{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:37:32Z","timestamp":1761917852826,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:00:00Z","timestamp":1514073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The existence of genetic traits might explain the susceptibility to develop hypercholesterolemia and the inter-individual differences in statin response. This study was performed to evaluate whether individuals\u2019 polymorphisms in HMG-CoA and KIF6 genes are independently associated with hypercholesterolemia, other lipid-associated traits, and statin response in unselected individuals enrolled in the Brisighella heart study (Survey 2012). A total of 1622 individuals, of which 183 under statin medication, were genotyped for a total of five polymorphisms (KIF6 rs20455, rs9471077, rs9462535; HMG-CoA rs3761740, rs3846662). The relationships between the five loci and clinical characteristics were analyzed. The principal basic parameters calculated on 12 h fasting blood included total cholesterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C), and triglycerides (TG). Hypercholesterolemia was defined as a TC &gt;200 mg\/dL or use of lipid-lowering medication. 965 individuals were characterized by hypercholesterolemia; these subjects were significantly older (p &lt; 0.001), with body mass index (BMI) and waist circumference significantly higher (p &lt; 0.001) compared to the others. HMG-CoA rs3846662 GG genotype was significantly over-represented in the hypercholesterolemic group (p = 0.030). HMG-CoA rs3846662 genotype was associated with the level of TC and LDL-C. Furthermore, in the same subset of untreated subjects, we observed a significant correlation between the KIF6 rs20455 and HDL-C. KIF6 variants were associated with a significantly lower (rs20455) or higher (rs9471077 and rs9462535) risk of obesity, in males only. No association between responsiveness to statins and the polymorphisms under investigation were observed. Our results showed associations between HMG-CoA rs3846662 and KIF6 rs20455 and lipid phenotypes, which may have an influence on dyslipidemia-related events. Moreover, this represents the first study implicating KIF6 variants with obesity in men, and point to the possible involvement of this genetic locus in the known gender-related differences in coronary artery disease.<\/jats:p>","DOI":"10.3390\/ijms19010049","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T03:06:38Z","timestamp":1514257598000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-0421","authenticated-orcid":false,"given":"Sabrina","family":"Angelini","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Rosticci","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9461-9629","authenticated-orcid":false,"given":"Gianmichele","family":"Massimo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"},{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Musti","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiological Service, Local Health Authority of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-402X","authenticated-orcid":false,"given":"Gloria","family":"Ravegnini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Consolini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Sammarini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-4342","authenticated-orcid":false,"given":"Sergio","family":"D\u2019Addato","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dauren","family":"Botbayev","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"},{"name":"Department of Biotechnology, Faculty of Biology and Biotechnology, \u041aazakh National University Named after al-Farabi, 050040 Almaty, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-8781","authenticated-orcid":false,"given":"Claudio","family":"Borghi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Cantelli-Forti","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, Corso d\u2019Augusto 237, University of Bologna, 47921 Rimini, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-3884","authenticated-orcid":false,"given":"Arrigo","family":"Cicero","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Hrelia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, via Irnerio 48, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,24]]},"reference":[{"unstructured":"(2017, September 04). Global Atlas on Cardiovascular Disease Prevention and Control. Available online: http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241564373_eng.pdf.","key":"ref_1"},{"doi-asserted-by":"crossref","unstructured":"Expert panel on Detection, evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2001). Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel. JAMA, 285, 2486\u20132497.","key":"ref_2","DOI":"10.1001\/jama.285.19.2486"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0002-9149(02)02436-0","article-title":"The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease: Expert group recommendations","volume":"90","author":"Sacks","year":"2002","journal-title":"Am. J. Cardiol."},{"doi-asserted-by":"crossref","unstructured":"CTT Collaboration, Baigent, C., Blackwell, L., Emberson, J., Holland, L.E., Reith, C., Bhala, N., Peto, R., Barnes, E.H., and Keech, A. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet, 376, 1670\u20131681.","key":"ref_4","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.amjcard.2010.05.002","article-title":"Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control","volume":"106","author":"Carey","year":"2010","journal-title":"Am. J. Cardiol."},{"doi-asserted-by":"crossref","unstructured":"CTT Collaboration, Mihaylova, B., Emberson, J., Blackwell, L., Keech, A., Simes, J., Barnes, E.H., Voysey, M., Gray, A., and Collins, R. (2012). The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials. Lancet, 380, 581\u2013590.","key":"ref_6","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/eurheartj\/eht232","article-title":"Long-Term impact on healthcare resource utilization of statin treatment, and its cost effectiveness in the primary prevention of cardiovascular disease: A record linkage study","volume":"35","author":"McConnachie","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2012.06.052","article-title":"A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2","volume":"224","author":"Santos","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/1074248413492906","article-title":"Lipid-lowering agents","volume":"18","author":"Wierzbicki","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCGENETICS.111.960252","article-title":"The 719 Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies","volume":"5","author":"Arsenault","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.269","article-title":"Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts","volume":"41","author":"Aulchenko","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.291","article-title":"Common variants at 30 loci contribute to polygenic dyslipidemia","volume":"41","author":"Kathiresan","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/bmj.326.7404.1423","article-title":"Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis","volume":"326","author":"Law","year":"2003","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1073\/pnas.111145398","article-title":"All kinesin superfamily protein, KIF, genes in mouse and human","volume":"98","author":"Miki","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jacc.2007.05.057","article-title":"Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: The CARE and WOSCOPS trials","volume":"51","author":"Iakoubova","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jacc.2007.09.044","article-title":"A kinesin family member 6 variant is associated with coronary heart disease in the Women\u2019s Health Study","volume":"51","author":"Shiffman","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.amjcard.2010.05.033","article-title":"KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy","volume":"106","author":"Li","year":"2010","journal-title":"Am. J. Cardiol."},{"doi-asserted-by":"crossref","unstructured":"Ference, B.A., Yoo, W., Flack, J.M., and Clarke, M. (2011). A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: Two meta-analyses and a meta-regression analysis. PLoS ONE, 6.","key":"ref_18","DOI":"10.1371\/journal.pone.0028834"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00439-010-0892-6","article-title":"Genetic variants in the KIF6 region and coronary event reduction from statin therapy","volume":"129","author":"Li","year":"2011","journal-title":"Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11269","DOI":"10.3390\/molecules170911269","article-title":"Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population","volume":"17","author":"Wu","year":"2012","journal-title":"Molecules"},{"key":"ref_21","first-page":"328954","article-title":"The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women","volume":"2014","author":"Ancheta","year":"2014","journal-title":"Nurs. Res. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.gene.2013.07.056","article-title":"The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs3761740) and serum lipids in patients with coronary heart disease","volume":"528","author":"Kurnaz","year":"2013","journal-title":"Gene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/nu5041218","article-title":"Dyslipidemia in obesity: Mechanisms and potential targets","volume":"5","author":"Klop","year":"2013","journal-title":"Nutrients"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/jama.298.7.776","article-title":"Clinical utility of different lipid measures for prediction of coronary heart disease in man and women","volume":"298","author":"Ingelsson","year":"2007","journal-title":"JAMA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.atherosclerosis.2011.11.037","article-title":"KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly","volume":"220","author":"Akao","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3945\/ajcn.114.094557","article-title":"Genetic loci associated with circulating phospholipid trans fatty acids: A meta-analysis of genome-wide association studies from the CHARGE Consortium","volume":"101","author":"Mozaffarian","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1056\/NEJM199304223281603","article-title":"Genetic and environmental influences on serum lipid levels in twins","volume":"328","author":"Heller","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCGENETICS.108.773168","article-title":"Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density cholesterol, triglycerides, apolipoprotein A1, and apolipoprotein B among 6382 white women in genome-wide analysis with replication","volume":"1","author":"Chasman","year":"2008","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0140-6736(08)60208-1","article-title":"LDL-cholesterol concentrations: A genome-wide association study","volume":"371","author":"Sandhu","year":"2008","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2007.11.001","article-title":"Genome-wide association studies identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipidemia","volume":"82","author":"Wallace","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng.76","article-title":"Newly identified loci that influence lipid concentrations and risk of coronary artery disease","volume":"40","author":"Willer","year":"2008","journal-title":"Nat. Genet."},{"doi-asserted-by":"crossref","unstructured":"Lowe, J.K., Maller, J.B., Pe\u2019er, I., Neale, B.M., Salit, J., Kenny, E.E., Shea, J.L., Burkhardt, R., Smith, J.G., and Ji, W. (2009). Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet., 5.","key":"ref_32","DOI":"10.1371\/journal.pgen.1000365"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1253\/circj.CJ-08-1101","article-title":"Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population","volume":"73","author":"Hiura","year":"2009","journal-title":"Circ. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1253\/circj.CJ-09-0790","article-title":"Association of the functional variant in the 3-hydroxy-3-methylglutarylcoenzyme a reductase gene with low-density lipoprotein cholesterol in Japanese","volume":"74","author":"Hiura","year":"2010","journal-title":"Circ. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0091270011398239","article-title":"Effect of HMGCR variant alleles on low-density lipoprotein cholesterol-lowering response to atorvastatin in healthy Korean subjects","volume":"52","author":"Chung","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FPC.0000000000000178","article-title":"Role of rs3846662 and HMCCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia","volume":"26","author":"Leduc","year":"2016","journal-title":"Pharmacogenom. Genom."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1161\/ATVBAHA.108.172288","article-title":"Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13","volume":"28","author":"Burkhardt","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/hmg\/ddt422","article-title":"HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism","volume":"23","author":"Yu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17171","DOI":"10.1074\/jbc.274.24.17171","article-title":"Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase","volume":"274","author":"Cheng","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/emboj\/19.5.819","article-title":"Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis","volume":"19","author":"Istvan","year":"2000","journal-title":"Embo J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrm.2016.139","article-title":"The roles of RNA processing in translating genotype to phenotype","volume":"18","author":"Manning","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jacc.2010.06.022","article-title":"Lack of association between the Trp719Arg polymorphism in kinesin-like Protein-6 and coronary artery disease in 19 case-control studies","volume":"56","author":"Assimes","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"doi-asserted-by":"crossref","unstructured":"Peng, P., Lian, J., Huang, R., Xu, L., Huang, Y., Ba, Y., Yang, X., Huang, X., Dong, C., and Zhang, L. (2012). Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect. PLoS ONE, 7.","key":"ref_43","DOI":"10.1371\/journal.pone.0050126"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3233\/JAD-2012-121015","article-title":"KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer\u2019s disease patients","volume":"33","author":"Sabbagh","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"871439","DOI":"10.1155\/2014\/871439","article-title":"Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men","volume":"2014","author":"Wu","year":"2014","journal-title":"J. Diabetes Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/tpj.2013.27","article-title":"Providing patients with pharmacogenetic test results affects adherence to statin therapy: Results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial","volume":"14","author":"Charland","year":"2014","journal-title":"Pharmacogenom. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mgene.2015.07.001","article-title":"Genotyping and meta-analysis of KIF6 Trp719Arg polymorphism in South Indian Coronary Artery Disease patients: A case\u2013control study","volume":"5","author":"Vishnuprabu","year":"2015","journal-title":"Meta Gene"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1479-7364-7-15","article-title":"New susceptibility locus for obesity and dyslipidemia on chromosome 3q22.3","volume":"7","author":"Alshahid","year":"2013","journal-title":"Hum. Genom."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/s41598-017-01517-6","article-title":"A systems genetics approach identified GPD1L and its molecular mechanism for obesity in human adipose tissue","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"doi-asserted-by":"crossref","unstructured":"Graff, M., Scott, R.A., Justice, A.E., Young, K.L., Feitosa, M.F., Barata, L., Winkler, T.W., Chu, A.Y., Mahajan, A., and Hadley, D. (2017). Genome-wide physical activity interactions in adiposity\u2014A meta-analysis of 200,452 adults. PLoS Genet., 13.","key":"ref_50","DOI":"10.1371\/journal.pgen.1006528"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14977","DOI":"10.1038\/ncomms14977","article-title":"Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits","volume":"8","author":"Justice","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/oby.21869","article-title":"Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children","volume":"25","author":"Sabo","year":"2017","journal-title":"Obesity"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10552-008-9141-x","article-title":"A prospective study of waist circumference and body mass index in relation to colorectal cancer incidence","volume":"19","author":"Wang","year":"2008","journal-title":"Cancer Causes Control"},{"doi-asserted-by":"crossref","unstructured":"The Decoda Study Group, and Nyamdorj, R. (2008). BMI compared with central obesity indicators in relation to diabetes and hypertension in asians. Obesity, 16, 1622\u20131635.","key":"ref_54","DOI":"10.1038\/oby.2008.73"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/CIRCULATIONAHA.107.753483","article-title":"Relation between body mass index, waist circumference, and death after acute myocardial infarction","volume":"118","author":"Zeller","year":"2008","journal-title":"Circulation"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/aje\/kws172","article-title":"Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: A meta-analysis","volume":"176","author":"Kodama","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ejcn.2013.61","article-title":"General and abdominal obesity parameters and their combination in relation to mortality: A systematic review and meta-regression analysis","volume":"67","author":"Carmienke","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1056\/NEJMra1105239","article-title":"Genomics of cardiovascular disease","volume":"365","author":"Nabel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.atherosclerosis.2015.04.806","article-title":"Importance of sex and gender in atherosclerosis and cardiovascular disease","volume":"241","author":"Spence","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1475-2840-11-133","article-title":"Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: An epidemiological study","volume":"11","author":"Povel","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e002544","DOI":"10.1161\/JAHA.115.002544","article-title":"Sex-specific genetic variants are associated with coronary endothelial dysfunction","volume":"5","author":"Yoshino","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jacc.2007.10.017","article-title":"Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: Results from the PROVE IT-TIMI 22 study","volume":"51","author":"Iakoubova","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.107.153981","article-title":"Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study","volume":"28","author":"Shiffman","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/HJR.0b013e328336a0dd","article-title":"KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: Results from the PROSPER study","volume":"17","author":"Iakoubova","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.atherosclerosis.2016.08.018","article-title":"2016 ESC\/EAS guidelines for the management of dyslipidaemias: The task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"253","author":"Catapano","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_66","first-page":"547","article-title":"The Brisighella survey: A study of dietary habits","volume":"74","author":"Descovich","year":"1983","journal-title":"Minerva Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/eci.12325","article-title":"Serum LDL cholesterol and new onset of arterial hypertension: An 8-year follow-up","volume":"44","author":"Cicero","year":"2014","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.atherosclerosis.2017.03.036","article-title":"Effect of spontaneous changes in dietary components and lipoprotein (a) levels: Data from the Brisighella Heart Study","volume":"262","author":"Fogacci","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12529-012-9242-5","article-title":"European guidelines on cardiovascular disease prevention in clinical practice (version 2012): The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)","volume":"19","author":"Perk","year":"2012","journal-title":"Int. J. Behav. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1586\/14779072.2015.1082907","article-title":"Challenges in the care of familial hypercholesterolemia: A community care perspective","volume":"13","author":"Brett","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"unstructured":"Stata Corporation (Stata Statistical Software, Release 11, 2011). 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