{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:33Z","timestamp":1787028393884,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901249"],"award-info":[{"award-number":["30901249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101267"],"award-info":[{"award-number":["81101267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81541070"],"award-info":[{"award-number":["81541070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["10151063201000036"],"award-info":[{"award-number":["10151063201000036"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["S2011010002526"],"award-info":[{"award-number":["S2011010002526"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Province Medical Research Foundation","doi-asserted-by":"publisher","award":["A2014374"],"award-info":[{"award-number":["A2014374"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project from Jinan university","award":["21612426"],"award-info":[{"award-number":["21612426"]}]},{"name":"Project from Jinan university","award":["21615427"],"award-info":[{"award-number":["21615427"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs2816316 in RGS1 and rs17810546 in IL12A) with CD risk using meta-analysis. We searched PubMed and Web of Science on RGS1 rs2816316 and IL12A rs17810546 with CD risk. Odds ratio (OR) and 95% confidence interval (CI) of each SNP were estimated. All statistical analyses were performed on Stata 12.0. A total of seven studies were retrieved and analyzed. The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74\u20130.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31\u20131.43). The co-dominant model of genotype effect confirmed the significant associations between RGS1 rs2816316\/IL12A rs17810546 and CD. No evidence of publication bias was observed. Our meta-analysis supports the associations of RGS1 and IL12A with CD and strongly calls for further studies to better understand the roles of RGS1 and IL12A in the pathogenesis of CD.<\/jats:p>","DOI":"10.3390\/ijms17040457","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T16:47:27Z","timestamp":1459356447000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk"],"prefix":"10.3390","volume":"17","author":[{"given":"Cong-Cong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Di","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Stomatology of the First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Huang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Guang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ling","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine, Jinan University, Guangzhou 510632, China"},{"name":"Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xia","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China"},{"name":"Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2012.06.006","article-title":"Celiac disease: An immunological jigsaw","volume":"36","author":"Meresse","year":"2012","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1053\/j.gastro.2015.01.044","article-title":"Advances in diagnosis and management of celiac disease","volume":"148","author":"Kelly","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of celiac disease to a particular HLA-DQ \u03b1\/\u03b2 heterodimer","volume":"169","author":"Sollid","year":"1989","journal-title":"J. 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