{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:47:37Z","timestamp":1776581257595,"version":"3.51.2"},"reference-count":49,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>chlorpyrifos (CPF) is an organophosphate insecticide used to control pests on a variety of food and feed crops. In mammals, maternal exposure to CPF has been reported to induce cerebral cortex thinning, alteration of long-term brain cognitive function, and Parkinson-like symptoms, but the mechanisms of these processes are not fully understood. In this study, we aimed to gain a deeper understanding of the alterations induced in the brains of mice chronically exposed to CPF by dietary intake. For our purpose, we analysed F1 offspring (sacrificed at 3 and 8 months) of Mus musculus, treated in utero and postnatally with 3 different doses of CPF (0.1-1-10 mg\/kg\/day). Using RT2 Profiler PCR Arrays, we evaluated the alterations in the expression of 84 genes associated with neurodegenerative diseases. In the brains of exposed mice, we evidenced a clear dose\u2013response relationship for AChE inhibition and alterations of gene expression. Some of the genes that were steadily down-regulated, such as Pink1, Park 2, Sv2b, Gabbr2, Sept5 and Atxn2, were directly related to Parkinson\u2019s onset. Our experimental results shed light on the possibility that long-term CPF exposure may exert membrane signalling alterations which make brain cells more susceptible to develop neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms18112467","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T11:35:45Z","timestamp":1511177745000},"page":"2467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression\u2014A Mouse Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Maria","family":"Pallotta","sequence":"first","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 di Napoli Federico II, Via Cinthia 21, 80126 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Ronca","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 di Napoli Federico II, Via Cinthia 21, 80126 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Carotenuto","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 di Napoli Federico II, Via Cinthia 21, 80126 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immacolata","family":"Porreca","sequence":"additional","affiliation":[{"name":"IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimmo","family":"Turano","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 di Napoli Federico II, Via Cinthia 21, 80126 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy"},{"name":"Dipartimento di Scienze e Tecnologie, Universit\u00e0 del Sannio, Via Port\u2019Arsa 11, 82100 Benevento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Capriglione","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 di Napoli Federico II, Via Cinthia 21, 80126 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1289\/ehp.1002056","article-title":"Organophosphate pesticide exposure and attention in young Mexican-American children: The CHAMACOS study","volume":"118","author":"Marks","year":"2010","journal-title":"Environ. 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