{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:40:43Z","timestamp":1774928443554,"version":"3.50.1"},"reference-count":90,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia. Indeed, recent results suggest that H2S-induced hypothermia in aged, overweight rats could have a higher probability of success in treating stroke as compared to other monotherapies, by reducing post-stroke brain inflammation. Likewise, it was recently reported that weight reduction prior to stroke, in aged, overweight rats induced by caloric restriction, led to an early re-gain of weight and a significant improvement in recovery of complex sensorimotor skills, cutaneous sensitivity, or spatial memory. Conclusion: animal models of stroke done in young animals ignore age-associated comorbidities and may explain, at least in part, the unsuccessful bench-to-bedside translation of neuroprotective strategies for ischemic stroke in aged subjects.<\/jats:p>","DOI":"10.3390\/ijms19010099","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T10:58:47Z","timestamp":1514545127000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects"],"prefix":"10.3390","volume":"19","author":[{"given":"Raluca","family":"Sandu","sequence":"first","affiliation":[{"name":"Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danut","family":"Dumbrava","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Surugiu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela-Gabriela","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Gresita","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Petcu","sequence":"additional","affiliation":[{"name":"Gold Coast Campus, School of Medicine, Griffith University, Southport 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCULATIONAHA.109.849166","article-title":"Cardiovascular risk prediction: Basic concepts, current status, and future directions","volume":"121","year":"2010","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/01.STR.0000047852.05842.3C","article-title":"Poor outcome after first-ever stroke: Predictors for death, dependency, and recurrent stroke within the first year","volume":"34","author":"Appelros","year":"2003","journal-title":"Stroke"},{"key":"ref_3","first-page":"e2","article-title":"Heart disease and stroke statistics\u20142012 update: A report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10522-010-9265-8","article-title":"The NetAge database: A compendium of networks for longevity, age-related diseases and associated processes","volume":"11","author":"Tacutu","year":"2010","journal-title":"Biogerontology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.18632\/aging.100413","article-title":"Molecular links between cellular senescence, longevity and age-related diseases\u2014A systems biology perspective","volume":"3","author":"Tacutu","year":"2011","journal-title":"Aging"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biocel.2008.08.026","article-title":"The signaling hubs at the crossroad of longevity and age-related disease networks","volume":"41","author":"Wolfson","year":"2009","journal-title":"Int. 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