{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:16:29Z","timestamp":1784888189534,"version":"3.55.0"},"reference-count":49,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Background: Maintenance of brain circulation during shock is sufficient to prevent subcortical injury but the cerebral cortex is not spared. This suggests area-specific regulation of cerebral blood flow (CBF) during hemorrhage. Methods: Cortical and subcortical CBF were continuously measured during blood loss (\u226450%) and subsequent reperfusion using laser Doppler flowmetry. Blood gases, mean arterial blood pressure (MABP), heart rate and renal blood flow were also monitored. Urapidil was used for \u03b11A-adrenergic receptor blockade in dosages, which did not modify the MABP-response to blood loss. Western blot and quantitative reverse transcription polymerase chain reactions were used to determine adrenergic receptor expression in brain arterioles. Results: During hypovolemia subcortical CBF was maintained at 81 \u00b1 6% of baseline, whereas cortical CBF decreased to 40 \u00b1 4% (p &lt; 0.001). Reperfusion led to peak CBFs of about 70% above baseline in both brain regions. \u03b11A-Adrenergic blockade massively reduced subcortical CBF during hemorrhage and reperfusion, and prevented hyperperfusion during reperfusion in the cortex. \u03b11A-mRNA expression was significantly higher in the cortex, whereas \u03b11D-mRNA expression was higher in the subcortex (p &lt; 0.001). Conclusions: \u03b11-Adrenergic receptors are critical for perfusion redistribution: activity of the \u03b11A-receptor subtype is a prerequisite for redistribution of CBF, whereas the \u03b11D-receptor subtype may determine the magnitude of redistribution responses.<\/jats:p>","DOI":"10.3390\/ijms18051031","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T11:06:46Z","timestamp":1494500806000},"page":"1031","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of \u03b11-Adrenergic Signaling"],"prefix":"10.3390","volume":"18","author":[{"given":"Ren\u00e9","family":"Schiffner","sequence":"first","affiliation":[{"name":"Orthopedic Department, Campus Eisenberg, Jena University Hospital-Friedrich Schiller University, 07607 Eisenberg, Germany"},{"name":"Department of Neurology; Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bischoff","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Sciences and Welfare, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Computer Sciences and Documentation Science, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rakers","sequence":"additional","affiliation":[{"name":"Department of Neurology; Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Department of Neurology; Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Reiche","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry II, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Matziolis","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Campus Eisenberg, Jena University Hospital-Friedrich Schiller University, 07607 Eisenberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Schubert","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Sciences and Welfare, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Neurology; Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-1747","authenticated-orcid":false,"given":"Otmar","family":"Huber","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry II, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-4338","authenticated-orcid":false,"given":"Martin","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry II, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"ref_1","first-page":"3","article-title":"Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations","volume":"60","author":"Kauvar","year":"2006","journal-title":"J. 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