{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:44:08Z","timestamp":1789879448502,"version":"4.0.1"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells. In addition, NAT10 inhibition significantly increased cell cycle arrest in S-phase, thereby suppressing the growth and proliferation of malignant melanoma cells in vitro and in vivo. These results demonstrate the potential role of NAT10 in melanogenesis and melanoma growth through the regulation of microphthalmia-associated transcription factor (MITF) expression and provide a promising strategy for the treatment of various skin diseases (melanoma) and pigmentation disorders (chloasma and freckles).<\/jats:p>","DOI":"10.3390\/ijms18091924","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T13:59:10Z","timestamp":1504792750000},"page":"1924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression"],"prefix":"10.3390","volume":"18","author":[{"given":"Taek-In","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Bioscience, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea"},{"name":"Nanotechnology Research Center, Konkuk University, Chungju 27478, Chungbuk, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-5956","authenticated-orcid":false,"given":"Beong-Ou","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hong","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea"},{"name":"Nanotechnology Research Center, Konkuk University, Chungju 27478, Chungbuk, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.1252651","article-title":"Chemical inhibition of NAT10 corrects defects of laminopathic cells","volume":"344","author":"Larrieu","year":"2014","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.15252\/embr.201540505","article-title":"NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2","volume":"17","author":"Liu","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1158\/1078-0432.CCR-13-3477","article-title":"GSK-3beta-regulated N-acetyltransferase 10 is involved in colorectal cancer invasion","volume":"20","author":"Zhang","year":"2014","journal-title":"Clin. 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