{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:19:19Z","timestamp":1790421559741,"version":"4.1.0"},"reference-count":259,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Progetto di Ricerca di Ateneo (PRAT;Universit\u00e0 di Padova)","award":["CDA #152403"],"award-info":[{"award-number":["CDA #152403"]}]},{"name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca (MIUR) Ex 60%"},{"name":"Istituto Oncologico Veneto 5x1000"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth. Notwithstanding, T-ALL patients are still treated with high-dose multiagent chemotherapy, potentially exposing these patients to considerable acute and long-term side effects. This review summarizes recent advances in our understanding of the signaling pathways relevant for the pathogenesis of T-ALL and the opportunities offered for targeted therapy.<\/jats:p>","DOI":"10.3390\/ijms18091904","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:26:19Z","timestamp":1504610779000},"page":"1904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia"],"prefix":"10.3390","volume":"18","author":[{"given":"Deborah","family":"Bongiovanni","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova 35128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Saccomani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova 35128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-563X","authenticated-orcid":false,"given":"Erich","family":"Piovan","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova 35128, Italy"},{"name":"UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV\u2014IRCCS, Padova 35128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia","volume":"1","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Mullighan","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2141.2011.08955.x","article-title":"Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: Results of the Tokyo children\u2019s cancer study group study L99-15","volume":"156","author":"Inukai","year":"2012","journal-title":"Br. 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