{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:18:20Z","timestamp":1791328700824,"version":"4.3.1"},"reference-count":100,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother\u2013child interaction are also discussed.<\/jats:p>","DOI":"10.3390\/ijms18051093","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T01:47:33Z","timestamp":1495504053000},"page":"1093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring"],"prefix":"10.3390","volume":"18","author":[{"given":"Laura","family":"Contu","sequence":"first","affiliation":[{"name":"School of Life, Health and Chemical Sciences, Science, Technology, Engineering and Mathematics (STEM) Faculty, Open University, Walton Hall, Milton Keynes MK7 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-0130","authenticated-orcid":false,"given":"Cheryl","family":"Hawkes","sequence":"additional","affiliation":[{"name":"School of Life, Health and Chemical Sciences, Science, Technology, Engineering and Mathematics (STEM) Faculty, Open University, Walton Hall, Milton Keynes MK7 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the global burden of disease study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ijo.2009.250","article-title":"A nationally representative study of maternal obesity in england, uk: Trends in incidence and demographic inequalities in 619 323 births, 1989\u20132007","volume":"34","author":"Heslehurst","year":"2010","journal-title":"Int. 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