSP70 expression in Mytilus coruscus under various stressors","volume":"543","author":"Liu","year":"2014","journal-title":"Gene"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12192-009-0124-y","article-title":"Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses","volume":"15","author":"Luan","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1379\/1466-1268(2003)8<76:MIAEOH>2.0.CO;2","article-title":"Molecular identification and expression of heat shock cognate 70 (HSC70) and heat shock protein 70 (HSP70) genes in the Pacific oyster Crassostrea gigas","volume":"8","author":"Boutet","year":"2003","journal-title":"Cell Stress Chaperones"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1242\/jcs.108.8.2877","article-title":"cAMP increasing agents prevent the stimulation of heat-shock protein 70 (HSP70) gene expression by cadmium chloride in human myeloid cell lines","volume":"108 Pt 8","author":"Vilaboa","year":"1995","journal-title":"J. Cell Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.chemosphere.2013.01.014","article-title":"Acute effect of copper and cadmium exposure on the expression of heat shock protein 70 in the Cyprinidae fish Tanichthys albonubes","volume":"91","author":"Jing","year":"2013","journal-title":"Chemosphere"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/taap.1996.0149","article-title":"Cellular factors mediate cadmium-dependent actin depolymerization","volume":"139","author":"Wang","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"L831","DOI":"10.1152\/ajplung.00203.2013","article-title":"Actin cytoskeleton redox proteome oxidation by cadmium","volume":"305","author":"Go","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_128","first-page":"884.47","article-title":"Effects of cadmium on epigenetics of cytoskeletal genes in CHO cells","volume":"29","year":"2015","journal-title":"FASEB J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/cjpp-2012-0229","article-title":"Effects of cadmium on the actin cytoskeleton in renal mesangial cells","volume":"91","author":"Templeton","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/taap.1994.1097","article-title":"Alterations in cytoskeletal organization and homeostasis of cellular thiols in cadmium-resistant cells","volume":"126","author":"Li","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1158\/0008-5472.CAN-06-3771","article-title":"The possible role of cytokeratin 8 in cadmium-induced adaptation and carcinogenesis","volume":"67","author":"Lau","year":"2007","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Somji, S., Garrett, S.H., Toni, C., Zhou, X.D., Zheng, Y., Ajjimaporn, A., Sens, M.A., and Sens, D. (2011). A Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd+2 or As+3 transformed human urothelial cells. Cancer Cell Int., 11.","DOI":"10.1186\/1475-2867-11-2"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arr.2007.07.001","article-title":"Converging concepts: Adaptive response, preconditioning, and the Yerkes\u2013Dodson Law are manifestations of hormesis","volume":"7","author":"Calabrese","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2203\/dose-response.08-023.Hoffmann","article-title":"A perspective on the scientific, philosophical, and policy dimensions of hormesis","volume":"7","author":"Hoffmann","year":"2009","journal-title":"Dose Response"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yrtph.2011.06.003","article-title":"The hormesis database: The occurrence of hormetic dose responses in the toxicological literature","volume":"61","author":"Calabrese","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3109\/10408444.2013.808172","article-title":"Hormetic mechanisms","volume":"43","author":"Calabrese","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.aquatox.2014.10.018","article-title":"Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells","volume":"157","author":"Chen","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1191\/096032700678816133","article-title":"Hormesis: A stress response in cells exposed to low levels of heavy metals","volume":"19","author":"Damelin","year":"2000","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cbi.2014.10.034","article-title":"Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation","volume":"224","author":"Rannug","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cca.2004.10.006","article-title":"Physiological effects of dietary cadmium acclimation and waterborne cadmium challenge in rainbow trout: Respiratory, ionoregulatory, and stress parameters","volume":"139","author":"Chowdhury","year":"2004","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0041-008X(03)00256-4","article-title":"Use of HSF1(\u2212\/\u2212) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury","volume":"192","author":"Wirth","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1016\/j.envpol.2009.05.039","article-title":"The hormetic effect of cadmium on the activity of antioxidant enzymes in the earthworm Eisenia fetida","volume":"157","author":"Zhang","year":"2009","journal-title":"Environ. Pollut."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10393-008-0158-0","article-title":"Hormetic effects of heavy metals in aquatic snails: Is a little bit of pollution good?","volume":"5","author":"Lefcort","year":"2008","journal-title":"Ecohealth"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00284-003-4025-5","article-title":"Cadmium-induced adaptive resistance and cross-resistance to zinc in Xanthomonas campestris","volume":"47","author":"Banjerdkij","year":"2003","journal-title":"Curr. Microbiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tox.2010.12.002","article-title":"Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese","volume":"280","author":"Fujishiro","year":"2011","journal-title":"Toxicology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/bbrc.1996.1651","article-title":"Oxidative stress-induced cadmium resistance in Chinese hamster V79 cells","volume":"228","author":"Sengupta","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_147","first-page":"2225","article-title":"Hormesis results in trade-offs with immunity","volume":"68","author":"Mcclure","year":"2014","journal-title":"Evolution"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/rpd\/ncv269","article-title":"Combined effects of depleted uranium and ionising radiation on zebrafish embryos","volume":"167","author":"Ng","year":"2015","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"H901","DOI":"10.1152\/ajpheart.00715.2007","article-title":"Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat","volume":"294","author":"Belaidi","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/toxsci\/kfr256","article-title":"Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells","volume":"125","author":"Jing","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/BF00197973","article-title":"Improvement of acute cadmium toxicity by pretreatment with copper salt","volume":"54","author":"Li","year":"1995","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tox.2007.03.014","article-title":"Protective role of selenium against renal toxicity induced by cadmium in rats","volume":"235","author":"Newairy","year":"2007","journal-title":"Toxicology"},{"key":"ref_153","first-page":"403","article-title":"Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium","volume":"57","author":"Stajn","year":"2008","journal-title":"Physiol. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12011-015-0314-7","article-title":"Ameliorative effects of selenium on cadmium-induced oxidative stress and endoplasmic reticulum stress in the chicken kidney","volume":"167","author":"Liu","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.tiv.2008.12.009","article-title":"The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK1 cells","volume":"23","author":"Zhou","year":"2009","journal-title":"Toxicol. Vitro"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fct.2013.04.013","article-title":"The protective effects of selenium on cadmium-induced oxidative stress and apoptosis via mitochondria pathway in mice kidney","volume":"58","author":"Wang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12011-014-0070-0","article-title":"Cadmium-induced injury and the ameliorative effects of selenium on chicken splenic lymphocytes: Mechanisms of oxidative stress and apoptosis","volume":"160","author":"Liu","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.taap.2013.05.016","article-title":"Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK\/RANKL\/OPG system imbalance in the bone tissue of rats","volume":"272","author":"Rogalska","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0041-008X(92)90118-C","article-title":"Cadmium-induced DNA strand damage in cultured liver cells: Reduction in cadmium genotoxicity following zinc pretreatment","volume":"113","author":"Coogan","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Zhang, D., Liu, J., Gao, J., Shahzad, M., Han, Z., Wang, Z., Li, J., and Sj\u00f6linder, H. (2014). Zinc supplementation protects against cadmium accumulation and cytotoxicity in Madin\u2013Darby bovine kidney cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103427"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2478\/v10102-010-0013-3","article-title":"Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice","volume":"3","author":"Eybl","year":"2010","journal-title":"Interdiscip. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.biochi.2009.04.002","article-title":"The role of zinc transporters in cadmium and manganese transport in mammalian cells","volume":"91","author":"Himeno","year":"2009","journal-title":"Biochimie"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10534-010-9309-1","article-title":"Catch me if you can! Novel aspects of cadmium transport in mammalian cells","volume":"23","year":"2010","journal-title":"Biometals"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1124\/mol.105.014241","article-title":"Acquired cadmium resistance in metallothionein-I\/II(\u2212\/\u2212) knockout cells: Role of the T-type Calcium channel Cacn\u03b11G in cadmium uptake","volume":"69","author":"Leslie","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Santoyo-S\u00e1nchez, M.P., Pedraza-Chaverri, J., Molina-Jij\u00f3n, E., Arreola-Mendoza, L., Rodr\u00edguez-Mu\u00f1oz, R., and Barbier, O.C. (2013). Impaired endocytosis in proximal tubule from subchronic exposure to cadmium involves angiotensin II type 1 and cubilin receptors. BMC Nephrol., 14.","DOI":"10.1186\/1471-2369-14-211"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1289\/ehp.0901874","article-title":"Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells","volume":"118","author":"Gena","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/jpet.106.102574","article-title":"Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells","volume":"318","author":"Wolff","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10534-012-9526-x","article-title":"Physiologic implications of metal-ion transport by ZIP14 and ZIP8","volume":"25","author":"Jenkitkasemwong","year":"2012","journal-title":"Biometals"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Th\u00e9venod, F., and Wolff, N.A. (2016). Iron transport in the kidney: Implications for physiology and cadmium nephrotoxicity. Metallomics.","DOI":"10.1039\/C5MT00215J"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1074\/jbc.275.3.1887","article-title":"Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-\u03baB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis","volume":"275","author":"Thevenod","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cbpc.2010.12.001","article-title":"MRP proteins as potential mediators of heavy metal resistance in zebrafish cells","volume":"153","author":"Long","year":"2011","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.freeradbiomed.2008.12.009","article-title":"CFTR mediates cadmium-induced apoptosis through modulation of ROS level in mouse proximal tubule cells","volume":"46","author":"Chargui","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0166-445X(00)00088-6","article-title":"Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms","volume":"48","author":"Bard","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fphys.2014.00266","article-title":"ABC transporters in fish species: A review","volume":"5","author":"Ferreira","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_175","first-page":"757.11","article-title":"Effect of cadmium exposure on P-glycoprotein expression and activity in eastern oysters, Crassostrea virginica","volume":"22","author":"Ivanina","year":"2008","journal-title":"FASEB J."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aquatox.2005.05.015","article-title":"Impact of cadmium contamination and oxygenation levels on biochemical responses in the Asiatic clam Corbicula fluminea","volume":"74","author":"Legeay","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.aquatox.2004.01.014","article-title":"Induction of a multixenobiotic resistance protein (MXR) in the Asiatic clam Corbicula fluminea after heavy metals exposure","volume":"67","author":"Achard","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-445X(99)00068-5","article-title":"Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses","volume":"49","author":"Eufemia","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.envpol.2010.04.012","article-title":"Identification of five partial ABC genes in the liver of the Antarctic fish Trematomus bernacchii and sensitivity of ABCB1 and ABCC2 to Cd exposure","volume":"158","author":"Zucchi","year":"2010","journal-title":"Environ. Pollut."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"A819","DOI":"10.1096\/fasebj.21.6.A819-d","article-title":"Mitochondrial aconitase is sensitive to oxidative stress induced by cadmium and elevated temperatures but not protected by uncoupling proteins in eastern oysters Crassostrea virginica","volume":"21","author":"Sanni","year":"2007","journal-title":"FASEB J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1242\/jeb.02093","article-title":"Effects of acclimation temperature and cadmium exposure on cellular energy budgets in the marine mollusk Crassostrea virginica: Linking cellular and mitochondrial responses","volume":"209","author":"Cherkasov","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1242\/jeb.01054","article-title":"Cadmium effects on mitochondrial function are enhanced by elevated temperatures in a marine poikilotherm, Crassostrea virginica Gmelin (Bivalvia: Ostreidae)","volume":"207","author":"Sokolova","year":"2004","journal-title":"J. Exp. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.aquatox.2008.11.016","article-title":"Effects of elevated temperature and cadmium exposure on stress protein response in eastern oysters Crassostrea virginica (Gmelin)","volume":"91","author":"Ivanina","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.chemosphere.2012.12.028","article-title":"Hypothermal and hyperthermal acclimation differentially modulate cadmium accumulation and toxicity in the zebrafish","volume":"91","author":"Vergauwen","year":"2013","journal-title":"Chemosphere"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/etc.5620200929","article-title":"How water oxygenation level influences cadmium accumulation pattern in the Asiatic clam Corbicula fluminea\u202f: A laboratory and field study","volume":"20","author":"Tran","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0022-0981(02)00209-5","article-title":"Influence of static and fluctuating salinity on cadmium uptake and metallothionein expression by the dogwhelk Nucella lapillus (L.)","volume":"274","author":"Leung","year":"2002","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF01056559","article-title":"Heavy metal toxicity to fish and the influence of water hardness","volume":"15","author":"Pascoe","year":"1986","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/es0496524","article-title":"Biotic ligand model, a flexible tool for developing site-specific water quality guidelines for metals","volume":"38","author":"Niyogi","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/etc.1855","article-title":"Influence of essential elements on cadmium uptake and toxicity in a unicellular green alga: The protective effect of trace zinc and cobalt concentrations","volume":"31","author":"Lavoie","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1532-0456(02)00051-0","article-title":"Influence of temperature, pH, oxygenation, water-type and substrate on biomarker responses in the freshwater clam Corbicula fluminea (M\u00fcller)","volume":"132","author":"Vidal","year":"2002","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"10178","DOI":"10.1073\/pnas.181228598","article-title":"A cell-based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock","volume":"98","author":"Pando","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/biores.2012.0287","article-title":"A method to evaluate the efficiency of transfection reagents in an adherent zebrafish cell line","volume":"2","author":"Sandbichler","year":"2013","journal-title":"BioRes. Open Access"},{"key":"ref_193","unstructured":"Brz\u00f3ska, M.M., Borowska, S., and Tomczyk, M. (2015). Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium. Curr. Drug Targets, 16."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2478\/intox-2014-0015","article-title":"Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication","volume":"7","author":"Ivanova","year":"2014","journal-title":"Interdiscip. Toxicol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13181-013-0343-6","article-title":"The role of chelation in the treatment of other metal poisonings","volume":"9","author":"Smith","year":"2013","journal-title":"J. Med. Toxicol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/1\/139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:18:06Z","timestamp":1760210286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/1\/139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":195,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1]]}},"alternative-id":["ijms17010139"],"URL":"https:\/\/doi.org\/10.3390\/ijms17010139","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]}}}