{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:55Z","timestamp":1791357055870,"version":"4.3.1"},"reference-count":82,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160741"],"award-info":[{"award-number":["1160741"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1120138"],"award-info":[{"award-number":["1120138"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1090461"],"award-info":[{"award-number":["1090461"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the \u2018protease web\u2019 is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules\u2014such as cytokines, chemokines, and growth factors, among others\u2014regulating their biological functions and\/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.<\/jats:p>","DOI":"10.3390\/ijms18020440","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T12:10:34Z","timestamp":1487333434000},"page":"440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":278,"title":["Matrix Metalloproteinases as Regulators of Periodontal Inflammation"],"prefix":"10.3390","volume":"18","author":[{"given":"Cavalla","family":"Franco","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo (FOB\/USP), Bauru, S\u00e3o Paulo 17012-901, Brazil"},{"name":"Center for Craniofacial Research, University of Texas School of Dentistry at Houston, Houston, TX 77054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1ndez-R\u00edos","family":"Patricia","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorsa","family":"Timo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Helsinki University and Helsinki University Central Hospital, Helsinki 00290, Finland"},{"name":"Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge 14183, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biguetti","family":"Claudia","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo (FOB\/USP), Bauru, S\u00e3o Paulo 17012-901, Brazil"},{"name":"Center for Craniofacial Research, University of Texas School of Dentistry at Houston, Houston, TX 77054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-7314","authenticated-orcid":false,"given":"Hern\u00e1ndez","family":"Marcela","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"},{"name":"Dentistry Unit, Faculty of Health Sciences, Universidad Aut\u00f3noma de Chile, Santiago 8910060, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nature06247","article-title":"Manipulation of host-cell pathways by bacterial pathogens","volume":"449","author":"Bhavsar","year":"2007","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1902\/jop.2008.080183","article-title":"Cytokines that promote periodontal tissue destruction","volume":"79","author":"Graves","year":"2008","journal-title":"J. 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