{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:04:18Z","timestamp":1790125458498,"version":"4.0.1"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral\/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus\/Streptococcus pneumoniae (Sp) co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with Sp. Our results suggest that Sp contributes to a faster and possibly higher level of CXCL10\/IP-10 expression induced by RSV infection in human MDMs.<\/jats:p>","DOI":"10.3390\/ijms18122654","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:49:10Z","timestamp":1512647350000},"page":"2654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["RSV Infection in Human Macrophages Promotes CXCL10\/IP-10 Expression during Bacterial Co-Infection"],"prefix":"10.3390","volume":"18","author":[{"given":"Daniela","family":"Machado","sequence":"first","affiliation":[{"name":"Laboratoire des Pathog\u00e8nes Emergents, Fondation M\u00e9rieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69007 Lyon, France"},{"name":"Virologie et Pathologie Humaine\u2014VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Laboratoire des Pathog\u00e8nes Emergents, Fondation M\u00e9rieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Moroso","sequence":"additional","affiliation":[{"name":"Laboratoire des Pathog\u00e8nes Emergents, Fondation M\u00e9rieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rosa-Calatrava","sequence":"additional","affiliation":[{"name":"Virologie et Pathologie Humaine\u2014VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Endtz","sequence":"additional","affiliation":[{"name":"Laboratoire des Pathog\u00e8nes Emergents, Fondation M\u00e9rieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-7684","authenticated-orcid":false,"given":"Olivier","family":"Terrier","sequence":"additional","affiliation":[{"name":"Virologie et Pathologie Humaine\u2014VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia","family":"Paranhos-Baccal\u00e0","sequence":"additional","affiliation":[{"name":"Laboratoire des Pathog\u00e8nes Emergents, Fondation M\u00e9rieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2217\/ahe.09.74","article-title":"Community-acquired pneumonia in elderly patients","volume":"5","author":"Stupka","year":"2009","journal-title":"Aging Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccm.2016.12.005","article-title":"Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management","volume":"38","author":"Wong","year":"2017","journal-title":"Clin. 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