{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:03:38Z","timestamp":1791378218126,"version":"4.3.2"},"reference-count":227,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14-15-00112"],"award-info":[{"award-number":["14-15-00112"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thrombospondins (TSPs) represent extracellular matrix (ECM) proteins belonging to the TSP family that comprises five members. All TSPs have a complex multidomain structure that permits the interaction with various partners including other ECM proteins, cytokines, receptors, growth factors, etc. Among TSPs, TSP1, TSP2, and TSP4 are the most studied and functionally tested. TSP1 possesses anti-angiogenic activity and is able to activate transforming growth factor (TGF)-\u03b2, a potent profibrotic and anti-inflammatory factor. Both TSP2 and TSP4 are implicated in the control of ECM composition in hypertrophic hearts. TSP1, TSP2, and TSP4 also influence cardiac remodeling by affecting collagen production, activity of matrix metalloproteinases and TGF-\u03b2 signaling, myofibroblast differentiation, cardiomyocyte apoptosis, and stretch-mediated enhancement of myocardial contraction. The development and evaluation of TSP-deficient animal models provided an option to assess the contribution of TSPs to cardiovascular pathology such as (myocardial infarction) MI, cardiac hypertrophy, heart failure, atherosclerosis, and aortic valve stenosis. Targeting of TSPs has a significant therapeutic value for treatment of cardiovascular disease. The activation of cardiac TSP signaling in stress and pressure overload may be therefore beneficial.<\/jats:p>","DOI":"10.3390\/ijms18071540","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T03:45:16Z","timestamp":1500349516000},"page":"1540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Thrombospondins: A Role in Cardiovascular Disease"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-3607","authenticated-orcid":false,"given":"Dimitry","family":"Chistiakov","sequence":"first","affiliation":[{"name":"Department of Fundamental and Applied Neurobiology, Serbsky Federal Medical Research Center of Psychiatry and Narcology, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Melnichenko","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-5300","authenticated-orcid":false,"given":"Veronika","family":"Myasoedova","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Grechko","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 109240 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-1628","authenticated-orcid":false,"given":"Alexander","family":"Orekhov","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia"},{"name":"Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 121609, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/CRD.0b013e31828c5ced","article-title":"Vascular extracellular matrix in atherosclerosis","volume":"21","author":"Chistiakov","year":"2013","journal-title":"Cardiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1177\/0954411911406340","article-title":"Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment","volume":"225","author":"Lewinsohn","year":"2011","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"H1063","DOI":"10.1152\/ajpheart.00126.2016","article-title":"Extracellular matrix fibronectin mediates an endothelial cell response to shear stress via the heparin-binding, matricryptic RWRPK sequence of FNIII1H","volume":"311","author":"Okech","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1159\/000354513","article-title":"Factors involved in extracellular matrix turnover in human derived cardiomyocytes","volume":"32","author":"Casals","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1160\/TH12-06-0400","article-title":"Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells","volume":"109","author":"Luu","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/CIRCIMAGING.109.895607","article-title":"MRI of coronary wall remodeling in a swine model of coronary injury using an elastin-binding contrast agent","volume":"4","author":"Makowski","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2014.08.006","article-title":"\u03b2-Arrestins regulate human cardiac fibroblast transformation and collagen synthesis in adverse ventricular remodeling","volume":"76","author":"Li","year":"2014","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00004872-199917020-00011","article-title":"Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure","volume":"17","author":"Mujumdar","year":"1999","journal-title":"J. Hypertens."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trsl.2016.02.006","article-title":"Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure","volume":"172","author":"Sakamuri","year":"2016","journal-title":"Transl. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI12749","article-title":"Thrombospondins as matricellular modulators of cell function","volume":"107","author":"Bornstein","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2535\/ofaj.81.49","article-title":"Distribution of tenascin-C and -X, and soft X-ray analysis of the mandibular symphysis during mandible formation in the human fetus","volume":"81","author":"Kurihara","year":"2004","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11626-008-9145-6","article-title":"Tenascin-R distinct domains modulate migration of neural stem\/progenitor cells in vitro","volume":"45","author":"Huang","year":"2009","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"ref_13","first-page":"5358","article-title":"Periostin secreted by epithelial ovarian carcinoma is a ligand for \u03b1V\u03b23 and alphaVbeta5 integrins and promotes cell motility","volume":"62","author":"Gillan","year":"2002","journal-title":"Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hoersch, S., and Andrade-Navarro, M.A. (2010). Periostin shows increased evolutionary plasticity in its alternatively spliced region. BMC Evol. Biol., 10.","DOI":"10.1186\/1471-2148-10-30"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1172\/JCI40973","article-title":"Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents","volume":"120","author":"Hakuno","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0002-9440(10)64482-3","article-title":"Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification","volume":"161","author":"Steitz","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000091379","article-title":"Hierarchies of extracellular matrix and mineral organization in bone of the craniofacial complex and skeleton","volume":"181","author":"McKee","year":"2005","journal-title":"Cell. Tissues Organs"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cytogfr.2008.08.001","article-title":"Osteopontin: Role in immune regulation and stress responses","volume":"19","author":"Wang","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.bone.2011.09.039","article-title":"Separation of newly formed bone from older compact bone reveals clear compositional differences in bone matrix","volume":"49","author":"Midura","year":"2011","journal-title":"Bone"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.biocel.2008.07.025","article-title":"Functions and mechanisms of action of CCN matricellular proteins","volume":"41","author":"Chen","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","article-title":"The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction","volume":"48","author":"Dobaczewski","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s00018-007-7484-1","article-title":"Structures of thrombospondins","volume":"65","author":"Carlson","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"a009712","DOI":"10.1101\/cshperspect.a009712","article-title":"The thrombospondins","volume":"3","author":"Adams","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"McKenzie, P., Chadalavada, C., Bohrer, J., and Adams, J.C. (2006). Phylogenomic analysis of vertebrate thrombospondins, reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation. BMC Evol. Biol., 6.","DOI":"10.1186\/1471-2148-6-33"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/molbev\/msq107","article-title":"The evolution of thrombospondins and their ligand-binding activities","volume":"27","author":"Bentley","year":"2010","journal-title":"Mol. Biol. Evol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.matbio.2012.01.002","article-title":"Thrombospondins in physiology and disease: New tricks for old dogs","volume":"31","author":"Iozzo","year":"2012","journal-title":"Matrix Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.bbamcr.2006.08.001","article-title":"The C-terminal CD47\/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells","volume":"1763","author":"Rath","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0945-053X(00)00104-9","article-title":"Thrombospondin 2, a matricellular protein with diverse functions","volume":"19","author":"Bornstein","year":"2000","journal-title":"Matrix Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1160\/TH03-06-0399","article-title":"Matricellular proteins as modulators of wound healing and the foreign body response","volume":"90","author":"Kyriakides","year":"2003","journal-title":"Thromb. Haemost."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12079-009-0070-6","article-title":"Thrombospondins in the heart: Potential functions in cardiac remodeling","volume":"3","author":"Schellings","year":"2009","journal-title":"J. Cell Commun. Signal"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/CIRCRESAHA.110.232371","article-title":"Thrombospondin-4 regulates vascular inflammation and atherogenesis","volume":"107","author":"Frolova","year":"2010","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/bcpt.12026","article-title":"Thrombospondins, potential drug targets for cardiovascular diseases","volume":"112","author":"Mustonen","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Muppala, S., Xiao, R., Krukovets, I., Verbovetsky, D., Yendamuri, R., Habib, N., Raman, P., Plow, E., and Stenina-Adognravi, O. (2017). Thrombospondin-4 mediates TGF-\u03b2-induced angiogenesis. Oncogene, (in press).","DOI":"10.1038\/onc.2017.140"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1161\/hc4701.100910","article-title":"Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction","volume":"104","author":"Topol","year":"2001","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1161\/01.ATV.0000147304.67100.ee","article-title":"Gender dependent association of thrombospondin-4 A387P polymorphism with myocardial infarction","volume":"24","author":"Cui","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"543.e1","DOI":"10.1016\/j.ahj.2006.06.002","article-title":"Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: A large replication study with increased sample size from the same population","volume":"152","author":"Cui","year":"2006","journal-title":"Am. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ahj.2003.12.013","article-title":"Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction","volume":"147","author":"Wessel","year":"2004","journal-title":"Am. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1182\/blood-2006-04-015701","article-title":"The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size","volume":"108","author":"Zwicker","year":"2006","journal-title":"Blood"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1160\/TH11-03-0206","article-title":"Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels","volume":"106","author":"Corsetti","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1096\/fj.05-3712fje","article-title":"Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites","volume":"19","author":"Stenina","year":"2005","journal-title":"FASEB J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.thromres.2015.04.019","article-title":"Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis","volume":"136","author":"Zhang","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1006\/bbrc.1999.0710","article-title":"Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues","volume":"258","author":"Adolph","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.CIR.103.4.525","article-title":"Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts","volume":"103","author":"Zhao","year":"2001","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/153537020523000904","article-title":"Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia\/reperfusion","volume":"230","author":"Sezaki","year":"2005","journal-title":"Exp. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbrc.2008.05.164","article-title":"Thrombospondin-4 expression is rapidly upregulated by cardiac overload","volume":"373","author":"Mustonen","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MOL.0b013e3283642912","article-title":"Thrombospondins: Old players, new games","volume":"24","year":"2013","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.carpath.2012.03.005","article-title":"Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts","volume":"22","author":"Reinecke","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/eurheartj\/ehs375","article-title":"Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection","volume":"34","author":"Vanhoutte","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/CIRCRESAHA.111.256743","article-title":"Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle","volume":"109","author":"Cingolani","year":"2011","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1096\/fj.11-190728","article-title":"Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload","volume":"26","author":"Frolova","year":"2012","journal-title":"FASEB J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.yjmcc.2011.05.010","article-title":"Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy","volume":"51","author":"Swinnen","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2353\/ajpath.2007.070056","article-title":"A thrombospondin-1 antagonist of transforming growth factor-\u03b2 activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II","volume":"171","author":"Belmadani","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/CIRCRESAHA.113.302593","article-title":"Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation","volume":"113","author":"Cavalera","year":"2013","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/CIRCULATIONAHA.109.863266","article-title":"Absence of thrombospondin-2 causes age-related dilated cardiomyopathy","volume":"120","author":"Swinnen","year":"2009","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1161\/CIRCULATIONAHA.104.510354","article-title":"Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts","volume":"111","author":"Frangogiannis","year":"2005","journal-title":"Circulation"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/187152507779315813","article-title":"The role of the thrombospondins in healing myocardial infarcts","volume":"5","author":"Chatila","year":"2007","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3892\/etm.2011.426","article-title":"Investigation of thrombospondin-1 and transforming growth factor-\u03b2 expression in the heart of aging mice","volume":"3","author":"Cai","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13000-015-0246-8","article-title":"Valsartan blocks thrombospondin\/transforming growth factor\/Smads to inhibit aortic remodeling in diabetic rats","volume":"10","author":"Sun","year":"2015","journal-title":"Diagn. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/01.RES.0000141019.20332.3e","article-title":"Thrombospondin-2 is essential for myocardial matrix integrity: Increased expression identifies failure-prone cardiac hypertrophy","volume":"95","author":"Schroen","year":"2004","journal-title":"Circ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1242\/jcs.00600","article-title":"Thrombospondin signaling through the calreticulin\/LDL receptor-related protein co-complex stimulates random and directed cell migration","volume":"116","author":"Orr","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1096\/fj.07-104802","article-title":"Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis","volume":"22","author":"Pallero","year":"2008","journal-title":"FASEB J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1021\/bi902067f","article-title":"Structural insight into the role of thrombospondin-1 binding to calreticulin in calreticulin-induced focal adhesion disassembly","volume":"49","author":"Yan","year":"2010","journal-title":"Biochemistry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2012.03.050","article-title":"A thrombospondin-dependent pathway for a protective ER stress response","volume":"149","author":"Lynch","year":"2012","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matbio.2014.02.003","article-title":"Control of organization and function of muscle and tendon by thrombospondin-4","volume":"37","author":"Frolova","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.atherosclerosis.2011.10.003","article-title":"Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves","volume":"220","author":"Pohjolainen","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14888","DOI":"10.1073\/pnas.96.26.14888","article-title":"Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis","volume":"96","author":"Streit","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1582-4934.2002.tb00307.x","article-title":"Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth","volume":"6","author":"Lawler","year":"2002","journal-title":"J. Cell. Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.biocel.2004.01.008","article-title":"Tumor progression: The effects of thrombospondin-1 and -2","volume":"36","author":"Lawler","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mvr.2007.04.007","article-title":"Thrombospondin-based antiangiogenic therapy","volume":"74","author":"Zhang","year":"2007","journal-title":"Microvasc. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1096\/fj.05-3946fje","article-title":"Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis","volume":"20","author":"Almog","year":"2006","journal-title":"FASEB J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2010.03.004","article-title":"Molecular mechanisms underlying tumor dormancy","volume":"294","author":"Almog","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1158\/0008-5472.CAN-08-2590","article-title":"Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype","volume":"69","author":"Almog","year":"2009","journal-title":"Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e005967","DOI":"10.1161\/JAHA.112.005967","article-title":"Novel tissue-specific mechanism of regulation of angiogenesis and cancer growth in response to hyperglycemia","volume":"1","author":"Bhattacharyya","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1096\/fj.14-267799","article-title":"Inhibition of hyperglycemia-induced angiogenesis and breast cancer tumor growth by systemic injection of microRNA-467 antagonist","volume":"29","author":"Krukovets","year":"2015","journal-title":"FASEB J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.2174\/138161207782794185","article-title":"CD36-TSP-HRGP interactions in the regulation of angiogenesis","volume":"13","author":"Silverstein","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1074\/jbc.270.7.2981","article-title":"Rec mbinant GST\/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36","volume":"270","author":"Frieda","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"s874","DOI":"10.2741\/1168","article-title":"CD36: A critical anti-angiogenic receptor","volume":"8","author":"Simantov","year":"2003","journal-title":"Front. Biosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.matbio.2004.11.005","article-title":"The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein","volume":"24","author":"Simantov","year":"2005","journal-title":"Matrix Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"38923","DOI":"10.1074\/jbc.M110.172304","article-title":"Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47","volume":"285","author":"Kaur","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bazzazi, H., Isenberg, J.S., and Popel, A.S. (2017). Inhibition of VEGFR2 activation and its downstream signaling to ERK1\/2 and calcium by thrombospondin-1 (TSP1): In silico investigation. Front. Physiol, in press.","DOI":"10.3389\/fphys.2017.00048"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"26069","DOI":"10.1074\/jbc.M605040200","article-title":"CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1","volume":"281","author":"Isenberg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1074\/jbc.M701638200","article-title":"Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake","volume":"282","author":"Isenberg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1182\/blood-2006-08-041368","article-title":"Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation","volume":"109","author":"Isenberg","year":"2007","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1074\/jbc.M804860200","article-title":"Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses","volume":"284","author":"Isenberg","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.96.26.14753","article-title":"A molecular basis for nitric oxide sensing by soluble guanylate cyclase","volume":"96","author":"Zhao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1097\/00005344-198500073-00013","article-title":"Role of cyclic-GMP in relaxations of vascular smooth muscle","volume":"7","author":"Murad","year":"1985","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood-2007-06-098392","article-title":"Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide\/cGMP signaling","volume":"111","author":"Isenberg","year":"2008","journal-title":"Blood"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/09537100903337419","article-title":"Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines","volume":"20","author":"Koom","year":"2009","journal-title":"Platelets"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.matbio.2013.02.009","article-title":"Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation","volume":"32","author":"Miller","year":"2013","journal-title":"Matrix Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1161\/ATVBAHA.112.300031","article-title":"Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1","volume":"32","author":"Yao","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1124\/mol.108.052142","article-title":"Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosation","volume":"75","author":"Mayer","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"43182","DOI":"10.1074\/jbc.M111.290304","article-title":"Dynamic ligand exchange in soluble guanylyl cyclase (sGC): Implications for sGC regulation and desensitization","volume":"286","author":"Tsai","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1161\/ATVBAHA.115.305912","article-title":"Proangiogenic properties of thrombospondin-4","volume":"35","author":"Muppala","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1161\/01.CIR.0000074223.56882.97","article-title":"Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat","volume":"107","author":"Stenina","year":"2003","journal-title":"Circulation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.CIR.100.8.849","article-title":"Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery","volume":"100","author":"Chen","year":"1999","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/CIRCRESAHA.108.185645","article-title":"Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE\u2212\/\u2212 mice","volume":"103","author":"Moura","year":"2008","journal-title":"Circ. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/CIRCRESAHA.108.188870","article-title":"Counterbalancing forces: What is thrombospondin-1 doing in atherosclerotic lesions?","volume":"103","author":"Stenina","year":"2008","journal-title":"Circ. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00005344-200303000-00011","article-title":"Effects of cerivastatin on human arterial smooth muscle cell growth and extracellular matrix expression at varying glucose and low-density lipoprotein levels","volume":"41","author":"Runge","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_99","first-page":"1068","article-title":"Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1","volume":"147","author":"Reed","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.ATV.21.1.47","article-title":"Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells","volume":"21","author":"Riessen","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_101","first-page":"285","article-title":"ADAMTS-7, a novel proteolytic culprit in vascular remodeling","volume":"62","author":"Wang","year":"2010","journal-title":"Sheng Li Xue Bao"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/CIRCRESAHA.108.188425","article-title":"ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries","volume":"104","author":"Wang","year":"2009","journal-title":"Circ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1074\/jbc.271.1.21","article-title":"Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin","volume":"271","author":"Gao","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.phrs.2010.10.014","article-title":"Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP","volume":"63","author":"Yao","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2174\/138945008785909338","article-title":"Enhancing cardiovascular dynamics by inhibition of thrombospondin-1\/CD47 signaling","volume":"9","author":"Isenberg","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.matbio.2009.01.002","article-title":"Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress","volume":"28","author":"Isenberg","year":"2009","journal-title":"Matrix Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/cvr\/cvq218","article-title":"Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation","volume":"88","author":"Bauer","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3109\/10409238.2015.1014024","article-title":"CD47 signaling pathways controlling cellular differentiation and responses to stress","volume":"50","author":"Kaur","year":"2015","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.matbio.2012.01.005","article-title":"The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47","volume":"31","author":"Roberts","year":"2012","journal-title":"Matrix Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1681\/ASN.2013040433","article-title":"Thrombospondin-1 activation of signal-regulatory protein-\u03b1 stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury","volume":"25","author":"Yao","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yjmcc.2015.11.013","article-title":"Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia","volume":"89","author":"Tong","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yjmcc.2016.01.020","article-title":"Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase","volume":"92","author":"Tong","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1089\/ars.2016.6834","article-title":"CD47 and Nox1 mediate dynamic fluid-phase macropinocytosis of native LDL","volume":"26","author":"Feck","year":"2017","journal-title":"Antioxid. Redox. Signal"},{"key":"ref_114","first-page":"840","article-title":"Left ventricular remodeling after myocardial infarction: Past, present, and future","volume":"73","author":"Tiyyagura","year":"2006","journal-title":"Mt. Sinai J. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.carpath.2008.02.004","article-title":"Cardiomyocyte death and renewal in the normal and diseased heart","volume":"17","author":"Buja","year":"2008","journal-title":"Cardiovasc Pathol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/01.CIR.0000085658.98621.49","article-title":"Ventricular remodeling after infarction and the extracellular collagen matrix: When is enough enough?","volume":"108","author":"Jugdutt","year":"2003","journal-title":"Circulation"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yexmp.2016.09.002","article-title":"The role of cardiac fibroblasts in post-myocardial heart tissue repair","volume":"101","author":"Chistiakov","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bioeng.7.060804.100453","article-title":"Structure and mechanics of healing myocardial infarcts","volume":"7","author":"Holmes","year":"2005","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"23915","DOI":"10.1074\/jbc.M301869200","article-title":"CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis","volume":"278","author":"Lamy","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.4049\/jimmunol.178.9.5930","article-title":"Interactions between CD47 and thrombospondin reduce inflammation","volume":"178","author":"Lamy","year":"2007","journal-title":"J. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/ATVBAHA.107.158154","article-title":"CD47: A new target in cardiovascular therapy","volume":"28","author":"Isenberg","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1161\/ATVBAHA.107.155390","article-title":"Blocking thrombospondin-1\/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia","volume":"27","author":"Isenberg","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2174\/138945008785909347","article-title":"Thrombospondin and apoptosis: Molecular mechanisms and use for design of complementation treatments","volume":"9","author":"Mirochnik","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2353\/ajpath.2008.080128","article-title":"Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis","volume":"173","author":"Krady","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1369\/jhc.2008.952689","article-title":"Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF","volume":"57","author":"Maclauchlan","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1083\/jcb.140.2.419","article-title":"Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis","volume":"140","author":"Kyriakides","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1073\/pnas.96.8.4449","article-title":"Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity","volume":"96","author":"Kyriakides","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1087-0024.2000.00005.x","article-title":"Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis","volume":"5","author":"Bornstein","year":"2000","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1111\/j.1582-4934.2011.01270.x","article-title":"Low oxygen tension positively influences cardiomyocyte progenitor cell function","volume":"15","author":"Smits","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1742-7843.2010.00564.x","article-title":"Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy","volume":"107","author":"Mustonen","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.00607-15","article-title":"Dissection of thrombospondin-4 domains involved in intracellular adaptive endoplasmic reticulum stress-responsive signaling","volume":"36","author":"Brody","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1161\/CIRCRESAHA.116.310266","article-title":"ATF6 decreases myocardial ischemia\/reperfusion damage and links ER stress and oxidative stress signaling pathways in the heart","volume":"120","author":"Jin","year":"2017","journal-title":"Circ. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.carpath.2008.12.013","article-title":"Decreased frequency of the 3\u2032UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion","volume":"19","author":"Burke","year":"2010","journal-title":"Cardiovasc. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.93.7.1354","article-title":"Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death","volume":"93","author":"Farb","year":"1996","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/hmg\/ddn001","article-title":"Polymorphisms in thrombospondin genes and myocardial infarction: A case-control study and a meta-analysis of available evidence","volume":"17","author":"Koch","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.thromres.2011.05.026","article-title":"An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians","volume":"128","author":"Ashokkumar","year":"2011","journal-title":"Thromb. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1042\/CS20030322","article-title":"Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population","volume":"106","author":"Zhou","year":"2004","journal-title":"Clin. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.thromres.2004.02.016","article-title":"Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population","volume":"113","author":"Zhou","year":"2004","journal-title":"Thromb. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0733-8651(05)70154-5","article-title":"Connective tissue and the heart. Functional significance and regulatory mechanisms","volume":"18","author":"Burlew","year":"2000","journal-title":"Cardiol. Clin."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.yjmcc.2009.08.003","article-title":"Contribution of extracellular matrix to the mechanical properties of the heart","volume":"48","author":"Fomovsky","year":"2010","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","article-title":"Matrix metalloproteinases: Regulation and dysregulation in the failing heart","volume":"90","author":"Spinale","year":"2002","journal-title":"Circ. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/cvr\/cvn243","article-title":"Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling","volume":"81","author":"Dorn","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","article-title":"Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload","volume":"131","author":"Xia","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/HYPERTENSIONAHA.111.175323","article-title":"Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism","volume":"58","author":"Xia","year":"2011","journal-title":"Hypertension"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phrs.2009.11.012","article-title":"Molecular targets and regulators of cardiac hypertrophy","volume":"61","author":"Rohini","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1113\/expphysiol.2008.045989","article-title":"Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice","volume":"94","author":"Malek","year":"2009","journal-title":"Exp. Physiol."},{"key":"ref_147","first-page":"149","article-title":"Exacerbated cardiac remodeling to pressure-overload in mice lacking thrombospondin-4","volume":"7","author":"Moens","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11897-009-0038-0","article-title":"Diastolic and systolic heart failure: Different stages or distinct phenotypes of the heart failure syndrome?","volume":"6","author":"Bronzwaer","year":"2009","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cardfail.2007.04.006","article-title":"Systolic and diastolic heart failure: Differences and similarities","volume":"13","author":"Chatterjee","year":"2007","journal-title":"J. Card. Fail."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/physiol.00033.2006","article-title":"Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets","volume":"22","author":"Diwan","year":"2007","journal-title":"Physiology"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"A17","DOI":"10.1253\/circj.CJ-08-0669","article-title":"Cell death in heart failure","volume":"72","author":"Nishida","year":"2008","journal-title":"Circ. J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00001573-199705000-00002","article-title":"The role of cytokines in disease progression in heart failure","volume":"12","author":"Shan","year":"1997","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.transproceed.2009.06.009","article-title":"Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling","volume":"41","author":"Batlle","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1097\/HJH.0b013e328364abd6","article-title":"Eplerenone enhances cardioprotective effects of standard heart failure therapy through matricellular proteins in hypertensive heart failure","volume":"31","author":"Aragoncillo","year":"2013","journal-title":"J. Hypertens."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e000670","DOI":"10.1161\/JAHA.113.000670","article-title":"Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3","volume":"3","author":"Shoushtari","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1474-9726.2011.00714.x","article-title":"MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure","volume":"10","author":"Verhesen","year":"2011","journal-title":"Aging Cell"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/cvr\/cvs077","article-title":"Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells","volume":"94","author":"Papageorgiou","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1161\/01.HYP.0000161873.27088.4c","article-title":"Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure","volume":"45","author":"Leskinen","year":"2005","journal-title":"Hypertension"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-011-0808-3","article-title":"Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats","volume":"354","author":"Melenovsky","year":"2011","journal-title":"Mol. Cell Biochem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2009.03.108","article-title":"Molecular and cellular mechanisms of aortic stenosis","volume":"135","author":"Yetkin","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/HYPERTENSIONAHA.114.03261","article-title":"Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure","volume":"64","author":"Rawat","year":"2014","journal-title":"Hypertension"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1465-9921-9-19","article-title":"Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery","volume":"9","author":"Sage","year":"2008","journal-title":"Respir. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1292\/jvms.17-0053","article-title":"Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats","volume":"79","author":"Imoto","year":"2017","journal-title":"J. Vet. Med. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12931-016-0412-x","article-title":"The role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension","volume":"17","author":"Kaiser","year":"2016","journal-title":"Respir. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1749-8090-5-32","article-title":"Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension","volume":"5","author":"Ochoa","year":"2010","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"15494","DOI":"10.1038\/ncomms15494","article-title":"TGF-\u03b2 activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension","volume":"8","author":"Kumar","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4103\/2045-8932.105037","article-title":"Peroxisome proliferator-activated receptor gamma (PPAR\u03b3) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation","volume":"2","author":"Green","year":"2012","journal-title":"Pulm. Circ."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","article-title":"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"97","author":"Cucoranu","year":"2005","journal-title":"Circ. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"L661","DOI":"10.1152\/ajplung.00269.2005","article-title":"Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells","volume":"290","author":"Sturrock","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"L489","DOI":"10.1152\/ajplung.90488.2008","article-title":"NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: The role of autocrine production of transforming growth factor-\u03b2-1 and insulin-like growth factor binding protein-3","volume":"296","author":"Ismail","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"L559","DOI":"10.1152\/ajplung.00090.2010","article-title":"PPAR\u03b3 regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-\u03baB","volume":"299","author":"Lu","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.freeradbiomed.2013.05.013","article-title":"Hypoxia downregulates PPAR\u03b3 via an ERK1\/2-NF-\u03baB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells","volume":"63","author":"Lu","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/01.STR.0000047100.84604.BA","article-title":"Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia\/reperfusion","volume":"34","author":"Lin","year":"2003","journal-title":"Stroke"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"23654","DOI":"10.1074\/jbc.M116.750018","article-title":"Cell surface CD36 protein in monocyte\/macrophage contributes to phagocytosis during the resolution phase of ischemic stroke in mice","volume":"291","author":"Woo","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/jcbfm.2008.65","article-title":"Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke","volume":"28","author":"Liauw","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1160\/TH03-01-0044","article-title":"Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1)","volume":"91","author":"Jurk","year":"2004","journal-title":"Thromb. Haemost."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.ATV.16.8.1019","article-title":"Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators","volume":"16","author":"Yesner","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_178","first-page":"783","article-title":"Immunohistochemical identification of thrombospondin in normal human brain and in Alzheimer\u2019s disease","volume":"141","author":"Hof","year":"1992","journal-title":"Am. J. Pathol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1016\/j.neurobiolaging.2015.09.005","article-title":"Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer\u2019s disease","volume":"36","author":"Son","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/NEN.0b013e31829bd082","article-title":"Amyloid-\u03b2 inhibits thrombospondin 1 release from cultured astrocytes: Effects on synaptic protein expression","volume":"72","author":"Curtis","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Garcia, O., Torres, M., Helguera, P., Coskun, P., and Busciglio, J. (2010). A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down\u2018s syndrome. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014200"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13041-016-0256-9","article-title":"Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model","volume":"9","author":"Cheng","year":"2016","journal-title":"Mol. Brain"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.neurobiolaging.2014.11.020","article-title":"CCAAT\/enhancer-binding protein \u03b4\/miR135a\/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer\u2019s disease","volume":"36","author":"Ko","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Long, J., Liu, S., Zeng, X., Yang, X., Huang, H., Zhang, Y., Chen, J., Xu, Y., Huang, D., and Qiu, X. (2017). Population study confirms serum proteins\u2019 change and reveals diagnostic values in congenital ventricular septal defect. Pediatr. Cardiol, in press.","DOI":"10.1007\/s00246-017-1641-6"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Wang, J., Nagy, A., Larsson, J., Dudas, M., Sucov, H.M., and Kaartinen, V. (2006). Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol., 6.","DOI":"10.1186\/1471-213X-6-51"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1242\/dev.047696","article-title":"Ets1 is required for proper migration and differentiation of the cardiac neural crest","volume":"137","author":"Gao","year":"2010","journal-title":"Development"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1074\/jbc.M109.082347","article-title":"The ubiquitin ligase Nedd4\u20131 is required for heart development and is a suppressor of thrombospondin-1","volume":"285","author":"Fouladkou","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/cdd.2009.84","article-title":"Nedd4 and Nedd4\u20132: Closely related ubiquitin-protein ligases with distinct physiological functions","volume":"17","author":"Yang","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"26754","DOI":"10.1074\/jbc.M311802200","article-title":"Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation","volume":"279","author":"Murdaca","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/01.RES.0000136816.05109.89","article-title":"Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4\u20132 mediated ubiquitination","volume":"95","author":"Rougier","year":"2004","journal-title":"Circ. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1074\/jbc.M402820200","article-title":"Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4\u20132","volume":"279","author":"Fotia","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1242\/dev.01265","article-title":"The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system","volume":"131","author":"Moskowitz","year":"2004","journal-title":"Development"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2014.07.005","article-title":"Revisiting the matricellular concept","volume":"37","author":"Sage","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.RES.0000182630.29093.0d","article-title":"Targeting of a novel Ca+2\/calmodulin-dependent protein kinase II is essential for extracellular signal-regulated kinase-mediated signaling in differentiated smooth muscle cells","volume":"97","author":"Marganski","year":"2005","journal-title":"Circ. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuropharm.2017.02.019","article-title":"Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons","volume":"117","author":"Guo","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1017\/erm.2012.3","article-title":"Antiangiogenic and anticancer molecules in cartilage","volume":"14","author":"Patra","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3390\/ph3041241","article-title":"Thrombospondin-1 as a paradigm for the development of antiangiogenic agents endowed with multiple mechanisms of action","volume":"3","author":"Rusnati","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1517\/14728222.2011.640319","article-title":"Therapies using anti-angiogenic peptide mimetics of thrombospondin-1","volume":"15","author":"Henkin","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/mol.55.2.332","article-title":"Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat","volume":"55","author":"Dawson","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"ref_200","first-page":"451","article-title":"Technology evaluation: ABT-510, Abbott","volume":"6","author":"Westphal","year":"2004","journal-title":"Curr. Opin. Mol. Ther."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/annonc\/mdi002","article-title":"Renal cell carcinoma: Review of novel single-agent therapeutics and combination regimens","volume":"16","author":"Amato","year":"2005","journal-title":"Ann. Oncol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1200\/JCO.2005.05.013","article-title":"Phase I safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer","volume":"23","author":"Hoekstra","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejca.2005.08.040","article-title":"Phase I study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 with 5-fluorouracil and leucovorin: A safe combination","volume":"42","author":"Hoekstra","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/annonc\/mdl102","article-title":"A phase I study assessing the safety and pharmacokinetics of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 with gemcitabine and cisplatin in patients with solid tumors","volume":"17","author":"Gietema","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1002\/cncr.23953","article-title":"A phase 1 trial of 2 dose schedules of ABT-510, an antiangiogenic, thrombospondin-1-mimetic peptide, in patients with advanced cancer","volume":"113","author":"Gordon","year":"2008","journal-title":"Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/archneurol.2010.16","article-title":"A phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma","volume":"67","author":"Nabors","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/cam4.65","article-title":"A phase I study of ABT-510 plus bevacizumab in advanced solid tumors","volume":"2","author":"Uronis","year":"2013","journal-title":"Cancer Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.coc.0000256104.80089.35","article-title":"A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma","volume":"30","author":"Markovic","year":"2007","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1158\/1078-0432.CCR-07-1477","article-title":"Phase 2 study of ABT-510 in patients with previously untreated advanced renal cell carcinoma","volume":"13","author":"Ebbinghaus","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1200\/JCO.2008.17.4706","article-title":"Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma","volume":"26","author":"Baker","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/01.RES.0000259579.35787.4e","article-title":"Increasing survival of ischemic tissue by targeting CD47","volume":"100","author":"Isenberg","year":"2007","journal-title":"Circ. Res."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, L., Zhao, F., Tseng, S., Narayanan, C., Shura, L., Willingham, S., Howard, M., Prohaska, S., and Volkmer, J. (2015). Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137345"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2217\/imt.14.4","article-title":"Monoclonal antibodies against human cancer stem cells","volume":"6","author":"Naujokat","year":"2014","journal-title":"Immunotherapy"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.274.19.13586","article-title":"The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta","volume":"274","author":"Ribeiro","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1359-6101(99)00029-5","article-title":"Activation of latent TGF-\u03b2 by thrombospondin-1: Mechanisms and physiology","volume":"11","author":"Poczatek","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0168-8278(03)00377-5","article-title":"A blocking peptide for transforming growth factor-\u03b21 activation prevents hepatic fibrosis in vivo","volume":"39","author":"Kondou","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12272-010-0213-6","article-title":"LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction","volume":"33","author":"Xie","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1016\/j.ajpath.2011.02.039","article-title":"Blockade of TSP1-dependent TGF-\u03b2 activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy","volume":"178","author":"Lu","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3892\/etm.2016.3640","article-title":"LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-\u03b21 signaling activity following subarachnoid hemorrhage in rats","volume":"12","author":"Liao","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/ATVBAHA.114.304732","article-title":"A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse","volume":"35","author":"Krishna","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng1297","article-title":"Elastic fiber homeostasis requires lysyl oxidase-like 1 protein","volume":"36","author":"Liu","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"9404057","DOI":"10.1155\/2017\/9404057","article-title":"Cell therapies in cardiomyopathy: Current status of clinical trials","volume":"2017","author":"Hao","year":"2017","journal-title":"Anal. Cell Pathol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3727\/096368916X693329","article-title":"Thrombospondin-1-derived peptide RFYVVMWK improves the adhesive phenotype of CD34+ cells from atherosclerotic patients with type 2 diabetes","volume":"26","author":"Cointe","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-9-10","article-title":"Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning","volume":"9","author":"Efimenko","year":"2011","journal-title":"J. Transl. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1210\/en.2012-1402","article-title":"Preconditioning of stem cells by oxytocin to improve their therapeutic potential","volume":"153","author":"Noiseux","year":"2012","journal-title":"Endocrinology"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jacc.2015.07.035","article-title":"A novel collagen matricryptin reduces left ventricular dilation post-myocardial infarction by promoting scar formation and angiogenesis","volume":"66","author":"Lindsey","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"32167","DOI":"10.1074\/jbc.M003834200","article-title":"Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity","volume":"275","author":"Bein","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/7\/1540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:42:58Z","timestamp":1760208178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/7\/1540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":227,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["ijms18071540"],"URL":"https:\/\/doi.org\/10.3390\/ijms18071540","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,17]]}}}