{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:11:21Z","timestamp":1787980281351,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to evaluate the effect of a food supplement containing \u03b1-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of \u03b1-lipoic acid, 165 mg of L-carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). There was a reduction of FPG, PPG, and HbA1c with the food supplement containing \u03b1-lipoic acid compared with a baseline, and with the placebo. Concerning lipid profile, we observed a reduction of LDL-C, and Tg with the food supplement, compared with both the baseline, and the placebo. There was a reduction of Hs-CRP with the food supplement containing \u03b1-lipoic acid, both compared with the baseline and the placebo. An increase of SOD, and GSH-Px, and a decrease of MDA were reached by the food supplement containing \u03b1-lipoic acid, both compared with the baseline and the placebo. We can conclude that the food supplement containing \u03b1-lipoic acid, L-carnosin, zinc, and vitamins of group B improved glycemic control, lipid profile, and anti-oxidative stress markers.<\/jats:p>","DOI":"10.3390\/ijms17111802","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T10:14:04Z","timestamp":1477649644000},"page":"1802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["A Clinical Trial about a Food Supplement Containing \u03b1-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-4760","authenticated-orcid":false,"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"},{"name":"Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"},{"name":"Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, 2-27100 Pavia, Italy"},{"name":"Laboratory of Molecular Medicine, University of Pavia, 2-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"},{"name":"Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"},{"name":"Laboratory of Molecular Medicine, University of Pavia, 2-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Romano","sequence":"additional","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-6507","authenticated-orcid":false,"given":"Pamela","family":"Maffioli","sequence":"additional","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy"},{"name":"Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, 2-27100 Pavia, Italy"},{"name":"PhD School in Experimental Medicine, University of Pavia, 2-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"ref_1","first-page":"2123","article-title":"Evaluation and prevention of diabetic neuropathy","volume":"71","author":"Aring","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/pgmj.2005.036137","article-title":"Diabetic neuropathy","volume":"82","author":"Bansal","year":"2006","journal-title":"Postgrad. Med. 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