{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:23:45Z","timestamp":1783409025022,"version":"3.54.6"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%\u201315% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in the early phase of the disease. We included 66 patients with AP, admitted within the first 24 h from the onset of symptoms. TBA were measured in serum at 24, 48, and 72 h from the onset of AP, using an automated fifth generation assay. The bilirubin-to-TBA ratio (B\/TBA) was calculated. TBA was highest on the first day of AP and decreased subsequently. In patients with biliary etiology, serum TBA was significantly higher compared to those with alcoholic and other etiologies. B\/TBA was significantly higher in patients with alcoholic etiology. At admission, the cut-off values of 4.7 \u00b5mol\/L for TBA and 4.22 for the B\/TBA ratio allowed for a differentiation between biliary and other etiologies of AP with a diagnostic accuracy of 85 and 83%. Both TBA and B\/TBA may help in the diagnosis of AP etiology in the early phase of AP.<\/jats:p>","DOI":"10.3390\/ijms18010106","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T10:08:12Z","timestamp":1483697292000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies"],"prefix":"10.3390","volume":"18","author":[{"given":"Aleksandra","family":"Maleszka","sequence":"first","affiliation":[{"name":"Department of Diagnostics, University Hospital, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Dumnicka","sequence":"additional","affiliation":[{"name":"Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Matuszyk","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9073-2667","authenticated-orcid":false,"given":"Micha\u0142","family":"P\u0119dziwiatr","sequence":"additional","affiliation":[{"name":"2nd Department of Surgery, Jagiellonian University Medical College, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Mazur-Laskowska","sequence":"additional","affiliation":[{"name":"Department of Diagnostics, University Hospital, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Sporek","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-0108","authenticated-orcid":false,"given":"Piotr","family":"Ceranowicz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jagiellonian University Medical College, 31-531 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Olszanecki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Jagiellonian University Medical College, 31-531 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Ku\u017aniewski","sequence":"additional","affiliation":[{"name":"Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Ku\u015bnierz-Cabala","sequence":"additional","affiliation":[{"name":"Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10354-013-0260-y","article-title":"An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?)","volume":"164","author":"Hammer","year":"2014","journal-title":"Wien. 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