{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:01:47Z","timestamp":1783576907120,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology","award":["MOST 106-2320-B-077-003-MY3"],"award-info":[{"award-number":["MOST 106-2320-B-077-003-MY3"]}]},{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare","award":["NRICM102-DBCM04-D1"],"award-info":[{"award-number":["NRICM102-DBCM04-D1"]}]},{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare","award":["MOHW103-NRICM-D-315-122104"],"award-info":[{"award-number":["MOHW103-NRICM-D-315-122104"]}]},{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare","award":["MOHW103-NRICM-D-315-122104"],"award-info":[{"award-number":["MOHW103-NRICM-D-315-122104"]}]},{"name":"Medical Research Center, Cardinal Tien Hospital","award":["CTH-101-1-2A01"],"award-info":[{"award-number":["CTH-101-1-2A01"]}]},{"name":"Medical Research Center, Cardinal Tien Hospital","award":["CTH-102-1-2A13"],"award-info":[{"award-number":["CTH-102-1-2A13"]}]},{"name":"Medical Research Center, Cardinal Tien Hospital","award":["CTH-102-1-2A12"],"award-info":[{"award-number":["CTH-102-1-2A12"]}]},{"name":"Medical Research Center, Cardinal Tien Hospital","award":["CTH-103-1-2A15"],"award-info":[{"award-number":["CTH-103-1-2A15"]}]},{"name":"Medical Research Center, Cardinal Tien Hospital","award":["CTH-104-1-2A11"],"award-info":[{"award-number":["CTH-104-1-2A11"]}]},{"name":"Ministry of Health and Welfare","award":["5257451000"],"award-info":[{"award-number":["5257451000"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Liu Jun Zi Tang (LJZT) has been used to treat functional dyspepsia and depression, suggesting its effects on gastrointestinal and neurological functions. LJZT is currently used as a complementary therapy to attenuate cisplatin-induced side effects, such as dyspepsia. However, its effect on chemotherapy-induced neuropathic pain or neurotoxicity has rarely been studied. Thus, we explored potential mechanisms underlying LJZT protection against cisplatin-induced neurotoxicity. We observed that LJZT attenuated cisplatin-induced thermal hyperalgesia in mice and apoptosis in human neuroblastoma SH-SY5Y cells. Furthermore, it also attenuated cisplatin-induced cytosolic and mitochondrial free radical formation, reversed the cisplatin-induced decrease in mitochondrial membrane potential, and increased the release of mitochondrial pro-apoptotic factors. LJZT not only activated the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1\u03b1) promoter region, but also attenuated the cisplatin-induced reduction of PGC-1\u03b1 expression. Silencing of the PGC-1\u03b1 gene counteracted the protection of LJZT. Taken together, LJZT mediated, through anti-oxidative effect and mitochondrial function regulation, to prevent cisplatin-induced neurotoxicity.<\/jats:p>","DOI":"10.3390\/ijms19041258","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T04:44:48Z","timestamp":1524545088000},"page":"1258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Liu Jun Zi Tang\u2014A Potential, Multi-Herbal Complementary Therapy for Chemotherapy-Induced Neurotoxicity"],"prefix":"10.3390","volume":"19","author":[{"given":"Chun-Tang","family":"Chiou","sequence":"first","affiliation":[{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaw-Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardinal-Tien Hospital, New Taipei City 231, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen-Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Research Center, Cardinal Tien Hospital, Hsintien, New Taipei City 231, Taiwan"},{"name":"Graduate Institute of Physiology &amp; Department of Physiology and Biophysics, National Defense Medical Center, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien-Hung","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Chang Gung University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Haur","family":"Kuo","sequence":"additional","affiliation":[{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11031, Taiwan"},{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-1856","authenticated-orcid":false,"given":"Nai-Kuei","family":"Huang","sequence":"additional","affiliation":[{"name":"National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11031, Taiwan"},{"name":"Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"ref_1","unstructured":"Yang, J., Huang, H., and Zhu, L.J. 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