{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:11:10Z","timestamp":1792080670544,"version":"4.4.0"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>From a series of (1R, 1S)-1[\u03b2-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) (IC50 25 \u03bcM) on the PLP-B lymphocyte cell line. A successful resolution of (\u00b1) 1-phenyl-2-(1H-pyrazol-1-yl)ethan-1-ol has been developed by using the method of \u201chalf-concentration\u201d in the presence of (+)-(1S)- or (\u2212)-(1R)-CSA.<\/jats:p>","DOI":"10.3390\/ijms19030856","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T05:06:43Z","timestamp":1521090403000},"page":"856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors"],"prefix":"10.3390","volume":"19","author":[{"given":"Camille","family":"Dago","sequence":"first","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, Groupe CORINT, Universit\u00e9 de Rennes 1 (UR1), Campus de Beaulieu, B\u00e2t. 10A, 263 Avesnue du G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 Rennes CEDEX, France"},{"name":"Laboratoire de Chimie Bio Organique et de Substances Naturelles (LCBOSN), Universit\u00e9 Nangui Abrogoua (UNA), Abidjan BP 802, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maux","sequence":"additional","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, Groupe CORINT, Universit\u00e9 de Rennes 1 (UR1), Campus de Beaulieu, B\u00e2t. 10A, 263 Avesnue du G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 Rennes CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-4472","authenticated-orcid":false,"given":"Thierry","family":"Roisnel","sequence":"additional","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, Centre de Diffractom\u00e9trie X (cdifx), Universit\u00e9 de Rennes 1 (UR1), Campus de Beaulieu, B\u00e2t. 10B, 263 Avenue du G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 Rennes CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Brigaudeau","sequence":"additional","affiliation":[{"name":"Laboratoire Canalopathies & Signalisation Calcique, Inserm U1227, Universit\u00e9 de Bretagne Occidentale (UBO), 22 Avenue Camille Desmoulins, 29200 Brest CEDEX, France"},{"name":"CalciScreen Platform, Universit\u00e9 de Bretagne Occidentale (UBO), 22 Avenue Camille Desmoulins, 29200 Brest CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Alain","family":"Bekro","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Bio Organique et de Substances Naturelles (LCBOSN), Universit\u00e9 Nangui Abrogoua (UNA), Abidjan BP 802, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-6119","authenticated-orcid":false,"given":"Olivier","family":"Mignen","sequence":"additional","affiliation":[{"name":"Laboratoire Canalopathies & Signalisation Calcique, Inserm U1227, Universit\u00e9 de Bretagne Occidentale (UBO), 22 Avenue Camille Desmoulins, 29200 Brest CEDEX, France"},{"name":"CalciScreen Platform, Universit\u00e9 de Bretagne Occidentale (UBO), 22 Avenue Camille Desmoulins, 29200 Brest CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Bazureau","sequence":"additional","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, Groupe CORINT, Universit\u00e9 de Rennes 1 (UR1), Campus de Beaulieu, B\u00e2t. 10A, 263 Avesnue du G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 Rennes CEDEX, France"},{"name":"S2Wave Platform, ScanMAT UMS 2001 CNRS, Universit\u00e9 de Rennes 1 (UR1), Campus de Beaulieu, B\u00e2t. 10A, 263 Avenue du G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 Rennes CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/jm3011433","article-title":"Ion Channels as Therapeutic Targets: A Drug Discovery Perspective","volume":"56","author":"Bagal","year":"2013","journal-title":"J. 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