{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:58:11Z","timestamp":1781222291439,"version":"3.54.1"},"reference-count":119,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.<\/jats:p>","DOI":"10.3390\/ijms19020377","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T07:46:20Z","timestamp":1517211980000},"page":"377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Autoimmunity and Gastric Cancer"],"prefix":"10.3390","volume":"19","author":[{"given":"Nicola","family":"Bizzaro","sequence":"first","affiliation":[{"name":"Laboratorio di Patologia Clinica, Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Antico","sequence":"additional","affiliation":[{"name":"Laboratorio Analisi ULSS 4, 36014 Santorso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Villalta","sequence":"additional","affiliation":[{"name":"Immunologia e Allergologia, Presidio Ospedaliero S. Maria degli Angeli, 33170 Pordenone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0140-6736(72)91842-9","article-title":"Antinuclear antibodies in patients with malignancies","volume":"2","author":"Burnham","year":"1972","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0140-6736(72)92453-1","article-title":"Malignancy associated with antinuclear antibodies","volume":"2","author":"Zermosky","year":"1972","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1191\/0961203304lu521oa","article-title":"Clinical significance of antinuclear antibodies in malignant diseases: Association with rheumatic and connective tissue paraneoplastic syndromes","volume":"13","author":"Rodrigo","year":"2004","journal-title":"Lupus"},{"key":"ref_4","first-page":"32","article-title":"The role of anti-CENP-B and anti-SS-B antibodies in breast cancer","volume":"52","author":"Atalay","year":"2005","journal-title":"Neoplasma"},{"key":"ref_5","first-page":"245","article-title":"protective autoimmunity in cancer","volume":"17","author":"Toubi","year":"2007","journal-title":"Oncol. 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