{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:24:09Z","timestamp":1790771049694,"version":"4.1.0"},"reference-count":169,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2016M3A9B6918676"],"award-info":[{"award-number":["NRF-2016M3A9B6918676"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2015R1C1A1A01054160"],"award-info":[{"award-number":["NRF-2015R1C1A1A01054160"]}]},{"DOI":"10.13039\/501100002461","name":"Chungbuk National University","doi-asserted-by":"publisher","award":["2015"],"award-info":[{"award-number":["2015"]}],"id":[{"id":"10.13039\/501100002461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the last decade, a wide range of avian influenza viruses (AIVs) have infected various mammalian hosts and continuously threaten both human and animal health. It is a result of overcoming the inter-species barrier which is mostly associated with gene reassortment and accumulation of mutations in their gene segments. Several recent studies have shed insights into the phenotypic and genetic changes that are involved in the interspecies transmission of AIVs. These studies have a major focus on transmission from avian to mammalian species due to the high zoonotic potential of the viruses. As more mammalian species have been infected with these viruses, there is higher risk of genetic evolution of these viruses that may lead to the next human pandemic which represents and raises public health concern. Thus, understanding the mechanism of interspecies transmission and molecular determinants through which the emerging AIVs can acquire the ability to transmit to humans and other mammals is an important key in evaluating the potential risk caused by AIVs among humans. Here, we summarize previous and recent studies on molecular markers that are specifically involved in the transmission of avian-derived influenza viruses to various mammalian hosts including humans, pigs, horses, dogs, and marine mammals.<\/jats:p>","DOI":"10.3390\/ijms18122706","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T04:30:55Z","timestamp":1513225855000},"page":"2706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-9452","authenticated-orcid":false,"given":"Khristine Kaith S.","family":"Lloren","sequence":"first","affiliation":[{"name":"College of Medicine and Medical Research Institute, Chungbuk National University, Chungdae-ro 1, Seowon-Ku, Cheongju 28644, Korea"},{"name":"College of Veterinary Medicine and Agricultural Sciences, De La Salle Araneta University, 303 Victoneta Avenue, Potrero Malabon City 1475, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taehyung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute, Chungbuk National University, Chungdae-ro 1, Seowon-Ku, Cheongju 28644, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-1280","authenticated-orcid":false,"given":"Jin Jung","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute, Chungbuk National University, Chungdae-ro 1, Seowon-Ku, Cheongju 28644, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6073-0783","authenticated-orcid":false,"given":"Min-Suk","family":"Song","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute, Chungbuk National University, Chungdae-ro 1, Seowon-Ku, Cheongju 28644, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/mr.56.1.152-179.1992","article-title":"Evolution and ecology of influenza a viruses","volume":"56","author":"Webster","year":"1992","journal-title":"Microbiol. 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