{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:10:13Z","timestamp":1774318213386,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Health, Executive Yuan, Taiwan, ROC","award":["DOH102-TD-C-111-002"],"award-info":[{"award-number":["DOH102-TD-C-111-002"]}]},{"name":"National Science Council, Taiwan, ROC","award":["MOST 104-2320-B-038-016"],"award-info":[{"award-number":["MOST 104-2320-B-038-016"]}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["12310-0223"],"award-info":[{"award-number":["12310-0223"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2011-C-004"],"award-info":[{"award-number":["CSH-2011-C-004"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls. Although none of single-nucleotide polymorphisms (SNPs) were associated with the susceptibility to AS, the AS disease index Bath AS Global (BAS-G) clinical phenotype was observed as significantly correlated to the AA genotype of rs657075 (CSF2). The significance remains after gender\/age\/disease duration adjustment and after group categorization by human leukocyte antigen-B 27 (HLA-B27) genotype. We further investigated the possible functions of rs657075 through bioinformatics approaches. Results revealed that polymorphism of rs657075 is able to influence the expression of acyl-CoA synthetase long-chain family member 6 (ACSL6). In conclusion, our study indicated that rs657075 (CSF2) is strongly associated with the AS disease index Bath AS Global (BAS-G) clinical phenotype.<\/jats:p>","DOI":"10.3390\/ijms18010083","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T10:26:49Z","timestamp":1483439209000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["rs657075 (CSF2) Is Associated with the Disease Phenotype (BAS-G) of Ankylosing Spondylitis"],"prefix":"10.3390","volume":"18","author":[{"given":"Wei-Chiao","family":"Chen","sequence":"first","affiliation":[{"name":"Institude of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Institute of Integrative Medicine, China Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Fang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11014, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11014, Taiwan"},{"name":"Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11014, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Woon","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ding","family":"Huang","sequence":"additional","affiliation":[{"name":"Institude of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11014, Taiwan"},{"name":"Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11014, Taiwan"},{"name":"The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan"},{"name":"Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taipei 116, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet"},{"key":"ref_2","first-page":"785","article-title":"Ankylosing spondylitis, a seronegative spondarthritis","volume":"231","author":"Pal","year":"1987","journal-title":"Practitioner"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0140-6736(99)03219-5","article-title":"Impact of sex on inheritance of ankylosing spondylitis: A cohort study","volume":"354","author":"Calin","year":"1999","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1136\/ard.59.11.883","article-title":"Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis","volume":"59","author":"Brown","year":"2000","journal-title":"Ann. 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