{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:36:04Z","timestamp":1771529764945,"version":"3.50.1"},"reference-count":100,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T00:00:00Z","timestamp":1518825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates in the pleura, is diagnosed in advanced stages and has a poor prognosis. Accurate diagnosis of MPM is often difficult and complex, and the gold standard diagnosis test is based on qualitative analysis of markers in pleural tissue by immunohistochemical staining. Therefore, it is necessary to develop quantitative and non-subjective alternative diagnostic tools. MicroRNAs are non-coding RNAs that regulate essential cellular mechanisms at the post-transcriptional level. Recent evidence indicates that miRNA expression in tissue and body fluids is aberrant in various tumors, revealing miRNAs as promising diagnostic biomarkers. This review summarizes evidence regarding secreted and tissue miRNAs as biomarkers of MPM and the biological characteristics associated with their potential diagnostic value. In addition to studies regarding miRNAs with potential diagnostic value for MPM, studies that aimed to identify the miRNAs involved in molecular mechanisms associated with MPM development are described with an emphasis on relevant aspects of the experimental designs that may influence the accuracy, consistency and real diagnostic value of currently reported data.<\/jats:p>","DOI":"10.3390\/ijms19020595","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T03:54:22Z","timestamp":1519098862000},"page":"595","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma"],"prefix":"10.3390","volume":"19","author":[{"given":"Vanessa","family":"Mart\u00ednez-Rivera","sequence":"first","affiliation":[{"name":"Research Unit, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cosio Villegas\u201d, Calzada de Tlalpan 4502, Colonia Secci\u00f3n XVI, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Negrete-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Research Unit, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cosio Villegas\u201d, Calzada de Tlalpan 4502, Colonia Secci\u00f3n XVI, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"\u00c1vila-Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Cancer Epigenomics and Lung Disease Laboratory 12, Facultad de Estudios Superiores (FES)-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida de los Barrios #1 Colonia los Reyes Iztacala, 54090 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Ortiz-Quintero","sequence":"additional","affiliation":[{"name":"Research Unit, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cosio Villegas\u201d, Calzada de Tlalpan 4502, Colonia Secci\u00f3n XVI, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1586\/14737140.8.2.293","article-title":"Current concepts in malignant pleural mesothelioma","volume":"8","author":"Kaufman","year":"2008","journal-title":"Expert Rev. 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