{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:49:32Z","timestamp":1773924572235,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Coffea arabica extract (CAE) containing 48.3 \u00b1 0.4 mg\/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB\/c hairless mice. The results indicated that 500 \u03bcg\/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46.4%, and hydroxyl radical scavenging activity of 20.3%. The CAE dose dependently reduced UVB-induced reactive oxygen species (ROS) generation in fibroblasts. Furthermore, CAE inhibited the UVB-induced expression of cyclooxygenase-2 and p-inhibitor \u03baB, and the translocation of nuclear factor-kappa B (NF-\u03baB) to the nucleus of fibroblasts. In addition, CAE alleviated UVB-induced photoaging and photodamage in BALB\/c hairless mice by restoring the collagen content and reduced UVB-induced epidermal hyperplasia. CAE also inhibited UVB-induced NF-\u03baB, interleukin-6, and matrix metalloproteinase-1 expression in the hairless mouse skin. The results indicated that CAE exhibits antiphotodamage activity by inhibiting UV-induced oxidative stress and inflammation. Therefore, CAE is a candidate for use in antioxidant, antiinflammatory, and antiphotodamage products.<\/jats:p>","DOI":"10.3390\/ijms18040782","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T10:49:53Z","timestamp":1491562193000},"page":"782","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin"],"prefix":"10.3390","volume":"18","author":[{"given":"Po-Yuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology, China Medical University Hospital, Taichung 40402, Taiwan"},{"name":"School of Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Han","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Ching","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yih","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Asia University, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Chich","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-910X","authenticated-orcid":false,"given":"Hsiu-Mei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/jid.2009.99","article-title":"Uvb and caffeine: Inhibiting the DNA damage response to protect against the adverse effects of UVB","volume":"129","author":"Kerzendorfer","year":"2009","journal-title":"J. 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