{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:19:17Z","timestamp":1771543157521,"version":"3.50.1"},"reference-count":92,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Skin wounds may lead to scar formation and impaired functionality. Remote ischemic preconditioning (RIPC) can induce the anti-inflammatory enzyme heme oxygenase-1 (HO-1) and protect against tissue injury. We aim to improve cutaneous wound repair by RIPC treatment via induction of HO-1. RIPC was applied to HO-1-luc transgenic mice and HO-1 promoter activity and mRNA expression in skin and several other organs were determined in real-time. In parallel, RIPC was applied directly or 24h prior to excisional wounding in mice to investigate the early and late protective effects of RIPC on cutaneous wound repair, respectively. HO-1 promoter activity was significantly induced on the dorsal side and locally in the kidneys following RIPC treatment. Next, we investigated the origin of this RIPC-induced HO-1 promoter activity and demonstrated increased mRNA in the ligated muscle, heart and kidneys, but not in the skin. RIPC did not change HO-1 mRNA and protein levels in the wound 7 days after cutaneous injury. Both early and late RIPC did not accelerate wound closure nor affect collagen deposition. RIPC induces HO-1 expression in several organs, but not the skin, and did not improve excisional wound repair, suggesting that the skin is insensitive to RIPC-mediated protection.<\/jats:p>","DOI":"10.3390\/ijms18020438","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T12:10:34Z","timestamp":1487333434000},"page":"438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair"],"prefix":"10.3390","volume":"18","author":[{"given":"Niels","family":"Cremers","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Wever","sequence":"additional","affiliation":[{"name":"Central Animal Laboratory, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Health Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-6936","authenticated-orcid":false,"given":"Ronald","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Van Rheden","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"Vermeij","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gooitzen","family":"Van Dam","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Groningen, Groningen 9700RB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-9223","authenticated-orcid":false,"given":"Carine","family":"Carels","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"},{"name":"Department of Human Genetics, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Department of Oral Health Sciences, Faculty of Medicine, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Lundvig","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Wagener","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Nijmegen 6500HB, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.6061\/clinics\/2014(08)11","article-title":"Update on hypertrophic scar treatment","volume":"69","author":"Rabello","year":"2014","journal-title":"Clinics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"265sr266","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1468-3083.2011.04200.x","article-title":"Extracellular matrix molecules implicated in hypertrophic and keloid scarring","volume":"26","author":"Sidgwick","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4614-0106-3_4","article-title":"Interaction of the microbiome with the innate immune response in chronic wounds","volume":"946","author":"Grice","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1089\/wound.2013.0506","article-title":"Traditional therapies for skin wound healing","volume":"5","author":"Pereira","year":"2016","journal-title":"Adv. Wound Care"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Aarabi, S., Longaker, M.T., and Gurtner, G.C. (2007). Hypertrophic scar formation following burns and trauma: New approaches to treatment. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040234"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaad.2011.08.035","article-title":"Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics part II. Strategies to reduce scar formation after dermatologic procedures","volume":"66","author":"Tziotzios","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9726503","DOI":"10.1155\/2016\/9726503","article-title":"Heme oxygenase-1 promotes delayed wound healing in diabetic rats","volume":"2016","author":"Chen","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2010.06.048","article-title":"Pro-healing potential of hemin: An inducer of heme oxygenase-1","volume":"645","author":"Ahanger","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11010-006-9170-2","article-title":"Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species","volume":"290","author":"Panchatcharam","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/1389201017666160721123109","article-title":"Wound healing effects of curcumin: A short review","volume":"17","author":"Tejada","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jss.2014.10.019","article-title":"Curcumin-induced angiogenesis hastens wound healing in diabetic rats","volume":"193","author":"Kant","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17974","DOI":"10.3390\/ijms151017974","article-title":"Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells","volume":"15","author":"Cremers","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.08.016","article-title":"Curcumin as a wound healing agent","volume":"116","author":"Akbik","year":"2014","journal-title":"Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1124\/pr.55.3.5","article-title":"Different faces of the heme-heme oxygenase system in inflammation","volume":"55","author":"Wagener","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of cell protection by heme oxygenase-1","volume":"50","author":"Gozzelino","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.200404-465SO","article-title":"Heme oxygenase-1: From bench to bedside","volume":"172","author":"Morse","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1089\/ars.2013.5666","article-title":"Coupling heme and iron metabolism via ferritin h chain","volume":"20","author":"Gozzelino","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Grochot-Przeczek, A., Lach, R., Mis, J., Skrzypek, K., Gozdecka, M., Sroczynska, P., Dubiel, M., Rutkowski, A., Kozakowska, M., and Zagorska, A. (2009). Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005803"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ahanger, A.A., Leo, M.D., Gopal, A., Kant, V., Tandan, S.K., and Kumar, D. (2014). Pro-healing effects of bilirubin in open excision wound model in rats. Int. Wound J.","DOI":"10.1111\/iwj.12319"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1590\/S0100-879X2009005000025","article-title":"Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats","volume":"42","author":"Loiola","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/cvr\/cvn114","article-title":"Remote ischaemic preconditioning: Underlying mechanisms and clinical application","volume":"79","author":"Hausenloy","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/01.tp.0000203555.14546.63","article-title":"Transient limb ischemia induces remote preconditioning in liver among rats: The protective role of heme oxygenase-1","volume":"81","author":"Lai","year":"2006","journal-title":"Transplantation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1477-2574.2009.00006.x","article-title":"Effect of remote ischemic preconditioning on hepatic microcirculation and function in a rat model of hepatic ischemia reperfusion injury","volume":"11","author":"Tapuria","year":"2009","journal-title":"HPB (Oxford)"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kageyama, S., Hata, K., Tanaka, H., Hirao, H., Kubota, T., Okamura, Y., Iwaisako, K., Takada, Y., and Uemoto, S. (2014). Intestinal ischemic preconditioning ameliorates hepatic ischemia reperfusion injury in rats: Role of heme oxygenase-1 in the second-window of protection. Liver Transpl.","DOI":"10.1002\/lt.24006"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wang, Y., Shen, J., Xiong, X., Xu, Y., Zhang, H., Huang, C., Tian, Y., Jiao, C., Wang, X., and Li, X. (2014). Remote ischemic preconditioning protects against liver ischemia-reperfusion injury via heme oxygenase-1-induced autophagy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098834"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(13)61450-6","article-title":"Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: A single-centre randomised, double-blind, controlled trial","volume":"382","author":"Thielmann","year":"2013","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00383-010-2810-3","article-title":"Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine","volume":"27","author":"Saeki","year":"2011","journal-title":"Pediatr. Surg. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1161\/01.CIR.0000043806.51912.9B","article-title":"Transient limb ischemia induces remote ischemic preconditioning in vivo","volume":"106","author":"Kharbanda","year":"2002","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fphys.2012.00027","article-title":"Remote ischemic conditioning: From bench to bedside","volume":"3","author":"Lim","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1093\/ndt\/gfs601","article-title":"Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor","volume":"28","author":"Wever","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1093\/ndt\/gfr103","article-title":"Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: The role of adenosine","volume":"26","author":"Wever","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.resuscitation.2011.02.010","article-title":"Limb ischemic preconditioning mitigates lung injury induced by haemorrhagic shock\/resuscitation in rats","volume":"82","author":"Jan","year":"2011","journal-title":"Resuscitation"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WCO.0b013e32835bf200","article-title":"Ischemic preconditioning and clinical scenarios","volume":"26","author":"Narayanan","year":"2013","journal-title":"Curr. Opin. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"H752","DOI":"10.1152\/ajpheart.00147.2010","article-title":"Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window","volume":"299","author":"Depre","year":"2010","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1161\/CIRCULATIONAHA.108.788240","article-title":"Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning","volume":"118","author":"Shen","year":"2008","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/cvr\/cvs131","article-title":"Cardioprotection during cardiac surgery","volume":"94","author":"Hausenloy","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa1413534","article-title":"Remote ischemic preconditioning and outcomes of cardiac surgery","volume":"373","author":"Hausenloy","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"i5599","DOI":"10.1136\/bmj.i5599","article-title":"Effects of ischaemic conditioning on major clinical outcomes in people undergoing invasive procedures: Systematic review and meta-analysis","volume":"355","author":"Sukkar","year":"2016","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/CIRCRESAHA.115.308102","article-title":"Remote ischemic conditioning and the long road to clinical translation: Lessons learned from ericca and ripheart","volume":"118","author":"Garratt","year":"2016","journal-title":"Circ. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrsc.2016.03.001","article-title":"Remote ischaemic pre-conditioning does not affect clinical outcomes following coronary artery bypass grafting. A systematic review and meta-analysis","volume":"17","author":"King","year":"2016","journal-title":"Clin. Trials Regul. Sci. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/bph.13064","article-title":"Ischaemic conditioning: Pitfalls on the path to clinical translation","volume":"172","author":"Przyklenk","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2014.10.579","article-title":"Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via bach1 in primary human mononuclear cells","volume":"78","author":"Dorresteijn","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kraemer, R., Lorenzen, J., Kabbani, M., Herold, C., Busche, M., Vogt, P.M., and Knobloch, K. (2011). Acute effects of remote ischemic preconditioning on cutaneous microcirculation--a controlled prospective cohort study. BMC Surg., 11.","DOI":"10.1186\/1471-2482-11-32"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/PRS.0000000000002664","article-title":"Remote ischemic conditioning improves blood flow and oxygen saturation in pedicled and free surgical flaps","volume":"138","author":"Kolbenschlag","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/2000656X.2015.1106410","article-title":"Value of remote ischaemic preconditioning in rat dorsal skin flaps and clamping time","volume":"50","author":"Masaoka","year":"2015","journal-title":"J. Plast. Surg. Hand. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/wrr.12269","article-title":"Intermittent cycles of remote ischemic preconditioning augment diabetic foot ulcer healing","volume":"23","author":"Shaked","year":"2015","journal-title":"Wound Repair Regen."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12933-016-0444-z","article-title":"Remote ischaemic conditioning in the context of type 2 diabetes and neuropathy: The case for repeat application as a novel therapy for lower extremity ulceration","volume":"15","author":"Epps","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00109-002-0375-x","article-title":"Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1","volume":"80","author":"Zhang","year":"2002","journal-title":"J. Molecular Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F254","DOI":"10.1152\/ajprenal.00594.2010","article-title":"Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1","volume":"300","author":"Zarjou","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/jcp.22502","article-title":"Knockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing","volume":"226","author":"Halilovic","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/CIRCULATIONAHA.107.698316","article-title":"Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis","volume":"117","author":"Dulak","year":"2008","journal-title":"Circulation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00210-011-0653-7","article-title":"Wound healing activity of carbon monoxide liberated from co-releasing molecule (co-rm)","volume":"384","author":"Ahanger","year":"2011","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.0812010106","article-title":"Regulatory effects of ferritin on angiogenesis","volume":"106","author":"Coffman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2174\/1389450116666150309115536","article-title":"Endogenous cardioprotective agents: Role in pre and postconditioning","volume":"16","author":"Penna","year":"2015","journal-title":"Curr. Drug Target."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1590\/S0102-865020150070000002","article-title":"Effect of remote ischemic preconditioning in the expression of IL-6 and IL-10 in a rat model of liver ischemia-reperfusion injury","volume":"30","author":"Cortez","year":"2015","journal-title":"Acta Cir. Bras."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.yjmcc.2008.08.011","article-title":"Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin","volume":"45","author":"Chevion","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jss.2007.12.747","article-title":"Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury\u2014A review","volume":"150","author":"Tapuria","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj3530459","article-title":"Haem oxygenase-1: A novel player in cutaneous wound repair and psoriasis?","volume":"353","author":"Hanselmann","year":"2001","journal-title":"Biochem. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF03401854","article-title":"Macrophage-derived heme-oxygenase-1: Expression, regulation, and possible functions in skin repair","volume":"7","author":"Kampfer","year":"2001","journal-title":"Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/SLA.0b013e31819a8d6c","article-title":"Tight spatial and temporal control in dynamic basal to distal migration of epithelial inflammatory responses and infiltration of cytoprotective macrophages determine healing skin flap transplants in mice","volume":"249","author":"Schurmann","year":"2009","journal-title":"Ann. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood-2002-07-2248","article-title":"The heme-heme oxygenase system: A molecular switch in wound healing","volume":"102","author":"Wagener","year":"2003","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3748\/wjg.v17.i10.1308","article-title":"Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses","volume":"17","author":"Holzner","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jss.2006.10.030","article-title":"The effect of remote ischemic preconditioning on healing of colonic anastomoses","volume":"143","author":"Colak","year":"2007","journal-title":"J. Surg. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.SAP.0000054186.10681.E2","article-title":"Late remote ischemic preconditioning in rat muscle and adipocutaneous flap models","volume":"51","author":"Kuntscher","year":"2003","journal-title":"Ann. Plastic Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1097\/00006534-200206000-00034","article-title":"Ischemic preconditioning by brief extremity ischemia before flap ischemia in a rat model","volume":"109","author":"Kuntscher","year":"2002","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1055\/s-0029-1238220","article-title":"The effect of ischemic preconditioning on secondary ischemia in myocutaneous flaps","volume":"25","author":"Shah","year":"2009","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00006534-199807000-00022","article-title":"Ischemic preconditioning improves the survival of skin and myocutaneous flaps in a rat model","volume":"102","author":"Zahir","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/eurheartj\/eht517","article-title":"Remote ischaemic pre-conditioning in cardiac surgery: Benefit or not?","volume":"35","author":"Kolh","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10557-011-6321-9","article-title":"Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome p450 epoxygenase pathway in canine hearts","volume":"25","author":"Gross","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1074248412437586","article-title":"Factors mediating remote preconditioning of trauma in the rat heart: Central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction","volume":"18","author":"Gross","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1161\/CIRCULATIONAHA.108.843938","article-title":"Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase c signaling","volume":"120","author":"Jones","year":"2009","journal-title":"Circulation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3892\/etm.2015.2320","article-title":"Cardioprotective effect of remote preconditioning of trauma and remote ischemia preconditioning in a rat model of myocardial ischemia\/reperfusion injury","volume":"9","author":"Chai","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.2174\/1389450111009011571","article-title":"The heme-heme oxygenase system in wound healing; implications for scar formation","volume":"11","author":"Wagener","year":"2010","journal-title":"Curr. Drug Target"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fphar.2012.00081","article-title":"Heme oxygenase, inflammation, and fibrosis: The good, the bad, and the ugly?","volume":"3","author":"Lundvig","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1111\/jcmm.12389","article-title":"Delayed cutaneous wound closure in ho-2 deficient mice despite normal ho-1 expression","volume":"18","author":"Lundvig","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.jidsymp.5650001","article-title":"Reactive oxygen species and their detoxification in healing skin wounds","volume":"11","author":"Kumin","year":"2006","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fmed.2015.00086","article-title":"Mechanical stress changes the complex interplay between HO-1, inflammation and fibrosis, during excisional wound repair","volume":"2","author":"Cremers","year":"2015","journal-title":"Front. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10715769900300921","article-title":"Oxidative stress-inducible proteins in macrophages","volume":"31","author":"Ishii","year":"1999","journal-title":"Free Radical Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/ATVBAHA.110.211789","article-title":"The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus","volume":"31","author":"Dekker","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCULATIONAHA.112.105775","article-title":"Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in gilbert syndrome","volume":"126","author":"Maruhashi","year":"2012","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wever, K.E., Hooijmans, C.R., Riksen, N.P., Sterenborg, T.B., Sena, E.S., Ritskes-Hoitinga, M., and Warle, M.C. (2015). Determinants of the efficacy of cardiac ischemic preconditioning: A systematic review and meta-analysis of animal studies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142021"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wever, K.E., Wagener, F.A., Frielink, C., Boerman, O.C., Scheffer, G.J., Allison, A., Masereeuw, R., and Rongen, G.A. (2011). Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024276"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/lt.20852","article-title":"Spatiotemporal expression of heme oxygenase-1 detected by in vivo bioluminescence after hepatic ischemia in HO-1\/luc mice","volume":"12","author":"Su","year":"2006","journal-title":"Liver Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s00540-014-1850-6","article-title":"Remote ischemic preconditioning prevents lipopolysaccharide-induced liver injury through inhibition of NF-\u03baB activation in mice","volume":"28","author":"Shin","year":"2014","journal-title":"J. Anesth."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/lt.22204","article-title":"Effect of remote ischemic preconditioning on liver ischemia\/reperfusion injury using a new mouse model","volume":"17","author":"Yang","year":"2011","journal-title":"Liver Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00395-012-0277-1","article-title":"Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10","volume":"107","author":"Cai","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"van den Brand, B.T., Vermeij, E.A., Waterborg, C.E., Arntz, O.J., Kracht, M., Bennink, M.B., van den Berg, W.B., and van de Loo, F.A. (2013). Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4\/80+ and ly-6c+ cells in spleen, important target cells in autoimmune arthritis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055356"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s13402-011-0035-7","article-title":"Rapid quantification of myocardial fibrosis: A new macro-based automated analysis","volume":"34","author":"Hadi","year":"2011","journal-title":"Cell. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.3748\/wjg.v20.i28.9506","article-title":"Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia\/reperfusion","volume":"20","author":"Bjornsson","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/labinvest.2012.160","article-title":"Delayed preconditioning prevents ischemia\/reperfusion-induced endothelial injury in rats: Role of ROS and eNOS","volume":"93","author":"He","year":"2013","journal-title":"Lab. Investig."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/2\/438\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:28:30Z","timestamp":1760207310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/2\/438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":92,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2]]}},"alternative-id":["ijms18020438"],"URL":"https:\/\/doi.org\/10.3390\/ijms18020438","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}