{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:03:04Z","timestamp":1792789384930,"version":"4.5.0"},"reference-count":121,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M592134"],"award-info":[{"award-number":["2016M592134"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qingdao Postdoctoral Application Research Project","award":["2016074"],"award-info":[{"award-number":["2016074"]}]},{"name":"National Natural Science Foundation","award":["31430041"],"award-info":[{"award-number":["31430041"]}]},{"name":"National Natural Science Foundation","award":["81230005"],"award-info":[{"award-number":["81230005"]}]},{"name":"National Natural Science Foundation","award":["81622005"],"award-info":[{"award-number":["81622005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review.<\/jats:p>","DOI":"10.3390\/ijms18040745","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T10:35:49Z","timestamp":1490956549000},"page":"745","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application"],"prefix":"10.3390","volume":"18","author":[{"given":"Teng","family":"Sun","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Han","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ying","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad-Akram","family":"Tariq","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Qingdao University, Qingdao 266021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"ref_1","first-page":"29","article-title":"Heart disease and stroke statistics\u20142015 Update: A report from the american heart association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIR.0b013e3182285a81","article-title":"Value of primordial and primary prevention for cardiovascular disease: A policy statement from the american heart association","volume":"124","author":"Weintraub","year":"2011","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J. 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