{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:12:27Z","timestamp":1790071947080,"version":"4.0.1"},"reference-count":210,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carlos III Institute of Health","award":["PI13\/00865"],"award-info":[{"award-number":["PI13\/00865"]}]},{"name":"Biomedical Research Network Center on Rare Diseases, CIBERER"},{"name":"NINDS, NIH","award":["P01NS097197"],"award-info":[{"award-number":["P01NS097197"]}]},{"name":"Spanish Ministry of Economy","award":["SAF2014-59594-R"],"award-info":[{"award-number":["SAF2014-59594-R"]}]},{"DOI":"10.13039\/501100012006","name":"Conchita R\u00e1bago Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer\u2019s disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures. Brains of patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, amyloid-\u03b2 plaques and neuropil threads. Increasing evidence suggests the existence of overlapping mechanisms related to the generation of network hyperexcitability and cognitive decline. Neuronal overexpression of tau with various mutations found in FTD with parkinsonism-linked to chromosome 17 (FTDP-17) in mice produces epileptic activity. On the other hand, the use of certain antiepileptic drugs in animal models with AD prevents cognitive impairment. Further efforts should be made to search for plausible common targets for both conditions. Moreover, attempts should also be made to evaluate the use of drugs targeting tau and amyloid-\u03b2 as suitable pharmacological interventions in epileptic disorders. The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration.<\/jats:p>","DOI":"10.3390\/ijms19041092","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T16:50:58Z","timestamp":1522947058000},"page":"1092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-7680","authenticated-orcid":false,"given":"Marina","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Laboratory of Neurology, IIS (Instituto Investigaci\u00f3n Sanitaria\/Health Research Institute)-Jim\u00e9nez D\u00edaz Foundation, UAM (Universidad Autonoma de Madrid\/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda-Cabrero","sequence":"additional","affiliation":[{"name":"Laboratory of Neurology, IIS (Instituto Investigaci\u00f3n Sanitaria\/Health Research Institute)-Jim\u00e9nez D\u00edaz Foundation, UAM (Universidad Autonoma de Madrid\/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain"},{"name":"Department of Immunology and Oncology and Protein Tools Unit, Biotechnology National Center (CNB\/CSIC), 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentzane","family":"S\u00e1nchez-Elexpuru","sequence":"additional","affiliation":[{"name":"Laboratory of Neurology, IIS (Instituto Investigaci\u00f3n Sanitaria\/Health Research Institute)-Jim\u00e9nez D\u00edaz Foundation, UAM (Universidad Autonoma de Madrid\/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burgos","sequence":"additional","affiliation":[{"name":"Laboratory of Neurology, IIS (Instituto Investigaci\u00f3n Sanitaria\/Health Research Institute)-Jim\u00e9nez D\u00edaz Foundation, UAM (Universidad Autonoma de Madrid\/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Serratosa","sequence":"additional","affiliation":[{"name":"Laboratory of Neurology, IIS (Instituto Investigaci\u00f3n Sanitaria\/Health Research Institute)-Jim\u00e9nez D\u00edaz Foundation, UAM (Universidad Autonoma de Madrid\/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0920-1211(90)90079-B","article-title":"Epilepsy in a population of mentally retarded children and adults","volume":"6","author":"Forsgren","year":"1990","journal-title":"Epilepsy Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1212\/WNL.46.3.727","article-title":"Dementia and adult-onset unprovoked seizures","volume":"46","author":"Hesdorffer","year":"1996","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yebeh.2014.04.015","article-title":"Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999\u20132008","volume":"36","author":"Sherzai","year":"2014","journal-title":"Epilepsy Behav."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1528-1167.2006.00554.x","article-title":"Incidence and predictors of seizures in patients with Alzheimer\u2019s disease","volume":"47","author":"Amatniek","year":"2006","journal-title":"Epilepsia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/089198879400700407","article-title":"Seizures in Alzheimer\u2019s disease: Clinicopathologic study","volume":"7","author":"Mendez","year":"1994","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/archneurol.2009.130","article-title":"Seizures in Alzheimer disease: Who, when, and how common?","volume":"66","author":"Scarmeas","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archneur.1990.00530080029006","article-title":"Advanced Alzheimer\u2019s disease is a risk factor for late-onset seizures","volume":"47","author":"Romanelli","year":"1990","journal-title":"Arch. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.braindev.2004.07.008","article-title":"Down syndrome, Alzheimer\u2019s disease and seizures","volume":"27","year":"2005","journal-title":"Brain Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archneurol.2011.830","article-title":"Incidence of new-onset seizures in mild to moderate Alzheimer disease","volume":"69","author":"Irizarry","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/epd.2016.0808","article-title":"From here to epilepsy: The risk of seizure in patients with Alzheimer\u2019s disease","volume":"18","author":"Nicastro","year":"2016","journal-title":"Epileptic Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JAD-170031","article-title":"Relative Incidence of Seizures and Myoclonus in Alzheimer\u2019s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia","volume":"60","author":"Beagle","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1212\/WNL.39.1.138","article-title":"Seizures in progressive supranuclear palsy","volume":"39","author":"Nygaard","year":"1989","journal-title":"Neurology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1212\/WNL.36.9.1226","article-title":"Seizures and myoclonus in patients with Alzheimer\u2019s disease","volume":"36","author":"Hauser","year":"1986","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1001\/archneur.1991.00530230049020","article-title":"Cumulative risks of developing extrapyramidal signs, psychosis, or myoclonus in the course of Alzheimer\u2019s disease","volume":"48","author":"Chen","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/brain\/awm213","article-title":"Focal cortical presentations of Alzheimer\u2019s disease","volume":"130","author":"Alladi","year":"2007","journal-title":"Brain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.22424","article-title":"Clinicopathological correlations in corticobasal degeneration","volume":"70","author":"Lee","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mds.870090318","article-title":"What is it? Case 1, 1994: Rapidly progressive aphasia, apraxia, dementia, myoclonus, and parkinsonism","volume":"9","author":"Wojcieszek","year":"1994","journal-title":"Mov. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/1531-8249(200007)48:1<126::AID-ANA21>3.0.CO;2-N","article-title":"FTDP-17: Phenotypical heterogeneity within P301S","volume":"48","author":"Bugiani","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/1531-8249(199911)46:5<708::AID-ANA5>3.0.CO;2-K","article-title":"FTDP-17: An early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation","volume":"46","author":"Sperfeld","year":"1999","journal-title":"Ann. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/nan.12367","article-title":"Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy","volume":"43","author":"Tacik","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12017-009-8076-z","article-title":"Epileptic seizures in AD patients","volume":"12","author":"Larner","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000093664","article-title":"Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer\u2019s disease","volume":"22","author":"Lozsadi","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer\u2019s disease: Causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1528-1167.2010.02909.x","article-title":"A perfect storm: Converging paths of epilepsy and Alzheimer\u2019s dementia intersect in the hippocampal formation","volume":"52","author":"Noebels","year":"2011","journal-title":"Epilepsia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1212\/WNL.52.3.566","article-title":"A presenilin 1 mutation (Ser169Pro) associated with early-onset AD and myoclonic seizures","volume":"52","author":"Ezquerra","year":"1999","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1212\/WNL.45.1.80","article-title":"A large pedigree with early-onset Alzheimer\u2019s disease: Clinical, neuropathologic, and genetic characterization","volume":"45","author":"Campion","year":"1995","journal-title":"Neurology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1212\/WNL.58.6.922","article-title":"Early onset autosomal dominant dementia with ataxia, extrapyramidal features, and epilepsy","volume":"58","author":"Filla","year":"2002","journal-title":"Neurology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jns.2007.11.021","article-title":"Atypical early-onset Alzheimer\u2019s disease caused by the Iranian APP mutation","volume":"268","author":"Lindquist","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00415-005-0019-5","article-title":"Clinical phenotypic heterogeneity of Alzheimer\u2019s disease associated with mutations of the presenilin-1 gene","volume":"253","author":"Larner","year":"2006","journal-title":"J. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1093\/brain\/awl237","article-title":"Phenotype associated with APP duplication in five families","volume":"129","author":"Cabrejo","year":"2006","journal-title":"Brain"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/archneur.62.12.1821","article-title":"Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life","volume":"62","author":"Snider","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/1531-8249(199910)46:4<617::AID-ANA10>3.0.CO;2-I","article-title":"Phenotypic variation in hereditary frontotemporal dementia with tau mutations","volume":"46","author":"Stevens","year":"1999","journal-title":"Ann. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.neuron.2011.04.009","article-title":"The many faces of tau","volume":"70","author":"Morris","year":"2011","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/mp.2016.226","article-title":"17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression","volume":"22","author":"Quenez","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00401-012-0996-2","article-title":"The genetics and neuropathology of Alzheimer\u2019s disease","volume":"124","author":"Schellenberg","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18295","DOI":"10.1074\/jbc.271.31.18295","article-title":"Amyloid beta-protein and the genetics of Alzheimer\u2019s disease","volume":"271","author":"Selkoe","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1212\/WNL.0000000000003048","article-title":"Seizures in dominantly inherited Alzheimer disease","volume":"87","author":"Zarea","year":"2016","journal-title":"Neurology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jfma.2015.08.004","article-title":"A systematic review of familial Alzheimer\u2019s disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences","volume":"115","author":"Shea","year":"2016","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/brain\/awq033","article-title":"Alzheimer\u2019s disease phenotypes and genotypes associated with mutations in presenilin 2","volume":"133","author":"Jayadev","year":"2010","journal-title":"Brain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S1474-4422(16)30193-4","article-title":"Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer\u2019s disease: A case series","volume":"15","author":"Ryan","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1001\/archneur.60.6.818","article-title":"Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele","volume":"60","author":"Gong","year":"2003","journal-title":"Arch. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJM199712043372306","article-title":"The effect of different diagnostic criteria on the prevalence of dementia","volume":"337","author":"Erkinjuntti","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1046\/j.1528-1157.2003.27302.x","article-title":"Interictal epileptic spiking during sleep and wakefulness in mesial temporal lobe epilepsy: A comparative study of scalp and foramen ovale electrodes","volume":"44","author":"Clemens","year":"2003","journal-title":"Epilepsia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/j.1528-1167.2009.02135.x","article-title":"Foramen ovale electrodes in the preoperative evaluation of temporal lobe epilepsy in children","volume":"50","author":"Nilsson","year":"2009","journal-title":"Epilepsia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1755-5949.2011.00251.x","article-title":"Seizures and epilepsy in Alzheimer\u2019s disease","volume":"18","author":"Friedman","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/epi.13744","article-title":"The association between dementia and epilepsy: A systematic review and meta-analysis","volume":"58","author":"Subota","year":"2017","journal-title":"Epilepsia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0006-291X(86)80242-X","article-title":"Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease","volume":"141","author":"Serrano","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0896-6273(92)90117-V","article-title":"Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms","volume":"8","author":"Goedert","year":"1992","journal-title":"Neuron"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(74)90798-7","article-title":"Protein changes in senile dementia","volume":"77","author":"Iqbal","year":"1974","journal-title":"Brain Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0140-6736(86)92134-3","article-title":"Defective brain microtubule assembly in Alzheimer\u2019s disease","volume":"2","author":"Iqbal","year":"1986","journal-title":"Lancet"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0896-6273(95)90232-5","article-title":"beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding","volume":"14","author":"Busciglio","year":"1995","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer\u2019s disease","volume":"16","author":"Price","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/WAD.0000000000000134","article-title":"Epileptic Seizures in Alzheimer Disease: A Review","volume":"30","author":"Barcs","year":"2016","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_60","first-page":"221","article-title":"N-methyl-d-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3beta and cyclin-dependent kinase 5","volume":"23","author":"Liu","year":"2017","journal-title":"Discov. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1528-1167.2012.03476.x","article-title":"Common factors among Alzheimer\u2019s disease, Parkinson\u2019s disease, and epilepsy: Possible role of the noradrenergic nervous system","volume":"53","author":"Szot","year":"2012","journal-title":"Epilepsia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1523\/JNEUROSCI.4152-10.2011","article-title":"Amyloid-\u03b2\/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer\u2019s disease","volume":"31","author":"Roberson","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2217\/fnl.12.8","article-title":"Alzheimer\u2019s disease and epilepsy: Insight from animal models","volume":"7","author":"Scharfman","year":"2012","journal-title":"Future Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.5215-08.2009","article-title":"Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy","volume":"29","author":"Minkeviciene","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41467-017-00618-0","article-title":"Tau exacerbates excitotoxic brain damage in an animal model of stroke","volume":"8","author":"Bi","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1126\/science.aah6205","article-title":"Site-specific phosphorylation of tau inhibits amyloid-\u03b2 toxicity in Alzheimer\u2019s mice","volume":"354","author":"Ittner","year":"2016","journal-title":"Science"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer\u2019s disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2010.10.020","article-title":"Transsynaptic progression of amyloid-\u03b2-induced neuronal dysfunction within the entorhinal-hippocampal network","volume":"68","author":"Harris","year":"2010","journal-title":"Neuron"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: From synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/j.1528-1167.2007.01107.x","article-title":"Pathological tau tangles localize to focal cortical dysplasia in older patients","volume":"48","author":"Sen","year":"2007","journal-title":"Epilepsia"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1222.e1","DOI":"10.1016\/j.neurobiolaging.2014.09.005","article-title":"Homozygous nonsense mutation in SYNJ1 associated with intractable epilepsy and tau pathology","volume":"36","author":"Dyment","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/brain\/aww187","article-title":"Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: A study of temporal lobe resections","volume":"139","author":"Tai","year":"2016","journal-title":"Brain"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jocn.2016.10.012","article-title":"Dysregulation of PINCH signaling in mesial temporal epilepsy","volume":"36","author":"Liu","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/brain\/awr209","article-title":"Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: A post-mortem study","volume":"134","author":"Thom","year":"2011","journal-title":"Brain"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.neuint.2006.10.002","article-title":"Kainate induces AKT, ERK and cdk5\/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus","volume":"50","author":"Canudas","year":"2007","journal-title":"Neurochem. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3233\/JAD-2009-1069","article-title":"Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage","volume":"17","author":"Liang","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_79","first-page":"127","article-title":"Potential roles of Cdk5\/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model","volume":"56","author":"Tian","year":"2010","journal-title":"Clin. Lab."},{"key":"ref_80","first-page":"CD011922","article-title":"Treatment of epilepsy for people with Alzheimer\u2019s disease","volume":"11","author":"Liu","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0959-4388(95)80073-5","article-title":"Disruption of the cytoskeleton in Alzheimer\u2019s disease","volume":"5","author":"Lee","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s004010050513","article-title":"Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I\/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II","volume":"92","author":"Yamaguchi","year":"1996","journal-title":"Acta Neuropathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuroscience.2016.03.044","article-title":"Tau pathology-mediated presynaptic dysfunction","volume":"325","author":"Moreno","year":"2016","journal-title":"Neuroscience"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1083\/jcb.107.4.1449","article-title":"Tau proteins: The molecular structure and mode of binding on microtubules","volume":"107","author":"Hirokawa","year":"1988","journal-title":"J. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1016\/S0021-9258(17)42989-9","article-title":"Phosphorylation affects the ability of tau protein to promote microtubule assembly","volume":"259","author":"Lindwall","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0304-3940(92)90774-2","article-title":"Glycogen synthase kinase-3 induces Alzheimer\u2019s disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase","volume":"147","author":"Hanger","year":"1992","journal-title":"Neurosci. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0092-8674(94)90012-4","article-title":"KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria","volume":"79","author":"Nangaku","year":"1994","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0092-8674(00)81459-2","article-title":"Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria","volume":"93","author":"Tanaka","year":"1998","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1073\/pnas.81.3.788","article-title":"Lysosomes are associated with microtubules and not with intermediate filaments in cultured fibroblasts","volume":"81","author":"Collot","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fncel.2017.00173","article-title":"Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks","volume":"11","author":"Verstraelen","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40478-017-0489-6","article-title":"Atypical, non-standard functions of the microtubule associated Tau protein","volume":"5","author":"Sotiropoulos","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer\u2019s disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/bmj.2.6150.1457","article-title":"Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia","volume":"2","author":"Perry","year":"1978","journal-title":"Br. Med. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"10071","DOI":"10.1073\/pnas.1204606109","article-title":"Loss of functional GABA(A) receptors in the Alzheimer diseased brain","volume":"109","author":"Limon","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/288279a0","article-title":"Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa","volume":"288","author":"Davies","year":"1980","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0197-4580(81)90032-4","article-title":"Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes","volume":"2","author":"Perry","year":"1981","journal-title":"Neurobiol. Aging"},{"key":"ref_99","first-page":"14","article-title":"Neurotransmitter measures in the cerebrospinal fluid of patients with Alzheimer\u2019s disease: A review","volume":"27","author":"Strac","year":"2015","journal-title":"Psychiatr. Danub."},{"key":"ref_100","first-page":"22","article-title":"Revisiting the Role of Acetylcholinesterase in Alzheimer\u2019s Disease: Cross-Talk with P-tau and \u03b2-Amyloid","volume":"4","author":"Small","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: Correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(90)90671-W","article-title":"NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex","volume":"530","author":"Baskys","year":"1990","journal-title":"Brain Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4161\/cam.3.1.7254","article-title":"Neuronal protein trafficking associated with Alzheimer disease: From APP and BACE1 to glutamate receptors","volume":"3","author":"Tang","year":"2009","journal-title":"Cell Adh. Migr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+\/calmodulin-dependent protein kinase II synaptic distribution","volume":"284","author":"Gu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers\u2014A decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-510X(97)00180-9","article-title":"Changes in glutamate receptor subunit composition in hippocampus and cortex in patients with refractory epilepsy","volume":"153","author":"Grigorenko","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2013.09.018","article-title":"A role for tau at the synapse in Alzheimer\u2019s disease pathogenesis","volume":"76","author":"Pooler","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer\u2019s disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1523\/JNEUROSCI.2107-13.2013","article-title":"Antisense reduction of tau in adult mice protects against seizures","volume":"33","author":"DeVos","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ana.24230","article-title":"Tau reduction prevents disease in a mouse model of Dravet syndrome","volume":"76","author":"Gheyara","year":"2014","journal-title":"Ann. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"R1524","DOI":"10.1152\/ajpregu.00888.2007","article-title":"Calcium sensitivity and cooperativity of permeabilized rat mesenteric lymphatics","volume":"294","author":"Dougherty","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"28079","DOI":"10.1074\/jbc.M605081200","article-title":"beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-d-aspartate receptors in hippocampal neurons","volume":"281","author":"Kelly","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2013.01.030","article-title":"Synthetic A\u03b2 oligomers (A\u03b2(1-42) globulomer) modulate presynaptic calcium currents: Prevention of A\u03b2-induced synaptic deficits by calcium channel blockers","volume":"702","author":"Hermann","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0006-8993(02)03547-3","article-title":"Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubility status","volume":"956","author":"Ramsden","year":"2002","journal-title":"Brain Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/387500a0","article-title":"Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein","volume":"387","author":"Nalbantoglu","year":"1997","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li","year":"2009","journal-title":"Neuron"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVNEURO.2009.20.1.1","article-title":"Is Alzheimer\u2019s disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid","volume":"20","author":"Nimmrich","year":"2009","journal-title":"Rev. Neurosci."},{"key":"ref_121","first-page":"75","article-title":"Epilepsy at the prodromal stages of neurodegenerative diseases","volume":"15","author":"Cretin","year":"2017","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuron.2007.08.014","article-title":"Does epileptiform activity contribute to cognitive impairment in Alzheimer\u2019s disease?","volume":"55","author":"Leonard","year":"2007","journal-title":"Neuron"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mehy.2016.12.006","article-title":"Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer\u2019s disease","volume":"99","author":"Damar","year":"2017","journal-title":"Med. Hypotheses"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.yebeh.2010.01.015","article-title":"Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer\u2019s disease","volume":"17","author":"Cumbo","year":"2010","journal-title":"Epilepsy Behav."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/epi.12926","article-title":"A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy","volume":"56","author":"Werhahn","year":"2015","journal-title":"Epilepsia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00004691-200009000-00011","article-title":"Alzheimer\u2019s disease underlies some cases of complex partial status epilepticus","volume":"17","author":"Armon","year":"2000","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yebeh.2008.08.012","article-title":"Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome","volume":"14","author":"Rao","year":"2009","journal-title":"Epilepsy Behav."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer\u2019s disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1101\/lm.80504","article-title":"Declarative memory consolidation: Mechanisms acting during human sleep","volume":"11","author":"Gais","year":"2004","journal-title":"Learn. Mem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0074-7742(08)60665-0","article-title":"The cytoskeleton and neurotransmitter receptors","volume":"39","author":"Whatley","year":"1996","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12017-009-8100-3","article-title":"Alzheimer\u2019s disease and neuronal network activity","volume":"12","author":"Gleichmann","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12017-009-8107-9","article-title":"Adverse stress, hippocampal networks, and Alzheimer\u2019s disease","volume":"12","author":"Rothman","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Garg, N., Joshi, R., and Medhi, B. (2018). Cracking novel shared targets between epilepsy and Alzheimer\u2019s disease: Need of the hour. Rev. Neurosci.","DOI":"10.1515\/revneuro-2017-0064"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ana.410220411","article-title":"Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders","volume":"22","author":"Joachim","year":"1987","journal-title":"Ann. Neurol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s004010050576","article-title":"Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer\u2019s disease, Lewy body disease and progressive supranuclear palsy","volume":"93","author":"Wakabayashi","year":"1997","journal-title":"Acta Neuropathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/WNL.41.9.1402","article-title":"Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer\u2019s disease: Light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD","volume":"41","author":"Dickson","year":"1991","journal-title":"Neurology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005072-197101000-00003","article-title":"Neuronal fibrous protein in human pathology","volume":"30","author":"Terry","year":"1971","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ana.410410606","article-title":"Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference. Conference Participants","volume":"41","author":"Foster","year":"1997","journal-title":"Ann. Neurol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-1172-1-30","article-title":"Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)","volume":"1","author":"Wszolek","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"a006254","DOI":"10.1101\/cshperspect.a006254","article-title":"Frontotemporal dementia: Implications for understanding Alzheimer disease","volume":"2","author":"Goedert","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1750-3639.1998.tb00162.x","article-title":"Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies","volume":"8","author":"Spillantini","year":"1998","journal-title":"Brain Pathol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/1531-8249(200004)47:4<422::AID-ANA4>3.0.CO;2-G","article-title":"A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)","volume":"47","author":"Yasuda","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_145","first-page":"193","article-title":"Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)","volume":"2","author":"Spillantini","year":"2000","journal-title":"Neurogenetics"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1046\/j.1471-4159.2000.0742583.x","article-title":"The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules","volume":"74","author":"Lim","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s004010051148","article-title":"Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein","volume":"99","author":"Probst","year":"2000","journal-title":"Acta Neuropathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000322228","article-title":"Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation","volume":"8","author":"Bellucci","year":"2011","journal-title":"Neurodegener. Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1006\/mcne.2001.1051","article-title":"FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain","volume":"18","author":"Lim","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.neurobiolaging.2005.06.010","article-title":"Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration","volume":"27","author":"Engel","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuroscience.2011.08.057","article-title":"Expression of frontotemporal dementia with parkinsonism associated to chromosome 17 tau induces specific degeneration of the ventral dentate gyrus and depressive-like behavior in mice","volume":"196","author":"Hernandez","year":"2011","journal-title":"Neuroscience"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2013.06.005","article-title":"Hyperexcitability and epileptic seizures in a model of frontotemporal dementia","volume":"58","author":"Giraldez","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/archneur.1964.00460160003001","article-title":"Progressive Supranuclear Palsy. A Heterogeneous Degeneration Involving the Brain Stem, Basal Ganglia and Cerebellum with Vertical Gaze and Pseudobulbar Palsy, Nuchal Dystonia and Dementia","volume":"10","author":"Steele","year":"1964","journal-title":"Arch. Neurol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP international workshop","volume":"47","author":"Litvan","year":"1996","journal-title":"Neurology"},{"key":"ref_155","first-page":"1531","article-title":"Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy","volume":"152","author":"Valpuesta","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/WCO.0b013e32833be924","article-title":"Neuropathology of variants of progressive supranuclear palsy","volume":"23","author":"Dickson","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00688244","article-title":"Progressive supranuclear palsy: Extensive neuropil threads in addition to neurofibrillary tangles. Very similar antigenicity of subcortical neuronal pathology in progressive supranuclear palsy and Alzheimer\u2019s disease","volume":"77","author":"Probst","year":"1988","journal-title":"Acta Neuropathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3233\/JAD-2002-4506","article-title":"Progressive supranuclear palsy and tau hyperphosphorylation in a patient with a C212Y parkin mutation","volume":"4","author":"Sanchez","year":"2002","journal-title":"J. Alzheimers Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/mds.10264","article-title":"Steele-Richardson-Olszewski syndrome in a patient with a single C212Y mutation in the parkin protein","volume":"17","author":"Morales","year":"2002","journal-title":"Mov. Disord."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/jnnp.56.5.473","article-title":"Familial progressive supranuclear palsy","volume":"56","author":"Brown","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/brain\/118.5.1095","article-title":"Familial progressive supranuclear palsy. Description of a pedigree and review of the literature","volume":"118","author":"Sarasa","year":"1995","journal-title":"Brain"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/brain\/122.7.1233","article-title":"Clinical genetics of familial progressive supranuclear palsy","volume":"122","author":"Rojo","year":"1999","journal-title":"Brain"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ng.859","article-title":"Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy","volume":"43","author":"Melhem","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1474-4422(09)70042-0","article-title":"Progressive supranuclear palsy: Clinicopathological concepts and diagnostic challenges","volume":"8","author":"Williams","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000354975","article-title":"Familial progressive supranuclear palsy: A literature review","volume":"13","author":"Fujioka","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/archneur.55.8.1122","article-title":"Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detection","volume":"55","author":"Oliva","year":"1998","journal-title":"Arch. Neurol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/brain\/123.5.880","article-title":"Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: Expansion of the disease phenotype caused by tau gene mutations","volume":"123","author":"Stanford","year":"2000","journal-title":"Brain"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1212\/WNL.0b013e3181a92bcc","article-title":"Familial aggregation of parkinsonism in progressive supranuclear palsy","volume":"73","author":"Boon","year":"2009","journal-title":"Neurology"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/1531-8249(20010201)49:2<263::AID-ANA50>3.0.CO;2-K","article-title":"Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene","volume":"49","author":"Pastor","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1001\/archneur.62.9.1444","article-title":"A new mutation of the tau gene, G303V, in early-onset familial progressive supranuclear palsy","volume":"62","author":"Ros","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"122","DOI":"10.14802\/jmd.15033","article-title":"Genetics of Progressive Supranuclear Palsy","volume":"8","author":"Im","year":"2015","journal-title":"J. Mov. Disord."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1212\/WNL.24.3.219","article-title":"Progressive supranuclear palsy with action myoclonus, seizures","volume":"24","author":"Kurihara","year":"1974","journal-title":"Neurology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1017\/S0317167100038099","article-title":"Progressive supranuclear palsy","volume":"14","author":"Duvoisin","year":"1987","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.12.043","article-title":"Epileptic seizure as a precipitating factor of vascular progressive supranuclear palsy: A case report","volume":"23","author":"Lanza","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2165\/00002512-200118060-00002","article-title":"Dementia with Lewy bodies: Clinical features and treatment","volume":"18","author":"Campbell","year":"2001","journal-title":"Drugs Aging"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jnen\/62.4.389","article-title":"Colocalization of tau and alpha-synuclein epitopes in Lewy bodies","volume":"62","author":"Ishizawa","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/NEN.0b013e3181927577","article-title":"Early-onset familial lewy body dementia with extensive tauopathy: A clinical, genetic, and neuropathological study","volume":"68","author":"Blesa","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"230.e3","DOI":"10.1016\/j.genhosppsych.2013.10.015","article-title":"Epileptic seizure presenting as dementia with Lewy bodies","volume":"36","author":"Park","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/psyg.12199","article-title":"Similarity of symptoms between transient epileptic amnesia and Lewy body disease","volume":"17","author":"Ukai","year":"2017","journal-title":"Psychogeriatrics"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yebeh.2016.12.014","article-title":"The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy","volume":"68","author":"Gholipour","year":"2017","journal-title":"Epilepsy Behav."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1007\/s00415-014-7376-x","article-title":"Progressive myoclonus epilepsy in Down syndrome patients with dementia","volume":"261","author":"Specchio","year":"2014","journal-title":"J. Neurol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/JAD-2012-111613","article-title":"Down syndrome and dementia: Seizures and cognitive decline","volume":"29","author":"Lott","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.seizure.2010.04.008","article-title":"Senile myoclonic epilepsy: Delineation of a common condition associated with Alzheimer\u2019s disease in Down syndrome","volume":"19","author":"Puig","year":"2010","journal-title":"Seizure"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archneur.1990.00530030029011","article-title":"The natural history of dementia in Down\u2019s syndrome","volume":"47","author":"Evenhuis","year":"1990","journal-title":"Arch. Neurol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","article-title":"A prospective study of Alzheimer disease in Down syndrome","volume":"46","author":"Lai","year":"1989","journal-title":"Arch. Neurol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neulet.2016.11.023","article-title":"Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity","volume":"636","author":"Zis","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1742-1241.2001.tb11087.x","article-title":"Age of seizure onset in adults with Down\u2019s syndrome","volume":"55","author":"Puri","year":"2001","journal-title":"Int. J. Clin. Pract."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2017.08.024","article-title":"Clinical aspects and biomarkers of Alzheimer\u2019s disease in Down syndrome","volume":"114","author":"Zis","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2353\/ajpath.2006.051250","article-title":"Cortical neuronal and glial pathology in TgTauP301L transgenic mice: Neuronal degeneration, memory disturbance, and phenotypic variation","volume":"169","author":"Murakami","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1523\/JNEUROSCI.3191-12.2013","article-title":"Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy","volume":"33","author":"Holth","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JAD-2008-13206","article-title":"Park2-null\/tau transgenic mice reveal a functional relationship between parkin and tau","volume":"13","author":"Guerrero","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-008-0470-3","article-title":"Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene","volume":"117","author":"Guerrero","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.neurobiolaging.2014.05.001","article-title":"Seizure resistance without parkinsonism in aged mice after tau reduction","volume":"35","author":"Li","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ncb1602","article-title":"BACE1 regulates voltage-gated sodium channels and neuronal activity","volume":"9","author":"Kim","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/WAD.0b013e31828cc357","article-title":"Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease","volume":"27","author":"Lee","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5414\/NPP30003","article-title":"Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7","volume":"30","author":"Kovacs","year":"2011","journal-title":"Clin. Neuropathol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1093\/hmg\/dds161","article-title":"Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer\u2019s diseases","volume":"21","author":"Coppola","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/alzrt137","article-title":"Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer\u2019s disease Ibero-American cohort","volume":"4","author":"Jin","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2231.e7","DOI":"10.1016\/j.neurobiolaging.2012.04.006","article-title":"The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features","volume":"33","author":"Kara","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"530","DOI":"10.15252\/embr.201541438","article-title":"Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice","volume":"17","author":"Maeda","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"552","DOI":"10.15252\/embr.201541439","article-title":"The Tau\/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity","volume":"17","author":"Decker","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awx005","article-title":"A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction","volume":"140","author":"Lopez","year":"2017","journal-title":"Brain"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.nbd.2011.12.005","article-title":"Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models","volume":"45","author":"Jones","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/brain\/awv053","article-title":"Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury","volume":"138","author":"Shultz","year":"2015","journal-title":"Brain"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1007\/s12035-013-8601-9","article-title":"Hyperphosphorylated tau is implicated in acquired epilepsy and neuropsychiatric comorbidities","volume":"49","author":"Zheng","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuron.2008.12.023","article-title":"The legacy of patient H.M. for neuroscience","volume":"61","author":"Squire","year":"2009","journal-title":"Neuron"},{"key":"ref_210","first-page":"113","article-title":"Enhanced expression of glial fibrillary acidic protein and the cupric silver degeneration reaction can be used as sensitive and early indicators of neurotoxicity","volume":"13","author":"Jensen","year":"1992","journal-title":"Neurotoxicology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/4\/1092\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:59:45Z","timestamp":1760194785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/19\/4\/1092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":210,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4]]}},"alternative-id":["ijms19041092"],"URL":"https:\/\/doi.org\/10.3390\/ijms19041092","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]}}}