{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:34:07Z","timestamp":1790843647008,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Three new \u03b3-ionylideneacetic acid derivatives, phellinulins A\u2013C (1\u20133), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.<\/jats:p>","DOI":"10.3390\/ijms17050681","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T10:19:23Z","timestamp":1462529963000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells"],"prefix":"10.3390","volume":"17","author":[{"given":"Shiow-Chyn","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-1138","authenticated-orcid":false,"given":"Ping-Chung","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yi","family":"Hung","sequence":"additional","affiliation":[{"name":"School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Long","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan"},{"name":"Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-An","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Shung","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"},{"name":"Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Friedman","year":"2011","journal-title":"Annu. 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