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Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na+\/K+-ATPase) and type A natriuretic peptide receptor (NPR-A). Accordingly, SGK1 is implicated in the physiology and pathophysiology of Na+ homeostasis. Here, we focus particularly on recent findings of SGK1\u2019s involvement in Na+ transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance and discuss the abnormal SGK1-mediated Na+ reabsorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure.<\/jats:p>","DOI":"10.3390\/ijms17081307","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T10:14:10Z","timestamp":1470824050000},"page":"1307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-5422","authenticated-orcid":false,"given":"Yiyun","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"},{"name":"Department of Gynaecology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"},{"name":"Key Laboratory of Reproductive Genetics, National Ministry of Education (Zhejiang University), Women\u2019s Reproductive Healthy Laboratory of Zhejiang Province, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1016\/S0021-9258(19)50221-6","article-title":"Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine\/threonine protein kinase","volume":"268","author":"Webster","year":"1993","journal-title":"J. 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