{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:42:48Z","timestamp":1782276168031,"version":"3.54.5"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I\u2013IV) and the majority of sporadic unilateral aldosterone-producing adenomas has now been resolved. Familial forms of hyperaldosteronism are, however, rare. The sporadic forms of the disease prevail and these are usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Aldosterone-producing adenomas frequently carry a causative somatic mutation in either of a number of genes with the KCNJ5 gene, encoding an inwardly rectifying potassium channel, a recurrent target harboring mutations at a prevalence of more than 40% worldwide. Other than genetic variations, gene expression profiling of aldosterone-producing adenomas has shed light on the genes and intracellular signalling pathways that may play a role in the pathogenesis and pathophysiology of these tumors.<\/jats:p>","DOI":"10.3390\/ijms19041124","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T13:06:08Z","timestamp":1523365568000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism"],"prefix":"10.3390","volume":"19","author":[{"given":"Elke","family":"Aristizabal Prada","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Castellano","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Medical Sciences, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Su\u0161nik","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Meyer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tetti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"},{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische Ern\u00e4hrung, Universit\u00e4tsSpital Z\u00fcrich, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Williams","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 Munich, Germany"},{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: A systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/jc.2016-1472","article-title":"Study Heterogeneity and Estimation of Prevalence of Primary Aldosteronism: A Systematic Review and Meta-Regression Analysis","volume":"101","author":"Kayser","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: An international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2213-8587(17)30367-4","article-title":"Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: A retrospective cohort study","volume":"6","author":"Hundemer","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.2716","article-title":"Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1038\/srep19546","article-title":"Activating mutations in CTNNB1 in aldosterone producing adenomas","volume":"6","author":"Akerstrom","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-0042-105278","article-title":"Recent Developments in Primary Aldosteronism","volume":"124","author":"Asbach","year":"2016","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/HYPERTENSIONAHA.117.10111","article-title":"Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism","volume":"70","author":"Prada","year":"2017","journal-title":"Hypertension"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/355262a0","article-title":"A chimaeric 11 beta-hydroxylase\/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension","volume":"355","author":"Lifton","year":"1992","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng0992-66","article-title":"Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase","volume":"2","author":"Lifton","year":"1992","journal-title":"Nat. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1440-1681.1992.tb00462.x","article-title":"Familial hyperaldosteronism type II: Five families with a new variety of primary aldosteronism","volume":"19","author":"Stowasser","year":"1992","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1097\/01.hjh.0000174299.66369.26","article-title":"Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity","volume":"23","author":"So","year":"2005","journal-title":"J. Hypertens."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41588-018-0048-5","article-title":"CLCN2 chloride channel mutations in familial hyperaldosteronism type II","volume":"50","author":"Scholl","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41588-018-0053-8","article-title":"A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism","volume":"50","author":"Daniil","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/en.2011-1733","article-title":"Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis","volume":"153","author":"Oki","year":"2012","journal-title":"Endocrinology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jhh.2017.34","article-title":"Familial hyperaldosteronism type III","volume":"31","author":"Monticone","year":"2017","journal-title":"J. Hum. Hypertens."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49537","DOI":"10.1074\/jbc.M307723200","article-title":"Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1\/Kir3.4 K(+) channel","volume":"278","author":"Dibb","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e06315","DOI":"10.7554\/eLife.06315","article-title":"Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism","volume":"4","author":"Scholl","year":"2015","journal-title":"eLife"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1210\/en.2016-1170","article-title":"CACNA1H(M1549V) Mutant Calcium Channel Causes Autonomous Aldosterone Production in HAC15 Cells and Is Inhibited by Mibefradil","volume":"157","author":"Reimer","year":"2016","journal-title":"Endocrinology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2016.10.002","article-title":"CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism","volume":"13","author":"Daniil","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/HYPERTENSIONAHA.114.04636","article-title":"KCNJ5 mutations are the most frequent genetic alteration in primary aldosteronism","volume":"65","author":"Williams","year":"2015","journal-title":"Hypertension"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Akerstrom, T., Crona, J., Delgado Verdugo, A., Starker, L.F., Cupisti, K., Willenberg, H.S., Knoefel, W.T., Saeger, W., Feller, A., and Ip, J. (2012). Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041926"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrendo.2012.230","article-title":"Role of KCNJ5 in familial and sporadic primary aldosteronism","volume":"9","author":"Mulatero","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.113.01733","article-title":"Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas","volume":"63","author":"Williams","year":"2014","journal-title":"Hypertension"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Williams","year":"2014","journal-title":"Hypertension"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E1089","DOI":"10.1210\/jc.2015-2149","article-title":"A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma","volume":"100","author":"Lenzini","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1055\/s-0035-1565090","article-title":"KCNJ5 Mutations: Sex, Salt and Selection","volume":"47","author":"Williams","year":"2015","journal-title":"Horm. Metab. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1158\/0008-5472.CAN-05-0593","article-title":"Mutations of beta-catenin in adrenocortical tumors: Activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors","volume":"65","author":"Tissier","year":"2005","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/1470320310376424","article-title":"Factors influencing left ventricular mass regression in patients with primary aldosteronism post adrenalectomy","volume":"12","author":"Lin","year":"2011","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1097\/HJH.0000000000000186","article-title":"KCNJ5 gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism","volume":"32","author":"Rossi","year":"2014","journal-title":"J. Hypertens."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00423-013-1093-2","article-title":"Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: A population-based study from Western Norway","volume":"398","author":"Arnesen","year":"2013","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/HYPERTENSIONAHA.113.02097","article-title":"An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism","volume":"63","author":"Rossi","year":"2014","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S2213-8587(14)70069-5","article-title":"Adrenal vein sampling in primary aldosteronism: Towards a standardised protocol","volume":"3","author":"Monticone","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1210\/jc.2005-0836","article-title":"Expression profiles for steroidogenic enzymes in adrenocortical disease","volume":"90","author":"Bassett","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1210\/jc.2005-1298","article-title":"Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas","volume":"91","author":"Mayhew","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/HYPERTENSIONAHA.110.150318","article-title":"Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro","volume":"55","author":"Williams","year":"2010","journal-title":"Hypertension"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1210\/jc.2005-1309","article-title":"Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis","volume":"90","author":"Assie","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/HYPERTENSIONAHA.107.100438","article-title":"Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis","volume":"50","author":"Lenzini","year":"2007","journal-title":"Hypertension"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E4591","DOI":"10.1073\/pnas.1505529112","article-title":"Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands","volume":"112","author":"Nishimoto","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1055\/s-0043-122394","article-title":"Aldosterone-Producing Cell Clusters in Normal and Pathological States","volume":"49","author":"Omata","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1055\/s-0043-122238","article-title":"Disordered CYP11B2 Expression in Primary Aldosteronism","volume":"49","author":"Kuppusamy","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E819","DOI":"10.1210\/jc.2011-2965","article-title":"Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors","volume":"97","author":"Azizan","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E1341","DOI":"10.1210\/jc.2013-4255","article-title":"Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?","volume":"99","author":"Dekkers","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mce.2015.04.022","article-title":"Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas","volume":"411","author":"Monticone","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/cen.12873","article-title":"Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype","volume":"83","author":"Scholl","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/jc.2015-3284","article-title":"Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations","volume":"101","author":"Kitamoto","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/HYPERTENSIONAHA.115.06186","article-title":"Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas","volume":"67","author":"Williams","year":"2016","journal-title":"Hypertension"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E1567","DOI":"10.1210\/jc.2011-3132","article-title":"Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells","volume":"97","author":"Monticone","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1530\/ERC-15-0321","article-title":"Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas","volume":"22","author":"Akerstrom","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EJE-17-0563","article-title":"DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-hydroxycortisol: Is there clinical utility of these steroids?","volume":"178","author":"Lenders","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"37622","DOI":"10.1074\/jbc.M405431200","article-title":"The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. implications for the control of adrenal functional zonation","volume":"279","author":"Bassett","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1210\/jcem.83.7.5095","article-title":"DAX-1 expression in human adrenocortical neoplasms: Implications for steroidogenesis","volume":"83","author":"Reincke","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"E663","DOI":"10.1210\/jc.2010-2021","article-title":"Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal","volume":"96","author":"Lin","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.111.188532","article-title":"Visinin-like 1 is upregulated in aldosterone-producing adenomas with KCNJ5 mutations and protects from calcium-induced apoptosis","volume":"59","author":"Williams","year":"2012","journal-title":"Hypertension"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1677\/JOE-07-0037","article-title":"G-protein-coupled receptors in aldosterone-producing adenomas: A potential cause of hyperaldosteronism","volume":"195","author":"Ye","year":"2007","journal-title":"J. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1530\/EJE-10-0879","article-title":"A case of primary aldosteronism in pregnancy: Do LH and GNRH receptors have a potential role in regulating aldosterone secretion?","volume":"164","author":"Albiger","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/HYPERTENSIONAHA.116.08033","article-title":"Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues","volume":"68","author":"Zhou","year":"2016","journal-title":"Hypertension"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/HYPERTENSIONAHA.117.09231","article-title":"NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone","volume":"70","author":"Maniero","year":"2017","journal-title":"Hypertension"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mce.2017.08.019","article-title":"Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma","volume":"461","author":"Itcho","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kobuke, K., Oki, K., Gomez-Sanchez, C.E., Ohno, H., Itcho, K., Yoshii, Y., Yoneda, M., and Hattori, N. (2017). Purkinje cell protein 4 expression is associated with DNA methylation status in aldosterone-producing adenoma. J. Clin. Endocrinol. Metab.","DOI":"10.1210\/jc.2017-01996"},{"key":"ref_66","first-page":"649","article-title":"Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses","volume":"16","author":"Rasmussen","year":"1995","journal-title":"Endocr. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1161\/HYPERTENSIONAHA.117.10205","article-title":"Calneuron 1 Increased Ca(2+) in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma","volume":"71","author":"Kobuke","year":"2018","journal-title":"Hypertension"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1530\/EJE-10-1085","article-title":"Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands","volume":"164","author":"Wang","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Li, X., Wang, B., Tang, L., Zhang, Y., Chen, L., Gu, L., Zhang, F., Ouyang, J., and Zhang, X. (2017). GSTA1 expression is correlated with aldosterone level in KCNJ5-mutated adrenal aldosterone-producing adenoma. J. Clin. Endocrinol. Metab.","DOI":"10.1210\/jc.2017-00950"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2010.11.014","article-title":"The Wnt\/beta-catenin pathway in adrenocortical development and cancer","volume":"332","author":"Lalli","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/hmg\/ddt484","article-title":"WNT\/beta-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production","volume":"23","author":"Berthon","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/HYPERTENSIONAHA.117.09156","article-title":"Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin)","volume":"69","author":"Teo","year":"2017","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/HYPERTENSIONAHA.113.02234","article-title":"Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism","volume":"63","author":"Murthy","year":"2014","journal-title":"Hypertension"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Li, N.F., Li, H.J., Zhang, D.L., Zhang, J.H., Yao, X.G., Wang, H.M., Abulikemu, S., Zhou, K.M., and Zhang, X.Y. (2013). Genetic variations in the KCNJ5 gene in primary aldosteronism patients from Xinjiang, China. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054051"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.4103\/0366-6999.158318","article-title":"Gene Expression Profile of Persistent Postoperative Hypertension Patients with Aldosterone-producing Adenomas","volume":"128","author":"Xie","year":"2015","journal-title":"Chin. Med. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"29984","DOI":"10.18632\/oncotarget.16269","article-title":"Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy","volume":"8","author":"Chang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5551\/jat.24455","article-title":"Comparison of cardiovascular complications in patients with and without KCNJ5 gene mutations harboring aldosterone-producing adenomas","volume":"22","author":"Kitamoto","year":"2015","journal-title":"J. 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