{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:20:03Z","timestamp":1768450803900,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MEXT KAKENHI","award":["24592040"],"award-info":[{"award-number":["24592040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study evaluated the clinical use of serum metabolomics to discriminate malignant cancers including pancreatic cancer (PC) from malignant diseases, such as biliary tract cancer (BTC), intraductal papillary mucinous carcinoma (IPMC), and various benign pancreaticobiliary diseases. Capillary electrophoresismass spectrometry was used to analyze charged metabolites. We repeatedly analyzed serum samples (n = 41) of different storage durations to identify metabolites showing high quantitative reproducibility, and subsequently analyzed all samples (n = 140). Overall, 189 metabolites were quantified and 66 metabolites had a 20% coefficient of variation and, of these, 24 metabolites showed significant differences among control, benign, and malignant groups (p &lt; 0.05; Steel\u2013Dwass test). Four multiple logistic regression models (MLR) were developed and one MLR model clearly discriminated all disease patients from healthy controls with an area under receiver operating characteristic curve (AUC) of 0.970 (95% confidential interval (CI), 0.946\u20130.994, p &lt; 0.0001). Another model to discriminate PC from BTC and IPMC yielded AUC = 0.831 (95% CI, 0.650\u20131.01, p = 0.0020) with higher accuracy compared with tumor markers including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), pancreatic cancer-associated antigen (DUPAN2) and s-pancreas-1 antigen (SPAN1). Changes in metabolomic profiles might be used to screen for malignant cancers as well as to differentiate between PC and other malignant diseases.<\/jats:p>","DOI":"10.3390\/ijms18040767","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T10:15:12Z","timestamp":1491300912000},"page":"767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination"],"prefix":"10.3390","volume":"18","author":[{"given":"Takao","family":"Itoi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-2543","authenticated-orcid":false,"given":"Masahiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Umeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sofuni","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujiro","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Tonozuka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Honjo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Moriyasu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Kasuya","sequence":"additional","affiliation":[{"name":"Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Nagakawa","sequence":"additional","affiliation":[{"name":"Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Abe","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiro","family":"Takano","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyoshi","family":"Soga","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Tomita","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, 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