{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:41:17Z","timestamp":1791297677268,"version":"4.1.0"},"reference-count":109,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ultraviolet (UV) radiation from sunlight represents a constant threat to genome stability by generating modified DNA bases such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP). If unrepaired, these lesions can have deleterious effects, including skin cancer. Mammalian cells are able to neutralize UV-induced photolesions through nucleotide excision repair (NER). The NER pathway has multiple components including seven xeroderma pigmentosum (XP) proteins (XPA to XPG) and numerous auxiliary factors, including ataxia telangiectasia and Rad3-related (ATR) protein kinase and RCC1 like domain (RLD) and homologous to the E6-AP carboxyl terminus (HECT) domain containing E3 ubiquitin protein ligase 2 (HERC2). In this review we highlight recent data on the transcriptional and posttranslational regulation of NER activity.<\/jats:p>","DOI":"10.3390\/ijms17111840","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T11:18:38Z","timestamp":1478258318000},"page":"1840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation"],"prefix":"10.3390","volume":"17","author":[{"given":"Jeong-Min","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biological Science, Dong-A University, Busan 49315, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-900X","authenticated-orcid":false,"given":"Tae-Hong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Dong-A University, Busan 49315, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV radiation and the skin","volume":"14","author":"Jarrett","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_2","first-page":"1371","article-title":"Photocarcinogenesis and skin cancer prevention strategies","volume":"36","author":"Seebode","year":"2016","journal-title":"Anticancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00105-013-2587-0","article-title":"Phototherapy and carcinogenesis","volume":"64","author":"Hofbauer","year":"2013","journal-title":"Hautarzt"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Young, A.R., Moan, J., Bj\u00f6rn, L.O., and Nultsch, W. (1993). Environmental UV Photobiology, Springer.","DOI":"10.1007\/978-1-4899-2406-3"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbcan.2005.04.003","article-title":"Cellular UV damage responses\u2014Functions of tumor suppressor p53","volume":"1755","author":"Latonen","year":"2005","journal-title":"Biochim. Biophys. Acta-Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/1011-1344(95)07130-T","article-title":"The specificity of p53 mutation spectra in sunlight induced human cancers","volume":"28","author":"Dumaz","year":"1995","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/php.12377","article-title":"UV signature mutations","volume":"91","author":"Brash","year":"2015","journal-title":"Photochem. Photobiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1242\/jcs.075325","article-title":"UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways","volume":"124","author":"Vrouwe","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"a012609","DOI":"10.1101\/cshperspect.a012609","article-title":"Nucleotide excision repair in eukaryotes","volume":"5","author":"Scharer","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrm2549","article-title":"Transcription-coupled DNA repair: Two decades of progress and surprises","volume":"9","author":"Hanawalt","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg2663","article-title":"Disorders of nucleotide excision repair: The genetic and molecular basis of heterogeneity","volume":"10","author":"Cleaver","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/carcin\/21.3.453","article-title":"Nucleotide excision repair and human syndromes","volume":"21","author":"Hoeijmakers","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-1119(99)00489-8","article-title":"Damage recognition in nucleotide excision repair of DNA","volume":"241","author":"Batty","year":"2000","journal-title":"Gene"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1073\/pnas.0812638106","article-title":"Circadian oscillation of nucleotide excision repair in mammalian brain","volume":"106","author":"Kang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1073\/pnas.0915085107","article-title":"Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase","volume":"107","author":"Kang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1158\/0008-5472.CAN-06-1689","article-title":"High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A","volume":"67","author":"Adair","year":"2007","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/carcin\/bgs142","article-title":"HIF1\u03b1 regulated expression of XPA contributes to cisplatin resistance in lung cancer","volume":"33","author":"Liu","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/nar\/20.2.217","article-title":"Molecular and functional analysis of the XPBC\/ERCC-3 promoter: Transcription activity is dependent on the integrity of an Sp1-binding site","volume":"20","author":"Ma","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14124","DOI":"10.1074\/jbc.M010852200","article-title":"Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue","volume":"276","author":"Benlimame","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12985","DOI":"10.1073\/pnas.202485699","article-title":"p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene","volume":"99","author":"Adimoolam","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1038\/onc.2013.141","article-title":"Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2\/XPC-mediated DNA repair","volume":"33","author":"Barckhausen","year":"2014","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.dnarep.2011.10.016","article-title":"TAp63\u03b3 enhances nucleotide excision repair through transcriptional regulation of DNA repair genes","volume":"11","author":"Liu","year":"2012","journal-title":"DNA Repair"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng953","article-title":"BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair","volume":"32","author":"Hartman","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.3390\/md13095629","article-title":"Protective effect of diphlorethohydroxycarmalol against ultraviolet B radiation-Induced DNA damage by inducing the nucleotide excision repair system in HaCaT human keratinocytes","volume":"13","author":"Piao","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/nar\/gkp1072","article-title":"Hypoxia-inducible factor-1\u03b1 regulates the expression of nucleotide excision repair proteins in keratinocytes","volume":"38","author":"Rezvani","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"22623","DOI":"10.1073\/pnas.1010377108","article-title":"Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C","volume":"107","author":"Ming","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/embor.2009.139","article-title":"ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4","volume":"10","author":"Chen","year":"2009","journal-title":"EMBO Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1038\/onc.2015.390","article-title":"TGF-\u03b2 signaling links E-cadherin loss to suppression of nucleotide excision repair","volume":"35","author":"Qiang","year":"2016","journal-title":"Oncogene"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/pcmr.12252","article-title":"Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation","volume":"27","author":"Swope","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0303-7207(02)00432-X","article-title":"Insulin and glucose regulate the expression of the DNA repair enzyme XPD","volume":"201","author":"Merkel","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1128\/MCB.22.10.3247-3254.2002","article-title":"p53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice","volume":"22","author":"Tan","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1093\/nar\/gkl895","article-title":"c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF","volume":"34","author":"Christmann","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s00018-010-0546-9","article-title":"Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity","volume":"68","author":"Tomicic","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/carcin\/bgm214","article-title":"CEBPG regulates ERCC5\/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1\/YY1 interactions","volume":"28","author":"Crawford","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1093\/nar\/gkq1318","article-title":"Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein","volume":"39","author":"Kang","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nsmb1061","article-title":"Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair","volume":"13","author":"Camenisch","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1074\/jbc.M109.067538","article-title":"The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways","volume":"285","author":"Orelli","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.4161\/cc.8.11.8707","article-title":"Circadian regulation of DNA excision repair implications for chrono-chemotherapy","volume":"8","author":"Kang","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.dnarep.2015.09.015","article-title":"High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells","volume":"36","author":"Reeves","year":"2015","journal-title":"DNA Repair"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm3350","article-title":"TFIIH: When transcription met DNA repair","volume":"13","author":"Compe","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2003-4-2-206","article-title":"Sp1- and Kruppel-like transcription factors","volume":"4","author":"Kaczynski","year":"2003","journal-title":"Genome Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1038\/sj.onc.1201760","article-title":"The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4","volume":"16","author":"Lee","year":"1998","journal-title":"Oncogene"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1101\/gad.866301","article-title":"A multistep damage recognition mechanism for global genomic nucleotide excision repair","volume":"15","author":"Sugasawa","year":"2001","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nature06155","article-title":"Recognition of DNA damage by the Rad4 nucleotide excision repair protein","volume":"449","author":"Min","year":"2007","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1074\/jbc.C100610200","article-title":"DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair","volume":"277","author":"Wakasugi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"a004887","DOI":"10.1101\/cshperspect.a004887","article-title":"p63 and p73, the ancestors of p53","volume":"2","author":"Dotsch","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.dnarep.2011.04.022","article-title":"Regulation of endonuclease activity in human nucleotide excision repair","volume":"10","author":"Fagbemi","year":"2011","journal-title":"DNA Repair"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1093\/nar\/gkt635","article-title":"Transcriptional regulation of human DNA repair genes following genotoxic stress: Trigger mechanisms, inducible responses and genotoxic adaptation","volume":"41","author":"Christmann","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1158\/0008-5472.CAN-04-0348","article-title":"Oncogenic H-Ras up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents","volume":"64","author":"Youn","year":"2004","journal-title":"Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1038\/onc.2011.610","article-title":"Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair","volume":"31","author":"Kudo","year":"2012","journal-title":"Oncogene"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature07963","article-title":"Principles of ubiquitin and SUMO modifications in DNA repair","volume":"458","author":"Bergink","year":"2009","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2005.02.035","article-title":"UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex","volume":"121","author":"Sugasawa","year":"2005","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cell.2011.10.035","article-title":"The molecular basis of CRL4DDB2\/CSA ubiquitin ligase architecture, targeting, and activation","volume":"147","author":"Fischer","year":"2011","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.dnarep.2009.01.011","article-title":"Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases","volume":"8","author":"Hannah","year":"2009","journal-title":"DNA Repair"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2008.10.045","article-title":"Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex","volume":"135","author":"Scrima","year":"2008","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1158\/0008-5472.CAN-07-6162","article-title":"The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A","volume":"68","author":"Kapetanaki","year":"2008","journal-title":"Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.molcel.2006.03.035","article-title":"Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage","volume":"22","author":"Wang","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1128\/MCB.01460-09","article-title":"DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA","volume":"30","author":"Takedachi","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1128\/MCB.21.20.6738-6747.2001","article-title":"The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells","volume":"21","author":"Nag","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.4161\/cc.22688","article-title":"The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability","volume":"11","author":"Zhang","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00018-015-2075-z","article-title":"Xeroderma pigmentosum group C sensor: Unprecedented recognition strategy and tight spatiotemporal regulation","volume":"73","author":"Puumalainen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"32553","DOI":"10.1074\/jbc.M803963200","article-title":"The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation","volume":"283","author":"Zhao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.04.014","article-title":"Autophagic UVRAG promotes UV-induced photolesion repair by activation of the CRL4(DDB2) E3 ligase","volume":"62","author":"Yang","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1038\/ncomms8499","article-title":"SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair","volume":"6","author":"Turkyilmaz","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1083\/jcb.201212075","article-title":"RNF111\/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response","volume":"201","author":"Poulsen","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1093\/nar\/gki684","article-title":"DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation","volume":"33","author":"Wang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1038\/srep10984","article-title":"SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair","volume":"5","author":"Akita","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1093\/nar\/gkm550","article-title":"Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair","volume":"35","author":"Wang","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1101\/gad.378206","article-title":"CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome","volume":"20","author":"Groisman","year":"2006","journal-title":"Genes Dev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.molcel.2010.04.017","article-title":"A ubiquitin-binding domain in cockayne syndrome B required for transcription-coupled nucleotide excision repair","volume":"38","author":"Anindya","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ng.2230","article-title":"UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair","volume":"44","author":"Schwertman","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1074\/jbc.M115.683235","article-title":"The C-terminal region and SUMOylation of cockayne syndrome group B protein play critical roles in transcription-coupled nucleotide excision repair","volume":"291","author":"Sin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"326","DOI":"10.15252\/embj.201489184","article-title":"USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses","volume":"34","author":"Lachaud","year":"2015","journal-title":"EMBO J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.4161\/15384101.2014.973740","article-title":"Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair","volume":"14","author":"Han","year":"2015","journal-title":"Cell Cycle"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"24213","DOI":"10.1074\/jbc.M109.000745","article-title":"Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A","volume":"284","author":"Shell","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/onc.2012.539","article-title":"Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair","volume":"33","author":"Lee","year":"2014","journal-title":"Oncogene"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.dnarep.2010.04.005","article-title":"The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair","volume":"9","author":"Nguyen","year":"2010","journal-title":"DNA Repair"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molcel.2010.07.006","article-title":"SIRT1 regulates UV-induced DNA repair through deacetylating XPA","volume":"39","author":"Fan","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1038\/sj.emboj.7600480","article-title":"Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity","volume":"23","author":"Coin","year":"2004","journal-title":"EMBO J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbrc.2006.07.076","article-title":"Identification and Herc5-mediated ISGylation of novel target proteins","volume":"348","author":"Takeuchi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Kim, D.S., and Hahn, Y. (2012). Gains of ubiquitylation sites in highly conserved proteins in the human lineage. BMC Bioinform., 13.","DOI":"10.1186\/1471-2105-13-306"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1083\/jcb.201112132","article-title":"PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1","volume":"199","author":"Pines","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1073\/pnas.1209507110","article-title":"Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair","volume":"110","author":"Robu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.dnarep.2012.08.001","article-title":"p300\/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG","volume":"11","author":"Tillhon","year":"2012","journal-title":"DNA Repair"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1093\/nar\/gkm386","article-title":"Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase","volume":"35","author":"Imam","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1128\/MCB.25.17.7625-7636.2005","article-title":"Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress","volume":"25","author":"Thorslund","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: An essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Li, Z.K., Musich, P.R., Cartwright, B.M., Wang, H., and Zou, Y. (2013). UV-induced nuclear import of XPA is mediated by importin-\u03b14 in an ATR-dependent manner. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068297"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bbrc.2015.04.071","article-title":"NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair","volume":"461","author":"Park","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"19308","DOI":"10.1074\/jbc.M110.121939","article-title":"E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair","volume":"285","author":"Guo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1158\/0008-5472.CAN-13-3216","article-title":"E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis","volume":"74","author":"Biswas","year":"2014","journal-title":"Cancer Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/nar\/gkq983","article-title":"GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage","volume":"39","author":"Guo","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mad.2013.02.004","article-title":"Structure, function and regulation of CSB: A multi-talented gymnast","volume":"134","author":"Lake","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"22575","DOI":"10.18632\/oncotarget.4610","article-title":"Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents","volume":"6","author":"Choi","year":"2015","journal-title":"Oncotarget"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/MCB.00202-14","article-title":"The RASSF1A tumor suppressor regulates XPA-mediated DNA repair","volume":"35","author":"Donninger","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mrrev.2014.12.002","article-title":"Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications","volume":"763","author":"Feltes","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/nar\/gks1312","article-title":"p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1128\/MCB.25.15.6592-6602.2005","article-title":"Akt-phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity","volume":"25","author":"Huang","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/bies.20085","article-title":"The PARP superfamily","volume":"26","author":"Ame","year":"2004","journal-title":"Bioessays"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrc2812","article-title":"PARP inhibition: PARP1 and beyond","volume":"10","author":"Rouleau","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"32980","DOI":"10.18632\/oncotarget.9087","article-title":"Non-thermal plasma-induced apoptosis is modulated by ATR-and PARP1-mediated DNA damage responses and circadian clock","volume":"7","author":"Choi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.tibs.2013.03.002","article-title":"Touching base with PARPs: Moonlighting in the repair of UV lesions and double-strand breaks","volume":"38","author":"Pines","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1093\/nar\/gkm944","article-title":"Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length","volume":"35","author":"Fahrer","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1111\/febs.12885","article-title":"Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function","volume":"281","author":"Fischer","year":"2014","journal-title":"FEBS J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1074\/jbc.M112.393504","article-title":"Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair","volume":"287","author":"King","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature17437","article-title":"Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes","volume":"532","author":"Perera","year":"2016","journal-title":"Nature"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature17661","article-title":"Nucleotide excision repair is impaired by binding of transcription factors to DNA","volume":"532","author":"Sabarinathan","year":"2016","journal-title":"Nature"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/11\/1840\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:34:47Z","timestamp":1760211287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/17\/11\/1840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,4]]},"references-count":109,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11]]}},"alternative-id":["ijms17111840"],"URL":"https:\/\/doi.org\/10.3390\/ijms17111840","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,4]]}}}