{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:25:48Z","timestamp":1792805148807,"version":"4.5.0"},"reference-count":73,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Creative Materials Discovery Program through the National Research Foundation of Korea (NRF)","award":["2016M3D1A1021387"],"award-info":[{"award-number":["2016M3D1A1021387"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF)","award":["NRF-2013R1A1A2062797"],"award-info":[{"award-number":["NRF-2013R1A1A2062797"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.<\/jats:p>","DOI":"10.3390\/ijms17122059","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T10:39:01Z","timestamp":1481193541000},"page":"2059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases"],"prefix":"10.3390","volume":"17","author":[{"given":"Youn","family":"Houh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Sookmyung Women\u2019s University, Seoul 04310, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-1280","authenticated-orcid":false,"given":"Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Sciences, Sookmyung Women\u2019s University, Seoul 04310, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yeouido St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul 07345, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Sookmyung Women\u2019s University, Seoul 04310, Korea"},{"name":"Department of Cosmetic Sciences, Sookmyung Women\u2019s University, Seoul 04310, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cyto.2004.02.005","article-title":"Erythroid differentiation regulator (Edr), a novel, highly conserved factor I. 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