{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:21:33Z","timestamp":1777893693832,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.<\/jats:p>","DOI":"10.3390\/ijms18081819","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T11:08:25Z","timestamp":1503400105000},"page":"1819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation"],"prefix":"10.3390","volume":"18","author":[{"given":"Yvonne","family":"Reinders","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"},{"name":"Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Felthaus","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gero","family":"Brockhoff","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, University Medical Centre Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Prantl","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Haubner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"},{"name":"Department of Otorhinolaryngology, University Hospital Goettingen, 37075 Goettingen, Germany"},{"name":"Department of Otorhinolaryngology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1748-717X-7-162","article-title":"Wound healing after radiation therapy: Review of the literature","volume":"7","author":"Haubner","year":"2012","journal-title":"Radiat. 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