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Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR\u03b3), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect this transcription factor to several human metabolic diseases. Due to obvious limitations concerning experimentation in humans, animal models\u2014mainly mouse models\u2014have been generated to investigate the role of PPAR\u03b3 in different tissues. This review focuses on the metabolic features of human and mouse PPAR\u03b3-related diseases and the utility of the mouse as a model.<\/jats:p>","DOI":"10.3390\/ijms17081236","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T03:47:39Z","timestamp":1470196059000},"page":"1236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Is the Mouse a Good Model of Human PPAR\u03b3-Related Metabolic Diseases?"],"prefix":"10.3390","volume":"17","author":[{"given":"Attila","family":"Pap","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ixchelt","family":"Cuaranta-Monroy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Peloquin","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32877, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary"},{"name":"Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32877, USA"},{"name":"MTA-DE \u201cLendulet\u201d Immunogenomics Research Group, University of Debrecen, Debrecen H-4012, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: Opening the x-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: The diverse biology of ppargamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. 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