{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:32:51Z","timestamp":1784914371673,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["No. 2011-0030074"],"award-info":[{"award-number":["No. 2011-0030074"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2015R1D1A4A01019006"],"award-info":[{"award-number":["NRF-2015R1D1A4A01019006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as \u201cBo-Gol-Zhee\u201d in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total plasma cholesterol levels in type 2 diabetic rats. In this study, we purified six compounds from PC and investigated their anti-diabetic effect. Among the purified compounds, bavachin most potently accumulated lipids during adipocyte differentiation. Intracellular lipid accumulation was measured by Oil Red-O (ORO) cell staining to investigate the effect of compounds on adipogenesis. Consistently, bavachin activated gene expression of adipogenic transcriptional factors, proliferator-activated receptor\u03b3 (PPAR\u03b3) and CCAAT\/enhancer binding protein-\u03b1 (C\/EBP\u03b1). Bavachin also increased adiponectin expression and secretion in adipocytes. Moreover, bavachin increased insulin-induced glucose uptake by differentiated adipocytes and myoblasts. In differentiated adipocytes, we found that bavachin enhanced glucose uptake via glucose transporter 4 (GLUT4) translocation by activating the Akt and 5\u2032AMP-activated protein kinase (AMPK) pathway in the presence or absence of insulin. These results suggest that bavachin from Psoralea corylifolia might have therapeutic potential for type 2 diabetes by activating insulin signaling pathways.<\/jats:p>","DOI":"10.3390\/ijms17040527","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:02:38Z","timestamp":1460149358000},"page":"527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes"],"prefix":"10.3390","volume":"17","author":[{"given":"Hyejin","family":"Lee","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women\u2019s University, 52 Hyochangwongil, Yongsan-gu, Seoul 140-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women\u2019s University, 52 Hyochangwongil, Yongsan-gu, Seoul 140-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsoo","family":"Noh","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-Gu, Seoul 151-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Ha","family":"Ryu","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women\u2019s University, 52 Hyochangwongil, Yongsan-gu, Seoul 140-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jep.2011.03.037","article-title":"The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-\u03b3 pathways in in vitro and in vivo studies","volume":"135","author":"Kwon","year":"2011","journal-title":"J. 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