{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:25:48Z","timestamp":1790803548080,"version":"4.1.0"},"reference-count":159,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_163395"],"award-info":[{"award-number":["31003A_163395"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.<\/jats:p>","DOI":"10.3390\/ijms17050638","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T10:25:55Z","timestamp":1461839155000},"page":"638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["The Dark Side of Cell Fusion"],"prefix":"10.3390","volume":"17","author":[{"given":"Daniel","family":"Bastida-Ruiz","sequence":"first","affiliation":[{"name":"Department of Gynecology Obstetrics, Faculty of Medicine, University of Geneva, \u200eGeneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Van Hoesen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics, Faculty of Medicine, University of Geneva, \u200eGeneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics, Faculty of Medicine, University of Geneva, \u200eGeneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/carcin\/21.3.497","article-title":"Tumor progression and metastasis","volume":"21","author":"Yokota","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrc1165","article-title":"The significance of unstable chromosomes in colorectal cancer","volume":"3","author":"Rajagopalan","year":"2003","journal-title":"Nat. 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