{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:46:41Z","timestamp":1792432001607,"version":"4.5.0"},"reference-count":467,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Galectin-3 (Gal-3) regulates basic cellular functions such as cell\u2013cell and cell\u2013matrix interactions, growth, proliferation, differentiation, and inflammation. It is not surprising, therefore, that this protein is involved in the pathogenesis of many relevant human diseases, including cancer, fibrosis, chronic inflammation and scarring affecting many different tissues. The papers published in the literature have progressively increased in number during the last decades, testifying the great interest given to this protein by numerous researchers involved in many different clinical contexts. Considering the crucial role exerted by Gal-3 in many different clinical conditions, Gal-3 is emerging as a new diagnostic, prognostic biomarker and as a new promising therapeutic target. The current review aims to extensively examine the studies published so far on the role of Gal-3 in all the clinical conditions and diseases, listed in alphabetical order, where it was analyzed.<\/jats:p>","DOI":"10.3390\/ijms19020379","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T07:46:20Z","timestamp":1517211980000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":350,"title":["Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5365","authenticated-orcid":false,"given":"Salvatore","family":"Sciacchitano","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sapienza University, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy"},{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lavra","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Morgante","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Ulivieri","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenza","family":"Magi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"De Francesco","sequence":"additional","affiliation":[{"name":"Department of Oncological Science, Breast Unit, St Andrea University Hospital, Via di Grottarossa, 1035\/39, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Bellotti","sequence":"additional","affiliation":[{"name":"Operative Unit Surgery of Thyroid and Parathyroid, Sapienza University of Rome, S. Andrea Hospital, Via di Grottarossa, 1035\/39, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Salehi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Niccol\u00f2 Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy"},{"name":"Department of Biopathology and Diagnostic Imaging, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sapienza University, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-4165(02)00310-0","article-title":"Galectinomics: Finding themes in complexity","volume":"1572","author":"Cooper","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bss0690059","article-title":"Genomic analysis of C-type lectins","volume":"69","author":"Drickamer","year":"2002","journal-title":"Biochem. Soc. Symp."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13047","DOI":"10.1074\/jbc.273.21.13047","article-title":"X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution","volume":"273","author":"Seetharaman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0304-4165(99)00177-4","article-title":"Secretion of the galectin family of mammalian carbohydrate-binding proteins","volume":"1473","author":"Hughes","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10719-009-9262-9","article-title":"Galectin-3 is associated with prostasomes in human semen","volume":"27","author":"Jones","year":"2010","journal-title":"Glycoconj. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/jcs.151159","article-title":"The galectin lattice at a glance","volume":"128","author":"Nabi","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1042\/bst0251194","article-title":"The galectin family of mammalian carbohydrate-binding molecules","volume":"25","author":"Hughes","year":"1997","journal-title":"Biochem. Soc. Trans."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(94)90498-7","article-title":"Galectins: A family of animal beta-galactoside-binding lectins","volume":"76","author":"Barondes","year":"1994","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4049\/jimmunol.128.3.1221","article-title":"Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies","volume":"128","author":"Ho","year":"1982","journal-title":"J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1016\/S0021-9258(17)44507-8","article-title":"Endogenous lectins from cultured cells: Isolation and characterization of carbohydrate-binding proteins from 3T3 fibroblasts","volume":"258","author":"Roff","year":"1983","journal-title":"J. Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-1119(91)90139-3","article-title":"Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen","volume":"99","author":"Da","year":"1991","journal-title":"Gene"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.170.6.1959","article-title":"The Mac-2 antigen is a galactose-specific lectin that binds IgE","volume":"170","author":"Cherayil","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_13","first-page":"3489","article-title":"Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein","volume":"49","author":"Raz","year":"1989","journal-title":"Cancer Res."},{"key":"ref_14","first-page":"2173","article-title":"Molecular cloning and chromosomal mapping of a human galactoside-binding protein","volume":"51","author":"Raz","year":"1991","journal-title":"Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1016\/S0021-9258(18)48248-8","article-title":"Multiple soluble beta-galactoside-binding lectins from human lung","volume":"262","author":"Sparrow","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1021\/bi00449a039","article-title":"Soluble lactose-binding vertebrate lectins: A growing family","volume":"28","author":"Leffler","year":"1989","journal-title":"Biochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1021\/bi00487a015","article-title":"Human IgE-binding protein: A soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms","volume":"29","author":"Robertson","year":"1990","journal-title":"Biochemistry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1073\/pnas.84.19.6859","article-title":"An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor","volume":"84","author":"Albrandt","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10474","DOI":"10.1016\/S0021-9258(19)85107-4","article-title":"Three soluble rat beta-galactoside-binding lectins","volume":"260","author":"Cerra","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref_20","first-page":"1261","article-title":"Biochemical and immunological characterization of K-1735P melanoma galactoside-binding lectins and their modulation by differentiation inducers","volume":"49","author":"Lotan","year":"1989","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1016\/S0021-9258(19)50525-7","article-title":"Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin","volume":"267","author":"Sato","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1016\/S0021-9258(18)68739-3","article-title":"Carbohydrate binding protein 35. Complementary DNA sequence reveals homology with proteins of the heterogeneous nuclear RNP","volume":"263","author":"Jia","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1016\/S0021-9258(19)39081-7","article-title":"The major nonintegrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2)","volume":"265","author":"Woo","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: An open-ended story","volume":"1760","author":"Dumic","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_25","first-page":"537","article-title":"Expression of galectins in cancer: A critical review","volume":"19","author":"Califice","year":"2004","journal-title":"Glycoconj. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cca.2014.01.019","article-title":"Galectin-3 in cancer","volume":"431","author":"Song","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/glycob\/3.4.297","article-title":"The family of metazoan metal-independent beta-galactoside-binding lectins: Structure, function and molecular evolution","volume":"4","author":"Hirabayashi","year":"1993","journal-title":"Glycobiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/glycob\/1.3.243","article-title":"Lectins in the cell nucleus","volume":"3","author":"Wang","year":"1991","journal-title":"Glycobiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/glycob\/4.1.5","article-title":"Mac-2: A versatile galactose-binding protein of mammalian tissues","volume":"4","author":"Hughes","year":"1994","journal-title":"Glycobiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1021\/bi002907f","article-title":"NMR solution studies of hamster Gal-3 and electron microscopic visualization of surface-adsorbed complexes: Evidence for interactions between the N- and C-terminal domains","volume":"40","author":"Birdsall","year":"2001","journal-title":"Biochemistry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"26712","DOI":"10.1016\/S0021-9258(19)74371-3","article-title":"L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I","volume":"268","author":"Huflejt","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36311","DOI":"10.1074\/jbc.M003831200","article-title":"Phosphorylation of the \u03b2-galactoside-binding protein Gal-3 modulates binding to its ligands","volume":"275","author":"Mazurek","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1046\/j.1432-1327.1999.00671.x","article-title":"Determinants in the N-terminal domains of Gal-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex","volume":"264","author":"Menon","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0304-4165(02)00311-2","article-title":"Oligosaccharide specificity of galectins: A search by frontal affinity chromatography","volume":"1572","author":"Hirabayashi","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/B:GLYC.0000014082.99675.2f","article-title":"Extracellular functions of Gal-3","volume":"19","author":"Ochieng","year":"2004","journal-title":"Glycoconj. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/glycob\/12.5.329","article-title":"Shuttling of Gal-3 between the nucleus and cytoplasm","volume":"12","author":"Davidson","year":"2002","journal-title":"Glycobiology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/B:GLYC.0000014080.95829.52","article-title":"Regulation of cellular homeostasis by galectins","volume":"19","author":"Hsu","year":"2004","journal-title":"Glycoconj. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3892\/ijo.25.4.983","article-title":"Galectin-3 and cancer (Review)","volume":"25","author":"Califice","year":"2004","journal-title":"Int. J. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.102.2.477","article-title":"Endogenous lectins from cultured cells: Subcellular localization of carbohydrate binding protein 35 in 3T3 fibroblasts","volume":"102","author":"Moutsatsos","year":"1986","journal-title":"J. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1073\/pnas.84.18.6452","article-title":"Endogenous lectins from cultured cells: Nuclear localization of carbohydrate binding protein 35 in proliferating 3T3 fibroblasts","volume":"84","author":"Moutsatsos","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17236","DOI":"10.1016\/S0021-9258(18)71483-X","article-title":"Carbohydrate-binding protein 35. Levels of transcription and mRNA accumulation in quiescent and proliferating cells","volume":"264","author":"Agrwal","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0531-5565(89)90061-2","article-title":"Expression of carbohydrate binding protein 35 in human fibroblasts: Comparisons between cells with different proliferative capacities","volume":"24","author":"Cowles","year":"1989","journal-title":"Exp. Gerontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/excr.1995.1331","article-title":"Intranuclear distribution of galectin-3 in mouse 3T3 fibroblasts: Comparative analyses by immunofluorescence and immunoelectron microscopy","volume":"220","author":"Hubert","year":"1995","journal-title":"Exp. Cell Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/excr.1993.1157","article-title":"Secretion of the baby hamster kidney 30-kDa galactose-binding lectin from polarized and nonpolarized cells: A pathway independent of the endoplasmic reticulum-Golgi complex","volume":"207","author":"Sato","year":"1993","journal-title":"Exp. Cell Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1046\/j.1432-1033.2003.03577.x","article-title":"The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes","volume":"270","author":"Nickel","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1242\/jcs.110.10.1169","article-title":"Plasma membrane targeting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion","volume":"110","author":"Mehul","year":"1997","journal-title":"J. Cell Sci."},{"key":"ref_47","first-page":"268","article-title":"Ligands for Galectin-3: Binding interactions","volume":"Volume 1","author":"Gupta","year":"2012","journal-title":"Animal Lectins: Form, Function and Clinical Applications"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1021\/acs.biochem.6b00504","article-title":"Multitasking Human Lectin Galectin-3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans","volume":"55","author":"Talaga","year":"2016","journal-title":"Biochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"18731","DOI":"10.1016\/S0021-9258(18)55124-3","article-title":"Mac-2-binding glycoproteins. Putative ligands for a cytosolic \u03b2-galactoside lectin","volume":"266","author":"Rosenberg","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1016\/S0021-9258(19)85233-X","article-title":"Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain","volume":"268","author":"Koths","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1046\/j.1471-4159.1995.64062465.x","article-title":"Gal-3, a \u03b2- galactoside-binding animal lectin, binds to neural recognition molecules","volume":"64","author":"Probstmeier","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/bbrc.1995.2790","article-title":"Gal-3 binding potentials of mouse tumor RHS and human placental laminins","volume":"217","author":"Ochieng","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0300-9084(01)01289-5","article-title":"Galectins as modulators of cell adhesion","volume":"83","author":"Hughes","year":"2001","journal-title":"Biochimie"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1018554124545","article-title":"Macrophage surface glycoproteins binding to Gal-3 (Mac-2-antigen)","volume":"14","author":"Dong","year":"1997","journal-title":"Glycoconj. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1006\/bbrc.1998.8708","article-title":"Regulation of cellular adhesion to extracellular matrix proteins by Gal-3","volume":"246","author":"Ochieng","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1242\/jcs.110.14.1585","article-title":"Novel \u03b1GalNAc containing glycans on cytokeratins are recognized in vitro by galectins with type II carbohydrate recognition domains","volume":"110","author":"Goletz","year":"1997","journal-title":"J. Cell Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/glycob\/3.1.23","article-title":"Evidence for a lactose-mediated association between two nuclear carbohydrate-binding proteins","volume":"3","author":"Felin","year":"1993","journal-title":"Glycobiology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-5793(00)01310-7","article-title":"Interaction of a novel cysteine and histidine-rich cytoplasmic protein with Gal-3 in a carbohydrate independent manner","volume":"470","author":"Menon","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1093\/nar\/29.17.3595","article-title":"Association of galectin-1 and Gal-3 with Gemin4 in complexes containing the SMN protein","volume":"27","author":"Park","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0304-4165(02)00313-6","article-title":"Intracellular functions of galectins","volume":"1572","author":"Liu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_61","first-page":"5272","article-title":"Gal-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family","volume":"57","author":"Akahani","year":"1997","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.cdd.4400456","article-title":"Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein","volume":"6","author":"Missotten","year":"1999","journal-title":"Cell Death Differ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1074\/jbc.274.3.1533","article-title":"Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction","volume":"274","author":"Vito","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_64","first-page":"599","article-title":"Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)","volume":"41","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1398-9995.1993.tb00687.x","article-title":"The discovery of IgE","volume":"48","author":"Stanworth","year":"1993","journal-title":"Allergy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jaci.2007.05.025","article-title":"Advances in asthma, allergy mechanisms, and genetics in 2006","volume":"120","author":"Finkelman","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1084\/jem.134.6.1403","article-title":"Electron Microscopic Localization of Immunoglobulin E on the Surface Membrane of Human Basophils","volume":"134","author":"Sullivan","year":"1971","journal-title":"J. Exp. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0002-9440(10)63255-5","article-title":"Critical role for Gal-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma","volume":"165","author":"Zuberi","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.4049\/jimmunol.1000039","article-title":"Allergen-induced airway remodeling is impaired in Gal-3-deficient mice","volume":"185","author":"Ge","year":"2010","journal-title":"J. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.4049\/jimmunol.176.3.1943","article-title":"Inhibition of Chronic Airway Inflammation and Remodeling by Gal-3 Gene Therapy in a Murine Model","volume":"176","author":"Lopez","year":"2006","journal-title":"J. Immunol."},{"key":"ref_72","first-page":"823279","article-title":"Gene Expression Profiling in Lungs of Chronic Asthmatic Mice Treated with Gal-3: Downregulation of Inflammatory and Regulatory Genes","volume":"2011","author":"Zafra","year":"2011","journal-title":"Mediat. Inflamm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1189\/jlb.1204702","article-title":"Gal-3 interacts with naive and primed neutrophils, inducing innate immune responses","volume":"78","author":"Nieminen","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.4049\/jimmunol.180.4.2466","article-title":"Role of Gal-3 in leukocyte recruitment in a murine model of lung infection by Streptococcus pneumoniae","volume":"180","author":"Nieminen","year":"2008","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/glycob\/cwn104","article-title":"Gal-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils","volume":"19","author":"Karlsson","year":"2009","journal-title":"Glycobiology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12931-014-0163-5","article-title":"Anti-inflammatory deficiencies in neutrophilic asthma: Reduced Gal-3 and IL-1RA\/IL-1\u03b2","volume":"16","author":"Gao","year":"2015","journal-title":"Respir. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13601-017-0143-1","article-title":"Galectin\u20113: An early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months","volume":"7","author":"Riccio","year":"2017","journal-title":"Clin. Transl. Allergy"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1465-9921-14-136","article-title":"Galectin-3: Its role in asthma and potential as an anti-inflammatory target","volume":"14","author":"Gao","year":"2013","journal-title":"Respir. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1164\/rccm.2111031","article-title":"Gene therapy with Galectin-3 inhibits bronchial obstruction and Inflammation in Antigen-challenged rats through Interleukin-5 Gene downregulation","volume":"166","author":"Rojo","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: A perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"ref_81","first-page":"249","article-title":"The pathogenesis of atherosclerosis: Atherogenesis and inflammation","volume":"58","author":"Munro","year":"1988","journal-title":"Lab. Investig."},{"key":"ref_82","first-page":"263","article-title":"The fine structure of human atherosclerotic lesions","volume":"38","author":"Geer","year":"1961","journal-title":"Am. J. Pathol."},{"key":"ref_83","first-page":"181","article-title":"The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions","volume":"103","author":"Gerrity","year":"1981","journal-title":"Am. J. Pathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1136\/hrt.69.1_Suppl.S19","article-title":"Mechanisms of monocyte recruitment and accumulation","volume":"69","author":"Faruqi","year":"1993","journal-title":"Br. Heart J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.85.1.391","article-title":"A definition of the intima of human arteries and of its atherosclerosis-prone regions: A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"85","author":"Stary","year":"1992","journal-title":"Circulation"},{"key":"ref_86","first-page":"1199","article-title":"Gal-3 Expression in Human Atherosclerotic Lesions","volume":"152","author":"Nachtigal","year":"1998","journal-title":"Am. J. Patol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0625.1994.tb00260.x","article-title":"Expression of epsilon BP, a beta- galactoside-binding soluble lectin, in normal and neoplastic epidermis","volume":"3","author":"Konstantinov","year":"1994","journal-title":"Exp. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000059408","article-title":"Enhancement of IgE production in B cells by neutrophils via Gal-3 in IgE-associated atopic eczema\/dermatitis syndrome","volume":"128","author":"Kimata","year":"2002","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/1523-1747.ep12286482","article-title":"The high-affinity receptor for Ige is the predominant IgE-binding structure in lesional skin of atopic dermatitis patients","volume":"108","author":"Klubal","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2353\/ajpath.2009.080500","article-title":"Gal-3 Is Critical for the Development of the Allergic Inflammatory Response in a Mouse Model of Atopic Dermatitis","volume":"174","author":"Saegusa","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_91","unstructured":"(2017, December 22). GR-MD-02 Demonstrates Clinically Significant Effect in Patients with Severe and Refractory Atopic Dermatitis (Eczema). Available online: http:\/\/globenewswire.com\/news-release\/2017\/03\/14\/936280\/0\/en\/GR-MD-02 Demonstrates-Clinically-Significant-Effect-in-Patients-with-Severe-and-Refractory-Atopic-Dermatitis-Eczema.html."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","article-title":"Gal-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction","volume":"110","author":"Sharma","year":"2004","journal-title":"Circulation"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/eurjhf\/hfp097","article-title":"Gal-3: A novel mediator of heart failure development and progression","volume":"11","author":"Voors","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00392-010-0125-y","article-title":"Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: Data from the DEAL-HF study","volume":"99","author":"Lok","year":"2010","journal-title":"Clin. Res. Cardiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3109\/07853890.2010.538080","article-title":"Predictive value of plasma Gal-3 levels in heart failure with reduced and preserved ejection fraction","volume":"43","author":"Lok","year":"2011","journal-title":"Ann. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jacc.2006.03.061","article-title":"Utility of amino-terminal pro-brain natriuretic peptide, Gal-3, and apelin for the evaluation of patients with acute heart failure","volume":"48","author":"Januzzi","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archinternmed.2007.83","article-title":"Effect of moderate or intensive disease management program on outcome in patients with heart failure: Coordinating Study Evaluating Outcomes of Advising and Counseling in Heart Failure (COACH)","volume":"168","author":"Jaarsma","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.amjcard.2004.12.032","article-title":"The N-terminal pro- BNP investigation of dyspnea in the emergency department (PRIDE) study","volume":"95","author":"Januzzi","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ahj.2014.02.011","article-title":"Elevated plasma Gal-3 is associated with near-term rehospitalization in heart failure: A pooled analysis of 3 clinical trials","volume":"167","author":"Meijers","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1161\/CIRCHEARTFAILURE.111.963637","article-title":"Galectin-3 in ambulatory patients with heart failure: Results from the HF-ACTION study","volume":"5","author":"Felker","year":"2012","journal-title":"Cir. Heart Fail."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2796.2011.02476.x","article-title":"The fibrosis marker Gal-3 and outcome in the general population","volume":"272","author":"Gansevoort","year":"2012","journal-title":"J. Intern. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2012.04.053","article-title":"Gal-3, a marker of cardiac fibrosis, predicts incident heart failure in the community","volume":"60","author":"Ho","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ahj.2013.12.031","article-title":"Gal-3 is independently associated with cardiovascular mortality in community-dwelling older adults without known cardiovascular disease: The Rancho Bernardo Study","volume":"167","author":"Daniels","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.ahj.2014.02.009","article-title":"Galectin 3 and incident atrial fibrillation in the community","volume":"167","author":"Ho","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3909\/ricm0624","article-title":"Gal-3: A novel blood test for the evaluation and management of patients with heart failure","volume":"12","author":"McCullough","year":"2011","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0304-4165(02)00315-X","article-title":"Galectins and cancer","volume":"1572","author":"Danguy","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1023\/B:GLYC.0000014084.01324.15","article-title":"Gal-3 and metastasis","volume":"19","author":"Takenaka","year":"2004","journal-title":"Glycoconj. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","article-title":"Galectins as modulators of tumour progression","volume":"5","author":"Liu","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1073\/pnas.92.4.1213","article-title":"Identification of galectin-3 as a factor in pre-mRNA splicing","volume":"92","author":"Dagher","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10495-005-0801-y","article-title":"On the role of Gal-3 in cancer apoptosis","volume":"10","author":"Nakahara","year":"2005","journal-title":"Apoptosis"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbamcr.2015.08.008","article-title":"Galectin 3 as a guardian of the tumor microenvironment","volume":"1863","author":"Ruvolo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000030131","article-title":"Increased Gal-3 expression in gastric cancer: Correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation","volume":"21","author":"Baldus","year":"2000","journal-title":"Tumour Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10585-011-9383-y","article-title":"Deletion of Gal-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity","volume":"28","author":"Radosavljevic","year":"2011","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1158\/1078-0432.CCR-06-0758","article-title":"Gal-3 expression is associated with tumor progression and pattern of sun exposure in melanoma","volume":"12","author":"Prieto","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_115","first-page":"235","article-title":"Impact of nuclear Gal-3 expression on histological differentiation and vascular invasion in patients with esophageal squamous cell carcinoma","volume":"139","author":"Shibata","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/sj.onc.1207997","article-title":"Dual activities of Gal-3 in human prostate cancer: Tumor suppression of nuclear Gal-3 vs tumor promotion of cytoplasmic Gal-3","volume":"23","author":"Califice","year":"2004","journal-title":"Oncogene"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/1097-0215(20000720)89:4<361::AID-IJC8>3.0.CO;2-U","article-title":"Alteration of the cytoplasmic\/nuclear expression pattern of Gal-3 correlates with prostate carcinoma progression","volume":"89","author":"Waltregny","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.canlet.2004.03.006","article-title":"Gal-3 expression in non-small cell lung carcinoma","volume":"212","author":"Puglisi","year":"2004","journal-title":"Cancer Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"39649","DOI":"10.1074\/jbc.M608069200","article-title":"Importin-mediated nuclear translocation of galectin-3","volume":"281","author":"Nakahara","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcancer.2014.03.004","article-title":"Nuclear transport of galectin-3 and its ther- apeutic implications","volume":"27","author":"Funasaka","year":"2014","journal-title":"Semin. Cancer Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbagen.2009.07.005","article-title":"Dynamics of Galectin-3 in the Nucleus and Cytoplasm","volume":"1800","author":"Haudek","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.prp.2008.09.001","article-title":"Immunohistochemical galectin-3 expression in non-melanoma skin cancers","volume":"205","author":"Kapucuoglu","year":"2009","journal-title":"Pathol. Res. Pract."},{"key":"ref_123","first-page":"235","article-title":"Galectin expression in cancer diagnosis and prognosis: A systematic review","volume":"1855","author":"Thijssen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_124","first-page":"138","article-title":"Extracellular galectin-3 in tumor progression and metastasis","volume":"4","author":"Gomes","year":"2014","journal-title":"Front. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biopha.2014.11.024","article-title":"Role of the interaction between galectin-3 and cell adhesion molecules in cancer metastasis","volume":"69","author":"Xin","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/14728222.2013.750651","article-title":"Context-dependent multifunctionality of galectin-1: A challenge for defining the lectin as therapeutic target","volume":"17","author":"Smetana","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1074\/jbc.M107668200","article-title":"Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest","volume":"277","author":"Yoshii","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1128\/MCB.00959-05","article-title":"Repression of the antiapoptotic molecule Gal-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis","volume":"26","author":"Cecchinelli","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/path.2510","article-title":"Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas","volume":"218","author":"Lavra","year":"2009","journal-title":"J. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.drup.2007.04.001","article-title":"The role of galectin-3 in cancer drug resistance","volume":"10","author":"Fukumori","year":"2007","journal-title":"Drug Resist. Updates"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10555-013-9450-8","article-title":"Why anti-Bcl-2 clinical trials fail: A solution","volume":"33","author":"Harazono","year":"2014","journal-title":"Cancer Metastasis Rev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0002-9440(10)63177-X","article-title":"An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B-Cell Lymphoma","volume":"164","author":"Hoyer","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"9992","DOI":"10.18632\/oncotarget.2486","article-title":"Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells","volume":"5","author":"Harazono","year":"2014","journal-title":"Oncotarget"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Song, S., Ji, B., Ramachandran, V., Wang, H., Hafley, M., Logsdon, C., and Bresalier, R.S. (2012). Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042699"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"34922","DOI":"10.1074\/jbc.M312697200","article-title":"Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity","volume":"279","author":"Haklai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1158\/1535-7163.MCT-10-0262","article-title":"Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas","volume":"9","author":"Levy","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Veschi, V., Petroni, M., Cardinali, B., Dominici, C., Screpanti, I., Frati, L., Bartolazzi, A., Gulino, A., and Giannini, G. (2012). Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049139"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jmb.2013.12.004","article-title":"Galectin-3 interactions with glycosphingolipids","volume":"426","author":"Collins","year":"2014","journal-title":"J. Mol. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fonc.2014.00028","article-title":"Altered tumor-cell glycosylation promotes metastasis","volume":"4","author":"Hauselmann","year":"2014","journal-title":"Front. Oncol."},{"key":"ref_140","first-page":"430","article-title":"Endocytosis: Bend it like galectin 3","volume":"15","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/ncb2983","article-title":"Galectins CLIC cargo inside","volume":"16","author":"Stanley","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"28398","DOI":"10.1074\/jbc.M113.487793","article-title":"Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms","volume":"288","author":"Carlsson","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ncb2970","article-title":"Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrinindependent carriers","volume":"16","author":"Lakshminarayan","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coi.2016.12.003","article-title":"Galectins: Emerging regulatory checkpoints linking tumor immunity and angiogenesis","volume":"45","author":"Blidner","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2011.09.003","article-title":"Galectin-3\u2014A jack-of-all-trades in cancer","volume":"313","author":"Newlaczyl","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_146","first-page":"1","article-title":"Immunohistochemical expression of Gal-3 in cancer: A review of the literature","volume":"28","author":"Cay","year":"2012","journal-title":"Turk Patoloji Derg."},{"key":"ref_147","first-page":"88","article-title":"Galectins in cancer: Carcinogenesis, diagnosis and therapy","volume":"2","author":"Ebrahim","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_148","first-page":"387","article-title":"Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages","volume":"51","author":"Irimura","year":"1991","journal-title":"Cancer Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0008-6215(00)90597-4","article-title":"Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression","volume":"213","author":"Lotan","year":"1991","journal-title":"Carbohydr. Res."},{"key":"ref_150","first-page":"143","article-title":"Involvement of galectin-3 expression in colorectal cancer progression and metastasis","volume":"15","author":"Nakamura","year":"1999","journal-title":"Int. J. Oncol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1002\/1097-0142(19950615)75:12<2818::AID-CNCR2820751206>3.0.CO;2-#","article-title":"Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon","volume":"75","author":"Schoeppner","year":"1995","journal-title":"Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/jnci\/84.15.1161","article-title":"Inverse modulation of steady-state messenger RNA levels of two nonintegrin laminin-binding proteins in human colon carcinoma","volume":"84","author":"Castronovo","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1073\/pnas.90.8.3466","article-title":"Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma","volume":"90","author":"Lotz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0016-5085(97)70010-6","article-title":"Differential expression of galectin 3 and galectin 1 in colorectal cancer progression","volume":"113","author":"Sanjuan","year":"1997","journal-title":"Gastroenterology"},{"key":"ref_155","first-page":"815","article-title":"Differential expression of galectin-1 and Gal-3 in thyroid tumors. Potential diagnostic implications","volume":"147","author":"Xu","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_156","first-page":"3015","article-title":"Gal-3 is a presurgical marker of human thyroid carcinoma","volume":"58","author":"Orlandi","year":"1998","journal-title":"Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1200\/JCO.1999.17.11.3494","article-title":"Gal-3 and CD44v6 isoforms in the preoperative evaluation of thyroid nodules","volume":"17","author":"Gasbarri","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2475::AID-CNCR25>3.0.CO;2-1","article-title":"Expression of Gal-3 in fine-needle aspirates as a diagnostic marker differentiating benign from malignant thyroid neoplasms","volume":"85","author":"Inohara","year":"1999","journal-title":"Cancer"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1046\/j.1365-2559.2000.00988.x","article-title":"Gal-3 and carcinoembryonic antigen expression in medullary thyroid carcinoma: Possible relation to tumour progression","volume":"37","author":"Cvejic","year":"2000","journal-title":"Histopathology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(00)04817-0","article-title":"Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions","volume":"357","author":"Bartolazzi","year":"2001","journal-title":"Lancet"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1210\/jcem.86.11.8043","article-title":"Gal-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma","volume":"86","author":"Saggiorato","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/(SICI)1097-0142(19970815)80:4<776::AID-CNCR17>3.0.CO;2-Q","article-title":"Expression of the endogenous galactose-binding protein Gal-3 correlates with the malignant potential of tumors in the central nervous system","volume":"80","author":"Bresalier","year":"1997","journal-title":"Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00381-010-1262-3","article-title":"Gal-3 expression: A useful tool in the differential diagnosis of posterior fossa tumors in children","volume":"27","author":"Borges","year":"2011","journal-title":"Childs Nerv. Syst."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e1100","DOI":"10.1038\/cddis.2014.68","article-title":"Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors","volume":"5","author":"Veschi","year":"2014","journal-title":"Cell. Death Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/(SICI)1097-0347(199609\/10)18:5<422::AID-HED5>3.0.CO;2-7","article-title":"Expression of galectins in head and neck squamous cell carcinoma","volume":"18","author":"Gillenwater","year":"1996","journal-title":"Head Neck"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02787497","article-title":"Localization of Gal-3 in normal and diseased pancreatic tissue","volume":"23","author":"Schaffert","year":"1998","journal-title":"Int. J. Pancreatol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0215(19990219)84:1<39::AID-IJC8>3.0.CO;2-E","article-title":"Galectin-1 and Gal-3 expression in human bladder transitional-cell carcinomas","volume":"84","author":"Cindolo","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"90","DOI":"10.5858\/2008-0392-OAR1.1","article-title":"Expression of Gal-3 in renal neoplasms: A diagnostic, possible prognostic marker","volume":"134","author":"Dancer","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0002-9440(10)64120-X","article-title":"Expression profiling of renal epithelial neoplasms: A method for tumor classification and discovery of diagnostic molecular markers","volume":"158","author":"Young","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<519::AID-IJC3>3.0.CO;2-0","article-title":"Gal-3 expression is induced in cirrhotic liver and hepatocellular carcinoma","volume":"81","author":"Hsu","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5001\/omj.2015.84","article-title":"The role of parafibromin, Gal-3, HBME-1, and Ki-67 in the differential diagnosis of parathyroid tumors","volume":"30","author":"Karaarslan","year":"2015","journal-title":"Oman Med. J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1309\/9NXP7FRF87MU2PCK","article-title":"Gal-3 and Ki-67 expression in multiglandular parathyroid lesions","volume":"126","author":"Saggiorato","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2559.2011.03776.x","article-title":"Quantitative immunohistochemical fingerprinting of adhesion\/growth-regulatory galectins in salivary gland tumours: Divergent profiles with diagnostic potential","volume":"58","author":"Remmelink","year":"2011","journal-title":"Histopathology"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000193223","article-title":"Increased serum 90 K and Gal-3 expression are associated with advanced stage and a worse prognosis in diffuse large B-cell lymphomas","volume":"120","author":"Kim","year":"2008","journal-title":"Acta Haematol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/DAD.0b013e3181e02f29","article-title":"Diagnostic and Prognostic Role of Galectin 3 Expression in Cutaneous Melanoma","volume":"32","author":"Abdou","year":"2010","journal-title":"Am. J. Dermatopathol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/PAI.0b013e31821ee9bb","article-title":"Methodology and technical requirements of the Gal-3 test for the preoperative characterization of thyroid nodules","volume":"20","author":"Bartolazzi","year":"2012","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.bjc.6603232","article-title":"Large needle aspiration biopsy and Gal-3 determination in selected thyroid nodules with indeterminate FNA-cytology","volume":"95","author":"Carpi","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.canlet.2008.02.056","article-title":"Thyroid fine needle aspiration: How to improve clinicians' confidence and performance with the technique","volume":"264","author":"Carpi","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1470-2045(08)70132-3","article-title":"Italian Thyroid Cancer Study Group (ITCSG). Gal-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: A prospective multicentre study","volume":"9","author":"Bartolazzi","year":"2008","journal-title":"Lancet Oncol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1746-1596-7-97","article-title":"Expression of ck-19, Gal-3 and hbme-1 in the differentiation of thyroid lesions: Systematic review and diagnostic meta-analysis","volume":"7","author":"Matsubayashi","year":"2012","journal-title":"Diagn. Pathol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"49421","DOI":"10.18632\/oncotarget.17220","article-title":"Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology","volume":"8","author":"Sciacchitano","year":"2017","journal-title":"Oncotarget"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12020-015-0774-8","article-title":"Combined clinical and ultrasound follow-up assists in malignancy detection in Gal-3 negative Thy-3 thyroid nodules","volume":"54","author":"Sciacchitano","year":"2016","journal-title":"Endocrine"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Bartolazzi, A., D\u2019Alessandria, C., Parisella, M.G., Signore, A., Del Prete, F., Lavra, L., Braesch-Andersen, S., Massari, R., Trotta, C., and Soluri, A. (2008). Thyroid cancer imaging in vivo by targeting the anti-apoptotic molecule Gal-3. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003768"},{"key":"ref_184","first-page":"1389","article-title":"Concentrations of Gal-3 in the sera of normal controls and cancer patients","volume":"6","author":"Iurisci","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2353\/ajpath.2010.090353","article-title":"Diagnostic utility of Gal-3 in thyroid cancer","volume":"176","author":"Chiu","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"542","DOI":"10.18632\/oncotarget.923","article-title":"Gal-3: A possible complementary marker to the PSA blood test","volume":"4","author":"Balan","year":"2013","journal-title":"Oncotarget"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000353574","article-title":"The role of Gal-3 as a marker of cancer and inflammation in a stage IV ovarian cancer patient with underlying pro-inflammatory comorbidities","volume":"6","author":"Eliaz","year":"2013","journal-title":"Case Rep. Oncol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1523\/JNEUROSCI.1498-12.2012","article-title":"Gal-3 is required for resident microglia activation and proliferation in response to ischemic injury","volume":"32","author":"Swarup","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nbd.2009.12.024","article-title":"Gal-3 contributes to neonatal hypoxic-ischemic brain injury","volume":"38","author":"Doverhag","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/1119-3077.187311","article-title":"Utilization of glial fibrillary acidic protein and Gal-3 in the dagnosis of cerebral infarction patients with normal cranial tomography","volume":"20","author":"Ekingen","year":"2017","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_191","first-page":"487","article-title":"Correlations between echocardiographic parameters of right ventricular dysfunction and Galectin-3 in patients with chronic obstructive pulmonary disease and pulmonary hypertension","volume":"17","author":"Lupu","year":"2015","journal-title":"Med. Ultrason."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1183\/09031936.00073005","article-title":"Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD","volume":"29","author":"Pilette","year":"2007","journal-title":"Eur. Respir. J."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Mukaro, V.R., Bylund, J., Hodge, G., Holmes, M., Jersmann, H., Reynolds, P.N., and Hodge, S. (2013). Lectins offer new perspectives in the development of macrophage-targeted therapies for COPD\/emphysema. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056147"},{"key":"ref_194","first-page":"5","article-title":"Lectins as Potential Adjunct Therapeutics for COPD\/Emphysema?","volume":"3","author":"Hodge","year":"2013","journal-title":"J. Pulm. Respir. Med."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.12659\/MSM.903472","article-title":"Association of serum Galectin-3 with the acute exacerbation of chronic obstructive pulmonary disease","volume":"23","author":"Feng","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Bobrowska, B., Wieczorek-Surdacka, E., Kruszelnicka, O., Chyrchel, B., Surdacki, A., and Dudek, D. (2017). Clinical correlates and prognostic value of plasma Gal-3 levels in degenerative aortic stenosis: A single-center prospective study of patients referred for invasive treatment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18050947"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2009.00794.x","article-title":"The regulation of inflammation by Gal-3","volume":"230","author":"Henderson","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/GBI.S13921","article-title":"Gal-3 and inflammation","volume":"6","author":"Wan","year":"2016","journal-title":"Glycobiol. Insights"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1210\/jc.2009-1619","article-title":"Serum Gal-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes","volume":"95","author":"Weigert","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3760\/cmaj.issn.0366-6999.20130217","article-title":"Serum Gal-3: A risk factor for vascular complications in type 2 diabetes mellitus","volume":"126","author":"Jin","year":"2013","journal-title":"Chin. Med. J."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s40618-014-0222-2","article-title":"Increased levels of Gal-3 were associated with prediabetes and diabetes: New risk factor?","volume":"38","author":"Yilmaz","year":"2014","journal-title":"J. Endocrinol. Investig."},{"key":"ref_202","first-page":"1499","article-title":"Structural myocardial alterations in diabetes and hypertension: The role of Gal-3","volume":"52","author":"Seferovic","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/MCA.0000000000000252","article-title":"Association between serum Gal-3 levels and coronary atherosclerosis and plaque burden\/structure in patients with type 2 diabetes mellitus","volume":"26","author":"Ozturk","year":"2015","journal-title":"Coron. Artery Dis."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1152\/physiolgenomics.00035.2011","article-title":"Transcriptional analysis of the endothelial response to diabetes reveals a role for Gal-3","volume":"43","author":"Darrow","year":"2011","journal-title":"Physiol. Genom."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/oby.2007.526","article-title":"Gal-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue","volume":"15","author":"Kiwaki","year":"2007","journal-title":"Obesity"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1210\/en.2014-1374","article-title":"Gal-3 activates PPARgamma and supports white adipose tissue formation and high-fat diet-induced obesity","volume":"156","author":"Baek","year":"2015","journal-title":"Endocrinology"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.jnutbio.2013.05.006","article-title":"High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease","volume":"24","author":"Chen","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clim.2008.08.024","article-title":"Targeted disruption of the Gal-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice","volume":"130","author":"Shahin","year":"2009","journal-title":"Clin. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1515\/cclm-2014-0187","article-title":"Gal-3 in diabetic patients","volume":"52","author":"Pugliese","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1758-5996-6-106","article-title":"Low serum Gal-3 concentrations are associated with insulin resistance in patients with type 2 diabetes mellitus","volume":"6","author":"Ohkura","year":"2014","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.2337\/db12-0222","article-title":"Gal-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets","volume":"62","author":"Pejnovic","year":"2013","journal-title":"Diabetes"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Pang, J., Rhodes, D.H., Pini, M., Akasheh, R.T., Castellanos, K.J., Cabay, R.J., Cooper, D., Perretti, M., and Fantuzzi, G. (2013). Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Gal-3 KO mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057915"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12933-015-0230-3","article-title":"Gal-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes","volume":"14","author":"Darrow","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/oby.20016","article-title":"Adipose Tissue-Specific Modulation of Galectin Expression in Lean and Obese Mice: Evidence for Regulatory Function","volume":"21","author":"Rhodes","year":"2013","journal-title":"Obesity"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1096\/fj.01-0006com","article-title":"Accelerated diabetic glomerulopathy in Gal-3\/AGE receptor-3 knockout mice","volume":"15","author":"Pugliese","year":"2001","journal-title":"FASEB J."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1096\/fj.04-2031fje","article-title":"Gal-3\/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury. Evidence for a protective role of Gal-3 as an AGE-receptor","volume":"18","author":"Iacobini","year":"2004","journal-title":"FASEB J."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(00)01630-7","article-title":"Immunobiology of endometriosis","volume":"75","author":"Lebovic","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/humrep\/dep382","article-title":"Role of TGF-betas in normal human endometrium and endometriosis","volume":"25","author":"Omwandho","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/PAI.0b013e3181f5a05e","article-title":"Gal-3 is over- expressed in various forms of endometriosis","volume":"19","author":"Chapron","year":"2011","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3109\/09513590.2014.943728","article-title":"Levels of Gal-3 and stimulation expressed gene 2 in the peritoneal fluid of women with endometriosis: A pilot study","volume":"30","author":"Caserta","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/978-1-4939-1154-7_24","article-title":"Galectins and neuroinflammation","volume":"9","author":"Chen","year":"2014","journal-title":"Adv. Neurobiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.gyobfe.2010.05.005","article-title":"Neurotrophins and pain in endometriosis","volume":"38","author":"Borghese","year":"2010","journal-title":"Gynecol. Obstet. Fertil."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Furness, J.B. (2008). The Enteric Nervous System, John Wiley & Sons.","DOI":"10.1002\/9780470988756"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0262-4079(12)63204-7","article-title":"Gut instincts: The secrets of your second brain","volume":"216","author":"Young","year":"2012","journal-title":"New Sci."},{"key":"ref_225","unstructured":"Gershon, M. (1998). The Second Brain: The Scientific Basis of Gut Instinct and a Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestines, Harper Collins."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1074\/jbc.M113.538538","article-title":"Gal-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion","volume":"289","author":"Jiang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1242\/jcs.020800","article-title":"Loss of Gal-3 impairs membrane polarisation of mouse enterocytes in vivo","volume":"121","author":"Delacour","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1053\/gast.2002.35395","article-title":"Expression of human intestinal mucin is modulated by the beta-galactoside binding protein Gal-3 in colon cancer","volume":"123","author":"Dudas","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2249.2008.03618.x","article-title":"Regulation of Gal-3 function in mucosal fibroblasts: Potential role in mucosal inflammation","volume":"152","author":"Lippert","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"32893","DOI":"10.1038\/srep32893","article-title":"Gal-3 causes enteric neuronal loss in mice after left sided permanent middle cerebral artery occlusion, a model of stroke","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"40994","DOI":"10.1038\/srep40994","article-title":"Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1038\/cdd.2011.40","article-title":"Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function","volume":"18","author":"Pasquini","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1242\/jcs.079954","article-title":"Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb","volume":"124","author":"Comte","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neulet.2011.07.007","article-title":"Gal-3 is upregulated in activated glia during Junin virus-induced murine encephalitis","volume":"501","author":"Alberdi","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neulet.2015.02.061","article-title":"Early microlesion of viral encephalitis confirmed by Gal-3 expression after a virus inoculation","volume":"592","author":"Kobayashi","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.pain.2011.11.022","article-title":"Contribution of spinal galectin-3 to acute herpetic allodynia in mice","volume":"153","author":"Takasaki","year":"2012","journal-title":"Pain"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1476-5381.2012.01847.x","article-title":"cAMP and Epac in the regulation of tissue fibrosis","volume":"166","author":"Insel","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.3748\/wjg.v18.i28.3635","article-title":"Cellular and molecular mechanisms of intestinal fibrosis","volume":"18","author":"Speca","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"167sr1","DOI":"10.1126\/scitranslmed.3004700","article-title":"Therapy for fibrotic diseases: Nearing the starting line","volume":"5","author":"Friedman","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/bk-2012-1115.ch022","article-title":"Gal-3: A Central Regulator of Chronic Inflammation and Tissue Fibrosis","volume":"Volume 1115","author":"Henderson","year":"2012","journal-title":"Galectins and Disease Implications for Targeted Therapeutics"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1073\/pnas.0511167103","article-title":"Gal-3 regulates myofibroblast activation and hepatic fibrosis","volume":"103","author":"Henderson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2353\/ajpath.2008.070726","article-title":"Gal-3 expression and secretion links macrophages to the promotion of renal fibrosis","volume":"172","author":"Henderson","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/TP.0b013e318242f40a","article-title":"Tubular atrophy and interstitial fibrosis after renal transplantation is dependent on Gal-3","volume":"93","author":"Dang","year":"2012","journal-title":"Transplantation"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1164\/rccm.201106-0965OC","article-title":"Regulation of transforming growth factor-beta1-driven lung fibrosis by Gal-3","volume":"185","author":"Mackinnon","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2332\/allergolint.O-06-449","article-title":"Role of Gal-3 in human pulmonary fibrosis","volume":"56","author":"Nishi","year":"2007","journal-title":"Allergol. Int."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.bcp.2008.02.003","article-title":"14-3-3 Protein regulates Ask1 signaling and protects against diabetic cardiomyopathy","volume":"75","author":"Thandavarayan","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_248","first-page":"H1226","article-title":"Novel anti-inflammatory mechanisms of Nacetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage","volume":"294","author":"Sharma","year":"2008","journal-title":"Am. J. Physiol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.celrep.2015.02.012","article-title":"Microglia-Secreted Gal-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation","volume":"10","author":"Burguillos","year":"2015","journal-title":"Cell Rep."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3899\/jrheum.110755","article-title":"Serum Levels of Gal-3: Possible Association with Fibrosis, Aberrant Angiogenesis, and Immune Activation in Patients with Systemic Sclerosis","volume":"39","author":"Taniguchi","year":"2012","journal-title":"J. Rheumatol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10067-013-2346-8","article-title":"Serum Gal-3 level in systemic sclerosis","volume":"33","author":"Koca","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis","volume":"12","author":"Strober","year":"2006","journal-title":"Nat. Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.4049\/jimmunol.173.5.3425","article-title":"Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: Role of IL-4\/IL-13 and mediation via STAT-6","volume":"173","author":"Liu","year":"2004","journal-title":"J. Immunol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijcard.2016.12.140","article-title":"Gal-3 is an independent predictor of survival in systemic sclerosis","volume":"233","author":"Faludi","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/glycob\/cwh068","article-title":"Up-regulation of Gal-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells","volume":"14","author":"Vray","year":"2004","journal-title":"Glycobiology"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/glycob\/9.4.383","article-title":"The tat protein of HIV-1 induces galectin-3 expression","volume":"9","author":"Fogel","year":"1999","journal-title":"Glycobiology"},{"key":"ref_258","first-page":"1661","article-title":"Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta- galactoside-binding lectin, Gal-3","volume":"148","author":"Hsu","year":"1996","journal-title":"Am. J. Pathol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1462-5822.2005.00599.x","article-title":"Gal-3 binds to Helicobacter pylori O-antigen: It is upregulated and rapidly secreted by gastric epithelial cells in response to H. pylori adhesion","volume":"8","author":"Fowler","year":"2006","journal-title":"Cell. Microbiol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/IAI.01299-15","article-title":"Gal-3 Plays an important role in innate immunity to gastric infection by helicobacter pylori","volume":"84","author":"Park","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1099\/mic.0.000322","article-title":"Extracellular galectin-3 counteracts adhesion and exhibits chemoattraction in Helicobacter pylori infected gastric cancer cells","volume":"162","author":"Subhash","year":"2016","journal-title":"Microbiology"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"Parsonnet","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10565-016-9315-3","article-title":"Galectin 3 acts as an enhancer of survival responses in H. pylori-infected gastric cancer cells","volume":"32","author":"Subhash","year":"2016","journal-title":"Cell Biol. Toxicol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"H404","DOI":"10.1152\/ajpheart.00747.2008","article-title":"N-acetyl-seryl-aspartyllysyl-proline prevents cardiac remodeling and dysfunction induced by Gal-3, a mammalian adhesion\/growth-regulatory lectin","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_267","first-page":"13","article-title":"Galectin-3: Clinical utility and prognostic value in patients with heart failure","volume":"4","author":"Kramer","year":"2013","journal-title":"Res. Rep. Clin. Cardiol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/eurjhf\/hfq091","article-title":"Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompensated heart failure","volume":"12","author":"Shah","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1093\/eurheartj\/ehs077","article-title":"Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)","volume":"33","author":"Gullestad","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cardfail.2014.07.018","article-title":"Plasma Galectin-3 and Heart Failure Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)","volume":"20","author":"Stolen","year":"2014","journal-title":"J. Card. Fail."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.healun.2008.02.018","article-title":"Plasma biomarkers of myocardial fibrosis and remodeling in terminal heart failure patients supported by mechanical circulatory support devices","volume":"27","author":"Milting","year":"2008","journal-title":"J. Heart Lung Transplant."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.healun.2012.11.011","article-title":"The biomarker plasma galectin-3 in advanced heart failure and survival with mechanical circulatory support devices","volume":"32","author":"Erkilet","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1373\/clinchem.2011.174359","article-title":"Galectin-3 and the development of heart failure after acute coronary syndrome: Pilot experience from PROVE IT-TIMI 22","volume":"58","author":"Grandin","year":"2012","journal-title":"Clin. Chem."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00392-012-0500-y","article-title":"Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure","volume":"102","author":"Lok","year":"2013","journal-title":"Clin. Res. Cardiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/HPC.0000000000000012","article-title":"Emergency department use of Galectin-3","volume":"13","author":"Peacock","year":"2014","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/HPC.0000000000000031","article-title":"Challenges in acute heart failure clinical management: Optimizing care despite incomplete evidence and imperfect drugs","volume":"14","author":"Teichman","year":"2015","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref_277","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America","volume":"70","author":"Yancy","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/glycob\/cwu064","article-title":"Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6","volume":"24","author":"Wang","year":"2014","journal-title":"Glycobiology"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbamem.2013.06.020","article-title":"Plasma membrane signaling in HIV-1 infection","volume":"1838","author":"Abbas","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_281","first-page":"340","article-title":"Expression of nuclear lectin carbohydrate-binding protein 35 in human immunodeficiency virus type 1-infected molt-3 cells","volume":"9","author":"Ushijima","year":"1995","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.4049\/jimmunol.174.7.4120","article-title":"Galectin-1 Acts as a Soluble Host Factor That Promotes HIV-1 Infectivity through Stabilization of Virus Attachment to Host Cells","volume":"174","author":"Ouellet","year":"2005","journal-title":"J. Immunol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/febs.13955","article-title":"Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages","volume":"284","author":"Xue","year":"2017","journal-title":"FEBS J."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.bbagen.2005.11.020","article-title":"Gal-3 in macrophage-like cells exposed to immunomodulatory drugs","volume":"1760","author":"Dabelic","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.165.4.2156","article-title":"Human Gal-3 is a novel chemoattractant for monocytes and macrophages","volume":"165","author":"Sano","year":"2000","journal-title":"J. Immunol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2864::AID-IMMU2864>3.0.CO;2-U","article-title":"Lymphocyte triggering via L-selectin leads to enhanced Gal-3-mediated binding to dendritic cells","volume":"28","author":"Swarte","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/eji.1830231228","article-title":"IgE-binding molecules (Mac-2\/epsilon BP) expressed by human eosinophils. Implication in IgE-dependent eosinophil cytotoxicity","volume":"23","author":"Truong","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4049\/jimmunol.148.3.861","article-title":"Surface expression of function- al IgE binding protein, an endogenous lectin, on mast cells and macrophages","volume":"148","author":"Frigeri","year":"1992","journal-title":"J. Immunol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1038\/emboj.2011.215","article-title":"A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans","volume":"30","author":"Tsuboi","year":"2011","journal-title":"EMBO J."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1158\/0008-5472.CAN-08-1245","article-title":"Tumor-associated Gal-3 modulates the function of tumor-reactive T cells","volume":"68","author":"Peng","year":"2008","journal-title":"Cancer Res."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"493","DOI":"10.4049\/jimmunol.172.1.493","article-title":"Gal-3 mediates IL-4-induced survival and differentiation of B cells: Functional cross-talk and implications during Trypanosoma cruzi infection","volume":"172","author":"Montes","year":"2004","journal-title":"J. Immunol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.4049\/jimmunol.147.9.2957","article-title":"Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice","volume":"147","author":"Elliott","year":"1991","journal-title":"J. Immunol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nri2536","article-title":"Turning \u2018sweet\u2019 on immunity: Galectin\u2013glycan interactions in immune tolerance and inflammation","volume":"9","author":"Rabinovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-immunol-041015-055402","article-title":"Galectins and immune responses-just how do they do those things they do?","volume":"34","author":"Thiemann","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"ref_295","first-page":"497","article-title":"Roles of Gal-3 in immune responses","volume":"53","author":"Chen","year":"2005","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.4049\/jimmunol.156.10.3939","article-title":"Gal-3 promotes adhesion of human neutrophils to laminin","volume":"156","author":"Kuwabara","year":"1996","journal-title":"J. Immunol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1021\/bi00081a007","article-title":"Epsilon BP, a beta-galactoside-binding animal lectin, recognizes IgE receptor (Fc epsilon RI) and activates mast cells","volume":"32","author":"Frigeri","year":"1993","journal-title":"Biochemistry"},{"key":"ref_298","first-page":"1016","article-title":"Expression and function of Gal-3, a beta-galactoside binding lectin, in human monocytes and macrophages","volume":"147","author":"Liu","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/bbrc.2000.3372","article-title":"Maturation of human monocyte-derived dendritic cells studied by microarray hybridization","volume":"275","author":"Dietz","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/eji.200636788","article-title":"Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules","volume":"37","author":"Helming","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.168.4.1813","article-title":"Role of Gal-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia","volume":"168","author":"Sato","year":"2002","journal-title":"J. Immunol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.4049\/jimmunol.177.7.4718","article-title":"Gal-3 induces death of Candida species expressing specific beta-1,2-linked mannans","volume":"177","author":"Kohatsu","year":"2006","journal-title":"J. Immunol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0923-1811(02)00148-2","article-title":"Monocyte derived multinucleated giant cells and sarcoidosis","volume":"31","author":"Okamoto","year":"2003","journal-title":"J. Dermatol. Sci."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/excr.1998.4253","article-title":"Gal-3 stimulates cell proliferation","volume":"245","author":"Inohara","year":"1998","journal-title":"Exp. Cell Res."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/jhep.2000.9322","article-title":"Proteome analysis of rat hepatic stellate cells","volume":"32","author":"Kristensen","year":"2000","journal-title":"Hepatology"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1096-9896(199607)179:3<309::AID-PATH572>3.0.CO;2-D","article-title":"Immunocytochemical evidence for a modulation of galectin 3 (Mac-2), a carbohydrate binding protein, in pulmonary fibrosis","volume":"179","author":"Kasper","year":"1996","journal-title":"J. Pathol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1164\/rccm.201509-1753OC","article-title":"Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities","volume":"194","author":"Ho","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.170.3.655","article-title":"Tumor necrosis factor\/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis","volume":"170","author":"Piguet","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_311","first-page":"651","article-title":"Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis","volume":"143","author":"Piguet","year":"1993","journal-title":"Am. J. Pathol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/thx.18.3.225","article-title":"Precapillary systemic-pulmonary anastomoses","volume":"18","year":"1963","journal-title":"Thorax"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0002-9440(10)64959-0","article-title":"Galectin-3 induces endothelial cell morphogenesis and angiogenesis","volume":"156","author":"Honjo","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_314","first-page":"1914","article-title":"Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis","volume":"28","author":"Harjacek","year":"2001","journal-title":"J. Rheumatol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1756-185X.2011.01632.x","article-title":"Elevated production of Gal-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression","volume":"14","author":"Ezzat","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1681\/ASN.V123515","article-title":"Gal-3 modulates ureteric bud branching in organ culture of the developing mouse kidney","volume":"12","author":"Bullock","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/glycob\/cwj035","article-title":"Exploring the role of galectin 3 in kidney function: A genetic approach","volume":"16","author":"Bichara","year":"2006","journal-title":"Glycobiology"},{"key":"ref_318","doi-asserted-by":"crossref","unstructured":"Chen, S.Z., and Kuo, P.L. (2016). The Role of Gal-3 in the Kidneys. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040565"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0002-9440(10)64595-6","article-title":"Up-regulation of Gal-3 in acute renal failure of the rat","volume":"157","author":"Nishiyama","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<481::AID-PATH263>3.0.CO;2-2","article-title":"Gal-3 modulates rat mesangial cell proliferation and matrix synthesis during experimental glomerulonephritis induced by anti-Thy1.1 antibodies","volume":"187","author":"Sasaki","year":"1999","journal-title":"J. Pathol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/ndt\/gfg603","article-title":"Gal-3-positive cell infiltration in human diabetic nephropathy","volume":"19","author":"Kikuchi","year":"2004","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1517\/14622416.2.1.S1","article-title":"Rationale and design of the LURIC study-a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease","volume":"2","author":"Winkelmann","year":"2001","journal-title":"Pharmacogenomics"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000080241","article-title":"Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study): Demographic and baseline characteristics","volume":"27","author":"Wanner","year":"2004","journal-title":"Kidney Blood Press. Res."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1681\/ASN.2014010093","article-title":"Gal-3, Renal Function, and Clinical Outcomes: Results from the LURIC and 4D Studies","volume":"26","author":"Drechsler","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Kolatsi-Joannou, M., Price, K.L., Winyard, P.J., and Long, D.A. (2011). Modified citrus pectin reduces Gal-3 expression and disease severity in experimental acute kidney injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018683"},{"key":"ref_326","unstructured":"(2017, December 22). La Jolla Begins Phase IIb Trial of GCS-100 to Treat Advanced CKD. Available online: http:\/\/www.drugdevelopment-technology.com\/news\/newsla-jolla-begins-phase-iib-trial-of-gcs-100-totreat-advanced-ckd-4535972."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/labinvest.3780131","article-title":"Galectin-1 and galectin-3 in chronic pancreatitis","volume":"80","author":"Wang","year":"2000","journal-title":"Lab. Investig."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: The principal collagen-producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_330","unstructured":"(2017, December 22). Galectin Therapeutics Announces Results from Phase 2b NASH-CX Trial. Available online: http:\/\/investor.galectintherapeutics.com\/news-releases\/news-release-details\/galectin-therapeutics-announces-results-phase-2b-nash-cx-trial."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ejhf.21","article-title":"Plasma galectin 3 and heart failure risk in the Physicians\u2019 Health Study","volume":"16","author":"Matsumoto","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.3748\/wjg.v20.i42.15539","article-title":"Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Takahashi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1124\/jpet.114.218370","article-title":"Functions of Galectin-3 and Its Role in Fibrotic Diseases","volume":"351","author":"Li","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jhep.2010.09.020","article-title":"Gal-3 ablation protects mice from diet-induced NASH: A major scavenging role for Gal-3 in liver","volume":"54","author":"Iacobini","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/path.2065","article-title":"Disrupted Gal-3 causes non-alcoholic fatty liver disease in male mice","volume":"210","author":"Nomoto","year":"2006","journal-title":"J. Pathol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2119\/molmed.2014.00178","article-title":"Gal-3 ablation enhances liver steatosis, but attenuates Inflammation and IL-33-dependent fibrosis in obesogenic mouse model of nonalcoholic steatohepatitis","volume":"21","author":"Jeftic","year":"2015","journal-title":"Mol. Med."},{"key":"ref_337","doi-asserted-by":"crossref","unstructured":"Traber, P.G., and Zomer, E. (2013). Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083481"},{"key":"ref_338","doi-asserted-by":"crossref","unstructured":"Traber, P.G., Chou, H., Zomer, E., Hong, F., Klyosov, A., Fiel, M.I., and Friedman, S.L. (2013). Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075361"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/apt.13816","article-title":"Randomised clinical study: GR-MD-02, a Gal-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis","volume":"44","author":"Harrison","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_340","unstructured":"(2017, December 22). Galectin Tanks on Failure of NASH Treatment (GALT). Available online: https:\/\/www.investopedia.com\/news\/galectin-tanks-failure-nash-treatment-galt\/."},{"key":"ref_341","unstructured":"(2017, December 22). Results from the NASH-FX Study Underscore the Importance of Completing the NASH-CX Clinical Trial for Patients with NASH Cirrhosis. Available online: http:\/\/perspectives.galectintherapeutics.com\/importance-completing-nash-cx-trial-for-patients-with-nash-cirrhosis\/."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_343","first-page":"174","article-title":"Obesity-associated low-grade inflammation in type 2 diabetes mellitus: Causes and consequences","volume":"71","author":"Schalkwijk","year":"2013","journal-title":"Neth. J. Med."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3390\/biom5031563","article-title":"Roles of chemokines and chemokine receptors in obesity-associated insulin resistance and nonalcoholic fatty liver disease","volume":"5","author":"Xu","year":"2015","journal-title":"Biomolecules"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1073\/pnas.0905310107","article-title":"Inflammation and adipose tissue macrophages in lipodystrophic mice","volume":"107","author":"Herrero","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_347","doi-asserted-by":"crossref","unstructured":"Huang, J.Y., Chiang, M.T., Yet, S.F., and Chau, L.Y. (2012). Myeloid heme oxygenase-1 haploin- sufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038626"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.2337\/db08-0872","article-title":"Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes","volume":"57","author":"Lumeng","year":"2008","journal-title":"Diabetes"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2016.10.025","article-title":"Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"ref_350","first-page":"895","article-title":"Global estimate of the incidence of clinical pneumonia among children under five years of age","volume":"82","author":"Rudan","year":"2004","journal-title":"Bull. World Health Org."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2353\/ajpath.2008.070870","article-title":"Galectin-3 Reduces the Severity of Pneumococcal Pneumonia by Augmenting Neutrophil Function","volume":"172","author":"Farnworth","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1189\/jlb.3A0116-026RR","article-title":"Galectin-3\u2013null mice display defective neutrophil clearance during acute inflammation","volume":"101","author":"Wright","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and Molecular Basis of Pulmonary Arterial Hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1084\/jem.20090121","article-title":"Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response","volume":"207","author":"Markowska","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/2470-7511.248361","article-title":"Galectin-3: A potential biomarker in pulmonary arterial hypertension","volume":"1","author":"Song","year":"2016","journal-title":"Cardiol. Plus"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/heartjnl-2015-308365","article-title":"Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension","volume":"102","author":"Calvier","year":"2016","journal-title":"Heart"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jash.2017.03.008","article-title":"Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4","volume":"11","author":"He","year":"2017","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00380-015-0691-z","article-title":"Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension","volume":"31","author":"Fenster","year":"2016","journal-title":"Heart Vessels"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"89","DOI":"10.12988\/bmgt.2016.639","article-title":"Elevated Galectin-3 Level Predicts Pulmonary Artery Hypertension","volume":"3","author":"Berezin","year":"2016","journal-title":"Biol. Mark. Guid. Ther."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4172\/2471-2663.1000114","article-title":"Is elevated circulating galectin-3 level a predictor of pulmonary artery hypertension development and progression?","volume":"2","author":"Berezin","year":"2016","journal-title":"Clin. Med. Biochem."},{"key":"ref_361","first-page":"A7918","article-title":"Gal-3 mediates vascular remodeling in pulmonary arterial hypertension","volume":"193","author":"Barman","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jdermsci.2011.07.008","article-title":"Gal-3 and the skin","volume":"64","author":"Larsen","year":"2011","journal-title":"J. Dermatolol. Sci."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/path.3996","article-title":"Psoriasis in humans is associated with down-regulation of galectins in dendritic cells","volume":"228","author":"Bonay","year":"2012","journal-title":"J. Pathol."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14712\/fb2006052010010","article-title":"Glycophenotype of Psoriatic Skin","volume":"52","author":"Lacina","year":"2006","journal-title":"Folia Biol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2007.00901.x","article-title":"Lounging in a lysosome: The intracellular lifestyle of Coxiella burnetii","volume":"9","author":"Voth","year":"2007","journal-title":"Cell. Microbiol."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.4161\/auto.5.8.10218","article-title":"How autophagy regulates the host cell signaling associated with the postpartum bacteria cocoon experienced as a danger signal","volume":"5","author":"Dupont","year":"2009","journal-title":"Autophagy"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1462-5822.2009.01415.x","article-title":"Gal-3, a marker for vacuole lysis by invasive pathogens","volume":"12","author":"Paz","year":"2010","journal-title":"Cell. Microbiol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature10744","article-title":"Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion","volume":"482","author":"Thurston","year":"2012","journal-title":"Nature"},{"key":"ref_369","first-page":"160","article-title":"Listeria and Shigella actin-based motility in host cells","volume":"109","author":"Southwick","year":"1998","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1038\/emboj.2013.171","article-title":"Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury","volume":"32","author":"Maejima","year":"2013","journal-title":"EMBO J."},{"key":"ref_371","first-page":"1000164","article-title":"Galectins in the pathogenesis of rheumatoid arthritis","volume":"4","author":"Li","year":"2013","journal-title":"J. Clin. Cell. Immunol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar1883","article-title":"Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen induced arthritis model","volume":"8","author":"Shou","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/art.30118","article-title":"Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis","volume":"63","author":"Forsman","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/art.11287","article-title":"Galectin 3 and its binding protein in rheumatoid arthritis","volume":"48","author":"Ohshima","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/ard.2004.023135","article-title":"Gal-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric","volume":"64","author":"Neidhart","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/1529-0131(200012)43:12<2634::AID-ANR3>3.0.CO;2-1","article-title":"Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: Association with genomic DNA hypomethylation and influence on gene expression","volume":"43","author":"Neidhart","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_377","first-page":"S41","article-title":"Serum Gal-3 and Gal-3 binding protein levels in Beh\u00e7et\u2019s disease and their association with disease activity","volume":"25","author":"Lee","year":"2007","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10067-011-1741-2","article-title":"Gal-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan","volume":"30","author":"Hu","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/art.11166","article-title":"Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: Destructive potential in vitro and in vivo","volume":"4","author":"Neidhart","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1186\/ar1153","article-title":"The synovial proteome: Analysis of fibroblast-like synoviocytes","volume":"6","author":"Dasuri","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/art.24574","article-title":"Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways","volume":"60","author":"Filer","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.4049\/jimmunol.180.5.3091","article-title":"Differential roles of galectin-1 and Gal-3 in regulating leukocyte viability and cytokine secretion","volume":"180","author":"Stowell","year":"2008","journal-title":"J. Immunol."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13075-017-1282-4","article-title":"Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets","volume":"19","author":"Issa","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/gt.2010.78","article-title":"Intra-articular lentivirus-mediated delivery of Gal-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis","volume":"17","author":"Wang","year":"2010","journal-title":"Gene Ther."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jbspin.2016.02.029","article-title":"Gal-3: A key player in arthritis","volume":"84","author":"Hu","year":"2017","journal-title":"Joint Bone Spine"},{"key":"ref_386","doi-asserted-by":"crossref","unstructured":"Mishra, B.B., Li, Q., Steichen, A.L., Binstock, B.J., Metzger, D.W., Teale, J.M., and Sharma, J. (2013). Galectin-3 Functions as an Alarmin: Pathogenic role for sepsis development in murine respiratory tularemia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059616"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.4049\/jimmunol.181.4.2781","article-title":"Gal-3 is a negative regulator of lipopolysaccharide-mediated inflammation","volume":"181","author":"Li","year":"2008","journal-title":"J. Immunol."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1471-4906(02)02232-9","article-title":"Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response?","volume":"23","author":"Rabinovich","year":"2002","journal-title":"Trends Immunol."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1016\/S0021-9258(17)41797-2","article-title":"Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages","volume":"269","author":"Sato","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13613-017-0252-y","article-title":"Multi-marker approach using procalcitonin, presepsin, Gal-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis","volume":"7","author":"Kim","year":"2017","journal-title":"Ann. Intensive Care"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: An American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"Khanna","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.carres.2008.08.038","article-title":"Modified citrus pectin anti-metastatic properties: One bullet, multiple targets","volume":"344","author":"Glinsky","year":"2009","journal-title":"Carbohydr. Res."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1139\/cjpp-2015-0284","article-title":"Modified citrus pectin stops progression of liver fibrosis by inhibiting Gal-3 and inducing apoptosis of stellate cells","volume":"94","author":"Elkashef","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.7314\/APJCP.2015.16.13.5265","article-title":"Pectic-oligoshaccharides from apples induce apoptosis and cell cycle arrest in MDA-MB-231 cells, a model of human breast cancer","volume":"16","author":"Delphi","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.1200\/jco.2006.24.18_suppl.13023","article-title":"GCS-100, a galectin-3 antagonist, in refractory solid tumors: A phase I study","volume":"24","author":"Grous","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1074\/jbc.M312834200","article-title":"Gal-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes","volume":"279","author":"Ahmad","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1182\/blood-2009-10-251660","article-title":"GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death","volume":"115","author":"Streetly","year":"2010","journal-title":"Blood"},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1158\/0008-5472.CAN-05-0163","article-title":"A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells","volume":"65","author":"Chauhan","year":"2005","journal-title":"Cancer Res."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10557-014-6520-2","article-title":"Gal-3: A Modifiable Risk Factor in Heart Failure","volume":"28","author":"Mueller","year":"2014","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_401","unstructured":"(2017, December 22). National Institutes of Health (NIH), Available online: https:\/\/www.clinicaltrials.gov\/ct2\/search."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-065X.2009.00790.x","article-title":"Galectins in innate immunity: Dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs)","volume":"230","author":"Sato","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1462-5822.2002.00219.x","article-title":"Gal-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected","volume":"4","author":"John","year":"2002","journal-title":"Cell. Microbiol."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-3024.2005.00749.x","article-title":"Galectins as immunoregulators during infectious processes: From microbial invasion to the resolution of the disease","volume":"27","author":"Rabinovich","year":"2005","journal-title":"Parasite Immunol."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.biocel.2004.07.014","article-title":"Elevation of galectin-9 as an in ammatory response in the periodontal ligament cells exposed to Porphylomonas gingivalis lipopolysaccharide in vitro and in vivo","volume":"37","author":"Kasamatsu","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1749-6632.2012.06475.x","article-title":"Glycans, galectins, and HIV-1 infection","volume":"1253","author":"Sato","year":"2012","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1742-4690-5-105","article-title":"Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity","volume":"5","author":"Gauthier","year":"2008","journal-title":"Retrovirology"},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1111\/j.1462-5822.2008.01190.x","article-title":"Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis","volume":"10","author":"Okumura","year":"2008","journal-title":"Cell. Microbiol."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jri.2009.08.007","article-title":"Impact of T. vaginalis infection on innate immune responses and reproductive outcome","volume":"83","author":"Fichorova","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1099\/vir.0.066837-0","article-title":"Acute hantavirus infection induces Gal-3-binding protein","volume":"95","author":"Hepojoki","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0168-8278(96)80076-6","article-title":"Elevated serum levels of 90K\/MAC-2 BP predict unresponsiveness to alpha-interferon therapy in chronic HCV hepatitis patients","volume":"25","author":"Artini","year":"1996","journal-title":"J. Hepatol."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2141.1993.tb08674.x","article-title":"Prognostic value of a novel circulating serum 90K antigen in HIV-infected haemophilia patients","volume":"85","author":"Longo","year":"1993","journal-title":"Br. J. Haematol."},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1139\/o01-135","article-title":"Gal-3-mediated adherence of Proteus mirabilis to Madin-Darby canine kidney cells","volume":"79","author":"Altman","year":"2001","journal-title":"Biochem. Cell Biol."},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000446376","article-title":"Gal-3 in renal pathology: More than just an innocent bystander","volume":"43","author":"Desmedt","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/blood-2014-04-569939","article-title":"The role of Gal-3 and Gal-3\u2013binding protein in venous thrombosis","volume":"125","author":"DeRoo","year":"2015","journal-title":"Blood"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"42299","DOI":"10.1074\/jbc.M200981200","article-title":"Galectins-3 and -7, but not galectin-1, play a role in re- epithelialization of wounds","volume":"277","author":"Cao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-4165(97)00086-X","article-title":"Modulation of the biological functions of Gal-3 by matrix metalloproteinases","volume":"1379","author":"Ochieng","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1167\/iovs.08-3359","article-title":"Detection of differentially expressed wound-healing-related glycogenes in Gal-3-deficient mice","volume":"50","author":"Saravanan","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ijc.20977","article-title":"Ly6 family member C4.4A binds laminins 1 and 5, associates with Gal-3 and supports cell migration","volume":"115","author":"Paret","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2741\/2277","article-title":"Wound re-epithelialization: Modulating keratinocyte migration in wound healing","volume":"12","author":"Sivamani","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaad.2007.08.048","article-title":"Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings","volume":"58","author":"Fonder","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0039-6109(05)70575-2","article-title":"Chronic wounds","volume":"77","author":"Eaglstein","year":"1997","journal-title":"Surg. Clin. N. Am."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcp\/92.4.430","article-title":"Impaired migration of epidermal cells from decubitus ulcers in cell cultures. A cause of protracted wound healing?","volume":"92","author":"Seiler","year":"1989","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_426","first-page":"89","article-title":"Role of galectins in re-epithelialization of wounds","volume":"2","author":"Panjwani","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000355846","article-title":"Gal-3 enhances epithelial cell adhesion and wound healing in rat cornea","volume":"51","author":"Yabuta","year":"2014","journal-title":"Ophthalmic Res."},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.exer.2015.06.010","article-title":"Gal-3 enhances extracellular matrix associations and wound healing in monkey corneal epithelium","volume":"137","author":"Fujii","year":"2015","journal-title":"Exp. Eye Res."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.yexcr.2004.10.033","article-title":"Cellular and molecular facets of keratinocyte reepithelization during wound healing","volume":"304","author":"Santoro","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-4652(199808)176:2<255::AID-JCP4>3.0.CO;2-N","article-title":"Epidermal growth factor (EGF)- and scatter factor\/hepatocyte growth factor (SF\/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9","volume":"176","author":"McCawley","year":"1998","journal-title":"J. Cell. Physiol."},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.02346","article-title":"Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing","volume":"118","author":"Shirakata","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1038\/jid.2012.211","article-title":"Galectin-3 regulates intracellular trafficking of egfr through alix and promotes keratinocyte migration","volume":"132","author":"Liu","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ibd.21443","article-title":"Matrilysin-1 (MMP7) cleaves Gal-3 and inhibits wound healing in intestinal epithelial cells","volume":"17","author":"Puthenedam","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0002-9149(73)80150-X","article-title":"Left ventricular function in patients with anginal syndrome and normal coronary arteriograms","volume":"32","author":"Kemp","year":"1973","journal-title":"Am. J. Cardiol."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00392-010-0159-1","article-title":"Definitions and incidence of cardiac syndrome X: Review and analysis of clinical data","volume":"99","author":"Vermeltfoort","year":"2010","journal-title":"Clin. Res. Cardiol."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0735-1097(94)00507-M","article-title":"Cardiac syndrome X: Clinical characteristics and left ventricular function. Long-term follow-up study","volume":"25","author":"Kaski","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijcard.2008.11.026","article-title":"Long-term prognosis of patients with cardiac syndrome X","volume":"140","author":"Lamendola","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12471-012-0256-z","article-title":"Long-term prognosis of patients with cardiac syndrome X: A review","volume":"20","author":"Vermeltfoort","year":"2012","journal-title":"Neth. Heart J."},{"key":"ref_439","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archinternmed.2009.50","article-title":"Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: A report from the Women\u2019s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project","volume":"169","author":"Gulati","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cyto.2007.09.005","article-title":"Elevated circulating inflammatory markers in female patients with cardiac syndrome X","volume":"40","author":"Li","year":"2007","journal-title":"Cytokine"},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.ehj.2003.09.029","article-title":"Chronic inflammation and increased arterial stiffness in patients with cardiac syndrome X","volume":"24","author":"Mollichelli","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2143\/AC.64.2.2036139","article-title":"Serum levels of C-reactive protein and uric acid in patients with cardiac syndrome X","volume":"64","author":"Eroglu","year":"2009","journal-title":"Acta Cardiol."},{"key":"ref_443","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.atherosclerosis.2014.09.014","article-title":"Serum concentrations of galectin-3 in patients with cardiac syndrome X","volume":"237","author":"Bozcali","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"S369","DOI":"10.1086\/430917","article-title":"Bennett Forum on Deep Mycoses Study Design 2004: Candidiasis and salvage therapy for aspergillosis","volume":"41","author":"Wenzel","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/cc9239","article-title":"Bench-to-bedside review: Therapeutic management of invasive candidiasis in the intensive care unit","volume":"14","author":"Bassetti","year":"2010","journal-title":"Crit. Care"},{"key":"ref_446","doi-asserted-by":"crossref","first-page":"e865","DOI":"10.1542\/peds.2009-3412","article-title":"Eunice Kennedy shriver national institute of child health and human development neonatal research network. Neonatal candidiasis: Epidemiology, risk factors, and clinical judgment","volume":"126","author":"Benjamin","year":"2010","journal-title":"Pediatrics"},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1093\/clinids\/14.Supplement_1.S148","article-title":"Pathogenesis and treatment of recurrent vulvovaginal candidiasis","volume":"14","author":"Sobel","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1034\/j.1600-0463.2002.1101202.x","article-title":"Defining the glycophenotype of squamous epithelia using plant and mammalian lectins: Differentiation-dependent expression of 2,6- and 2,3-linked N-acetylneura-minic acid in squamous epithelia and carcinomas, and its differential effect on binding of the endogenous lectins galectins-1 and -3","volume":"110","author":"Holikova","year":"2002","journal-title":"APMIS"},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1136\/bjo.85.11.1336","article-title":"Detection of Gal-3 in tear fluid at disease states and immunohistochemical and lectin histochemical analysis in human corneal and conjunctival epithelium","volume":"85","author":"Plzak","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"ref_450","first-page":"4635","article-title":"Expression of cytoplasmic Gal-3 as a prognostic marker in tongue carcinoma","volume":"6","author":"Honjo","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00042737-200202000-00008","article-title":"The constitutive expression of Gal-3 is downregulated in the intestinal epithelia of Crohn\u2019s disease patients, and tumour necrosis factor decreases the level of Gal-3-specific mRNA in HCT-8 cells","volume":"14","author":"Gscheidlinger","year":"2002","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/cmi.12103","article-title":"The Role of Gal-3 in Phagocytosis of Candida albicans and Candida parapsilosis by Human Neutrophils","volume":"15","author":"Linden","year":"2013","journal-title":"Cell. Microbiol."},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3109\/13693786.2013.770607","article-title":"Galectin-3 plays an important role in protection against disseminated candidiasis","volume":"51","author":"Linden","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3109\/13693786.2012.690902","article-title":"Human genetic susceptibility to Candida infections","volume":"50","author":"Plantinga","year":"2012","journal-title":"Med. Mycol."},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/emmm.201201678","article-title":"Genetic susceptibility to Candida infections","volume":"5","author":"Smeekens","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00048","article-title":"Cell Intrinsic Gal-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation","volume":"8","author":"Wu","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"29457","DOI":"10.1038\/srep29457","article-title":"Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors","volume":"6","author":"Hsieh","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_458","unstructured":"Nilsson, U., Leffler, H., Mukhopadhyay, B., Rajput, V., and Galecto Biotech Ab, Assignee (2016). Galectoside Inhibitors of Galectins. (9,353,141), U.S. Patent, Available online: http:\/\/www.google.com\/patents\/US9353141."},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4065\/84.3.274","article-title":"Herpes zoster (shingles) and postherpetic neuralgia","volume":"84","author":"Sampathkumar","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1386-6532(10)70002-0","article-title":"Advances in the understanding of the pathogenesis and epidemiology of herpes zoster","volume":"48","author":"Gershon","year":"2010","journal-title":"J. Clin. Virol."},{"key":"ref_461","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0846.2011.00535.x","article-title":"Thermography as a predictor of postherpetic neuralgia in acute herpes zoster patients: A preliminary study","volume":"18","author":"Park","year":"2012","journal-title":"Skin Res. Technol."},{"key":"ref_462","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1212\/WNL.0b013e3182a3516e","article-title":"The global epidemiology of herpes zoster","volume":"81","author":"Yawn","year":"2013","journal-title":"Neurology"},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: Towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open"},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/brain\/119.2.347","article-title":"The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia","volume":"119","author":"Rowbotham","year":"1996","journal-title":"Brain"},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1073\/pnas.83.7.2248","article-title":"Selective expression of endogenous lactose-binding lectins and lactoseries glycoconjugates in subsets of rat sensory neurons","volume":"83","author":"Regan","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1097-0185(19990101)254:1<53::AID-AR7>3.0.CO;2-H","article-title":"Endogenous lectin (RL-29) expression of the autonomic preganglionic neurons in the rat spinal cord","volume":"254","author":"Park","year":"1999","journal-title":"Anat. Rec."},{"key":"ref_467","doi-asserted-by":"crossref","unstructured":"Ma, Z., Han, Q., Wang, X., Ai, Z., and Zheng, Y. (2016). Galectin-3 Inhibition Is Associated with Neuropathic Pain Attenuation after Peripheral Nerve Injury. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148792"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/2\/379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:52:45Z","timestamp":1760194365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/2\/379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":467,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["ijms19020379"],"URL":"https:\/\/doi.org\/10.3390\/ijms19020379","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,26]]}}}