{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:30:34Z","timestamp":1792611034158,"version":"4.5.0"},"reference-count":200,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR1301\/19-1"],"award-info":[{"award-number":["GR1301\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Joint tissues like synovium, articular cartilage, meniscus and subchondral bone, are targets for neuropeptides. Resident cells of these tissues express receptors for various neuroendocrine-derived peptides including proopiomelanocortin (POMC)-derived peptides, i.e., \u03b1-melanocyte-stimulating hormone (\u03b1-MSH), adrenocorticotropin (ACTH) and \u03b2-endorphin (\u03b2-ED), and sympathetic neuropeptides like vasoactive intestinal peptide (VIP) and neuropeptide y (NPY). Melanocortins attained particular attention due to their immunomodulatory and anti-inflammatory effects in several tissues and organs. In particular, \u03b1-MSH, ACTH and specific melanocortin-receptor (MCR) agonists appear to have promising anti-inflammatory actions demonstrated in animal models of experimentally induced arthritis and osteoarthritis (OA). Sympathetic neuropeptides have obtained increasing attention as they have crucial trophic effects that are critical for joint tissue and bone homeostasis. VIP and NPY are implicated in direct and indirect activation of several anabolic signaling pathways in bone and synovial cells. Additionally, pituitary adenylate cyclase-activating polypeptide (PACAP) proved to be chondroprotective and, thus, might be a novel target in OA. Taken together, it appears more and more likely that the anabolic effects of these neuroendocrine peptides or their respective receptor agonists\/antagonists may be exploited for the treatment of patients with inflammatory and degenerative joint diseases in the future.<\/jats:p>","DOI":"10.3390\/ijms19020367","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T03:08:06Z","timestamp":1516936086000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-8285","authenticated-orcid":false,"given":"Susanne","family":"Gr\u00e4ssel","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Exp. Orthopedics, ZMB\/Biopark 1, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-2070","authenticated-orcid":false,"given":"Dominique","family":"Muschter","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Exp. Orthopedics, ZMB\/Biopark 1, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. Med. Bull."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0022-3999(95)00620-6","article-title":"Psychological status among elderly people with chronic diseases: Does type of disease play a part?","volume":"40","author":"Penninx","year":"1996","journal-title":"J. Psychosom. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2165\/00002512-200522020-00005","article-title":"Disease-modifying therapies for osteoarthritis: Current status","volume":"22","author":"Fajardo","year":"2005","journal-title":"Drugs Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2174\/138945010791011893","article-title":"Disease modifying osteoarthritis drugs: Facing development challenges and choosing molecular targets","volume":"11","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.joca.2016.10.021","article-title":"Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis","volume":"25","author":"Veronesi","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.joca.2013.01.016","article-title":"Disease-modifying drugs for knee osteoarthritis: Can they be cost-effective?","volume":"21","author":"Losina","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/13543784.2013.770837","article-title":"Disease-modifying osteoarthritis drugs: In vitro and in vivo data on the development of DMOADs under investigation","volume":"22","author":"Davies","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev.ph.51.030189.003435","article-title":"Hormonal regulation of POMC gene expression","volume":"51","author":"Autelitano","year":"1989","journal-title":"Annu. Rev. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1152\/physrev.2000.80.3.979","article-title":"Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress","volume":"80","author":"Slominski","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1677\/joe.0.1770365","article-title":"Proopiomelanocortin gene expression and DNA methylation: Implications for Cushing\u2019s syndrome and beyond","volume":"177","year":"2003","journal-title":"J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/er.2011-1016","article-title":"Role of Proopiomelanocortin-Derived Peptides and Their Receptors in the Osteoarticular System: From Basic to Translational Research","volume":"33","author":"Bohm","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1096\/fj.06-7398com","article-title":"Proopiomelanocortin (POMC), the ACTH\/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis","volume":"21","author":"Rousseau","year":"2007","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0083-6729(01)63007-3","article-title":"The physiological role of melanocortin receptors","volume":"63","author":"Schioth","year":"2001","journal-title":"Vitam. Horm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.smim.2015.02.003","article-title":"ACTH: The forgotten therapy","volume":"27","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2007-0027","article-title":"\u03b1-melanocyte-stimulating hormone and related tripeptides: Biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases","volume":"29","author":"Brzoska","year":"2008","journal-title":"Endocr. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.2174\/092986608785133672","article-title":"Multiple ligands in opioid research","volume":"15","author":"Ballet","year":"2008","journal-title":"Protein Pept. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1242\/dev.115.2.617","article-title":"The expression of neuropeptide Y immunoreactivity in the avian sympathoadrenal system conforms with two models of coexpression development for neurons and chromaffin cells","volume":"115","year":"1992","journal-title":"Development (Cambridge England)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(93)91124-B","article-title":"Cell density regulates neuropeptide Y expression in cultured sympathetic neurons","volume":"615","author":"Freidin","year":"1993","journal-title":"Brain Res."},{"key":"ref_20","first-page":"5255","article-title":"Vasoactive intestinal polypeptide and cholinergic mechanisms in cat nasal mucosa: Studies on choline acetyltransferase and release of vasoactive intestinal polypeptide","volume":"78","author":"Lundberg","year":"1981","journal-title":"Orthopaedica"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1073\/pnas.77.3.1651","article-title":"Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion","volume":"77","author":"Lundberg","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1210\/en.2012-1829","article-title":"PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic nerve firing rates characteristic of stress transduction in male mice","volume":"154","author":"Stroth","year":"2013","journal-title":"Endocrinology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1515\/pjvs-2015-0044","article-title":"Pituitary adenylate cyclase-activating peptide-27 (PACAP-27) is co-stored with galanin, substance P and corticotropin releasing factor (CRF) in intrapancreatic ganglia of the sheep","volume":"18","author":"Arciszewski","year":"2015","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.79.18.5485","article-title":"Neuropeptide Y: Complete amino acid sequence of the brain peptide","volume":"79","author":"Tatemoto","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","first-page":"743","article-title":"Evolution of neuropeptide Y and its related peptides","volume":"106","author":"Larhammar","year":"1993","journal-title":"Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.pain.2007.09.016","article-title":"Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain","volume":"137","author":"Intondi","year":"2008","journal-title":"Pain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.npep.2012.08.005","article-title":"Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis","volume":"46","author":"Holzer","year":"2012","journal-title":"Neuropeptides"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.npep.2012.09.003","article-title":"Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells","volume":"46","author":"Perreault","year":"2012","journal-title":"Neuropeptides"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2016.02.033","article-title":"Neuropeptide Y is an angiogenic factor in cardiovascular regeneration","volume":"776","author":"Saraf","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.83.2.187","article-title":"Neuropeptide Y: A novel angiogenic factor from the sympathetic nerves and endothelium","volume":"83","author":"Rose","year":"1998","journal-title":"Circ. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/JOE-16-0223","article-title":"The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons","volume":"234","author":"Ailanen","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhang, P., Qi, Y.X., Yao, Q.P., Chen, X.H., Wang, G.L., Shen, B.R., Han, Y., Gao, L.Z., and Jiang, Z.L. (2015). Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131124"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.scr.2017.04.001","article-title":"Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt\/\u03b2-catenin pathway in vitro","volume":"21","author":"Wu","year":"2017","journal-title":"Stem Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.26350","article-title":"Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line","volume":"131","author":"Medeiros","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1096\/fj.13-243485","article-title":"Neuropeptide Y induces potent migration of human immature dendritic cells and promotes a Th2 polarization","volume":"28","author":"Buttari","year":"2014","journal-title":"FASEB J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/bbrc.2000.3656","article-title":"Neuropeptide Y receptor gene y6: Multiple deaths or resurrections?","volume":"277","author":"Starback","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(24)01352-8","article-title":"XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors","volume":"50","author":"Michel","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/S0021-9258(18)61367-5","article-title":"Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein","volume":"262","author":"Kassis","year":"1987","journal-title":"J. Boil. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0922-4106(95)90177-9","article-title":"Structural requirements for neuropeptide Y in mast cell and G protein activation","volume":"289","author":"Mousli","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1016\/S0021-9258(17)37183-1","article-title":"A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line","volume":"269","author":"Lynch","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/0006-291X(89)92721-6","article-title":"Neuropeptide Y mobilizes intracellular Ca2+ and increases inositol phosphate production in human erythroleukemia cells","volume":"165","author":"Daniels","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","first-page":"E880","article-title":"Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells","volume":"255","author":"Motulsky","year":"1988","journal-title":"Am. J. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuroscience.2003.10.041","article-title":"Y2 receptor expression and inhibition of voltage-dependent Ca2+ influx into rod bipolar cell terminals","volume":"125","author":"Brecha","year":"2004","journal-title":"Neuroscience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0022-3565(25)10538-7","article-title":"Neuropeptide Y (18\u201336) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel","volume":"274","author":"Zheng","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0006-291X(89)91757-9","article-title":"Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells","volume":"164","author":"Miyata","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0006-291X(90)92140-U","article-title":"Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)","volume":"170","author":"Miyata","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.169.3951.1217","article-title":"Polypeptide with Broad Biological Activity: Isolation from Small Intestine","volume":"169","author":"Said","year":"1970","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/304547a0","article-title":"Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27","volume":"304","author":"Itoh","year":"1983","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0169-328X(90)90036-D","article-title":"The complete structure of the rat VIP gene","volume":"7","author":"Giladi","year":"1990","journal-title":"Mol. Brain Res."},{"key":"ref_51","first-page":"199","article-title":"Localization of VIP and PHI-27 messenger RNA in rat thalamic and cortical neurons","volume":"1","author":"Baldino","year":"1989","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s004290050096","article-title":"VIP\u2014A \u2018very important peptide\u2019 in the sympathetic nervous system?","volume":"196","author":"Klimaschewski","year":"1997","journal-title":"Anat. Embryol."},{"key":"ref_53","first-page":"619","article-title":"The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)\/glucagon superfamily","volume":"21","author":"Sherwood","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1476-5381.2012.01871.x","article-title":"Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1","volume":"166","author":"Harmar","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Langer, I. (2012). Mechanisms involved in VPAC receptors activation and regulation: Lessons from pharmacological and mutagenesis studies. Front. Endocrinol., 3.","DOI":"10.3389\/fendo.2012.00129"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1196\/annals.1317.021","article-title":"VIP and PACAP receptor pharmacology: A comparison of intracellular signaling pathways","volume":"1070","author":"Dickson","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"C5","DOI":"10.1016\/0303-7207(94)90212-7","article-title":"PACAP, PACAP receptors, and intracellular signalling","volume":"101","author":"Rawlings","year":"1994","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1677\/jme.0.0210109","article-title":"Multiple splice variants of the pituitary adenylate cyclase-activating polypeptide type 1 receptor detected by RT-PCR in single rat pituitary cells","volume":"21","author":"Jacquot","year":"1998","journal-title":"J. Mol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Barr","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","article-title":"Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review","volume":"20","author":"Zuurmond","year":"2012","journal-title":"Osteoarthr. Cartel."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10067-010-1573-5","article-title":"Synovial fluid \u03b2-endorphin level in avascular necrosis, rheumatoid arthritis, and osteoarthritis of the femoral head and knee. A controlled pilot study","volume":"30","author":"Toth","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000097183","article-title":"The anticytokine neuropeptide \u03b1-melanocyte-stimulating hormone in synovial fluid of patients with rheumatic diseases: Comparisons with other anticytokine molecules","volume":"1","author":"Catania","year":"1994","journal-title":"Neuroimmunomodulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.7754\/Clin.Lab.2016.151222","article-title":"Decreased Synovial Fluid \u03b1-Melanocyte-Stimulating-Hormone (\u03b1-MSH) Levels Reflect Disease Severity in Patients with Posttraumatic Ankle Osteoarthritis","volume":"62","author":"Liu","year":"2016","journal-title":"Clin. Lab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bcp.2016.07.003","article-title":"\u03b1-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients","volume":"116","author":"Bohm","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_65","first-page":"1592","article-title":"Peptide containing nerves in human synovium: Immunohistochemical evidence for decreased innervation in rheumatoid arthritis","volume":"17","year":"1990","journal-title":"J. Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1096\/fj.99-1082com","article-title":"The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages","volume":"14","author":"Miller","year":"2000","journal-title":"FASEB J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.joca.2013.06.018","article-title":"The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium","volume":"21","author":"Eitner","year":"2013","journal-title":"Osteoarthr. Cartel."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/art.1780330613","article-title":"Noradrenergic and peptidergic nerves in the synovial membrane of the Sprague-Dawley rat","volume":"33","author":"Bjurholm","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_69","first-page":"583","article-title":"Interleukin-1 immunoreactive nerve fibres in rat joint synovium","volume":"12","author":"Bjurholm","year":"1994","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0143-4179(95)90054-3","article-title":"Neuropeptide Y- and vasoactive intestinal polypeptide-like immunoreactivity in adjuvant arthritis: Effects of capsaicin treatment","volume":"29","author":"Ahmed","year":"1995","journal-title":"Neuropeptides"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2460\/ajvr.1993.54.11.1831","article-title":"Neuropeptidergic innervation of equine synovial joints","volume":"54","author":"Bowker","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s004290050139","article-title":"The innervation of the synovium of the knee joint in the guinea pig: An immunohistochemical and ultrastructural study","volume":"197","author":"Elfvin","year":"1998","journal-title":"Anat. Embryol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3109\/03009749109096808","article-title":"Concentration of substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid from knee joints in patients suffering from rheumatoid arthritis","volume":"20","author":"Larsson","year":"1991","journal-title":"Scand. J. Rheumatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3940(93)90071-R","article-title":"Bilateral changes of substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in rat knee joint synovial fluid during acute monoarthritis","volume":"153","author":"Bileviciute","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_75","first-page":"9","article-title":"A model for the study of experimentally induced temporomandibular arthritis in rats: The effect of human recombinant interleukin-1\u03b1 on neuropeptide-like immunoreactivity","volume":"10","author":"Carleson","year":"1996","journal-title":"J. Orofac. Pain"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wang, L., Zhang, L., Pan, H., Peng, S., Lv, M., and Lu, W.W. (2014). Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis. BMC Musculoskelet. Disord., 15.","DOI":"10.1186\/1471-2474-15-319"},{"key":"ref_77","first-page":"50","article-title":"Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat","volume":"8","author":"Adaes","year":"2012","journal-title":"Mol. Pain"},{"key":"ref_78","first-page":"469","article-title":"The distribution of peptide-containing nerves in the synovia of the cat knee joint","volume":"6","author":"Abramovici","year":"1991","journal-title":"Histol. Histopathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/1097-0185(20000901)260:1<51::AID-AR60>3.0.CO;2-9","article-title":"Neurovascular plasticity in the knee joint of an arthritic mouse model","volume":"260","author":"Buma","year":"2000","journal-title":"Anat. Rec."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/jcmm.12777","article-title":"VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts","volume":"20","author":"Carrion","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/art.23403","article-title":"Differential expression of vasoactive intestinal peptide and its functional receptors in human osteoarthritic and rheumatoid synovial fibroblasts","volume":"58","author":"Juarranz","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/rheumatology\/kei219","article-title":"VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts","volume":"45","author":"Juarranz","year":"2006","journal-title":"Rheumatology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1081\/IMM-55809","article-title":"Vasoactive intestinal peptide ameliorates synovial cell functions of collagen-induced arthritis rats by down-regulating NF-\u03baB activity","volume":"34","author":"Yin","year":"2005","journal-title":"Immunol. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.molimm.2008.03.011","article-title":"VIP reverses the expression profiling of TLR4-stimulated signaling pathway in rheumatoid arthritis synovial fibroblasts","volume":"45","author":"Arranz","year":"2008","journal-title":"Mol. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/rheumatology\/32.1.31","article-title":"Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease","volume":"32","author":"Hernanz","year":"1993","journal-title":"Br. J. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s004290050137","article-title":"Distribution and origin of nerve fibers in the rat temporomandibular joint capsule","volume":"197","author":"Uddman","year":"1998","journal-title":"Anat. Embryol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.3390\/ijms16035922","article-title":"Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis","volume":"16","author":"Giunta","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Poole, A.R., Kojima, T., Yasuda, T., Mwale, F., Kobayashi, M., and Laverty, S. (2001). Composition and structure of articular cartilage: A template for tissue repair. Clin. Orthop. Relat. Res., S26\u2013S33.","DOI":"10.1097\/00003086-200110001-00004"},{"key":"ref_89","unstructured":"Seibel, M.J., Robins, S.P., and Bilezikian, J.P. (1999). Supramolecular Structure of cartilage matrix. Bone and Cartilage Metabolism, Academic Press."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/jars.2002.32839","article-title":"Articular cartilage defects in 1000 knee arthroscopies","volume":"18","author":"Hjelle","year":"2002","journal-title":"Arthroscopy"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1002\/art.24846","article-title":"The melanocortin system in articular chondrocytes: Melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of \u03b1-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components","volume":"60","author":"Grassel","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.joca.2007.05.026","article-title":"\u03b1-MSH inhibits TNF-\u03b1-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor \u03baB signaling in human chondrosarcoma HTB-94 cells","volume":"16","author":"Yoon","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/cbf.1226","article-title":"Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage","volume":"24","author":"Andjelkov","year":"2006","journal-title":"Cell Biochem. Funct."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bcp.2014.08.019","article-title":"Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury","volume":"92","author":"Kaneva","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Lorenz, J., Seebach, E., Hackmayer, G., Greth, C., Bauer, R.J., Kleinschmidt, K., Bettenworth, D., Bohm, M., Grifka, J., and Grassel, S. (2014). Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105858"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1258\/ebm.2010.010319","article-title":"Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis","volume":"236","author":"Shen","year":"2011","journal-title":"Exp. Biol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1742-4658.2009.07482.x","article-title":"Neuropeptide Y expression and function during osteoblast differentiation\u2014Insights from transthyretin knockout mice","volume":"277","author":"Nunes","year":"2010","journal-title":"FEBS J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2006.063354","article-title":"Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis","volume":"66","author":"Suri","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0143-4179(97)90082-2","article-title":"Immunocytochemical demonstration of pituitary adenylate cyclase activating polypeptide (PACAP) in the porcine epiphyseal cartilage canals","volume":"31","author":"Arnbjerg","year":"1997","journal-title":"Neuropeptides"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Juhasz, T., Matta, C., Katona, E., Somogyi, C., Takacs, R., Gergely, P., Csernoch, L., Panyi, G., Toth, G., and Reglodi, D. (2014). Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: Implication of calcineurin as a downstream target. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091541"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"17344","DOI":"10.3390\/ijms160817344","article-title":"Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures","volume":"16","author":"Juhasz","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.peptides.2015.02.001","article-title":"PACAP and VIP signaling in chondrogenesis and osteogenesis","volume":"66","author":"Juhasz","year":"2015","journal-title":"Peptides"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0167-0115(92)90660-M","article-title":"The regulation of connective tissue metabolism by vasoactive intestinal polypeptide","volume":"37","author":"Rahman","year":"1992","journal-title":"Regul. Pept."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.clinbiochem.2012.08.020","article-title":"Expression of synovial fluid and articular cartilage VIP in human osteoarthritic knee: A new indicator of disease severity?","volume":"45","author":"Jiang","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/87887","article-title":"Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease","volume":"7","author":"Delgado","year":"2001","journal-title":"Nat. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1469-7580.1999.19510101.x","article-title":"The electron microscope appearance of the subchondral bone plate in the human femoral head in osteoarthritis and osteoporosis","volume":"195","author":"Li","year":"1999","journal-title":"J. Anat."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: Relevance and biology","volume":"15","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.peptides.2004.12.034","article-title":"Evidence for direct actions of melanocortin peptides on bone metabolism","volume":"26","author":"Dumont","year":"2005","journal-title":"Peptides"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bone.2005.01.020","article-title":"Multiple melanocortin receptors are expressed in bone cells","volume":"36","author":"Zhong","year":"2005","journal-title":"Bone"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1073\/pnas.0912176107","article-title":"ACTH protects against glucocorticoid-induced osteonecrosis of bone","volume":"107","author":"Zaidi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2009.05231.x","article-title":"ACTH is a novel regulator of bone mass","volume":"1192","author":"Isales","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"E1181","DOI":"10.1152\/ajpendo.00412.2002","article-title":"\u03b1-melanocyte-stimulating hormone is a novel regulator of bone","volume":"284","author":"Cornish","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.3518059","article-title":"Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers","volume":"232","author":"Hohmann","year":"1986","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000276591","article-title":"Development of rat tibia innervation: Colocalization of autonomic nerve fiber markers with growth-associated protein 43","volume":"191","author":"Gajda","year":"2010","journal-title":"Cells Tissues Org."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00018-005-5175-3","article-title":"Neuronal signaling and the regulation of bone remodeling","volume":"62","author":"Elefteriou","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_117","first-page":"154","article-title":"Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide","volume":"8","author":"Lerner","year":"2008","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(97)00649-6","article-title":"Expression of mRNAs for neuropeptide receptors and \u03b2-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells","volume":"233","author":"Togari","year":"1997","journal-title":"Neurosci. Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1006\/bbrc.2000.3151","article-title":"Microisolated mouse osteoclasts express VIP-1 and PACAP receptors","volume":"274","author":"Ransjo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bbrc.2005.07.135","article-title":"The neuropeptide VIP potentiates IL-6 production induced by proinflammatory osteotropic cytokines in calvarial osteoblasts and the osteoblastic cell line MC3T3-E1","volume":"335","author":"Persson","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1002\/jcb.23304","article-title":"The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts","volume":"112","author":"Persson","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Muschter, D., Schafer, N., Stangl, H., Straub, R.H., and Grassel, S. (2015). Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139726"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1113\/expphysiol.1997.sp004070","article-title":"Pituitary adenylyl cyclase-activating polypeptides and vasoactive intestinal peptide inhibit bone resorption by isolated rabbit osteoclasts","volume":"82","author":"Winding","year":"1997","journal-title":"Exp. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.1038\/srep22373","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12031-014-0389-1","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) signalling enhances osteogenesis in UMR-106 cell line","volume":"54","author":"Juhasz","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jcp.21831","article-title":"cAMP activation by PACAP\/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells","volume":"221","author":"Nagata","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10571-013-9953-4","article-title":"Expression of pituitary adenylate cyclase-activating peptide (PACAP) and PAC1 in the periodontal ligament after tooth luxation","volume":"33","author":"Nonaka","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00319037","article-title":"Distribution of CGRP-, VIP-, D\u03b2H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat","volume":"264","author":"Hill","year":"1991","journal-title":"Cell Tissue Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0165-1838(88)90016-1","article-title":"Neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues","volume":"25","author":"Bjurholm","year":"1988","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3109\/17453674.2010.504609","article-title":"Neuropeptide Y innervation during fracture healing and remodeling. A study of angulated tibial fractures in the rat","volume":"81","author":"Long","year":"2010","journal-title":"Acta Orthop."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/jor.22400","article-title":"Neuropeptide Y modulates fracture healing through Y1 receptor signaling","volume":"31","author":"Sousa","year":"2013","journal-title":"J. Orthop. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jcb.22294","article-title":"Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity","volume":"108","author":"Igwe","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.npep.2016.09.005","article-title":"Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells","volume":"60","author":"Gu","year":"2016","journal-title":"Neuropeptides"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11914-016-0300-9","article-title":"Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis","volume":"14","author":"Horsnell","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bone.2015.12.011","article-title":"The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay","volume":"84","author":"Khor","year":"2016","journal-title":"Bone"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.bbagen.2007.02.009","article-title":"Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells","volume":"1770","author":"Amano","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_137","first-page":"625","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nature reviews","volume":"6","author":"Sellam","year":"2010","journal-title":"Rheumatology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/0003-4819-109-1-18","article-title":"Obesity and knee osteoarthritis. The Framingham Study","volume":"109","author":"Felson","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/BOR.0b013e32835a9414","article-title":"Osteoarthritis, inflammation and obesity","volume":"25","author":"Berenbaum","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/157339906775473626","article-title":"Chronic inflammation: Role of adipose tissue and modulation by weight loss","volume":"2","author":"You","year":"2006","journal-title":"Curr. Diabetes Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.joca.2014.11.005","article-title":"Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis","volume":"23","author":"Beavers","year":"2015","journal-title":"Osteoarthr. Cartel."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.pmrj.2012.01.005","article-title":"Obesity and weight loss in the treatment and prevention of osteoarthritis","volume":"4","author":"Vincent","year":"2012","journal-title":"PM R"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1210\/en.2004-0263","article-title":"Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice","volume":"145","author":"Savontaus","year":"2004","journal-title":"Endocrinology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/01.bor.0000133662.60223.ee","article-title":"Angiogenesis in osteoarthritis and spondylosis: Successful repair with undesirable outcomes","volume":"16","author":"Walsh","year":"2004","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_146","first-page":"782","article-title":"Blockade of endothelin-1 release contributes to the anti-angiogenic effect by pro-opiomelanocortin overexpression in endothelial cells","volume":"231","author":"Lam","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0306-3623(91)90580-Y","article-title":"Angiogenesis: Modulation with opioids","volume":"22","author":"Pasi","year":"1991","journal-title":"Gen. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00018-016-2419-3","article-title":"Old drugs with new skills: Fenoprofen as an allosteric enhancer at melanocortin receptor 3","volume":"74","author":"Forfar","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/annrheumdis-2011-200100","article-title":"Molecular engineering of short half-life small peptides (VIP, \u03b1MSH and \u03b3(3)MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics","volume":"71","author":"Vessillier","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_150","first-page":"4835","article-title":"Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis","volume":"24","author":"Patel","year":"2010","journal-title":"FASEB J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.ajpath.2014.04.009","article-title":"Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3","volume":"184","author":"Madeira","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1096\/fj.201600790R","article-title":"Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection","volume":"30","author":"Madeira","year":"2016","journal-title":"FASEB J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0960-5428(96)00008-3","article-title":"The significance of vasoactive intestinal polypeptide (VIP) in immunomodulation","volume":"6","author":"Bellinger","year":"1996","journal-title":"Adv. Neuroimmunol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0196-9781(97)00075-2","article-title":"Vasoactive intestinal polypeptide (VIP) innervation of rat spleen, thymus, and lymph nodes","volume":"18","author":"Bellinger","year":"1997","journal-title":"Peptides"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00306107","article-title":"Pituitary adenylate cyclase-activating peptide (PACAP) immunolocalization in lymphoid tissues of the rat","volume":"276","author":"Gaytan","year":"1994","journal-title":"Cell Tissue Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000067180","article-title":"Pituitary adenylate-cyclase-activating polypeptide expression in the immune system","volume":"10","author":"Abad","year":"2002","journal-title":"Neuroimmunomodulation"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00726-011-1184-8","article-title":"Vasoactive intestinal peptide: A neuropeptide with pleiotropic immune functions","volume":"45","author":"Delgado","year":"2013","journal-title":"Amino Acids"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/apha.12427","article-title":"The neuropeptide vasoactive intestinal peptide: Direct effects on immune cells and involvement in inflammatory and autoimmune diseases","volume":"213","author":"Ganea","year":"2015","journal-title":"Acta Physiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1749-6632.2003.tb03145.x","article-title":"PACAP in immunity and inflammation","volume":"992","author":"Delgado","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1189\/jlb.3A0116-032RR","article-title":"VIP impairs acquisition of the macrophage proinflammatory polarization profile","volume":"100","author":"Carrion","year":"2016","journal-title":"J. Leukoc. Boil."},{"key":"ref_161","first-page":"55","article-title":"Trophoblast cells inhibit neutrophil extracellular trap formation and enhance apoptosis through vasoactive intestinal peptide-mediated pathways","volume":"32","author":"Calo","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/intimm\/dxl103","article-title":"Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis","volume":"18","author":"Sun","year":"2006","journal-title":"Int. Immunol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/art.23482","article-title":"Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: Altered expression and signal in immune cells","volume":"58","author":"Delgado","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/gene.2008.60","article-title":"A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia","volume":"9","author":"Paladini","year":"2008","journal-title":"Genes Immun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1021\/mp300539f","article-title":"Novel, biocompatible, and disease modifying VIP nanomedicine for rheumatoid arthritis","volume":"10","author":"Sethi","year":"2013","journal-title":"Mol. Pharm."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1021\/acs.molpharmaceut.7b00452","article-title":"Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease","volume":"14","author":"Jayawardena","year":"2017","journal-title":"Mol. Pharm."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ejphar.2016.10.014","article-title":"Conjugated Alpha-Alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice","volume":"791","author":"Athari","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.1021\/acsami.5b11332","article-title":"In-Situ-Generated Vasoactive Intestinal Peptide Loaded Microspheres in Mussel-Inspired Polycaprolactone Nanosheets Creating Spatiotemporal Releasing Microenvironment to Promote Wound Healing and Angiogenesis","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2015.09.001","article-title":"Vasoactive intestinal peptide administration after stroke in rats enhances neurogenesis and improves neurological function","volume":"1625","author":"Yang","year":"2015","journal-title":"Brain Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.npep.2017.07.003","article-title":"Differently polarized macrophages affect the viability and growth of NSPCs by regulating the expression of PACAP","volume":"65","author":"Liu","year":"2017","journal-title":"Neuropeptides"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00726-011-1185-7","article-title":"The intriguing mission of neuropeptide Y in the immune system","volume":"45","author":"Dimitrijevic","year":"2013","journal-title":"Amino Acids"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/apa.13684","article-title":"Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas","volume":"106","author":"Tan","year":"2017","journal-title":"Acta Paediatr."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2013.04.019","article-title":"The neuropeptides \u03b1-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells","volume":"260","author":"Phan","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.peptides.2006.07.029","article-title":"A role for neuropeptide Y (NPY) in phagocytosis: Implications for innate and adaptive immunity","volume":"28","author":"Bedoui","year":"2007","journal-title":"Peptides"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jneuroim.2013.04.005","article-title":"Neuropeptide Y induces secretion of high-mobility group box 1 protein in mouse macrophage via PKC\/ERK dependent pathway","volume":"260","author":"Zhou","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Singer, K., Morris, D.L., Oatmen, K.E., Wang, T., DelProposto, J., Mergian, T., Cho, K.W., and Lumeng, C.N. (2013). Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation. PLoS ONE, 8.","DOI":"10.1371\/annotation\/c2432ace-1dd7-4b02-8980-e4e6c085beba"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0165-5728(94)90128-7","article-title":"Neuropeptide Y is an inducible gene in the human immune system","volume":"51","author":"Schwarz","year":"1994","journal-title":"J. Neuroimmunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1159\/000468405","article-title":"NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing","volume":"41","author":"Tang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"645","DOI":"10.5483\/BMBRep.2015.48.12.22","article-title":"Role of neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment","volume":"48","author":"Park","year":"2015","journal-title":"BMB Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1002\/stem.2383","article-title":"Neuropeptide Y Induces Hematopoietic Stem\/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts","volume":"34","author":"Park","year":"2016","journal-title":"Stem Cells (Dayton Ohio)"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"6823917","DOI":"10.1155\/2017\/6823917","article-title":"Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy","volume":"2017","author":"Peng","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1097\/01.blo.0000143938.30681.9d","article-title":"The impact of osteoarthritis: Implications for research","volume":"427","author":"Buckwalter","year":"2004","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.blo.0000131638.81519.de","article-title":"Joint injury, repair, and remodeling: Roles in post-traumatic osteoarthritis","volume":"423","author":"Buckwalter","year":"2004","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s11926-014-0452-5","article-title":"Tissue-engineering strategies to repair chondral and osteochondral tissue in osteoarthritis: Use of mesenchymal stem cells","volume":"16","author":"Grassel","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.joca.2016.07.017","article-title":"Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: Lessons learned from failures and opportunities for the future","volume":"24","author":"Karsdal","year":"2016","journal-title":"Osteoarthr. Cartel."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1189\/jlb.0706426","article-title":"The melanocortin system in leukocyte biology","volume":"81","author":"Catania","year":"2007","journal-title":"J. Leukoc. Biol"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cellimm.2017.03.001","article-title":"Role of immune cells in obesity induced low grade inflammation and insulin resistance","volume":"315","author":"Asghar","year":"2017","journal-title":"Cell. Immunol."},{"key":"ref_188","first-page":"173","article-title":"Modulation of host defense by the neuropeptide \u03b1-MSH","volume":"63","author":"Lipton","year":"1990","journal-title":"Yale J. Biol. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0305-0491(84)90090-7","article-title":"Enzymological studies of melanotropins","volume":"78","author":"Castrucci","year":"1984","journal-title":"Comp. Biochem. Physiol. B"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.4049\/jimmunol.0902298","article-title":"KdPT, a tripeptide derivative of \u03b1-melanocyte-stimulating hormone, suppresses IL-1\u03b2-mediated cytokine expression and signaling in human sebocytes","volume":"185","author":"Mastrofrancesco","year":"2010","journal-title":"J. Immunol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12929-016-0280-1","article-title":"Role of vasoactive intestinal peptide in osteoarthritis","volume":"23","author":"Jiang","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: Mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3390\/ijms15045874","article-title":"Effects of neuropeptides and mechanical loading on bone cell resorption in vitro","volume":"15","author":"Yoo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/jcp.25969","article-title":"Osteoblast role in osteoarthritis pathogenesis","volume":"232","author":"Maruotti","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1515\/bc.2010.035","article-title":"Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis","volume":"391","author":"Pozgan","year":"2010","journal-title":"Biol. Chem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000350892","article-title":"Inflammatory mediators alter interleukin-17 receptor, interleukin-12 and -23 expression in human osteoarthritic and rheumatoid arthritis synovial fibroblasts: Immunomodulation by vasoactive intestinal Peptide","volume":"20","author":"Carrion","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pain.2006.02.015","article-title":"Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis","volume":"123","author":"McDougall","year":"2006","journal-title":"Pain"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pain.2008.10.028","article-title":"Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice","volume":"141","author":"Sandor","year":"2009","journal-title":"Pain"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.4049\/jimmunol.167.6.3182","article-title":"Pituitary adenylate cyclase-activating polypeptide inhibits collagen-induced arthritis: An experimental immunomodulatory therapy","volume":"167","author":"Abad","year":"2001","journal-title":"J. Immunol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1002\/art.38772","article-title":"Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model","volume":"66","author":"Botz","year":"2014","journal-title":"Arthritis Rheumatol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/2\/367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:52:37Z","timestamp":1760194357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/2\/367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":200,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["ijms19020367"],"URL":"https:\/\/doi.org\/10.3390\/ijms19020367","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,26]]}}}