{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:43:51Z","timestamp":1790779431055,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner and Localizer of Breast Cancer 2 (BRCA2)) plays an important role in maintaining genome integrity through its role in the Fanconi anemia (FA) and homologous recombination (HR) DNA repair pathways. Since its identification as a BRCA2 interacting partner, PALB2 has emerged as a pivotal tumor suppressor protein associated to hereditary cancer susceptibility to breast and pancreatic cancers. In this review, we discuss how other DDR proteins (such as the kinases Ataxia Telangiectasia Mutated (ATM) and ATM- and Rad3-Related (ATR), mediators BRCA1 (Breast Cancer 1)\/BRCA2 and effectors RAD51\/DNA Polymerase \u03b7 (Pol\u03b7) interact with PALB2 to orchestrate DNA repair. We also examine the involvement of PALB2 mutations in the predisposition to cancer and the role of PALB2 in stimulating error-free DNA repair through the FA\/HR pathway.<\/jats:p>","DOI":"10.3390\/ijms18091886","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T10:54:44Z","timestamp":1504176884000},"page":"1886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["The Role of PALB2 in the DNA Damage Response and Cancer Predisposition"],"prefix":"10.3390","volume":"18","author":[{"given":"Thales","family":"Nepomuceno","sequence":"first","affiliation":[{"name":"Programa de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"De Gregoriis","sequence":"additional","affiliation":[{"name":"Programa de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M. Bastos","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho\u2013Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Suarez-Kurtz","sequence":"additional","affiliation":[{"name":"Programa de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-4801","authenticated-orcid":false,"given":"Alvaro","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-0053","authenticated-orcid":false,"given":"Marcelo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Programa de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, Brazil"},{"name":"Instituto Federal do Rio de Janeiro-IFRJ, Rio de Janeiro 20270-021, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","article-title":"Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21","volume":"250","author":"Hall","year":"1990","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1126\/science.8091231","article-title":"Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12\u201313","volume":"265","author":"Wooster","year":"1994","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., and Micklem, G. 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