{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:38:09Z","timestamp":1790501889348,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Extended sleep improves sustained attention and reduces sleep pressure in humans. Downregulation of adenosine A1 receptor (A1R) and modulation of the neurotrophic factor insulin growth factor-1 (IGF-I) in brain structures controlling attentional capacities could be involved. In the frontal cortex and hippocampus of rats, we measured adenosine A1R and IGF-I protein concentrations after photoperiod-induced sleep extension. Two groups of twelve rats were adapted over 14 days to a habitual (CON) 12:12 light\u2013dark (LD) schedule and an extended (EXT) 16:8 LD schedule. IGF-I content was also measured in plasma, liver, and skeletal muscle. In EXT, compared to CON rats, A1R content in the frontal cortex was significantly lower (p &lt; 0.05), while IGF-I content was higher (p &lt; 0.001), and no significant change was observed in the hippocampus. IGF-I content in plasma and muscle was higher (p &lt; 0.001 and p &lt; 0.01), while it was lower in liver (p &lt; 0.001). The absolute weight and weight gain were higher in EXT rats (p &lt; 0.01). These data suggest that 14 days under a 16:8 LD photoperiod respectively down- and upregulated cortical A1R and IGF-I levels. This photoperiod induced an anabolic profile with increased weight gain and circulating and muscular IGF-I levels. An extension of sleep duration might favor cerebral and peripheral anabolism, which may help attentional and physical capacities.<\/jats:p>","DOI":"10.3390\/ijms18112439","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T12:00:20Z","timestamp":1510920020000},"page":"2439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Changes of Cerebral and\/or Peripheral Adenosine A1 Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-813X","authenticated-orcid":false,"given":"Mounir","family":"Chennaoui","sequence":"first","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), D\u00e9partement Neurosciences et Contraintes Op\u00e9rationnelles, 91223 Br\u00e9tigny sur Orge, France"},{"name":"Equipe d\u2019accueil EA7330 VIFASOM, Universit\u00e9 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EA7330 VIFASOM, Universit\u00e9 Paris Descartes, H\u00f4tel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-2319","authenticated-orcid":false,"given":"Fabien","family":"Sauvet","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), D\u00e9partement Neurosciences et Contraintes Op\u00e9rationnelles, 91223 Br\u00e9tigny sur Orge, France"},{"name":"Equipe d\u2019accueil EA7330 VIFASOM, Universit\u00e9 Paris Descartes, H\u00f4tel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Ciret","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), D\u00e9partement Neurosciences et Contraintes Op\u00e9rationnelles, 91223 Br\u00e9tigny sur Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-3738","authenticated-orcid":false,"given":"Thierry","family":"Gallopin","sequence":"additional","affiliation":[{"name":"ESPCI ParisTech, Laboratoire Plasticit\u00e9 du Cerveau, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Leger","sequence":"additional","affiliation":[{"name":"Equipe d\u2019accueil EA7330 VIFASOM, Universit\u00e9 Paris Descartes, H\u00f4tel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France"},{"name":"Centre du Sommeil et de la Vigilance, H\u00f4tel Dieu, APHP, 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Drogou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), D\u00e9partement Neurosciences et Contraintes Op\u00e9rationnelles, 91223 Br\u00e9tigny sur Orge, France"},{"name":"Equipe d\u2019accueil EA7330 VIFASOM, Universit\u00e9 Paris Descartes, H\u00f4tel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Gomez-Merino","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), D\u00e9partement Neurosciences et Contraintes Op\u00e9rationnelles, 91223 Br\u00e9tigny sur Orge, France"},{"name":"Equipe d\u2019accueil EA7330 VIFASOM, Universit\u00e9 Paris Descartes, H\u00f4tel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"ref_1","first-page":"35","article-title":"The neuroprotective aspects of sleep","volume":"3","author":"Eugene","year":"2015","journal-title":"Medtube 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