{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:13Z","timestamp":1792789513519,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T00:00:00Z","timestamp":1509148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"publisher","award":["FIS PI13\/00666"],"award-info":[{"award-number":["FIS PI13\/00666"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology","award":["BIO2009-13903-C02-02"],"award-info":[{"award-number":["BIO2009-13903-C02-02"]}]},{"name":"Andalusian Government","award":["P07-CVI-2781, PAIDI BIO-217"],"award-info":[{"award-number":["P07-CVI-2781, PAIDI BIO-217"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology.<\/jats:p>","DOI":"10.3390\/ijms18112264","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T12:16:23Z","timestamp":1509365783000},"page":"2264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy"],"prefix":"10.3390","volume":"18","author":[{"given":"Antonio","family":"Villatoro","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Claros","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alcoholado","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3740-3754","authenticated-orcid":false,"given":"Jes\u00fas","family":"Merayo-Lloves","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Andrades","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Becerra","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Genetics and Physiology, University of M\u00e1laga, IBIMA, 29071 M\u00e1laga, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 M\u00e1laga, Spain"},{"name":"Laboratory of Bioingeneering and Tissue Regeneration, Andalusian Center for Nanomedicine and Biotechnology-BIONAND, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. 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