{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:58:45Z","timestamp":1767707925592,"version":"build-2065373602"},"reference-count":99,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2314-B-182-057"],"award-info":[{"award-number":["MOST 104-2314-B-182-057"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Salmonella spp. remains a major public health problem for the whole world. To reduce the use of antimicrobial agents and drug-resistant Salmonella, a better strategy is to explore alternative therapy rather than to discover another antibiotic. Sphingolipid- and cholesterol-enriched lipid microdomains attract signaling proteins and orchestrate them toward cell signaling and membrane trafficking pathways. Recent studies have highlighted the crucial role of sphingolipids in the innate immunity against infecting pathogens. It is therefore mandatory to exploit the role of the membrane sphingolipids in the innate immunity of intestinal epithelia infected by this pathogen. In the present review, we focus on the role of sphingolipids in the innate immunity of intestinal epithelia against Salmonella infection, including adhesion, autophagy, bactericidal effect, barrier function, membrane trafficking, cytokine and antimicrobial peptide expression. The intervention of sphingolipid-enhanced foods to make our life healthy or pharmacological agents regulating sphingolipids is provided at the end.<\/jats:p>","DOI":"10.3390\/ijms18081720","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T06:32:14Z","timestamp":1502260334000},"page":"1720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-6856","authenticated-orcid":false,"given":"Fu-Chen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrm2977","article-title":"Revitalizing membrane rafts: New tools and insights","volume":"11","author":"Simons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.1074\/jbc.R000005200","article-title":"Structure and function of sphingolipid- and cholesterol-rich membrane rafts","volume":"275","author":"Brown","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-0854.2004.0181.x","article-title":"Lipids as targeting signals: Lipid rafts and intracellular trafficking","volume":"5","author":"Helms","year":"2004","journal-title":"Traffic"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbamem.2013.07.018","article-title":"Interaction of membrane\/lipid rafts with the cytoskeleton: Impact on signaling and function: Membrane\/lipid rafts, mediators of cytoskeletal arrangement and cell signaling","volume":"1838","author":"Head","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"a004697","DOI":"10.1101\/cshperspect.a004697","article-title":"Membrane organization and lipid rafts","volume":"3","author":"Simons","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1194\/jlr.R031278","article-title":"Sphingolipids: Regulators of crosstalk between apoptosis and autophagy","volume":"54","author":"Young","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1007\/s10620-010-1202-9","article-title":"Generating ceramide from sphingomyelin by alkaline sphingomyelinase in the gut enhances sphingomyelin-induced inhibition of cholesterol uptake in Caco-2 cells","volume":"55","author":"Feng","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cellimm.2011.08.018","article-title":"Plasma membrane cholesterol plays a critical role in the Salmonella-induced anti-inflammatory response in intestinal epithelial cells","volume":"271","author":"Huang","year":"2011","journal-title":"Cell. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.3390\/ijms150712558","article-title":"The critical role of membrane cholesterol in Salmonella-induced autophagy in intestinal epithelial cells","volume":"15","author":"Huang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13099-016-0088-2","article-title":"De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human \u03b2-defensin 2 expression in intestinal epithelial cells","volume":"8","author":"Huang","year":"2016","journal-title":"Gut Pathog."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00109-004-0539-y","article-title":"Ceramide, membrane rafts and infections","volume":"82","author":"Gulbins","year":"2004","journal-title":"J. Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/bi002836k","article-title":"Enzymes of sphingolipid metabolism: From modular to integrative signaling","volume":"40","author":"Hannun","year":"2001","journal-title":"Biochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.7883\/yoken.JJID.2005.131","article-title":"Sphingolipids in infectious diseases","volume":"58","author":"Hanada","year":"2005","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nm823","article-title":"Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts","volume":"9","author":"Grassme","year":"2003","journal-title":"Nat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: Lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","first-page":"178910","article-title":"Sphingolipid metabolic pathway: An overview of major roles played in human diseases","volume":"2013","author":"Pralhada","year":"2013","journal-title":"J. Lipids"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"908907","DOI":"10.1155\/2013\/908907","article-title":"Metabolism, physiological role, and clinical implications of sphingolipids in gastrointestinal tract","volume":"2013","author":"Kurek","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2008.04.003","article-title":"Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development","volume":"48","author":"Duan","year":"2009","journal-title":"Prog. Lipid Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1751-2980.2011.00481.x","article-title":"Physiological functions and clinical implications of sphingolipids in the gut","volume":"12","author":"Duan","year":"2011","journal-title":"J. Dig. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0006-2952(02)01553-8","article-title":"\u201cMultivalent\u201d saccharides: Development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens","volume":"65","author":"Schengrund","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.micinf.2005.09.005","article-title":"Preventing the binding of pathogens to the host by controlling sphingolipid metabolism","volume":"8","author":"Radin","year":"2006","journal-title":"Microbes Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29356","DOI":"10.1074\/jbc.M111.261925","article-title":"Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT)","volume":"286","author":"Schwan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/eos.12200","article-title":"Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans","volume":"123","author":"Cukkemane","year":"2015","journal-title":"Eur. J. Oral Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/pmj.78.923.564","article-title":"Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher\u2019s disease","volume":"78","author":"Margalit","year":"2002","journal-title":"Postgrad. Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/toxsci\/kfh006","article-title":"The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells","volume":"77","author":"Bouhet","year":"2004","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.3748\/wjg.v13.i39.5217","article-title":"Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function","volume":"13","author":"Bock","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1091\/mbc.e05-12-1101","article-title":"Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements","volume":"17","author":"Cheng","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/IAI.71.2.872-881.2003","article-title":"Disruption of epithelial barrier integrity by Salmonella enterica serovar typhimurium requires geranylgeranylated proteins","volume":"71","author":"Tafazoli","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri1129","article-title":"Pathogens: Raft hijackers","volume":"3","author":"Manes","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1462-5822.2002.00181.x","article-title":"The Salmonella pathogenicity island 1 secretion system directs cellular cholesterol redistribution during mammalian cell entry and intracellular trafficking","volume":"4","author":"Garner","year":"2002","journal-title":"Cell. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1128\/IAI.70.6.3264-3270.2002","article-title":"Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells","volume":"70","author":"Brumell","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1462-5822.2002.00202.x","article-title":"Salmonella enterica serovar Typhimurium effector SigD\/SopB is membrane-associated and ubiquitinated inside host cells","volume":"4","author":"Marcus","year":"2002","journal-title":"Cell. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37718","DOI":"10.1074\/jbc.M008187200","article-title":"Activation of Akt\/proteininase B in epithelial cells by the Salmonella typhimurium effector sigD","volume":"275","author":"Knodler","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/msb.2011.7","article-title":"RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42","volume":"7","author":"Misselwitz","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.192.2.237","article-title":"Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo","volume":"192","author":"Mastroeni","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.192.2.237","article-title":"Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro","volume":"192","author":"Mastroeni","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1128\/IAI.00689-07","article-title":"Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium","volume":"75","author":"McCollister","year":"2007","journal-title":"Infect. Immun."},{"key":"ref_38","first-page":"1991","article-title":"Myo1c regulates lipid raft recycling to control cell spreading, migration and Salmonella invasion","volume":"125 Pt 8","author":"Brandstaetter","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/AAC.45.4.1298-1301.2001","article-title":"Bactericidal activities of milk lipids","volume":"45","author":"Sprong","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1128\/AAC.05151-11","article-title":"Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria","volume":"56","author":"Fischer","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1523-1747.ep12497842","article-title":"Antimicrobial activity of sphingosines","volume":"98","author":"Bibel","year":"1992","journal-title":"J. Investig. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.15252\/emmm.201404075","article-title":"Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa","volume":"6","author":"Grassme","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1159\/000445567","article-title":"Lack of sphingosine causes susceptibility to pulmonary Staphylococcus aureus infections in cystic fibrosis","volume":"38","author":"Seitz","year":"2016","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-065X.2008.00732.x","article-title":"Toll-like receptor signaling in the lysosomal pathways","volume":"227","author":"Sanjuan","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bbalip.2013.09.005","article-title":"Autophagy paradox and ceramide","volume":"1841","author":"Jiang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbalip.2013.08.019","article-title":"Ceramide synthases as potential targets for therapeutic intervention in human diseases","volume":"1841","author":"Park","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2011.06.061","article-title":"Sphingolipid synthesis is involved in autophagy in Saccharomyces Cerevisiae","volume":"410","author":"Yamagata","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"38568","DOI":"10.1074\/jbc.M110.170621","article-title":"Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy","volume":"285","author":"Sims","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Owen, K.A., Meyer, C.B., Bouton, A.H., and Casanova, J.E. (2014). Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt\/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004159"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chom.2012.04.012","article-title":"Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program","volume":"11","author":"Tattoli","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3389\/fimmu.2014.00558","article-title":"Ubiquitination as an efficient molecular strategy employed in salmonella infection","volume":"5","author":"Narayanan","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1080\/15548627.2016.1203490","article-title":"Unveiling ubiquitinome rearrangements induced by Salmonella infection","volume":"12","author":"Bionda","year":"2016","journal-title":"Autophagy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.molcel.2016.04.015","article-title":"Global analysis of host and bacterial ubiquitinome in response to Salmonella typhimurium infection","volume":"62","author":"Fiskin","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1242\/jcs.02635","article-title":"Downregulation of the HERG (KCNH2) K(+) channel by ceramide: Evidence for ubiquitin-mediated lysosomal degradation","volume":"118 Pt 22","author":"Chapman","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"32064","DOI":"10.1074\/jbc.M111.238030","article-title":"Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1\u03b2","volume":"286","author":"Dobierzewska","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/carcin\/bgi214","article-title":"Inhibition of Akt signaling and enhanced ERK1\/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells","volume":"27","author":"Ellington","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1074\/jbc.M306337200","article-title":"Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes","volume":"279","author":"Kanazawa","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39090","DOI":"10.1074\/jbc.M006198200","article-title":"Erk1\/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells","volume":"275","author":"Pattingre","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1254\/jphs.11181FP","article-title":"Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells","volume":"118","author":"Liu","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18384","DOI":"10.1074\/jbc.M313561200","article-title":"Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1","volume":"279","author":"Scarlatti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/onc.2008.441","article-title":"The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells","volume":"28","author":"Li","year":"2009","journal-title":"Oncogene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1479-5876-9-161","article-title":"c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells","volume":"9","author":"Sun","year":"2011","journal-title":"J. Trans. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1053\/j.gastro.2010.07.006","article-title":"ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn\u2019s disease pathogenesis","volume":"139","author":"Homer","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.femsle.2004.12.013","article-title":"A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells","volume":"243","author":"Huang","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1128\/AEM.69.10.5870-5874.2003","article-title":"Mycotoxin fumonisin B1 increases intestinal colonization by pathogenic Escherichia coli in pigs","volume":"69","author":"Oswald","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/MCG.0b013e3181dd4fa5","article-title":"Abnormalities in the handling of intracellular bacteria in Crohn\u2019s disease","volume":"44","author":"Lapaquette","year":"2010","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kuballa, P., Huett, A., Rioux, J.D., Daly, M.J., and Xavier, R.J. (2008). Impaired autophagy of an intracellular pathogen induced by a Crohn\u2019s disease associated ATG16L1 variant. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003391"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1172\/JCI11792","article-title":"Breaching the mucosal barrier by stealth: An emerging pathogenic mechanism for enteroadherent bacterial pathogens","volume":"107","author":"Fleckenstein","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1476-5381.2009.00281.x","article-title":"Sphingolipids in inflammation: Pathological implications and potential therapeutic targets","volume":"158","author":"Nixon","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/sur.2006.050","article-title":"Acid sphingomyelinase is required for lipid Raft TLR4 complex formation","volume":"8","author":"Cuschieri","year":"2007","journal-title":"Surg. Infect."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1462-5822.2006.00867.x","article-title":"Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4","volume":"9","author":"Fischer","year":"2007","journal-title":"Cell. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1194\/jlr.M600060-JLR200","article-title":"A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products","volume":"47","author":"Walton","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1038\/sj.onc.1207146","article-title":"Raft ceramide in molecular medicine","volume":"22","author":"Gulbins","year":"2003","journal-title":"Oncogene"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/IAI.05856-11","article-title":"Ceramide and Toll-like receptor 4 are mobilized into membrane rafts in response to Helicobacter pylori infection in gastric epithelial cells","volume":"80","author":"Lu","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"L849","DOI":"10.1152\/ajplung.90516.2008","article-title":"Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells","volume":"296","author":"Cornell","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1165\/rcmb.2008-0295OC","article-title":"Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis","volume":"41","author":"Yu","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cellimm.2007.03.005","article-title":"Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice","volume":"245","author":"Sakata","year":"2007","journal-title":"Cell. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.2337\/diabetes.50.10.2210","article-title":"A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B\/Akt and glycogen synthesis by palmitate","volume":"50","author":"Cazzolli","year":"2001","journal-title":"Diabetes"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/en.2006-0750","article-title":"Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine\/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells","volume":"148","author":"Ghosh","year":"2007","journal-title":"Endocrinology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nchembio.103","article-title":"Raft nanodomains contribute to Akt\/PKB plasma membrane recruitment and activation","volume":"4","author":"Lasserre","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4062\/biomolther.2013.058","article-title":"Sphingolipids and antimicrobial peptides: Function and roles in atopic dermatitis","volume":"21","author":"Park","year":"2013","journal-title":"Biomol. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1128\/MCB.00599-14","article-title":"An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating beta-defensin production","volume":"34","author":"Kim","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_84","first-page":"458","article-title":"Disruption of sphingolipid biosynthetic gene IPT1 reduces Candida albicans adhesion and prevents activation of human gingival epithelial cell innate immune defense","volume":"49","author":"Rouabhia","year":"2011","journal-title":"Med. Mycol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1074\/jbc.M511044200","article-title":"NOD2\/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2","volume":"281","author":"Voss","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1089\/10430340260395875","article-title":"A model for antimicrobial gene therapy: Demonstration of human beta-defensin 2 antimicrobial activities in vivo","volume":"13","author":"Huang","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.200502153","article-title":"Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition","volume":"170","author":"Barnich","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/gut.2010.223396","article-title":"Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease","volume":"60","author":"Jess","year":"2011","journal-title":"Gut"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/j.gastro.2011.02.012","article-title":"Interactions between the host innate immune system and microbes in inflammatory bowel disease","volume":"140","author":"Abraham","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Aldhous, M.C., Noble, C.L., and Satsangi, J. (2009). Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006285"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zilbauer, M., Jenke, A., Wenzel, G., Postberg, J., Heusch, A., Phillips, A.D., Noble-Jamieson, G., Torrente, F., Salvestrini, C., and Heuschkel, R. (2010). Expression of human beta-defensins in children with chronic inflammatory bowel disease. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015389"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.4049\/jimmunol.178.4.2458","article-title":"FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells","volume":"178","author":"Daniel","year":"2007","journal-title":"J. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1194\/jlr.M500357-JLR200","article-title":"Absorption and lipoprotein transport of sphingomyelin","volume":"47","author":"Nilsson","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/09687860500445604","article-title":"Lipid raft organization and function in brush borders of epithelial cells","volume":"23","author":"Danielsen","year":"2006","journal-title":"Mol. Membr. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.mpg.0000187567.79633.a7","article-title":"Dietary gangliosides enhance in vitro lipid uptake in weanling rats","volume":"42","author":"Birecki","year":"2006","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1017\/S0007114507832946","article-title":"The role of dietary gangliosides on immunity and the prevention of infection","volume":"98","author":"Rueda","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1271\/bbb.59.417","article-title":"Inhibition of cholera toxin by human milk fractions and sialyllactose","volume":"59","author":"Idota","year":"1995","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"280286","DOI":"10.1155\/2012\/280286","article-title":"Dietary ganglioside reduces proinflammatory signaling in the intestine","volume":"2012","author":"Miklavcic","year":"2012","journal-title":"J. Nutr. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/1523-1747.ep12363729","article-title":"Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis","volume":"101","author":"Feingold","year":"1993","journal-title":"J. Investig. Dermatol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/8\/1720\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:41:38Z","timestamp":1760208098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/18\/8\/1720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":99,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"alternative-id":["ijms18081720"],"URL":"https:\/\/doi.org\/10.3390\/ijms18081720","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}