{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:34:07Z","timestamp":1791228847191,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Actin remodelling proteins regulate cytoskeletal cell responses and are important in both innate and adaptive immunity. These responses play a major role in providing a fine balance in a cascade of biological events that results in either protective acute inflammation or chronic inflammation that leads to a host of diseases including autoimmune inflammation mediated epidermolysis bullosa acquisita (EBA). This review describes the role of the actin cytoskeleton and in particular the actin remodelling protein called Flightless I (Flii) in regulating cellular inflammatory responses and its subsequent effect on the autoimmune skin blistering disease EBA. It also outlines the potential of an antibody based therapy for decreasing Flii expression in vivo to ameliorate the symptoms associated with EBA.<\/jats:p>","DOI":"10.3390\/ijms17071116","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T09:48:45Z","timestamp":1468403325000},"page":"1116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita"],"prefix":"10.3390","volume":"17","author":[{"given":"Zlatko","family":"Kopecki","sequence":"first","affiliation":[{"name":"Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Institute of Experimental Dermatology, University of Lubeck, Lubeck 23562, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-2080","authenticated-orcid":false,"given":"Allison","family":"Cowin","sequence":"additional","affiliation":[{"name":"Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.autrev.2014.01.047","article-title":"Diagnosis and classification of autoimmune blistering diseases","volume":"13","author":"Baum","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clindermatol.2011.03.011","article-title":"Epidermolysis bullosa acquisita","volume":"30","author":"Gupta","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-4632.2009.03886.x","article-title":"Epidermolysis bullosa acquisita: Concise review and practical considerations","volume":"48","author":"Lehman","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"ref_4","first-page":"812029","article-title":"Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita","volume":"2013","author":"Ludwig","year":"2013","journal-title":"ISRN Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1586\/1744666X.2015.1085801","article-title":"Immune mechanism-targeted treatment of experimental epidermolysis bullosa acquisita","volume":"11","author":"Ludwig","year":"2015","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/jdv.12096","article-title":"Epidermolysis bullosa acquisita","volume":"27","author":"Kim","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"xiii","DOI":"10.1016\/j.iac.2012.04.015","article-title":"Autoimmune diseases of the skin","volume":"32","author":"Murrell","year":"2012","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457982","DOI":"10.1155\/2013\/457982","article-title":"Bullous skin diseases: Classical types of autoimmune diseases","volume":"2013","author":"Damoiseaux","year":"2013","journal-title":"Scientifica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molmed.2013.06.003","article-title":"Emerging treatments for pemphigoid diseases","volume":"19","author":"Ludwig","year":"2013","journal-title":"Trends Mol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1582-4934.2007.00033.x","article-title":"Immunopathology and molecular diagnosis of autoimmune bullous diseases","volume":"11","author":"Mihai","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/JID.2015.356","article-title":"Epidermolysis bullosa acquisita: From pathophysiology to novel therapeutic options","volume":"136","author":"Kasperkiewicz","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/path.2973","article-title":"Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita","volume":"225","author":"Kopecki","year":"2011","journal-title":"J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kopecki, Z., Ruzehaji, N., Turner, C., Iwata, H., Ludwig, R.J., Zillikens, D., Murrell, D.F., and Cowin, A.J. (2012). Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita. J. Investig. Dermatol.","DOI":"10.1038\/jid.2012.457"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1089\/scd.2015.0130","article-title":"cAMP promotes cell migration through cell junctional complex dynamics and actin cytoskeleton remodeling: Implications in skin wound healing","volume":"24","author":"Kim","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/path.4323","article-title":"Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering","volume":"232","author":"Kopecki","year":"2014","journal-title":"J. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbagen.2016.02.009","article-title":"TGF-\u03b2-induced early gene-1 overexpression promotes oxidative stress protection and actin cytoskeleton rearrangement in human skin fibroblasts","volume":"1860","author":"Leduc","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10059-011-0072-0","article-title":"Dynamic localization of the actin-bundling protein cortexillin I during cell migration","volume":"32","author":"Cha","year":"2011","journal-title":"Mol. Cells"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/onc.2009.444","article-title":"Actin: A novel interaction partner of WT1 influencing its cell dynamic properties","volume":"29","author":"Dudnakova","year":"2010","journal-title":"Oncogene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1091\/mbc.E14-12-1583","article-title":"Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane","volume":"26","author":"Gokhin","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.biocel.2004.01.024","article-title":"The actin cytoskeleton in normal and pathological cell motility","volume":"36","author":"Lambrechts","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00021.2007","article-title":"Regulation of actin assembly associated with protrusion and adhesion in cell migration","volume":"88","author":"Carlier","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1111\/bph.12658","article-title":"Targeting Rho-GTPases in immune cell migration and inflammation","volume":"171","author":"Biro","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4161\/cam.4.2.10888","article-title":"Tropomyosin isoform modulation of focal adhesion structure and cell migration","volume":"4","author":"Bach","year":"2010","journal-title":"Cell Adhes. Migr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/08916930903374634","article-title":"Immune pathology associated with altered actin cytoskeleton regulation","volume":"43","author":"Wickramarachchi","year":"2010","journal-title":"Autoimmunity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/BOR.0b013e32831cb939","article-title":"Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders","volume":"21","author":"Goyal","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/tan.12193","article-title":"Actin cytoskeleton control of the comings and goings of T lymphocytes","volume":"82","author":"Lafouresse","year":"2013","journal-title":"Tissue Antigens"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nri3641","article-title":"Leukocyte migration in the interstitial space of non-lymphoid organs","volume":"14","author":"Weninger","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0300985812469883","article-title":"Getting leukocytes to the site of inflammation","volume":"50","author":"Muller","year":"2013","journal-title":"Vet. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fimmu.2012.00130","article-title":"Cytoskeleton in mast cell signaling","volume":"3","author":"Draber","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.201406120","article-title":"The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility","volume":"208","author":"Comrie","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Stroka, K.M., Hayenga, H.N., and Aranda-Espinoza, H. (2013). Human neutrophil cytoskeletal dynamics and contractility actively contribute to trans-endothelial migration. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061377"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","author":"McWhorter","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","first-page":"405","article-title":"The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction","volume":"12","author":"Claudianos","year":"1995","journal-title":"Mol. Biol. Evol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1177\/0961203313507985","article-title":"The value of decreased plasma gelsolin levels in patients with systemic lupus erythematosus and rheumatoid arthritis in diagnosis and disease activity evaluation","volume":"22","author":"Hu","year":"2013","journal-title":"Lupus"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"R117","DOI":"10.1186\/ar2520","article-title":"Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis","volume":"10","author":"Osborn","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0625.2012.01441.x","article-title":"Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris","volume":"21","author":"Gil","year":"2012","journal-title":"Exp. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/ncomms3075","article-title":"LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition","volume":"4","author":"Jin","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/MCB.23.3.933-949.2003","article-title":"R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins","volume":"23","author":"Kwong","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/japplphysiol.01074.2002","article-title":"Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction","volume":"96","author":"Rothenbach","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33179","DOI":"10.1074\/jbc.274.47.33179","article-title":"Gelsolin, a multifunctional actin regulatory protein","volume":"274","author":"Sun","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1021\/bi0503504","article-title":"Inactivation of endotoxin by human plasma gelsolin","volume":"44","author":"Bucki","year":"2005","journal-title":"Biochemistry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/med.20231","article-title":"Multifunctional roles of gelsolin in health and diseases","volume":"32","author":"Li","year":"2012","journal-title":"Med. Res. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0959-440X(01)00266-4","article-title":"The leucine-rich repeat as a protein recognition motif","volume":"11","author":"Kobe","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cm.21117","article-title":"Gelsolin: The tail of a molecular gymnast","volume":"70","author":"Nag","year":"2013","journal-title":"Cytoskeleton"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/bbrc.1999.0420","article-title":"Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains","volume":"257","author":"Goshima","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1074\/jbc.273.14.7920","article-title":"Identification of the binding partners for flightless, I.; A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies","volume":"273","author":"Liu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1096\/fj.11-202051","article-title":"Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration","volume":"26","author":"Mohammad","year":"2012","journal-title":"FASEB J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/jid.2011.69","article-title":"Regulation of focal adhesions by flightless I involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway","volume":"131","author":"Kopecki","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-5793(03)00932-3","article-title":"The gelsolin family of actin regulatory proteins: Modular structures, versatile functions","volume":"552","author":"McGough","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1242\/jcs.114.3.549","article-title":"The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: Evidence for the involvement of PI 3-kinase and Ras-related small GTPases","volume":"114","author":"Davy","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00018-008-8019-0","article-title":"The leucine-rich repeat structure","volume":"65","author":"Bella","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4161\/cib.21928","article-title":"Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation","volume":"5","author":"Cowin","year":"2012","journal-title":"Commun. Integr. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1684\/ejd.2012.1878","article-title":"Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: Neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation","volume":"22","author":"Ruzehaji","year":"2012","journal-title":"Eur. J. Dermatol."},{"key":"ref_54","first-page":"4288","article-title":"Flightless, secreted through a late endosome\/lysosome pathway, binds LPS and dampens cytokine secretion","volume":"125","author":"Lei","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.febslet.2008.06.037","article-title":"Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II","volume":"582","author":"Seward","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.exppara.2008.10.014","article-title":"Differential diagnosis of Taenia asiatica using multiplex PCR","volume":"121","author":"Jeon","year":"2009","journal-title":"Exp. Parasitol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/MCB.24.5.2103-2117.2004","article-title":"Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity","volume":"24","author":"Lee","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.bbrc.2014.03.011","article-title":"Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor alpha target genes in MCF-7 breast cancer cells","volume":"446","author":"Jeong","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1016\/j.biocel.2013.09.004","article-title":"Flightless I homolog negatively regulates ChREBP activity in cancer cells","volume":"45","author":"Wu","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1093\/nar\/gkl652","article-title":"Interplay of Fli-I and FLAP1 for regulation of \u03b2-catenin dependent transcription","volume":"34","author":"Lee","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4049\/jimmunol.176.3.1355","article-title":"Flightless I homolog negatively modulates the TLR pathway","volume":"176","author":"Wang","year":"2006","journal-title":"J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jaad.2016.01.005","article-title":"Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epidermolysis bullosa acquisita (EBA)","volume":"74","author":"Seta","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nri3479","article-title":"Newly described pattern recognition receptors team up against intracellular pathogens","volume":"13","author":"Broz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.4049\/jimmunol.0802260","article-title":"Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins","volume":"182","author":"Dai","year":"2009","journal-title":"J. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/imr.12381","article-title":"Negative regulation of TLR signaling in myeloid cells\u2014Implications for autoimmune diseases","volume":"269","author":"Hamerman","year":"2016","journal-title":"Immunol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.celrep.2012.09.005","article-title":"Endogenous control of immunity against infection: Tenascin-C regulates TLR4-mediated inflammation via microRNA-155","volume":"2","author":"Piccinini","year":"2012","journal-title":"Cell Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S1097-2765(03)00406-4","article-title":"Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis","volume":"12","author":"Ishibe","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200711082","article-title":"Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity","volume":"181","author":"Li","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/jid.2008.461","article-title":"Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair","volume":"129","author":"Kopecki","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","first-page":"76","article-title":"Raising the roof on epidermolysis bullosa (EB): A focus on new therapies","volume":"17","author":"Kopecki","year":"2009","journal-title":"Wound Pract. Res."},{"key":"ref_71","first-page":"S108","article-title":"Widespread chronic skin ulcers in epidermolysis bullosa patients trigger Castleman\u2019s disease-like condition through Toll-like receptors","volume":"132","author":"Morizane","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/path.2143","article-title":"Flightless I deficiency enhances wound repair by increasing cell migration and proliferation","volume":"211","author":"Cowin","year":"2007","journal-title":"J. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2133.2009.09296.x","article-title":"Attenuation of Flightless, I.; an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-\u03b21 and TGF-\u03b23","volume":"161","author":"Adams","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00125-013-3107-6","article-title":"Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes","volume":"57","author":"Ruzehaji","year":"2014","journal-title":"Diabetologia"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1517\/14656566.2011.549127","article-title":"Current concepts in the treatment of epidermolysis bullosa acquisita","volume":"12","author":"Gurcan","year":"2011","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.1301556","article-title":"GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita","volume":"192","author":"Samavedam","year":"2014","journal-title":"J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/exd.12680","article-title":"Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita","volume":"24","author":"Tukaj","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/exd.12760","article-title":"Heat shock protein 90: A pathophysiological factor and novel treatment target in autoimmune bullous skin diseases","volume":"24","author":"Tukaj","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1524-475X.2012.00802.x","article-title":"Flii neutralizing antibodies improve wound healing in porcine preclinical studies","volume":"20","author":"Jackson","year":"2012","journal-title":"Wound Repair Regen."},{"key":"ref_80","first-page":"324","article-title":"Anti-epidermal growth factor\/epidermal growth factor receptortherapeutic anti-cancer drugs and the wound healing process","volume":"4","author":"Fuente","year":"2012","journal-title":"J. Cancer Sci. Ther."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/7\/1116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:26:04Z","timestamp":1760210764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/7\/1116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":80,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7]]}},"alternative-id":["ijms17071116"],"URL":"https:\/\/doi.org\/10.3390\/ijms17071116","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]}}}